Details of the Target

General Information of Target

Target ID LDTP09074
Target Name UDP-glucuronic acid decarboxylase 1 (UXS1)
Gene Name UXS1
Gene ID 80146
Synonyms
UDP-glucuronic acid decarboxylase 1; EC 4.1.1.35; UDP-glucuronate decarboxylase 1; UGD; UXS-1; hUXS; hUXS1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVSKALLRLVSAVNRRRMKLLLGIALLAYVASVWGNFVNMRSIQENGELKIESKIEEMVE
PLREKIRDLEKSFTQKYPPVKFLSEKDRKRILITGGAGFVGSHLTDKLMMDGHEVTVVDN
FFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASPPNYMYNPIKTLKTNT
IGTLNMLGLAKRVGARLLLASTSEVYGDPEVHPQSEDYWGHVNPIGPRACYDEGKRVAET
MCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQTRAFQ
YVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLSEAQDDPQK
RKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQANNQYIPKPKPARIKKGRTRHS
Target Bioclass
Enzyme
Family
NAD(P)-dependent epimerase/dehydratase family, UDP-glucuronic acid decarboxylase subfamily
Subcellular location
Golgi apparatus, Golgi stack membrane
Function Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
Uniprot ID
Q8NBZ7
Ensemble ID
ENST00000283148.12
HGNC ID
HGNC:17729

