Details of the Target

General Information of Target

Target ID LDTP12377
Target Name Mediator of RNA polymerase II transcription subunit 4 (MED4)
Gene Name MED4
Gene ID 29079
Synonyms
ARC36; DRIP36; VDRIP; Mediator of RNA polymerase II transcription subunit 4; Activator-recruited cofactor 36 kDa component; ARC36; Mediator complex subunit 4; TRAP/SMCC/PC2 subunit p36 subunit; Vitamin D3 receptor-interacting protein complex 36 kDa component; DRIP36
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGGGERYNIPAPQSRNVSKNQQQLNRQKTKEQNSQMKIVHKKKERGHGYNSSAAAWQAMQ
NGGKNKNFPNNQSWNSSLSGPRLLFKSQANQNYAGAKFSEPPSPSVLPKPPSHWVPVSFN
PSDKEIMTFQLKTLLKVQV
Target Bioclass
Other
Family
Mediator complex subunit 4 family
Subcellular location
Nucleus
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Uniprot ID
Q9NPJ6
Ensemble ID
ENST00000258648.7
HGNC ID
HGNC:17903

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.S228P .
LNCaP clone FGC SNV: p.K81N DBIA    Probe Info 
LU65 SNV: p.I120M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y126(7.16)  LDD3495  [2]
DBIA
 Probe Info  		C162(0.88)  LDD0531  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0177  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
Compound 10
 Probe Info  		N.A.  LDD2216  [8]
Compound 11
 Probe Info  		N.A.  LDD2213  [8]
IPM
 Probe Info  		N.A.  LDD2156  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C141
 Probe Info  		13.55  LDD1823  [12]
C143
 Probe Info  		16.56  LDD1825  [12]
C145
 Probe Info  		10.70  LDD1827  [12]
C147
 Probe Info  		6.68  LDD1829  [12]
C153
 Probe Info  		16.22  LDD1834  [12]
C234
 Probe Info  		5.54  LDD1907  [12]
C355
 Probe Info  		24.42  LDD2016  [12]
C361
 Probe Info  		24.25  LDD2022  [12]
C391
 Probe Info  		13.45  LDD2050  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C162(0.88)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C162(1.01)  LDD0813  [3]
 LDCM0226  AC11 HEK-293T C162(0.95)  LDD0824  [3]
 LDCM0237  AC12 HEK-293T C162(1.03)  LDD0835  [3]
 LDCM0246  AC128 HCT 116 C162(0.67)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C162(0.85)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C162(0.94)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C162(0.84)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C162(1.29)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C162(0.96)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C162(1.02)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C162(0.97)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C162(1.03)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C162(0.93)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C162(0.92)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C162(1.12)  LDD0575  [3]
 LDCM0259  AC14 HEK-293T C162(1.08)  LDD0857  [3]
 LDCM0260  AC140 HCT 116 C162(1.18)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C162(1.29)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C162(0.99)  LDD0579  [3]
 LDCM0270  AC15 HEK-293T C162(1.25)  LDD0868  [3]
 LDCM0276  AC17 HCT 116 C162(0.85)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C162(1.07)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C162(1.04)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C162(1.00)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C162(0.95)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C162(0.92)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C162(0.86)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C162(0.84)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C162(0.92)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C162(1.08)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C162(1.27)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C162(1.38)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C162(0.92)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C162(1.29)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C162(0.97)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C162(1.41)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C162(1.10)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C162(1.15)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C162(1.38)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C162(1.06)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C162(1.07)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C162(1.21)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C162(1.25)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C162(1.11)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C162(1.03)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C162(1.05)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C162(0.87)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C162(1.10)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C162(1.08)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C162(0.94)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C162(1.20)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C162(1.10)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C162(0.98)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C162(1.15)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C162(1.19)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C162(1.12)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C162(0.82)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C162(1.15)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C162(1.74)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C162(1.47)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C162(1.11)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C162(1.56)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C162(1.28)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C162(1.22)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C162(1.01)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C162(0.96)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C162(1.24)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C162(0.80)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C162(1.36)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C162(1.04)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C162(1.08)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C162(1.22)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C162(1.15)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C162(1.11)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C162(0.99)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C162(1.26)  LDD0648  [3]
 LDCM0332  AC68 HEK-293T C162(1.04)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C162(0.97)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C162(0.97)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C162(1.16)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C162(0.76)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C162(0.97)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C162(1.11)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C162(0.98)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C162(0.89)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C162(0.95)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C162(0.84)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C162(1.14)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C162(0.80)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C162(1.03)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C162(0.97)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C162(0.98)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C162(1.06)  LDD0946  [3]
 LDCM0349  AC83 HCT 116 C162(1.14)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C162(1.12)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C162(1.32)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C162(1.12)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C162(0.88)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C162(1.11)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C162(1.11)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C162(0.86)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C162(1.27)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C162(1.05)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C162(1.06)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C162(1.21)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C162(0.92)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C162(1.01)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C162(1.13)  LDD0681  [3]
 LDCM0248  AKOS034007472 HEK-293T C162(1.04)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C162(1.26)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C162(1.10)  LDD0873  [3]
 LDCM0367  CL1 HCT 116 C162(0.98)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C162(0.85)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C162(1.04)  LDD0686  [3]
 LDCM0370  CL101 HEK-293T C162(1.10)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C162(1.33)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C162(1.25)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C162(1.11)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C162(0.89)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C162(0.80)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C162(0.94)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C162(0.83)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C162(0.95)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C162(0.90)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C162(0.79)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C162(0.87)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C162(1.19)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C162(1.20)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C162(1.75)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C162(1.18)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C162(1.47)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C162(0.98)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C162(1.03)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C162(1.07)  LDD0987  [3]
