Details of the Target

General Information of Target

Target ID LDTP07655
Target Name Pre-mRNA 3'-end-processing factor FIP1 (FIP1L1)
Gene Name FIP1L1
Gene ID 81608
Synonyms
FIP1; RHE; Pre-mRNA 3'-end-processing factor FIP1; hFip1; FIP1-like 1 protein; Factor interacting with PAP; Rearranged in hypereosinophilia
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAGEVERLVSELSGGTGGDEEEEWLYGGPWDVHVHSDLAKDLDENEVERPEEENASANP
PSGIEDETAENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNL
NIKTGGRVYGTTGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGF
NEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITAEDCTMEVTPGAEIQDGRFNLFKVQQGR
TGNSEKETALPSTKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYG
RAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATEVDNNFSKPPPFF
PPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRS
ARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERE
RTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETR
HKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE
Target Bioclass
Other
Family
FIP1 family
Subcellular location
Nucleus
Function
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex.
Uniprot ID
Q6UN15
Ensemble ID
ENST00000306932.10
HGNC ID
HGNC:19124

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.E93K DBIA    Probe Info 
HT115 SNV: p.S37G .
IM95 SNV: p.R481H DBIA    Probe Info 
JHH7 SNV: p.N428K .
KASUMI1 Deletion: p.G126KfsTer16 .
KYSE510 SNV: p.G133E DBIA    Probe Info 
MEWO Deletion: p.I321LfsTer5;p.I323TfsTer4
SNV: p.P432L		 DBIA    Probe Info 
MM1S SNV: p.G179R .
SKMM2 SNV: p.D20G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.62  LDD0402  [1]
TH211
 Probe Info  		Y454(13.07)  LDD0257  [2]
STPyne
 Probe Info  		K191(10.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y129(151.80)  LDD3495  [4]
IA-alkyne
 Probe Info  		C216(1.11)  LDD0304  [5]
HHS-475
 Probe Info  		Y113(1.20)  LDD0264  [6]
DBIA
 Probe Info  		C216(1.09)  LDD0532  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
NAIA_5
 Probe Info  		N.A.  LDD2224  [9]
IPM
 Probe Info  		N.A.  LDD2156  [10]
SF
 Probe Info  		N.A.  LDD0028  [11]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
HHS-465
 Probe Info  		Y113(0.00); K123(0.00)  LDD2240  [16]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C229
 Probe Info  		8.63  LDD1902  [17]
C231
 Probe Info  		13.64  LDD1904  [17]
C232
 Probe Info  		53.45  LDD1905  [17]
C233
 Probe Info  		11.96  LDD1906  [17]
C234
 Probe Info  		6.87  LDD1907  [17]
C235
 Probe Info  		22.01  LDD1908  [17]
C361
 Probe Info  		17.03  LDD2022  [17]
FFF probe13
 Probe Info  		20.00  LDD0475  [18]
FFF probe2
 Probe Info  		12.70  LDD0463  [18]
FFF probe3
 Probe Info  		20.00  LDD0464  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C216(1.20)  LDD1507  [19]
 LDCM0215  AC10 HCT 116 C216(1.09)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C216(1.12)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C216(1.25)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C216(0.98)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C216(1.42)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C216(1.18)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C216(1.17)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C216(1.22)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C216(1.41)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C216(1.18)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C216(0.79)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C216(1.28)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C216(1.22)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C216(1.21)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C216(1.37)  LDD0546  [7]
 LDCM0237  AC12 HCT 116 C216(1.07)  LDD0554  [7]
 LDCM0259  AC14 HCT 116 C216(1.01)  LDD0576  [7]
 LDCM0270  AC15 HCT 116 C216(0.75)  LDD0587  [7]
 LDCM0276  AC17 HCT 116 C216(0.93)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C216(0.68)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C216(0.69)  LDD0595  [7]
 LDCM0279  AC2 HEK-293T C216(1.14)  LDD1518  [19]
 LDCM0280  AC20 HCT 116 C216(1.00)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C216(0.82)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C216(0.91)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C216(0.83)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C216(0.99)  LDD0601  [7]
 LDCM0285  AC25 HEK-293T C216(1.03)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C216(1.05)  LDD1525  [19]
 LDCM0287  AC27 HEK-293T C216(0.97)  LDD1526  [19]
 LDCM0288  AC28 HEK-293T C216(0.92)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C216(1.03)  LDD1528  [19]
 LDCM0290  AC3 HEK-293T C216(1.08)  LDD1529  [19]
 LDCM0291  AC30 HEK-293T C216(0.84)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C216(0.97)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C216(1.19)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C216(1.11)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C216(1.22)  LDD1534  [19]
 LDCM0296  AC35 HEK-293T C216(1.04)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C216(0.98)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C216(1.16)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C216(0.97)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C216(1.09)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C216(0.85)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C216(1.30)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C216(1.09)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C216(0.99)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C216(1.23)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C216(1.00)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C216(1.08)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C216(0.97)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C216(1.04)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C216(1.15)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C216(1.03)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C216(1.07)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C216(1.00)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C216(1.18)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C216(0.99)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C216(1.04)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C216(1.00)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C216(1.10)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C216(1.11)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C216(1.04)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C216(1.15)  LDD1560  [19]
 LDCM0322  AC59 HEK-293T C216(1.20)  LDD1561  [19]
 LDCM0323  AC6 HCT 116 C216(1.00)  LDD0640  [7]
 LDCM0324  AC60 HEK-293T C216(1.02)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C216(1.03)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C216(0.91)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C216(0.96)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C216(1.07)  LDD1567  [19]
 LDCM0334  AC7 HCT 116 C216(0.94)  LDD0651  [7]
 LDCM0345  AC8 HCT 116 C216(0.83)  LDD0662  [7]
 LDCM0349  AC83 HCT 116 C216(1.25)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C216(1.53)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C216(1.50)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C216(1.75)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C216(1.35)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C216(1.43)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C216(1.21)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C216(1.46)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C216(1.14)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C216(1.10)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C216(1.40)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C216(1.10)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C216(1.50)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C216(0.96)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C216(1.82)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C216(1.34)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C216(1.03)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C216(1.32)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C216(1.39)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C216(1.01)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 11.02  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [15]
