Details of the Target

General Information of Target

Target ID LDTP03247
Target Name Eukaryotic translation initiation factor 4B (EIF4B)
Gene Name EIF4B
Gene ID 1975
Synonyms
Eukaryotic translation initiation factor 4B; eIF-4B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADETDDLEGDVSTTWHSNDD
DVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLN
ISAVRLPREPSNPERLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQAQDKDRD
DRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDG
YRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYED
RYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKLNLKPRSTPKEDDSSASTSQSTRAASI
FGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEETQERERSRT
GSESSQTGTSTTSSRNARRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPK
ENAWVKRSSNPPARSQSSDTEQQSPTSGGGKVAPAQPSEEGPGRKDENKVDGMNAPKGQT
GNSSRGPGDGGNRDHWKESDRKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDG
EDENEGEDYAE
Target Bioclass
Other
Function
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
Uniprot ID
P23588
Ensemble ID
ENST00000262056.14
HGNC ID
HGNC:3285
ChEMBL ID
CHEMBL3308928

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.W199R DBIA    Probe Info 
HCT15 SNV: p.G428E .
Ishikawa (Heraklio) 02 ER SNV: p.N189K DBIA    Probe Info 
J82 SNV: p.Q388R DBIA    Probe Info 
SF295 SNV: p.P467H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AZ-9
 Probe Info  		8.93  LDD0393  [2]
C-Sul
 Probe Info  		6.91  LDD0066  [3]
FBP2
 Probe Info  		3.46  LDD0323  [4]
TH211
 Probe Info  		Y224(20.00); Y105(5.47)  LDD0257  [5]
STPyne
 Probe Info  		K223(10.00); K365(7.71); K386(4.71); K480(0.63)  LDD0277  [6]
ONAyne
 Probe Info  		K453(10.00)  LDD0275  [6]
Probe 1
 Probe Info  		Y211(14.02); Y228(44.29); Y233(92.71); Y237(26.61)  LDD3495  [7]
DBIA
 Probe Info  		C457(1.48)  LDD3319  [8]
AHL-Pu-1
 Probe Info  		C457(14.32)  LDD0168  [9]
HHS-482
 Probe Info  		Y224(1.26)  LDD0285  [10]
HHS-475
 Probe Info  		Y211(0.60); Y237(0.77); Y291(0.85); Y270(0.85)  LDD0264  [11]
HHS-465
 Probe Info  		Y228(10.00); Y233(10.00); Y237(10.00); Y258(10.00)  LDD2237  [12]
5E-2FA
 Probe Info  		N.A.  LDD2235  [13]
ATP probe
 Probe Info  		K365(0.00); K177(0.00); K223(0.00)  LDD0199  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [15]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [15]
ATP probe
 Probe Info  		K511(0.00); K223(0.00)  LDD0035  [17]
BTD
 Probe Info  		N.A.  LDD0004  [18]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [19]
NAIA_5
 Probe Info  		N.A.  LDD2224  [20]
WYneN
 Probe Info  		N.A.  LDD0021  [18]
WYneO
 Probe Info  		N.A.  LDD0022  [18]
aHNE
 Probe Info  		N.A.  LDD0001  [18]
1d-yne
 Probe Info  		K453(0.00); K463(0.00)  LDD0356  [21]
IPM
 Probe Info  		N.A.  LDD0005  [18]
NHS
 Probe Info  		K511(0.00); K480(0.00); K365(0.00)  LDD0010  [18]
PPMS
 Probe Info  		N.A.  LDD0008  [18]
SF
 Probe Info  		Y285(0.00); Y211(0.00); Y291(0.00); Y298(0.00)  LDD0028  [22]
VSF
 Probe Info  		N.A.  LDD0007  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [23]
Ox-W18
