Details of the Target

General Information of Target

Target ID LDTP10251
Target Name Protein Spindly (SPDL1)
Gene Name SPDL1
Gene ID 54908
Synonyms
CCDC99; Protein Spindly; hSpindly; Arsenite-related gene 1 protein; Coiled-coil domain-containing protein 99; Rhabdomyosarcoma antigen MU-RMS-40.4A; Spindle apparatus coiled-coil domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTDSVIYSMLELPTATQAQNDYGPQQKSSSSRPSCSCLVAIALGLLTAVLLSVLLYQWIL
CQGSNYSTCASCPSCPDRWMKYGNHCYYFSVEEKDWNSSLEFCLARDSHLLVITDNQEMS
LLQVFLSEAFCWIGLRNNSGWRWEDGSPLNFSRISSNSFVQTCGAINKNGLQASSCEVPL
HWVCKKCPFADQALF
Target Bioclass
Other
Family
Spindly family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Plays a role in cell migration. {|HAMAP-Rule:MF_03041}.
Uniprot ID
Q96EA4
Ensemble ID
ENST00000265295.9
HGNC ID
HGNC:26010

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 Substitution: p.R453S .
HUCCT1 SNV: p.Q193Ter .
HUH28 SNV: p.E227K .
JHH1 Deletion: p.E381KfsTer14 DBIA    Probe Info 
KMCH1 SNV: p.D348E .
LUDLU1 Substitution: p.R453S .
MFE319 SNV: p.L21P .
NCIH1299 SNV: p.S355Ter; p.V356I m-APA    Probe Info 
NCIH2291 SNV: p.E351K .
OCILY3 SNV: p.Q104R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K585(10.00)  LDD0277  [2]
DA-P3
 Probe Info  		4.08  LDD0179  [3]
AHL-Pu-1
 Probe Info  		C490(2.24)  LDD0168  [4]
DBIA
 Probe Info  		C490(1.02); C467(0.92)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [8]
IPM
 Probe Info  		C583(0.00); C467(0.00)  LDD0147  [9]
TFBX
 Probe Info  		C416(0.00); C143(0.00)  LDD0148  [9]
Phosphinate-6
 Probe Info  		C467(0.00); C143(0.00); C490(0.00)  LDD0018  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C361
 Probe Info  		22.32  LDD2022  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C490(2.24)  LDD0168  [4]
 LDCM0214  AC1 HEK-293T C78(0.88); C80(1.01)  LDD0812  [5]
 LDCM0215  AC10 HEK-293T C467(0.93); C78(1.40); C80(0.95)  LDD0813  [5]
 LDCM0216  AC100 HEK-293T C78(1.53); C80(0.71)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C78(0.91); C80(0.75)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C78(1.37); C80(0.70)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C78(1.48); C80(0.58)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C78(1.43); C80(0.73)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C78(0.83); C80(1.84)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C78(0.95); C80(1.43)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C78(1.12); C80(0.73)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C78(1.14); C80(1.32)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C78(0.87); C80(1.02)  LDD0823  [5]
 LDCM0226  AC11 HEK-293T C467(0.99); C78(1.30); C80(1.03)  LDD0824  [5]
 LDCM0227  AC110 HEK-293T C78(1.88); C80(0.65)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C78(1.73); C80(0.78)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C78(1.85); C80(0.69)  LDD0827  [5]
 LDCM0230  AC113 HEK-293T C78(1.06); C80(0.91)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C78(1.03); C80(0.90)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C78(1.19); C80(0.83)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C78(1.10); C80(0.77)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C78(1.19); C80(0.61)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C78(1.31); C80(0.51)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C78(1.39); C80(0.53)  LDD0834  [5]
 LDCM0237  AC12 HEK-293T C467(0.88); C78(1.17); C80(1.09)  LDD0835  [5]
 LDCM0238  AC120 HEK-293T C78(1.08); C80(0.60)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C78(1.32); C80(0.50)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C78(1.36); C80(0.49)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C78(1.40); C80(0.49)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C78(1.25); C80(0.53)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C78(1.35); C80(0.44)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C78(1.68); C80(0.52)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C78(2.00); C80(0.57)  LDD0843  [5]
 LDCM0246  AC128 HEK-293T C80(0.95)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C80(0.72)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C80(0.77)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C80(1.01)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C80(0.78)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C80(0.52)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C80(0.62)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C80(0.61)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C80(0.73)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C80(0.61)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C80(0.71)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C80(0.56)  LDD0856  [5]
 LDCM0259  AC14 HEK-293T C467(1.22); C78(1.22); C80(0.89)  LDD0857  [5]
 LDCM0260  AC140 HEK-293T C80(0.58)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C80(0.54)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C80(0.58)  LDD0860  [5]
 LDCM0263  AC143 HEK-293T C467(0.97); C78(0.88); C80(1.48)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C467(0.95); C78(0.94); C80(0.61)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C467(1.00); C78(0.90); C80(0.64)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C467(0.85); C78(1.23); C80(0.61)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C467(0.70); C78(1.44); C80(0.62)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C467(0.79); C78(1.00); C80(0.58)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C467(0.94); C78(0.74); C80(0.79)  LDD0867  [5]
