Details of the Target

General Information of Target

Target ID LDTP12603
Target Name NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)
Gene Name SIRT3
Gene ID 23410
Synonyms
SIR2L3; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; hSIRT3; EC 2.3.1.286; Regulatory protein SIR2 homolog 3; SIR2-like protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRPGPALLLLGVGLSLSVGRLPLPPVPRGAQAAVSGAPGGLLRGAPGLGVRGGRALLSLR
PSAVRAGGAVLSGRGSLCFPHGGTGRRWYCLDLRVLLSAQRLPWPAAPALALVDLQLSAR
GGRLSLTWSVRLPRSPGRLAWAFRLRLLGPGAARPASPAARVSPRSAAPGPRPQQGFVAR
TECPTDGPARVMLQAVNSSSHRAVESSVSCQINACVIQRVRINTDQKGAPVRLSMQAEAT
INASVQLDCPAARAIAQYWQVFSVPAVGQAPDWTQPLDLPQLEIRNSPLFIHIPNNSLQW
GVYVFNFTVSITTGNPKMPEVKDSDAVYVWIVRSSLQAVMLGDANITANFTEQLILDGST
SSDPDADSPLQGLQFFWYCTTDPRNYGGDRIILGSKEVCHPEQANLKWPWASGPVLTLLP
ETLKGDHVYFFRMVIRKDSRTAFSDKRVHVLQGPKAIAHITCIENCERNFIVSDRFSLFL
NCTNCASRDFYKWSILSSSGGEMLFDWMGETVTGRNGAYLSIKAFAFRHFLEAEFSISLY
LACWSGVTSVFRHSFIINHGPQIGECKINPAKGIALITKFVVQCSNFRDKHVPLTYKIIV
SDLHSVGEISSVKENTLGTILYLGPQSTVPPSFLPVGMLASQYGLKIYAQVYDSLGAFSQ
VTLHATAQAPTDKNSSKTVLNQLLSFTVGPSSLLSTLIQKKDFLPAGYLLYIVASVLNNM
KTELPLRDDRVNLRKHLIDQSFLLPVSTLVEIGQVVMTITKLTQKPSEFTWDAQKRATMR
VWQANQALQEYQQKDKRFRSEQIEIVSTGILMSLSNILKMTSPHQVVKDPFYVIESLSDT
ILANKVPGNKTTSMRTPNFNMYVKKVEKWGINQLFRNEKHCRNCFYPTLNVSSVPGLSAN
GPISTMFCDFTNDLFPWLNDQENTSVEVSGFRMTGVADNGSVLEITPDVAEVYLVRKNLT
FAAFNLTVGPNSEVDGSLKKTTGGFSFQVDSTVLREVLVHIVTEVMVLFTVLVYTGSQIT
PTALVATFLVPHDIPPFASQSALFDPACTVKKARVVCLPVSLLQLIAQHSHSPHCTVSIV
LQAPRFVMKLNDKLVRISIFSVQCLDMYGIQSEWREGYCILGEKTSWYEVHCICKNVVRA
RRQLGTIGLTGIHLHTHYVMAKVIVIPNPVDLRLNIIKSLHQNPVTLFTVLFIILLYVGL
AFWALYRDEMDQHLRGHVIVLPDNDPYDNLCYLVTIFTGSRWGSGTRANVFVQLRGTVST
SDVHCLSHPHFTTLYRGSINTFLLTTKSDLGDIHSIRVWHNNEGRSPSWYLSRIKVENLF
SRHIWLFICQKWLSVDTTLDRTFHVTHPDERLTRKDFFFIDVSSNLRKNHMWFSIFASVV
AKTFNRLQRLSCCLAMLLSSLLCNIMFFNLNRQEQTESRERKYMRSMMIGIESVLITIPV
QLLITFLFTCSQRKPQADLKEVSPQKHPLMSEASEHWEEYLRKWHAYETAKVHPREVAKP
ASKGKPRLPKASPKATSKPKHRHRKAQIKTPETLGPNTNSNNNIEDDQDVHSEQHPSQKD
LQQLKKKPRIVLPWWCVYVAWFLVFATSSISSFFIVFYGLTYGYDKSIEWLFASFCSFCQ
SVLLVQPSKIILLSGFRTNKPKYCKNLSWSTKYKYTEIRLDGMRMHPEEMQRIHDQIVRI
RGTRMYQPLTEDEIRIFKRKKRIKRRALLFLSYILTHFIFLALLLILIVLLRHTDCFYYN
QFIRDRFSMDLATVTKLEDIYRWLNSVLLPLLHNDLNPTFLPESSSKILGLPLMRQVRAK
SSEKMCLPAEKFVQNSIRREIHCHPKYGIDPEDTKNYSGFWNEVDKQAIDESTNGFTYKP
QGTQWLYYSYGLLHTYGSGGYALYFFPEQQRFNSTLRLKELQESNWLDEKTWAVVLELTT
FNPDINLFCSISVIFEVSQLGVVNTSISLHSFSLADFDRKASAEIYLYVAILIFFLAYVV
DEGCIIMQERASYVRSVYNLLNFALKCIFTVLIVLFLRKHFLATGIIRFYLSNPEDFIPF
HAVSQVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMAFVVSVYF
FVYMAFGYLVFGQHEWNYSNLIHSTQTVFSYCVSAFQNTEFSNNRILGVLFLSSFMLVMI
CVLINLFQAVILSAYEEMKQPVYEEPSDEVEAMTYLCRKLRTMFSFLTSQSKAKDEPEFF
IDMLYGQPEKNSHRYLGLKTRNINGKKMVYLVV
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Sirtuin family, Class I subfamily
Subcellular location
Mitochondrion matrix
Function
NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription. Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation. Regulates hepatic lipogenesis. Uses NAD(+) substrate imported by SLC25A47, triggering downstream activation of PRKAA1/AMPK-alpha signaling cascade that ultimately downregulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance.
TTD ID
T91959
Uniprot ID
Q9NTG7
DrugMap ID
TTVZLIJ
Ensemble ID
ENST00000382743.9
HGNC ID
HGNC:14931
ChEMBL ID
CHEMBL4461

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JHH1 SNV: p.P240R .
MELJUSO SNV: p.F294L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C280(0.58); C283(0.58)  LDD0531  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C361
 Probe Info  		26.54  LDD2022  [3]
C403
 Probe Info  		14.22  LDD2061  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C280(0.58); C283(0.58)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C280(0.78); C283(0.78)  LDD0532  [1]
 LDCM0216  AC100 HEK-293T C280(0.96); C283(0.96)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C280(0.95); C283(0.95)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C280(0.94); C283(0.94)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C280(0.98); C283(0.98)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C280(1.00); C283(1.00)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C280(1.09); C283(1.09)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C280(1.59); C283(1.59)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C280(0.97); C283(0.97)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C280(1.15); C283(1.15)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C280(1.11); C283(1.11)  LDD0823  [1]
 LDCM0226  AC11 HCT 116 C280(0.76); C283(0.76)  LDD0543  [1]
 LDCM0227  AC110 HEK-293T C280(1.15); C283(1.15)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C280(1.31); C283(1.31)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C280(1.07); C283(1.07)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C280(1.08); C283(1.08)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C280(2.04); C283(2.04)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C280(1.06); C283(1.06)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C280(1.29); C283(1.29)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C280(1.06); C283(1.06)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C280(1.26); C283(1.26)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C280(1.40); C283(1.40)  LDD0834  [1]