 Probe Info  		N.A.  LDD2175  [24]
1c-yne
 Probe Info  		K113(0.00); K343(0.00)  LDD0228  [21]
Acrolein
 Probe Info  		H56(0.00); C457(0.00)  LDD0217  [25]
AOyne
 Probe Info  		11.60  LDD0443  [26]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		7.16  LDD1779  [27]
C232
 Probe Info  		33.82  LDD1905  [27]
C284
 Probe Info  		22.01  LDD1954  [27]
C353
 Probe Info  		5.94  LDD2014  [27]
C361
 Probe Info  		23.92  LDD2022  [27]
FFF probe11
 Probe Info  		8.77  LDD0471  [28]
FFF probe12
 Probe Info  		12.21  LDD0473  [28]
FFF probe13
 Probe Info  		20.00  LDD0475  [28]
FFF probe2
 Probe Info  		16.07  LDD0463  [28]
FFF probe3
 Probe Info  		16.92  LDD0464  [28]
JN0003
 Probe Info  		9.73  LDD0469  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C457(0.71)  LDD2142  [29]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C457(1.13)  LDD2112  [29]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C457(0.95)  LDD2095  [29]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C457(0.73)  LDD2117  [29]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C457(1.45)  LDD2152  [29]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C457(0.81)  LDD2103  [29]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C457(0.80)  LDD2132  [29]
 LDCM0025  4SU-RNA HEK-293T C457(14.32)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C457(4.70)  LDD0169  [9]
 LDCM0214  AC1 HEK-293T C457(0.98)  LDD1507  [30]
 LDCM0215  AC10 HEK-293T C457(0.83)  LDD1508  [30]
 LDCM0226  AC11 HEK-293T C457(0.92)  LDD1509  [30]
 LDCM0237  AC12 HEK-293T C457(0.84)  LDD1510  [30]
 LDCM0259  AC14 HEK-293T C457(0.91)  LDD1512  [30]
 LDCM0270  AC15 HEK-293T C457(0.83)  LDD1513  [30]
 LDCM0276  AC17 HEK-293T C457(0.95)  LDD1515  [30]
 LDCM0277  AC18 HEK-293T C457(0.98)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C457(0.91)  LDD1517  [30]
 LDCM0279  AC2 HEK-293T C457(0.88)  LDD1518  [30]
 LDCM0280  AC20 HEK-293T C457(0.91)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C457(0.95)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C457(0.96)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C457(0.96)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C457(0.92)  LDD1523  [30]
 LDCM0285  AC25 HEK-293T C457(0.94)  LDD1524  [30]
 LDCM0286  AC26 HEK-293T C457(0.87)  LDD1525  [30]
 LDCM0287  AC27 HEK-293T C457(1.01)  LDD1526  [30]
 LDCM0288  AC28 HEK-293T C457(0.87)  LDD1527  [30]
 LDCM0289  AC29 HEK-293T C457(0.98)  LDD1528  [30]
 LDCM0290  AC3 HEK-293T C457(0.95)  LDD1529  [30]
 LDCM0291  AC30 HEK-293T C457(0.92)  LDD1530  [30]
 LDCM0292  AC31 HEK-293T C457(0.89)  LDD1531  [30]
 LDCM0293  AC32 HEK-293T C457(0.97)  LDD1532  [30]
 LDCM0294  AC33 HEK-293T C457(0.95)  LDD1533  [30]
 LDCM0295  AC34 HEK-293T C457(0.81)  LDD1534  [30]
 LDCM0296  AC35 HEK-293T C457(0.93)  LDD1535  [30]
 LDCM0297  AC36 HEK-293T C457(0.84)  LDD1536  [30]
 LDCM0298  AC37 HEK-293T C457(0.93)  LDD1537  [30]
 LDCM0299  AC38 HEK-293T C457(0.89)  LDD1538  [30]
 LDCM0300  AC39 HEK-293T C457(0.84)  LDD1539  [30]
 LDCM0301  AC4 HEK-293T C457(0.87)  LDD1540  [30]