 LDCM0367  CL1 HEK-293T C216(0.94)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C216(0.85)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C216(0.97)  LDD1573  [19]
 LDCM0370  CL101 HCT 116 C216(0.94)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C216(0.82)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C216(0.80)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C216(0.91)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C216(0.76)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C216(0.60)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C216(0.69)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C216(0.75)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C216(0.92)  LDD0695  [7]
 LDCM0379  CL11 HEK-293T C216(1.03)  LDD1583  [19]
 LDCM0380  CL110 HCT 116 C216(0.91)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C216(0.92)  LDD0698  [7]
 LDCM0382  CL112 HEK-293T C216(0.97)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C216(0.96)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C216(0.81)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C216(0.96)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C216(1.05)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C216(0.88)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C216(1.02)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C216(0.93)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C216(1.37)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C216(0.93)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C216(1.02)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C216(0.91)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C216(0.70)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C216(1.13)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C216(1.10)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C216(0.94)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C216(0.78)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C216(1.12)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C216(0.96)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C216(0.92)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C216(0.83)  LDD1606  [19]
 LDCM0403  CL16 HCT 116 C216(1.02)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C216(0.69)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C216(0.91)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C216(0.79)  LDD0723  [7]
 LDCM0407  CL2 HEK-293T C216(1.11)  LDD1611  [19]
 LDCM0408  CL20 HCT 116 C216(0.81)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C216(0.76)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C216(0.92)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C216(0.89)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C216(0.94)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C216(0.88)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C216(0.98)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C216(1.04)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C216(1.01)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C216(0.92)  LDD0734  [7]
 LDCM0418  CL3 HEK-293T C216(1.16)  LDD1622  [19]
 LDCM0419  CL30 HCT 116 C216(0.90)  LDD0736  [7]
 LDCM0420  CL31 HEK-293T C216(1.09)  LDD1624  [19]
 LDCM0421  CL32 HCT 116 C216(1.12)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C216(0.98)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C216(1.07)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C216(1.26)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C216(1.03)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C216(0.99)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C216(1.18)  LDD0745  [7]
 LDCM0429  CL4 HEK-293T C216(1.15)  LDD1633  [19]
 LDCM0430  CL40 HCT 116 C216(1.04)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C216(1.23)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C216(1.20)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C216(1.05)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C216(1.04)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C216(1.20)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C216(1.12)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C216(0.99)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C216(1.26)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C216(0.93)  LDD0756  [7]
 LDCM0440  CL5 HEK-293T C216(1.12)  LDD1644  [19]
 LDCM0441  CL50 HCT 116 C216(1.06)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C216(0.88)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C216(1.07)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C216(1.20)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C216(1.03)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C216(1.01)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C216(0.84)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C216(0.86)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C216(1.12)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C216(0.86)  LDD0767  [7]
 LDCM0451  CL6 HEK-293T C216(0.99)  LDD1654  [19]
 LDCM0452  CL60 HCT 116 C216(0.87)  LDD0769  [7]
 LDCM0453  CL61 HEK-293T C216(0.98)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C216(0.92)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C216(0.99)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C216(0.92)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C216(1.17)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C216(0.99)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C216(1.00)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C216(1.11)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C216(1.22)  LDD1664  [19]
 LDCM0462  CL7 HEK-293T C216(1.13)  LDD1665  [19]
 LDCM0463  CL70 HEK-293T C216(0.91)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C216(1.08)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C216(1.18)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C216(1.04)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C216(0.94)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C216(0.95)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C216(0.97)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C216(1.12)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C216(1.13)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C216(0.73)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C216(0.91)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C216(1.24)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C216(0.99)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C216(1.09)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C216(1.11)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C216(0.93)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C216(0.87)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C216(0.94)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C216(0.99)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C216(1.03)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C216(1.03)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C216(1.05)  LDD1688  [19]
 LDCM0486  CL91 HEK-293T C216(0.96)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C216(0.92)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C216(1.01)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C216(0.85)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C216(0.92)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C216(1.02)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C216(0.79)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C216(0.97)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C216(0.96)  LDD1697  [19]
 LDCM0495  E2913 HEK-293T C216(1.30)  LDD1698  [19]
 LDCM0468  Fragment33 HEK-293T C216(0.86)  LDD1671  [19]
 LDCM0427  Fragment51 HCT 116 C216(0.90)  LDD0744  [7]
 LDCM0116  HHS-0101 DM93 Y113(1.20)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y113(0.97)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y113(0.87)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y113(0.75)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y113(0.65)  LDD0268  [6]
 LDCM0022  KB02 HEK-293T C216(1.04)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C216(1.01)  LDD1497  [19]
 LDCM0024  KB05 SKMEL24 C216(1.23)  LDD3323  [20]
 LDCM0131  RA190 MM1.R C216(1.11)  LDD0304  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Zinc finger MYND domain-containing protein 19 (ZMYND19) . Q96E35

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840