 LDCM0390  CL12 HCT 116 C162(0.82)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C162(1.01)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C162(1.22)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C162(1.27)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C162(1.59)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C162(1.04)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C162(1.12)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C162(1.02)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C162(1.11)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C162(0.97)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C162(0.96)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C162(0.82)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C162(0.90)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C162(1.04)  LDD0720  [3]
 LDCM0404  CL17 HEK-293T C162(0.97)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C162(1.07)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C162(1.10)  LDD1610  [13]
 LDCM0407  CL2 HCT 116 C162(1.03)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C162(1.11)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C162(1.05)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C162(0.99)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C162(0.99)  LDD1615  [13]
 LDCM0413  CL25 HEK-293T C162(1.21)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C162(1.06)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C162(0.94)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C162(0.94)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C162(1.08)  LDD1621  [13]
 LDCM0418  CL3 HCT 116 C162(0.73)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C162(1.14)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C162(1.11)  LDD1624  [13]
 LDCM0421  CL32 HCT 116 C162(1.28)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C162(1.38)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C162(0.98)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C162(1.19)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C162(1.10)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C162(1.12)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C162(1.31)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C162(0.96)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C162(1.10)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C162(1.16)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C162(1.05)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C162(1.10)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C162(1.05)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C162(1.02)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C162(0.90)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C162(0.96)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C162(0.90)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C162(1.04)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C162(0.89)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C162(1.21)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C162(1.23)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C162(0.82)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C162(0.83)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C162(1.25)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C162(0.98)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C162(1.05)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C162(1.10)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C162(1.04)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C162(1.13)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C162(1.02)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C162(1.14)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C162(1.02)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C162(1.41)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C162(1.36)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C162(1.82)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C162(1.20)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C162(1.43)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C162(1.29)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C162(1.62)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C162(1.25)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C162(0.98)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C162(1.44)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C162(2.06)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C162(1.38)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C162(1.89)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C162(2.12)  LDD1065  [3]
 LDCM0469  CL76 HCT 116 C162(1.07)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C162(0.78)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C162(1.67)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C162(0.72)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C162(0.91)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C162(1.10)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C162(0.82)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C162(1.30)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C162(0.59)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C162(1.40)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C162(1.03)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C162(1.14)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C162(0.94)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C162(1.18)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C162(1.27)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C162(1.15)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C162(1.17)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C162(1.03)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C162(1.03)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C162(0.79)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C162(0.99)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C162(0.84)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C162(0.96)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C162(1.01)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C162(0.99)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C162(0.96)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C162(0.92)  LDD1698  [13]
 LDCM0625  F8 Ramos C162(0.47)  LDD2187  [14]
 LDCM0573  Fragment11 Ramos C162(0.84)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C162(0.57)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C162(0.45)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C162(0.50)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C162(0.38)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C162(0.42)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C162(0.38)  LDD2196  [14]
 LDCM0586  Fragment28 Ramos C162(1.00)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C162(0.53)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C162(0.49)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C162(0.78)  LDD2201  [14]
 LDCM0468  Fragment33 HEK-293T C162(2.06)  LDD1066  [3]
 LDCM0596  Fragment38 Ramos C162(0.91)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C162(0.46)  LDD2184  [14]
 LDCM0427  Fragment51 HCT 116 C162(1.17)  LDD0744  [3]
 LDCM0614  Fragment56 Ramos C162(0.96)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C162(0.43)  LDD2186  [14]
 LDCM0022  KB02 HEK-293T C162(0.94)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C162(1.02)  LDD1497  [13]
 LDCM0024  KB05 MEWO C162(1.80)  LDD3319  [15]
 LDCM0627  NUDT7-COV-1 HEK-293T C162(0.69)  LDD2206  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Formimidoyltransferase-cyclodeaminase (FTCD) Cyclodeaminase/cyclohydrolase family; Formiminotransferase family O95954
Inositol hexakisphosphate kinase 3 (IP6K3) Inositol phosphokinase (IPK) family Q96PC2
Protein mab-21-like 3 (MAB21L3) Mab-21 family Q8N8X9
Mediator of RNA polymerase II transcription subunit 21 (MED21) Mediator complex subunit 21 family Q13503
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
Other
Click To Hide/Show 24 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM13C (FAM13C) FAM13 family Q8NE31
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Mediator of RNA polymerase II transcription subunit 12 (MED12) Mediator complex subunit 12 family Q93074
Mediator of RNA polymerase II transcription subunit 26 (MED26) Mediator complex subunit 26 family O95402
Mediator of RNA polymerase II transcription subunit 9 (MED9) Mediator complex subunit 9 family Q9NWA0
Protein Mis18-beta (OIP5) Mis18 family O43482
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
SAGA-associated factor 29 (SGF29) SGF29 family Q96ES7
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Protein SSX3 (SSX3) SSX family Q99909
Synaptonemal complex central element protein 2 (SYCE2) SYCE family Q6PIF2
Alpha-taxilin (TXLNA) Taxilin family P40222
Beta-taxilin (TXLNB) Taxilin family Q8N3L3
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8) TNFAIP8 family O95379
Tumor necrosis factor alpha-induced protein 8-like protein 1 (TNFAIP8L1) TNFAIP8 family Q8WVP5
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Beta-catenin-like protein 1 (CTNNBL1) . Q8WYA6
FERM domain-containing protein 6 (FRMD6) . Q96NE9
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Intraflagellar transport protein 20 homolog (IFT20) . Q8IY31
Microspherule protein 1 (MCRS1) . Q96EZ8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
16 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.