 LDCM0237  AC12 HCT 116 C280(0.83); C283(0.83)  LDD0554  [1]
 LDCM0238  AC120 HEK-293T C280(1.55); C283(1.55)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C280(1.42); C283(1.42)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C280(1.09); C283(1.09)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C280(1.17); C283(1.17)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C280(0.98); C283(0.98)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C280(1.08); C283(1.08)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C280(1.17); C283(1.17)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C280(1.39); C283(1.39)  LDD0843  [1]
 LDCM0246  AC128 PaTu 8988t C280(1.18); C283(1.18)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C280(1.15); C283(1.15)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C280(1.29); C283(1.29)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C280(1.20); C283(1.20)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C280(1.15); C283(1.15)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C280(1.28); C283(1.28)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C280(1.04); C283(1.04)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C280(1.32); C283(1.32)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C280(0.95); C283(0.95)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C280(1.16); C283(1.16)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C280(1.04); C283(1.04)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C280(1.16); C283(1.16)  LDD1137  [1]
 LDCM0259  AC14 HCT 116 C280(0.88); C283(0.88)  LDD0576  [1]
 LDCM0260  AC140 PaTu 8988t C280(1.13); C283(1.13)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C280(0.99); C283(0.99)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C280(1.04); C283(1.04)  LDD1141  [1]
 LDCM0263  AC143 PaTu 8988t C280(0.89); C283(0.89)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C280(1.07); C283(1.07)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C280(0.97); C283(0.97)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C280(0.65); C283(0.65)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C280(1.04); C283(1.04)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C280(0.78); C283(0.78)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C280(0.73); C283(0.73)  LDD1148  [1]
 LDCM0270  AC15 HCT 116 C280(0.83); C283(0.83)  LDD0587  [1]
 LDCM0271  AC150 PaTu 8988t C280(0.87); C283(0.87)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C280(0.96); C283(0.96)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C280(0.81); C283(0.81)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C280(0.79); C283(0.79)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C280(0.88); C283(0.88)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C280(0.81); C283(0.81)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C280(0.79); C283(0.79)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C280(0.90); C283(0.90)  LDD2169  [1]
 LDCM0276  AC17 HCT 116 C280(0.92); C283(0.92)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C280(0.90); C283(0.90)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C280(1.37); C283(1.37)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C280(0.76); C283(0.76)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C280(1.21); C283(1.21)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C280(0.85); C283(0.85)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C280(0.88); C283(0.88)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C280(0.92); C283(0.92)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C280(1.52); C283(1.52)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C280(0.92); C283(0.92)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C280(0.78); C283(0.78)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C280(0.86); C283(0.86)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C280(0.77); C283(0.77)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C280(0.96); C283(0.96)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C280(0.75); C283(0.75)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C280(0.83); C283(0.83)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C280(0.58); C283(0.58)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C280(0.70); C283(0.70)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C280(0.76); C283(0.76)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C280(0.67); C283(0.67)  LDD0612  [1]
 LDCM0296  AC35 PaTu 8988t C280(0.83); C283(0.83)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C280(0.68); C283(0.68)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C280(0.75); C283(0.75)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C280(0.70); C283(0.70)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C280(0.74); C283(0.74)  LDD1179  [1]