 LDCM0270  AC15 HEK-293T C467(1.45); C78(1.39); C80(0.69)  LDD0868  [5]
 LDCM0271  AC150 HEK-293T C467(0.85); C78(1.09); C80(0.60)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C467(0.83); C78(1.10); C80(0.61)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C467(1.07); C78(1.16); C80(0.72)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C467(1.20); C78(1.30); C80(0.64)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C467(1.12); C78(0.78); C80(0.74)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C467(1.27); C78(1.03); C80(0.77)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C467(1.14); C78(1.13); C80(0.57)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C467(1.11); C78(1.70); C80(0.77)  LDD2165  [5]
 LDCM0276  AC17 HEK-293T C78(0.82); C80(0.82)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C78(0.76); C80(0.76)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C78(0.87); C80(0.87)  LDD0876  [5]
 LDCM0279  AC2 HEK-293T C78(1.17); C80(0.87)  LDD0877  [5]
 LDCM0280  AC20 HEK-293T C78(0.90); C80(0.90)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C78(0.88); C80(0.88)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C78(0.82); C80(0.82)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C78(0.82); C80(0.82)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C78(0.86); C80(0.86)  LDD0882  [5]
 LDCM0285  AC25 HEK-293T C78(0.97); C80(1.15)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C78(1.27); C80(1.02)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C78(0.94); C80(0.98)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C78(0.79); C80(1.07)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C78(1.13); C80(1.06)  LDD0887  [5]
 LDCM0290  AC3 HEK-293T C78(0.97); C80(1.00)  LDD0888  [5]
 LDCM0291  AC30 HEK-293T C78(1.24); C80(1.04)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C78(0.89); C80(1.04)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C78(0.87); C80(1.10)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C78(1.19); C80(1.01)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C78(0.93); C80(1.07)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C78(0.92); C80(0.85)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C78(0.78); C80(0.79)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C78(0.76); C80(0.75)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C78(0.76); C80(0.76)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C78(0.78); C80(0.76)  LDD0898  [5]
 LDCM0301  AC4 HEK-293T C78(1.38); C80(0.87)  LDD0899  [5]
 LDCM0302  AC40 HEK-293T C78(0.77); C80(0.82)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C78(0.65); C80(0.82)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C78(0.70); C80(0.75)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C78(0.90); C80(0.94)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C78(0.78); C80(0.73)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C78(0.86); C80(0.83)  LDD0905  [5]
 LDCM0308  AC46 HEK-293T C467(1.31); C80(0.79)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C467(1.24); C80(0.87)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C467(1.27); C80(0.89)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C467(1.25); C80(0.88)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C78(1.05); C80(1.12)  LDD0910  [5]
 LDCM0313  AC50 HEK-293T C467(1.29); C80(0.92)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C467(1.61); C80(0.72)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C467(1.92); C80(0.65)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C467(1.52); C80(0.85)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C467(1.58); C80(0.67)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C467(1.58); C80(0.80)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C467(1.56); C80(0.85)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C467(0.88); C78(1.56); C80(0.88)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C467(1.06); C78(1.03); C80(0.91)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C467(1.02); C78(1.26); C80(0.92)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C467(0.75); C78(1.19); C80(1.18)  LDD0921  [5]
 LDCM0324  AC60 HEK-293T C467(1.18); C78(1.12); C80(1.14)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C467(1.55); C78(1.33); C80(0.74)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C467(1.32); C78(1.29); C80(0.88)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C467(1.45); C78(1.37); C80(0.76)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C467(1.28); C78(0.90); C80(0.84)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C467(1.34); C78(1.21); C80(0.60)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C467(1.44); C78(1.12); C80(0.82)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C467(1.37); C78(1.23); C80(0.84)  LDD0929  [5]
 LDCM0332  AC68 HEK-293T C80(0.95)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C80(1.04)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C467(1.06); C78(1.02); C80(1.01)  LDD0932  [5]
 LDCM0335  AC70 HEK-293T C80(0.99)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C80(1.02)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C80(0.94)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C80(1.06)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C80(1.13)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C80(1.02)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C80(0.99)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C80(1.03)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C80(0.92)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C80(1.08)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C467(1.27); C78(1.43); C80(0.94)  LDD0943  [5]