 LDCM0302  AC40 HEK-293T C457(0.97)  LDD1541  [30]
 LDCM0303  AC41 HEK-293T C457(1.02)  LDD1542  [30]
 LDCM0304  AC42 HEK-293T C457(0.81)  LDD1543  [30]
 LDCM0305  AC43 HEK-293T C457(0.92)  LDD1544  [30]
 LDCM0306  AC44 HEK-293T C457(0.81)  LDD1545  [30]
 LDCM0307  AC45 HEK-293T C457(0.89)  LDD1546  [30]
 LDCM0308  AC46 HEK-293T C457(0.83)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C457(0.77)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C457(0.92)  LDD1549  [30]
 LDCM0311  AC49 HEK-293T C457(0.92)  LDD1550  [30]
 LDCM0312  AC5 HEK-293T C457(0.97)  LDD1551  [30]
 LDCM0313  AC50 HEK-293T C457(0.89)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C457(0.93)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C457(0.85)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C457(0.93)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C457(0.88)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C457(0.87)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C457(1.05)  LDD1558  [30]
 LDCM0320  AC57 HEK-293T C457(0.95)  LDD1559  [30]
 LDCM0321  AC58 HEK-293T C457(0.82)  LDD1560  [30]
 LDCM0322  AC59 HEK-293T C457(0.89)  LDD1561  [30]
 LDCM0323  AC6 HEK-293T C457(0.99)  LDD1562  [30]
 LDCM0324  AC60 HEK-293T C457(0.84)  LDD1563  [30]
 LDCM0325  AC61 HEK-293T C457(0.87)  LDD1564  [30]
 LDCM0326  AC62 HEK-293T C457(0.80)  LDD1565  [30]
 LDCM0327  AC63 HEK-293T C457(0.82)  LDD1566  [30]
 LDCM0328  AC64 HEK-293T C457(0.92)  LDD1567  [30]
 LDCM0334  AC7 HEK-293T C457(0.93)  LDD1568  [30]
 LDCM0345  AC8 HEK-293T C457(0.92)  LDD1569  [30]
 LDCM0545  Acetamide MDA-MB-231 C457(0.37)  LDD2138  [29]
 LDCM0248  AKOS034007472 HEK-293T C457(0.91)  LDD1511  [30]
 LDCM0356  AKOS034007680 HEK-293T C457(0.93)  LDD1570  [30]
 LDCM0275  AKOS034007705 HEK-293T C457(0.90)  LDD1514  [30]
 LDCM0156  Aniline NCI-H1299 14.56  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C457(0.56)  LDD2091  [29]
 LDCM0108  Chloroacetamide HeLa H56(0.00); H404(0.00); C457(0.00)  LDD0222  [25]
 LDCM0632  CL-Sc Hep-G2 C457(0.99); C457(0.51)  LDD2227  [20]
 LDCM0367  CL1 HEK-293T C457(0.83)  LDD1571  [30]
 LDCM0368  CL10 HEK-293T C457(0.84)  LDD1572  [30]
 LDCM0369  CL100 HEK-293T C457(0.94)  LDD1573  [30]
 LDCM0370  CL101 HEK-293T C457(0.88)  LDD1574  [30]
 LDCM0371  CL102 HEK-293T C457(0.78)  LDD1575  [30]
 LDCM0372  CL103 HEK-293T C457(0.91)  LDD1576  [30]
 LDCM0373  CL104 HEK-293T C457(0.90)  LDD1577  [30]
 LDCM0374  CL105 HEK-293T C457(0.94)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C457(0.95)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C457(0.95)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C457(1.02)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C457(0.89)  LDD1582  [30]
 LDCM0379  CL11 HEK-293T C457(0.90)  LDD1583  [30]
 LDCM0380  CL110 HEK-293T C457(0.84)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C457(0.88)  LDD1585  [30]
 LDCM0382  CL112 HEK-293T C457(0.95)  LDD1586  [30]
 LDCM0383  CL113 HEK-293T C457(0.89)  LDD1587  [30]
 LDCM0384  CL114 HEK-293T C457(0.79)  LDD1588  [30]
