Details of the Target

General Information of Target

Target ID LDTP06022
Target Name Cold-inducible RNA-binding protein (CIRBP)
Gene Name CIRBP
Gene ID 1153
Synonyms
A18HNRNP; CIRP; Cold-inducible RNA-binding protein; A18 hnRNP; Glycine-rich RNA-binding protein CIRP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDA
KDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGD
RGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYATHNE
Target Bioclass
Other
Subcellular location
Nucleus, nucleoplasm
Function
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed.
Uniprot ID
Q14011
Ensemble ID
ENST00000320936.9
HGNC ID
HGNC:1982

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K84(7.14)  LDD0274  [1]
Acrolein
 Probe Info  		N.A.  LDD0223  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
SF
 Probe Info  		Y151(0.00); Y164(0.00)  LDD0028  [5]
1c-yne
 Probe Info  		K84(0.00); K61(0.00)  LDD0228  [6]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [2]
PAL-AfBPP Probe
Click To Hide/Show 44 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		7.11  LDD1740  [7]
C041
 Probe Info  		5.70  LDD1741  [7]
C063
 Probe Info  		13.00  LDD1760  [7]
C087
 Probe Info  		13.00  LDD1779  [7]
C106
 Probe Info  		17.75  LDD1793  [7]
C108
 Probe Info  		8.22  LDD1795  [7]
C139
 Probe Info  		10.56  LDD1821  [7]
C145
 Probe Info  		12.47  LDD1827  [7]
C147
 Probe Info  		6.54  LDD1829  [7]
C228
 Probe Info  		15.67  LDD1901  [7]
C232
 Probe Info  		56.10  LDD1905  [7]
C249
 Probe Info  		13.18  LDD1922  [7]
C284
 Probe Info  		21.11  LDD1954  [7]
C293
 Probe Info  		18.51  LDD1963  [7]
C296
 Probe Info  		12.73  LDD1966  [7]
C302
 Probe Info  		6.23  LDD1971  [7]
C305
 Probe Info  		12.55  LDD1974  [7]
C313
 Probe Info  		17.51  LDD1980  [7]
C314
 Probe Info  		13.36  LDD1981  [7]
C322
 Probe Info  		6.28  LDD1988  [7]
C326
 Probe Info  		8.17  LDD1990  [7]
C338
 Probe Info  		16.68  LDD2001  [7]
C346
 Probe Info  		12.21  LDD2007  [7]
C347
 Probe Info  		5.17  LDD2008  [7]
C348
 Probe Info  		12.30  LDD2009  [7]
C350
 Probe Info  		23.75  LDD2011  [7]
C353
 Probe Info  		8.75  LDD2014  [7]
C354
 Probe Info  		7.73  LDD2015  [7]
C355
 Probe Info  		31.78  LDD2016  [7]
C356
 Probe Info  		7.89  LDD2017  [7]
C361
 Probe Info  		32.00  LDD2022  [7]
C364
 Probe Info  		14.83  LDD2025  [7]
C380
 Probe Info  		5.54  LDD2039  [7]
C382
 Probe Info  		10.34  LDD2041  [7]
C383
 Probe Info  		13.45  LDD2042  [7]
C389
 Probe Info  		5.70  LDD2048  [7]
C390
 Probe Info  		24.59  LDD2049  [7]
C391
 Probe Info  		23.59  LDD2050  [7]
C429
 Probe Info  		12.04  LDD2084  [7]
C430
 Probe Info  		5.46  LDD2085  [7]
C431
 Probe Info  		16.56  LDD2086  [7]
C433
 Probe Info  		6.59  LDD2088  [7]
FFF probe13
 Probe Info  		20.00  LDD0475  [8]
FFF probe2
 Probe Info  		20.00  LDD0463  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) KHDRBS family Q5VWX1
U1 small nuclear ribonucleoprotein A (SNRPA) RRM U1 A/B'' family P09012
Serine/arginine-rich splicing factor 3 (SRSF3) Splicing factor SR family P84103
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
RNA-binding motif protein, X chromosome (RBMX) . P38159
RNA-binding motif protein, Y chromosome, family 1 member A1 (RBMY1A1) . P0DJD3
RNA-binding motif protein, Y chromosome, family 1 member F/J (RBMY1F; RBMY1J) . Q15415

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.