 LDCM0346  AC80 HEK-293T C80(1.17)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C80(0.96)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C80(0.82)  LDD0946  [5]
 LDCM0349  AC83 HEK-293T C80(0.94)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C80(0.65)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C80(0.85)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C80(0.77)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C80(0.83)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C80(0.56)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C80(0.50)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C80(0.60)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C80(0.66)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C80(0.71)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C80(0.80)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C80(0.45)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C80(0.62)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C80(1.30)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C80(0.55)  LDD0962  [5]
 LDCM0365  AC98 HEK-293T C78(1.35); C80(0.88)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C78(1.15); C80(1.31)  LDD0964  [5]
 LDCM0248  AKOS034007472 HEK-293T C467(0.90); C78(1.24); C80(0.95)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C467(1.07); C78(1.95); C80(0.64)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C467(1.38); C78(1.40); C80(0.78)  LDD0873  [5]
 LDCM0156  Aniline NCI-H1299 11.67  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C490(1.02); C467(0.92)  LDD0078  [5]
 LDCM0632  CL-Sc Hep-G2 C416(20.00)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C80(1.35)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C80(0.54)  LDD0966  [5]
 LDCM0369  CL100 HEK-293T C78(1.12); C80(1.08)  LDD0967  [5]
 LDCM0370  CL101 HEK-293T C467(1.37); C78(1.73); C80(0.74)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C467(1.22); C78(1.28); C80(0.81)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C467(1.42); C78(1.33); C80(0.71)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C467(1.15); C78(1.22); C80(0.95)  LDD0971  [5]
 LDCM0374  CL105 HEK-293T C78(0.91); C80(0.91)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C78(0.82); C80(0.82)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C78(0.73); C80(0.73)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C78(0.88); C80(0.88)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C78(0.81); C80(0.81)  LDD0976  [5]
 LDCM0379  CL11 HEK-293T C80(0.49)  LDD0977  [5]
 LDCM0380  CL110 HEK-293T C78(0.95); C80(0.95)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C78(1.09); C80(1.09)  LDD0979  [5]
 LDCM0382  CL112 HEK-293T C78(0.91); C80(1.05)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C78(1.16); C80(1.07)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C78(1.31); C80(0.64)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C78(0.90); C80(0.93)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C78(1.09); C80(0.84)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C78(0.79); C80(0.76)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C78(0.91); C80(0.86)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C78(0.77); C80(0.80)  LDD0987  [5]
 LDCM0390  CL12 HEK-293T C80(1.07)  LDD0988  [5]
 LDCM0391  CL120 HEK-293T C78(0.79); C80(0.80)  LDD0989  [5]
 LDCM0392  CL121 HEK-293T C467(1.59); C80(0.78)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C467(1.35); C80(0.89)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C467(1.47); C80(1.26)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C467(1.38); C80(0.99)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C467(1.07); C78(0.96); C80(0.90)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C467(1.09); C78(1.33); C80(0.80)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C467(1.02); C78(1.40); C80(0.82)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C467(1.09); C78(1.38); C80(0.90)  LDD0997  [5]
 LDCM0400  CL13 HEK-293T C80(0.98)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C80(0.99)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C80(0.63)  LDD1000  [5]
 LDCM0403  CL16 HEK-293T C78(0.85); C80(1.28)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C78(0.75); C80(0.90)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C78(0.92); C80(0.80)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C78(1.00); C80(0.86)  LDD1004  [5]
 LDCM0407  CL2 HEK-293T C80(1.07)  LDD1005  [5]
 LDCM0408  CL20 HEK-293T C78(0.81); C80(0.87)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C78(0.91); C80(0.67)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C78(0.96); C80(0.57)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C78(1.51); C80(0.85)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C78(0.90); C80(0.96)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C78(0.90); C80(1.00)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C78(1.28); C80(1.17)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C78(1.01); C80(0.88)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C78(0.97); C80(0.89)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C78(1.00); C80(0.93)  LDD1015  [5]
 LDCM0418  CL3 HEK-293T C80(1.37)  LDD1016  [5]