 LDCM0385  CL115 HEK-293T C457(0.94)  LDD1589  [30]
 LDCM0386  CL116 HEK-293T C457(0.88)  LDD1590  [30]
 LDCM0387  CL117 HEK-293T C457(0.83)  LDD1591  [30]
 LDCM0388  CL118 HEK-293T C457(0.76)  LDD1592  [30]
 LDCM0389  CL119 HEK-293T C457(0.91)  LDD1593  [30]
 LDCM0390  CL12 HEK-293T C457(1.05)  LDD1594  [30]
 LDCM0391  CL120 HEK-293T C457(0.82)  LDD1595  [30]
 LDCM0392  CL121 HEK-293T C457(0.86)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C457(0.85)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C457(0.80)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C457(0.90)  LDD1599  [30]
 LDCM0396  CL125 HEK-293T C457(0.74)  LDD1600  [30]
 LDCM0397  CL126 HEK-293T C457(0.75)  LDD1601  [30]
 LDCM0398  CL127 HEK-293T C457(0.85)  LDD1602  [30]
 LDCM0399  CL128 HEK-293T C457(0.80)  LDD1603  [30]
 LDCM0400  CL13 HEK-293T C457(0.80)  LDD1604  [30]
 LDCM0401  CL14 HEK-293T C457(0.81)  LDD1605  [30]
 LDCM0402  CL15 HEK-293T C457(0.80)  LDD1606  [30]
 LDCM0403  CL16 HEK-293T C457(0.84)  LDD1607  [30]
 LDCM0404  CL17 HEK-293T C457(0.87)  LDD1608  [30]
 LDCM0405  CL18 HEK-293T C457(0.89)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C457(0.92)  LDD1610  [30]
 LDCM0407  CL2 HEK-293T C457(0.92)  LDD1611  [30]
 LDCM0408  CL20 HEK-293T C457(0.96)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C457(0.90)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C457(0.91)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C457(0.97)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C457(1.24)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C457(0.88)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C457(0.98)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C457(0.97)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C457(1.06)  LDD1620  [30]
 LDCM0417  CL29 HEK-293T C457(0.99)  LDD1621  [30]
 LDCM0418  CL3 HEK-293T C457(0.93)  LDD1622  [30]
 LDCM0419  CL30 HEK-293T C457(0.97)  LDD1623  [30]
 LDCM0420  CL31 HEK-293T C457(0.98)  LDD1624  [30]
 LDCM0421  CL32 HEK-293T C457(1.01)  LDD1625  [30]
 LDCM0422  CL33 HEK-293T C457(0.88)  LDD1626  [30]
 LDCM0423  CL34 HEK-293T C457(1.00)  LDD1627  [30]
 LDCM0424  CL35 HEK-293T C457(1.13)  LDD1628  [30]
 LDCM0425  CL36 HEK-293T C457(1.41)  LDD1629  [30]
 LDCM0426  CL37 HEK-293T C457(0.88)  LDD1630  [30]
 LDCM0428  CL39 HEK-293T C457(0.93)  LDD1632  [30]
 LDCM0429  CL4 HEK-293T C457(0.86)  LDD1633  [30]
 LDCM0430  CL40 HEK-293T C457(1.01)  LDD1634  [30]
 LDCM0431  CL41 HEK-293T C457(0.93)  LDD1635  [30]
 LDCM0432  CL42 HEK-293T C457(1.01)  LDD1636  [30]
 LDCM0433  CL43 HEK-293T C457(1.00)  LDD1637  [30]
 LDCM0434  CL44 HEK-293T C457(0.94)  LDD1638  [30]
 LDCM0435  CL45 HEK-293T C457(0.95)  LDD1639  [30]
 LDCM0436  CL46 HEK-293T C457(0.98)  LDD1640  [30]
 LDCM0437  CL47 HEK-293T C457(1.04)  LDD1641  [30]
 LDCM0438  CL48 HEK-293T C457(1.24)  LDD1642  [30]
 LDCM0439  CL49 HEK-293T C457(0.80)  LDD1643  [30]
 LDCM0440  CL5 HEK-293T C457(1.00)  LDD1644  [30]
 LDCM0441  CL50 HEK-293T C457(0.80)  LDD1645  [30]