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K177(4.59)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C74(2.58)  LDD3369  [3]
BTD
 Probe Info  		C230(0.52)  LDD2091  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
NAIA_5
 Probe Info  		C230(0.00); C242(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C169
 Probe Info  		20.82  LDD1849  [8]
C170
 Probe Info  		15.89  LDD1850  [8]
C173
 Probe Info  		5.66  LDD1853  [8]
C210
 Probe Info  		44.63  LDD1884  [8]
C249
 Probe Info  		37.27  LDD1922  [8]
C284
 Probe Info  		27.47  LDD1954  [8]
C305
 Probe Info  		12.55  LDD1974  [8]
C310
 Probe Info  		11.00  LDD1977  [8]
C313
 Probe Info  		19.70  LDD1980  [8]
C314
 Probe Info  		20.82  LDD1981  [8]
C317
 Probe Info  		8.22  LDD1983  [8]
C355
 Probe Info  		28.25  LDD2016  [8]
C361
 Probe Info  		27.67  LDD2022  [8]
C362
 Probe Info  		27.10  LDD2023  [8]
C363
 Probe Info  		18.13  LDD2024  [8]
C364
 Probe Info  		23.75  LDD2025  [8]
C397
 Probe Info  		9.92  LDD2056  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C230(0.35)  LDD2142  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C230(1.27)  LDD2117  [4]
 LDCM0215  AC10 HEK-293T C230(1.20)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C230(1.06)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C230(1.10)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C230(1.32)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C230(1.38)  LDD1513  [9]
 LDCM0277  AC18 HEK-293T C230(1.03)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C230(1.15)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C230(1.12)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C230(1.13)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C230(1.11)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C230(1.10)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C230(1.14)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C230(1.10)  LDD1523  [9]
 LDCM0286  AC26 HEK-293T C230(1.18)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C230(1.12)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C230(1.09)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C230(1.16)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C230(1.13)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C230(1.24)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C230(1.05)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C230(1.09)  LDD1532  [9]
 LDCM0295  AC34 HEK-293T C230(1.15)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C230(1.21)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C230(1.25)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C230(1.14)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C230(1.44)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C230(0.80)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C230(1.12)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C230(1.04)  LDD1541  [9]
 LDCM0304  AC42 HEK-293T C230(1.19)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C230(1.13)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C230(1.08)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C230(1.15)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C230(0.97)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C230(0.95)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C230(1.13)  LDD1549  [9]
 LDCM0312  AC5 HEK-293T C230(1.16)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C230(1.04)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C230(1.11)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C230(1.08)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C230(1.11)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C230(1.43)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C230(1.04)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C230(1.05)  LDD1558  [9]
 LDCM0321  AC58 HEK-293T C230(1.09)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C230(1.12)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C230(1.29)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C230(1.22)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C230(1.21)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C230(1.51)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C230(1.40)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C230(1.08)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C230(0.98)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C230(1.04)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C230(1.07)  LDD1511  [9]
 LDCM0275  AKOS034007705 HEK-293T C230(1.07)  LDD1514  [9]
 LDCM0498  BS-3668 MDA-MB-231 C230(0.52)  LDD2091  [4]
 LDCM0367  CL1 HEK-293T C230(1.20)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C230(0.82)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C230(1.12)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C230(1.10)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C230(1.06)  LDD1575  [9]
 LDCM0373  CL104 HEK-293T C230(1.10)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C230(1.10)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C230(1.00)  LDD1579  [9]
 LDCM0377  CL108 HEK-293T C230(1.11)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C230(1.07)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C230(1.06)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C230(1.01)  LDD1584  [9]
 LDCM0382  CL112 HEK-293T C230(1.15)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C230(1.20)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C230(1.14)  LDD1588  [9]
 LDCM0386  CL116 HEK-293T C230(1.19)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C230(1.15)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C230(1.02)  LDD1592  [9]
 LDCM0390  CL12 HEK-293T C230(0.75)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C230(1.11)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C230(1.08)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C230(1.01)  LDD1597  [9]
 LDCM0395  CL124 HEK-293T C230(1.12)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C230(1.45)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C230(1.18)  LDD1601  [9]
 LDCM0399  CL128 HEK-293T C230(1.19)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C230(1.27)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C230(1.11)  LDD1605  [9]
 LDCM0403  CL16 HEK-293T C230(1.18)  LDD1607  [9]
 LDCM0405  CL18 HEK-293T C230(0.98)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C230(0.95)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C230(1.29)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C230(0.94)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C230(0.71)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C230(0.74)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C230(0.67)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C230(0.70)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C230(1.22)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C230(1.07)  LDD1618  [9]
 LDCM0416  CL28 HEK-293T C230(1.10)  LDD1620  [9]
 LDCM0419  CL30 HEK-293T C230(0.98)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C230(0.98)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C230(0.90)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C230(0.78)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C230(0.73)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C230(0.78)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C230(0.68)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C230(1.21)  LDD1630  [9]
 LDCM0429  CL4 HEK-293T C230(1.21)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C230(1.13)  LDD1634  [9]
 LDCM0432  CL42 HEK-293T C230(0.89)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C230(0.96)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C230(0.96)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C230(0.80)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C230(0.84)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C230(0.90)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C230(0.62)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C230(1.36)  LDD1643  [9]
 LDCM0441  CL50 HEK-293T C230(1.12)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C230(1.12)  LDD1646  [9]
 LDCM0445  CL54 HEK-293T C230(0.96)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C230(0.92)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C230(0.88)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C230(0.76)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C230(0.79)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C230(0.83)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C230(0.99)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C230(0.66)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C230(1.28)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C230(1.10)  LDD1657  [9]
 LDCM0456  CL64 HEK-293T C230(1.14)  LDD1659  [9]
 LDCM0458  CL66 HEK-293T C230(0.98)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C230(0.98)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C230(0.85)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C230(0.73)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C230(1.04)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C230(0.91)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C230(0.80)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C230(0.69)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C230(1.28)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C230(1.17)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C230(1.14)  LDD1672  [9]
 LDCM0471  CL78 HEK-293T C230(1.06)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C230(1.01)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C230(0.90)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C230(0.87)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C230(0.79)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C230(0.90)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C230(0.94)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C230(0.74)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C230(1.53)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C230(1.24)  LDD1683  [9]
 LDCM0482  CL88 HEK-293T C230(1.26)  LDD1685  [9]
 LDCM0484  CL9 HEK-293T C230(0.75)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C230(1.18)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C230(1.02)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C230(0.98)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C230(0.84)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C230(1.00)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C230(0.88)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C230(0.88)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C230(1.23)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C230(1.08)  LDD1696  [9]
 LDCM0427  Fragment51 HEK-293T C230(1.05)  LDD1631  [9]
 LDCM0022  KB02 HEK-293T C230(1.04)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C230(0.96)  LDD1497  [9]
 LDCM0024  KB05 OAW-42 C74(2.58)  LDD3369  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C230(0.55)  LDD2121  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C230(0.82)  LDD2098  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C230(0.64)  LDD2101  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C230(0.58)  LDD2108  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C230(0.94)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C230(0.42)  LDD2115  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C230(0.82)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C230(0.49)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C230(1.08)  LDD2135  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C230(1.25)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C230(1.26)  LDD2140  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C230(0.93)  LDD2146  [4]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402