 LDCM0419  CL30 HEK-293T C78(1.24); C80(0.50)  LDD1017  [5]
 LDCM0420  CL31 HEK-293T C80(1.26)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C80(1.13)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C80(1.12)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C80(1.38)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C80(1.08)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C80(1.01)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C80(1.13)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C80(0.46)  LDD1026  [5]
 LDCM0429  CL4 HEK-293T C80(1.04)  LDD1027  [5]
 LDCM0430  CL40 HEK-293T C80(0.86)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C80(0.56)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C80(0.45)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C80(0.48)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C80(1.03)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C80(0.59)  LDD1033  [5]
 LDCM0436  CL46 HEK-293T C78(1.13); C80(0.89)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C78(0.97); C80(1.01)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C78(0.90); C80(1.22)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C78(1.08); C80(0.92)  LDD1037  [5]
 LDCM0440  CL5 HEK-293T C80(0.83)  LDD1038  [5]
 LDCM0441  CL50 HEK-293T C78(1.29); C80(0.59)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C78(1.09); C80(0.72)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C78(0.99); C80(1.20)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C78(1.05); C80(1.36)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C78(1.08); C80(0.97)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C78(1.04); C80(0.82)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C78(0.91); C80(1.07)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C78(1.20); C80(1.07)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C78(1.01); C80(0.99)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C78(1.21); C80(0.61)  LDD1048  [5]
 LDCM0451  CL6 HEK-293T C80(0.94)  LDD1049  [5]
 LDCM0452  CL60 HEK-293T C78(1.21); C80(0.52)  LDD1050  [5]
 LDCM0453  CL61 HEK-293T C78(1.20)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C78(0.91)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C78(1.15)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C78(1.25)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C78(1.44)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C78(0.98)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C78(1.40)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C78(1.70)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C78(1.22)  LDD1059  [5]
 LDCM0462  CL7 HEK-293T C80(0.54)  LDD1060  [5]
 LDCM0463  CL70 HEK-293T C78(1.12)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C78(1.37)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C78(1.38)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C78(1.07)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C78(1.65)  LDD1065  [5]
 LDCM0469  CL76 HEK-293T C78(1.09); C80(0.77)  LDD1067  [5]
 LDCM0470  CL77 HEK-293T C78(1.03); C80(0.72)  LDD1068  [5]
 LDCM0471  CL78 HEK-293T C78(1.79); C80(0.64)  LDD1069  [5]
 LDCM0472  CL79 HEK-293T C78(1.31); C80(0.53)  LDD1070  [5]
 LDCM0473  CL8 HEK-293T C80(1.27)  LDD1071  [5]
 LDCM0474  CL80 HEK-293T C78(1.37); C80(0.69)  LDD1072  [5]
 LDCM0475  CL81 HEK-293T C78(1.20); C80(0.67)  LDD1073  [5]
 LDCM0476  CL82 HEK-293T C78(0.95); C80(0.86)  LDD1074  [5]
 LDCM0477  CL83 HEK-293T C78(1.10); C80(1.05)  LDD1075  [5]
 LDCM0478  CL84 HEK-293T C78(1.34); C80(0.77)  LDD1076  [5]
 LDCM0479  CL85 HEK-293T C78(1.23); C80(0.63)  LDD1077  [5]
 LDCM0480  CL86 HEK-293T C78(1.96); C80(0.55)  LDD1078  [5]
 LDCM0481  CL87 HEK-293T C78(1.58); C80(0.64)  LDD1079  [5]
 LDCM0482  CL88 HEK-293T C78(1.12); C80(0.65)  LDD1080  [5]
 LDCM0483  CL89 HEK-293T C78(1.29); C80(0.79)  LDD1081  [5]
 LDCM0484  CL9 HEK-293T C80(1.23)  LDD1082  [5]
 LDCM0485  CL90 HEK-293T C78(1.27); C80(0.74)  LDD1083  [5]
 LDCM0486  CL91 HEK-293T C78(1.06); C80(1.04)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C78(0.84); C80(1.83)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C78(0.86); C80(1.20)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C78(1.03); C80(0.89)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C78(1.07); C80(0.64)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C78(1.14); C80(1.23)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C78(1.08); C80(1.38)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C78(1.66); C80(1.39)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C78(1.20); C80(0.93)  LDD1092  [5]
 LDCM0027  Dopamine HEK-293T 4.08  LDD0179  [3]
 LDCM0495  E2913 HEK-293T C467(0.90); C416(0.98); C490(1.43); C78(0.97)  LDD1698  [15]
 LDCM0468  Fragment33 HEK-293T C78(1.59)  LDD1066  [5]
 LDCM0427  Fragment51 HEK-293T C80(1.17)  LDD1025  [5]
 LDCM0022  KB02 HCT 116 C78(2.44); C80(2.44)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C78(2.08); C80(2.08)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C78(2.02); C80(2.02)  LDD0082  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carbonic anhydrase-related protein (CA8) Alpha-carbonic anhydrase family P35219
Ubiquitin carboxyl-terminal hydrolase 15 (USP15) Peptidase C19 family Q9Y4E8
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynein axonemal assembly factor 4 (DNAAF4) . Q8WXU2
Phostensin (PPP1R18) . Q6NYC8
Receptor-transporting protein 5 (RTP5) . Q14D33

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402