Details of the Target

General Information of Target

Target ID LDTP04248
Target Name Deoxyhypusine synthase (DHPS)
Gene Name DHPS
Gene ID 1725
Synonyms
DS; Deoxyhypusine synthase; DHS; EC 2.5.1.46
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGSLEREAPAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFG
RAVQQVNAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLV
QHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFE
DWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFSPALTDGS
LGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTGMIILGGGVVKHHIANANLMRNGA
DYAVYINTAQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMD
AFMHEKNED
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Deoxyhypusine synthase family
Function
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
TTD ID
T62265
Uniprot ID
P49366
DrugMap ID
TTBO2A9
Ensemble ID
ENST00000210060.12
HGNC ID
HGNC:2869
ChEMBL ID
CHEMBL4415

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER SNV: p.C275Y DBIA    Probe Info 
MKN1 SNV: p.S4F DBIA    Probe Info 
TOV21G SNV: p.E368Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.52  LDD0402  [1]
FBPP2
 Probe Info  		2.92  LDD0324  [2]
STPyne
 Probe Info  		K19(0.11)  LDD0277  [3]
BTD
 Probe Info  		C177(0.55)  LDD2091  [4]
DBIA
 Probe Info  		C177(0.88)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C142(0.00); C275(0.00); C177(0.00); C97(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C142(0.00); C275(0.00); C177(0.00); C97(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C142(0.00); C275(0.00); C177(0.00); C97(0.00)  LDD0037  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [7]
IPM
 Probe Info  		N.A.  LDD0147  [8]
PF-06672131
 Probe Info  		N.A.  LDD0017  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		7.11  LDD1779  [12]
C091
 Probe Info  		11.39  LDD1782  [12]
C178
 Probe Info  		18.64  LDD1857  [12]
C228
 Probe Info  		19.29  LDD1901  [12]
C361
 Probe Info  		18.77  LDD2022  [12]
C403
 Probe Info  		19.29  LDD2061  [12]
C407
 Probe Info  		13.55  LDD2064  [12]
C431
 Probe Info  		14.83  LDD2086  [12]
C433
 Probe Info  		5.82  LDD2088  [12]
FFF probe11
 Probe Info  		12.56  LDD0471  [13]
FFF probe13
 Probe Info  		18.95  LDD0476  [13]
FFF probe3
 Probe Info  		18.98  LDD0465  [13]
FFF probe6
 Probe Info  		13.88  LDD0468  [13]
VE-P
 Probe Info  		N.A.  LDD0396  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C177(0.63)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C177(1.12)  LDD2117  [4]
 LDCM0214  AC1 HCT 116 C177(1.13)  LDD0531  [5]
 LDCM0215  AC10 HEK-293T C177(0.81)  LDD0813  [5]
 LDCM0216  AC100 HCT 116 C177(0.91)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C177(0.99)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C177(0.99)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C177(1.06)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C177(1.01)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C177(1.07)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C177(1.03)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C177(1.15)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C177(0.99)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C177(0.94)  LDD0542  [5]
 LDCM0226  AC11 HEK-293T C177(0.95)  LDD0824  [5]
 LDCM0227  AC110 HCT 116 C177(0.94)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C177(0.93)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C177(1.07)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C177(0.95)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C177(1.66)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C177(1.32)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C177(1.31)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C177(1.25)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C177(2.05)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C177(1.36)  LDD0553  [5]
 LDCM0237  AC12 HEK-293T C177(0.99)  LDD0835  [5]
 LDCM0238  AC120 HCT 116 C177(1.29)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C177(1.68)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C177(1.49)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C177(1.27)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C177(1.00)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C177(1.26)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C177(1.54)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C177(1.60)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C177(1.15)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C177(0.87)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C177(1.03)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C177(0.77)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C177(0.85)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C177(1.12)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C177(1.07)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C177(1.06)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C177(1.14)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C177(1.11)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C177(1.21)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C177(1.12)  LDD0575  [5]
 LDCM0259  AC14 HEK-293T C177(0.94)  LDD0857  [5]
 LDCM0260  AC140 HCT 116 C177(1.10)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C177(0.98)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C177(0.83)  LDD0579  [5]
 LDCM0263  AC143 PaTu 8988t C177(1.08)  LDD1142  [5]
 LDCM0264  AC144 PaTu 8988t C177(1.04)  LDD1143  [5]
 LDCM0265  AC145 PaTu 8988t C177(1.09)  LDD1144  [5]
 LDCM0266  AC146 PaTu 8988t C177(1.09)  LDD1145  [5]
 LDCM0267  AC147 PaTu 8988t C177(1.00)  LDD1146  [5]
 LDCM0268  AC148 PaTu 8988t C177(1.18)  LDD1147  [5]
 LDCM0269  AC149 PaTu 8988t C177(1.21)  LDD1148  [5]
 LDCM0270  AC15 HEK-293T C177(0.92)  LDD0868  [5]
 LDCM0271  AC150 PaTu 8988t C177(1.11)  LDD1150  [5]
 LDCM0272  AC151 PaTu 8988t C177(1.30)  LDD1151  [5]
 LDCM0273  AC152 PaTu 8988t C177(1.26)  LDD1152  [5]
 LDCM0274  AC153 PaTu 8988t C177(1.30)  LDD1153  [5]
 LDCM0621  AC154 PaTu 8988t C177(1.23)  LDD2166  [5]
 LDCM0622  AC155 PaTu 8988t C177(1.23)  LDD2167  [5]
 LDCM0623  AC156 PaTu 8988t C177(1.30)  LDD2168  [5]
 LDCM0624  AC157 PaTu 8988t C177(1.15)  LDD2169  [5]
 LDCM0276  AC17 HEK-293T C177(0.93)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C177(1.18)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C177(0.94)  LDD1517  [15]
 LDCM0279  AC2 HCT 116 C177(1.07)  LDD0596  [5]
 LDCM0280  AC20 HEK-293T C177(0.92)  LDD1519  [15]
 LDCM0282  AC22 HEK-293T C177(0.99)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C177(1.06)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C177(0.98)  LDD1523  [15]
 LDCM0285  AC25 PaTu 8988t C177(1.02)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C177(1.13)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C177(1.28)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C177(1.35)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C177(1.28)  LDD1168  [5]
 LDCM0290  AC3 HCT 116 C177(1.07)  LDD0607  [5]
 LDCM0291  AC30 PaTu 8988t C177(1.20)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C177(1.05)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C177(1.14)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C177(1.19)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C177(1.22)  LDD1174  [5]