 LDCM0443  CL52 HEK-293T C457(0.92)  LDD1646  [30]
 LDCM0444  CL53 HEK-293T C457(0.85)  LDD1647  [30]
 LDCM0445  CL54 HEK-293T C457(0.79)  LDD1648  [30]
 LDCM0446  CL55 HEK-293T C457(0.96)  LDD1649  [30]
 LDCM0447  CL56 HEK-293T C457(0.96)  LDD1650  [30]
 LDCM0448  CL57 HEK-293T C457(0.85)  LDD1651  [30]
 LDCM0449  CL58 HEK-293T C457(0.95)  LDD1652  [30]
 LDCM0450  CL59 HEK-293T C457(0.90)  LDD1653  [30]
 LDCM0451  CL6 HEK-293T C457(0.88)  LDD1654  [30]
 LDCM0452  CL60 HEK-293T C457(1.20)  LDD1655  [30]
 LDCM0453  CL61 HEK-293T C457(0.82)  LDD1656  [30]
 LDCM0454  CL62 HEK-293T C457(0.87)  LDD1657  [30]
 LDCM0455  CL63 HEK-293T C457(0.96)  LDD1658  [30]
 LDCM0456  CL64 HEK-293T C457(0.84)  LDD1659  [30]
 LDCM0457  CL65 HEK-293T C457(0.95)  LDD1660  [30]
 LDCM0458  CL66 HEK-293T C457(0.86)  LDD1661  [30]
 LDCM0459  CL67 HEK-293T C457(0.93)  LDD1662  [30]
 LDCM0460  CL68 HEK-293T C457(0.93)  LDD1663  [30]
 LDCM0461  CL69 HEK-293T C457(0.94)  LDD1664  [30]
 LDCM0462  CL7 HEK-293T C457(0.97)  LDD1665  [30]
 LDCM0463  CL70 HEK-293T C457(0.93)  LDD1666  [30]
 LDCM0464  CL71 HEK-293T C457(0.86)  LDD1667  [30]
 LDCM0465  CL72 HEK-293T C457(1.02)  LDD1668  [30]
 LDCM0466  CL73 HEK-293T C457(0.84)  LDD1669  [30]
 LDCM0467  CL74 HEK-293T C457(0.90)  LDD1670  [30]
 LDCM0469  CL76 HEK-293T C457(1.01)  LDD1672  [30]
 LDCM0470  CL77 HEK-293T C457(0.88)  LDD1673  [30]
 LDCM0471  CL78 HEK-293T C457(0.90)  LDD1674  [30]
 LDCM0472  CL79 HEK-293T C457(0.94)  LDD1675  [30]
 LDCM0473  CL8 HEK-293T C457(0.68)  LDD1676  [30]
 LDCM0474  CL80 HEK-293T C457(0.97)  LDD1677  [30]
 LDCM0475  CL81 HEK-293T C457(1.03)  LDD1678  [30]
 LDCM0476  CL82 HEK-293T C457(0.93)  LDD1679  [30]
 LDCM0477  CL83 HEK-293T C457(0.96)  LDD1680  [30]
 LDCM0478  CL84 HEK-293T C457(1.01)  LDD1681  [30]
 LDCM0479  CL85 HEK-293T C457(0.76)  LDD1682  [30]
 LDCM0480  CL86 HEK-293T C457(0.74)  LDD1683  [30]
 LDCM0481  CL87 HEK-293T C457(0.82)  LDD1684  [30]
 LDCM0482  CL88 HEK-293T C457(0.78)  LDD1685  [30]
 LDCM0483  CL89 HEK-293T C457(0.93)  LDD1686  [30]
 LDCM0484  CL9 HEK-293T C457(0.97)  LDD1687  [30]
 LDCM0485  CL90 HEK-293T C457(0.63)  LDD1688  [30]
 LDCM0486  CL91 HEK-293T C457(0.85)  LDD1689  [30]
 LDCM0487  CL92 HEK-293T C457(0.82)  LDD1690  [30]
 LDCM0488  CL93 HEK-293T C457(0.82)  LDD1691  [30]
 LDCM0489  CL94 HEK-293T C457(0.90)  LDD1692  [30]
 LDCM0490  CL95 HEK-293T C457(0.69)  LDD1693  [30]
 LDCM0491  CL96 HEK-293T C457(1.05)  LDD1694  [30]
 LDCM0492  CL97 HEK-293T C457(0.89)  LDD1695  [30]
 LDCM0493  CL98 HEK-293T C457(0.95)  LDD1696  [30]
 LDCM0494  CL99 HEK-293T C457(0.95)  LDD1697  [30]
 LDCM0495  E2913 HEK-293T C457(0.98)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C457(0.83)  LDD1702  [29]
 LDCM0468  Fragment33 HEK-293T C457(0.92)  LDD1671  [30]
 LDCM0427  Fragment51 HEK-293T C457(0.92)  LDD1631  [30]