 LDCM0301  AC4 HCT 116 C280(0.65); C283(0.65)  LDD0618  [1]
 LDCM0302  AC40 PaTu 8988t C280(0.70); C283(0.70)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C280(0.71); C283(0.71)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C280(0.83); C283(0.83)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C280(0.82); C283(0.82)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C280(0.77); C283(0.77)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C280(0.73); C283(0.73)  LDD1186  [1]
 LDCM0308  AC46 HCT 116 C280(1.04); C283(1.04)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C280(0.93); C283(0.93)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C280(0.84); C283(0.84)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C280(0.81); C283(0.81)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C280(0.71); C283(0.71)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C280(0.97); C283(0.97)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C280(1.53); C283(1.53)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C280(0.94); C283(0.94)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C280(1.13); C283(1.13)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C280(1.06); C283(1.06)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C280(1.17); C283(1.17)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C280(0.96); C283(0.96)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C280(0.89); C283(0.89)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C280(0.96); C283(0.96)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C280(0.76); C283(0.76)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C280(0.88); C283(0.88)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C280(0.76); C283(0.76)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C280(0.68); C283(0.68)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C280(0.68); C283(0.68)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C280(0.71); C283(0.71)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C280(0.73); C283(0.73)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C280(0.87); C283(0.87)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C280(0.76); C283(0.76)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C280(0.68); C283(0.68)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C280(1.05); C283(1.05)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C280(1.11); C283(1.11)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C280(0.98); C283(0.98)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C280(0.76); C283(0.76)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C280(0.96); C283(0.96)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C280(1.04); C283(1.04)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C280(1.02); C283(1.02)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C280(1.04); C283(1.04)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C280(1.18); C283(1.18)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C280(1.08); C283(1.08)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C280(1.02); C283(1.02)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C280(1.03); C283(1.03)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C280(1.14); C283(1.14)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C280(0.65); C283(0.65)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C280(1.35); C283(1.35)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C280(0.99); C283(0.99)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C280(0.97); C283(0.97)  LDD0665  [1]
 LDCM0349  AC83 HEK-293T C280(1.13); C283(1.13)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C280(0.72); C283(0.72)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C280(0.88); C283(0.88)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C280(0.88); C283(0.88)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C280(0.76); C283(0.76)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C280(0.81); C283(0.81)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C280(0.68); C283(0.68)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C280(0.77); C283(0.77)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C280(0.85); C283(0.85)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C280(0.78); C283(0.78)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C280(0.72); C283(0.72)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C280(0.76); C283(0.76)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C280(0.77); C283(0.77)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C280(0.73); C283(0.73)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C280(0.79); C283(0.79)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C280(1.20); C283(1.20)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C280(1.15); C283(1.15)  LDD0964  [1]