 LDCM0296  AC35 HCT 116 C177(0.79)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C177(0.81)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C177(0.84)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C177(0.91)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C177(0.82)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C177(1.19)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C177(0.90)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C177(1.06)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C177(0.89)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C177(0.98)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C177(1.10)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C177(1.16)  LDD0624  [5]
 LDCM0308  AC46 HEK-293T C177(1.63)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C177(1.37)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C177(1.22)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C177(1.17)  LDD0909  [5]
 LDCM0312  AC5 HCT 116 C177(1.25)  LDD0629  [5]
 LDCM0313  AC50 HEK-293T C177(1.20)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C177(1.59)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C177(1.60)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C177(1.56)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C177(1.49)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C177(1.51)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C177(1.47)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C177(0.75)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C177(0.74)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C177(0.98)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C177(0.82)  LDD0921  [5]
 LDCM0324  AC60 HEK-293T C177(0.67)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C177(1.12)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C177(1.13)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C177(1.02)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C177(0.86)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C177(1.05)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C177(1.01)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C177(1.16)  LDD0929  [5]
 LDCM0332  AC68 HEK-293T C177(0.79)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C177(0.87)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C177(0.93)  LDD0932  [5]
 LDCM0335  AC70 HEK-293T C177(1.07)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C177(0.91)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C177(0.91)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C177(0.93)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C177(0.78)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C177(0.72)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C177(0.76)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C177(0.96)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C177(0.92)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C177(0.83)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C177(1.18)  LDD0943  [5]
 LDCM0346  AC80 HEK-293T C177(0.93)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C177(0.83)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C177(1.11)  LDD0946  [5]
 LDCM0349  AC83 HCT 116 C177(1.51)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C177(1.47)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C177(1.30)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C177(1.05)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C177(0.92)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C177(1.01)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C177(1.06)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C177(0.89)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C177(1.50)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C177(1.47)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C177(1.19)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C177(1.03)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C177(0.92)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C177(1.07)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C177(1.28)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C177(1.07)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C177(0.96)  LDD0683  [5]
 LDCM0248  AKOS034007472 HEK-293T C177(1.15)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C177(0.94)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C177(1.20)  LDD0873  [5]
 LDCM0156  Aniline NCI-H1299 10.46  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C177(0.88)  LDD0078  [5]
 LDCM0498  BS-3668 MDA-MB-231 C177(0.55)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa H288(0.00); C177(0.00); H289(0.00)  LDD0222  [10]
 LDCM0367  CL1 HCT 116 C177(1.19)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C177(1.36)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C177(1.18)  LDD0686  [5]
 LDCM0370  CL101 HEK-293T C177(0.93)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C177(0.96)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C177(1.13)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C177(0.86)  LDD0971  [5]
 LDCM0374  CL105 HEK-293T C177(0.99)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C177(0.93)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C177(0.91)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C177(1.08)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C177(0.96)  LDD1582  [15]
 LDCM0379  CL11 HCT 116 C177(1.24)  LDD0696  [5]
 LDCM0380  CL110 HEK-293T C177(0.89)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C177(0.90)  LDD1585  [15]
 LDCM0382  CL112 PaTu 8988t C177(1.12)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C177(1.09)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C177(1.30)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C177(1.19)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C177(1.12)  LDD1265  [5]
 LDCM0387  CL117 HCT 116 C177(0.76)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C177(0.94)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C177(0.88)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C177(1.17)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C177(0.94)  LDD0708  [5]
 LDCM0392  CL121 HEK-293T C177(1.52)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C177(1.42)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C177(1.12)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C177(1.32)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C177(0.75)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C177(0.69)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C177(0.72)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C177(0.73)  LDD0997  [5]
 LDCM0400  CL13 HCT 116 C177(1.11)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C177(1.04)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C177(1.33)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C177(1.14)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C177(1.31)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C177(1.27)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C177(1.28)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C177(1.01)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C177(1.42)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C177(1.90)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C177(1.79)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C177(1.28)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C177(1.50)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C177(1.72)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C177(1.26)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C177(1.32)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C177(1.38)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C177(1.39)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C177(1.05)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C177(1.22)