 LDCM0116  HHS-0101 DM93 Y211(0.60); Y237(0.77); Y291(0.85); Y270(0.85)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y211(0.48); Y224(0.70); Y258(0.73); Y302(0.78)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y258(0.44); Y211(0.58); Y237(0.59); Y233(0.82)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y211(0.25); Y237(0.55); Y105(0.71); Y302(0.76)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y258(0.39); Y291(0.56); Y302(0.58); Y233(0.65)  LDD0268  [11]
 LDCM0107  IAA HeLa H56(0.00); H404(0.00)  LDD0221  [25]
 LDCM0123  JWB131 DM93 Y224(1.26)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y224(1.46)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y224(0.99)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y224(4.02)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y224(1.91)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y224(0.08)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y224(1.04)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y224(0.96)  LDD0292  [10]
 LDCM0022  KB02 HEK-293T C457(1.01)  LDD1492  [30]
 LDCM0023  KB03 HEK-293T C457(1.04)  LDD1497  [30]
 LDCM0024  KB05 MEWO C457(1.48)  LDD3319  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C457(0.54)  LDD2121  [29]
 LDCM0109  NEM HeLa N.A.  LDD0223  [25]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C457(0.68)  LDD2089  [29]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C457(0.93)  LDD2092  [29]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C457(1.04)  LDD2093  [29]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C457(1.10)  LDD2096  [29]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C457(0.85)  LDD2100  [29]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C457(0.62)  LDD2106  [29]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C457(1.10)  LDD2108  [29]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C457(0.81)  LDD2109  [29]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C457(0.64)  LDD2114  [29]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C457(1.12)  LDD2116  [29]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C457(1.19)  LDD2118  [29]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C457(1.45)  LDD2122  [29]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C457(0.93)  LDD2123  [29]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C457(1.29)  LDD2126  [29]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C457(0.97)  LDD2127  [29]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C457(0.99)  LDD2134  [29]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C457(0.94)  LDD2146  [29]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C457(2.01)  LDD2147  [29]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C457(1.04)  LDD2149  [29]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C457(1.19)  LDD2151  [29]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Serine/threonine-protein kinase PLK1 (PLK1) Ser/Thr protein kinase family P53350
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

References

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2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
23 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
24 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402