 LDCM0248  AKOS034007472 HCT 116 C280(0.92); C283(0.92)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C280(0.85); C283(0.85)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C280(0.92); C283(0.92)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C280(1.51); C283(1.51)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C280(0.76); C283(0.76)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C280(0.69); C283(0.69)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C280(0.85); C283(0.85)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C280(1.25); C283(1.25)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C280(1.14); C283(1.14)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C280(1.02); C283(1.02)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C280(0.74); C283(0.74)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C280(0.71); C283(0.71)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C280(0.77); C283(0.77)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C280(0.71); C283(0.71)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C280(0.81); C283(0.81)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C280(0.87); C283(0.87)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C280(0.84); C283(0.84)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C280(0.84); C283(0.84)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C280(0.86); C283(0.86)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C280(0.73); C283(0.73)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C280(0.68); C283(0.68)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C280(0.82); C283(0.82)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C280(0.67); C283(0.67)  LDD0703  [1]
 LDCM0387  CL117 PaTu 8988t C280(0.83); C283(0.83)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C280(0.82); C283(0.82)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C280(0.69); C283(0.69)  LDD1268  [1]
 LDCM0390  CL12 HCT 116 C280(1.04); C283(1.04)  LDD0707  [1]
 LDCM0391  CL120 PaTu 8988t C280(0.71); C283(0.71)  LDD1270  [1]
 LDCM0392  CL121 HCT 116 C280(6.09); C283(6.09)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C280(1.11); C283(1.11)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C280(0.98); C283(0.98)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C280(1.00); C283(1.00)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C280(1.09); C283(1.09)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C280(0.88); C283(0.88)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C280(0.75); C283(0.75)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C280(0.79); C283(0.79)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C280(0.85); C283(0.85)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C280(0.97); C283(0.97)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C280(0.93); C283(0.93)  LDD0719  [1]
 LDCM0403  CL16 PaTu 8988t C280(1.10); C283(1.10)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C280(1.08); C283(1.08)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C280(0.73); C283(0.73)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C280(0.85); C283(0.85)  LDD1285  [1]
 LDCM0407  CL2 HCT 116 C280(1.33); C283(1.33)  LDD0724  [1]
 LDCM0408  CL20 PaTu 8988t C280(0.96); C283(0.96)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C280(0.96); C283(0.96)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C280(0.79); C283(0.79)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C280(1.01); C283(1.01)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C280(0.93); C283(0.93)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C280(0.77); C283(0.77)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C280(0.92); C283(0.92)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C280(1.02); C283(1.02)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C280(0.96); C283(0.96)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C280(0.97); C283(0.97)  LDD1296  [1]
 LDCM0418  CL3 HCT 116 C280(1.03); C283(1.03)  LDD0735  [1]
 LDCM0419  CL30 PaTu 8988t C280(0.75); C283(0.75)  LDD1298  [1]
 LDCM0420  CL31 HCT 116 C280(0.81); C283(0.81)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C280(0.46); C283(0.46)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C280(0.53); C283(0.53)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C280(0.70); C283(0.70)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C280(0.81); C283(0.81)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C280(0.70); C283(0.70)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C280(0.73); C283(0.73)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C280(0.63); C283(0.63)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C280(1.18); C283(1.18)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C280(0.74); C283(0.74)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C280(0.64); C283(0.64)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C280(0.68); C283(0.68)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C280(0.77); C283(0.77)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C280(0.53); C283(0.53)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C280(0.55); C283(0.55)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C280(1.39); C283(1.39)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C280(1.13); C283(1.13)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C280(1.34); C283(1.34)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C280(1.58); C283(1.58)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C280(0.97); C283(0.97)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C280(1.44); C283(1.44)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C280(1.42); C283(1.42)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C280(1.19); C283(1.19)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C280(1.34); C283(1.34)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C280(1.75); C283(1.75)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C280(1.71); C283(1.71)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C280(1.28); C283(1.28)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C280(1.49); C283(1.49)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C280(1.64); C283(1.64)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C280(1.08); C283(1.08)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C280(0.69); C283(0.69)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C280(1.18); C283(1.18)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C280(1.16); C283(1.16)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C280(1.01); C283(1.01)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C280(0.83); C283(0.83)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C280(0.85); C283(0.85)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C280(0.84); C283(0.84)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C280(0.81); C283(0.81)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C280(0.77); C283(0.77)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C280(0.75); C283(0.75)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C280(0.67); C283(0.67)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C280(0.85); C283(0.85)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C280(0.73); C283(0.73)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C280(0.74); C283(0.74)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C280(0.71); C283(0.71)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C280(0.90); C283(0.90)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C280(0.74); C283(0.74)  LDD0784  [1]
 LDCM0469  CL76 PaTu 8988t C280(0.94); C283(0.94)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C280(0.88); C283(0.88)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C280(0.92); C283(0.92)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C280(0.91); C283(0.91)  LDD1351  [1]
 LDCM0473  CL8 HCT 116 C280(0.89); C283(0.89)  LDD0790  [1]
 LDCM0474  CL80 PaTu 8988t C280(0.74); C283(0.74)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C280(0.88); C283(0.88)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C280(0.82); C283(0.82)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C280(0.79); C283(0.79)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C280(0.93); C283(0.93)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C280(0.96); C283(0.96)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C280(0.79); C283(0.79)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C280(0.83); C283(0.83)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C280(0.76); C283(0.76)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C280(1.03); C283(1.03)  LDD1362  [1]
 LDCM0484  CL9 HCT 116 C280(1.08); C283(1.08)  LDD0801  [1]
 LDCM0485  CL90 PaTu 8988t C280(0.84); C283(0.84)  LDD1364  [1]
 LDCM0486  CL91 HCT 116 C280(0.76); C283(0.76)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C280(0.76); C283(0.76)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C280(0.68); C283(0.68)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C280(0.72); C283(0.72)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C280(0.58); C283(0.58)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C280(0.82); C283(0.82)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C280(0.76); C283(0.76)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C280(0.67); C283(0.67)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C280(0.70); C283(0.70)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C280(0.82); C283(0.82)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C280(0.83); C283(0.83)  LDD0744  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynamin-like 120 kDa protein, mitochondrial (OPA1) Dynamin/Fzo/YdjA family O60313
S-phase kinase-associated protein 2 (SKP2) . Q13309
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase subunit alpha, mitochondrial (ATP5F1A) ATPase alpha/beta chains family P25705

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adenosine-5-diphosphoribose Small molecular drug DB02059

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587