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C177(1.26)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C177(1.09)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C177(1.43)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C177(1.17)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C177(1.09)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C177(1.09)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C177(1.07)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C177(1.12)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C177(1.42)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C177(1.29)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C177(1.10)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C177(1.17)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C177(0.98)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C177(1.08)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C177(1.20)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C177(0.96)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C177(1.07)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C177(0.86)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C177(1.01)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C177(0.98)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C177(0.88)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C177(0.92)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C177(0.88)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C177(1.01)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C177(1.22)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C177(0.97)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C177(1.06)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C177(1.21)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C177(0.84)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C177(0.86)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C177(1.13)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C177(0.98)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C177(1.01)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C177(1.04)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C177(1.22)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C177(1.35)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C177(1.05)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C177(1.71)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C177(1.38)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C177(1.57)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C177(1.17)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C177(1.15)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C177(1.30)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C177(1.09)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C177(1.08)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C177(1.57)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C177(1.26)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C177(1.05)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C177(1.08)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C177(1.25)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C177(1.18)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C177(1.23)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C177(1.08)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C177(1.07)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C177(1.22)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C177(1.24)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C177(1.48)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C177(1.23)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C177(1.07)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C177(1.10)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C177(1.09)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C177(1.42)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C177(1.28)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C177(1.30)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C177(1.14)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C177(1.19)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C177(1.10)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C177(1.20)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C177(1.36)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C177(1.15)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C177(1.15)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C177(1.21)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C177(1.18)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C177(1.10)  LDD1698  [15]
 LDCM0468  Fragment33 HCT 116 C177(1.16)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C177(1.09)  LDD0744  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0022  KB02 HCT 116 C177(1.26)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C177(1.17)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C177(1.05)  LDD0082  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C177(1.04)  LDD2121  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C177(1.07)  LDD2099  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C177(0.52)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C177(0.75)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C177(0.83)  LDD2109  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C177(1.20)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C177(0.96)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C177(1.00)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C177(0.88)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C177(0.93)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C177(1.01)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C177(1.02)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C177(0.87)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C177(0.99)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C177(0.51)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C177(2.25)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C177(0.84)  LDD2146  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C177(0.47)  LDD2150  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Deoxyhypusine synthase (DHPS) Deoxyhypusine synthase family P49366
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
8-oxo-dGDP phosphatase NUDT18 (NUDT18) Nudix hydrolase family Q6ZVK8
Mitogen-activated protein kinase 3 (MAPK3) CMGC Ser/Thr protein kinase family P27361
Receptor-type tyrosine-protein phosphatase H (PTPRH) Protein-tyrosine phosphatase family Q9HD43
Ras-related protein Rab-27B (RAB27B) Rab family O00194
Tubulinyl-Tyr carboxypeptidase 1 (VASH1) Vasohibin family Q7L8A9
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 5A-1 (EIF5A) EIF-5A family P63241
Eukaryotic translation initiation factor 5A-2 (EIF5A2) EIF-5A family Q9GZV4
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 138 (ZNF138) Krueppel C2H2-type zinc-finger protein family P52744
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Proto-oncogene c-Rel (REL) . Q04864
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Retinol-binding protein 1 (RBP1) Fatty-acid binding protein (FABP) family P09455
Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) Universal ribosomal protein uL6 family P32969

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-guanidinium-7-aminoheptane Small molecular drug D00UDX
N-guanyl-1,7-diaminoheptane Small molecular drug D08PKS
Nicotinamide-adenine-dinucleotide Small molecular drug D0R6JE
N1-guanyl-1,7-diaminoheptane . D0FI8L

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402