Details of the Target

General Information of Target

Target ID LDTP04299
Target Name Dual specificity protein kinase CLK3 (CLK3)
Gene Name CLK3
Gene ID 1198
Synonyms
Dual specificity protein kinase CLK3; EC 2.7.12.1; CDC-like kinase 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGG
GPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGL
PRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEG
RLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHR
RRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWL
QERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKD
KENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALR
FLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHT
TIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGP
IPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRM
LEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, Lammer subfamily
Subcellular location
Nucleus; Nucleus speckle
Function
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
TTD ID
T21585
Uniprot ID
P49761
DrugMap ID
TTQPE1U
Ensemble ID
ENST00000345005.8
HGNC ID
HGNC:2071
ChEMBL ID
CHEMBL4226

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.L274V DBIA    Probe Info 
CCK81 SNV: p.T243A DBIA    Probe Info 
IM95 SNV: p.G421S DBIA    Probe Info 
MFE319 SNV: p.G179R DBIA    Probe Info 
NUGC3 Deletion: p.P100HfsTer86 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C321(0.96)  LDD2137  [1]
DBIA
 Probe Info  		C258(0.87); C294(0.50); C321(1.05)  LDD0531  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		C416(0.00); C321(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C321(0.00); C416(0.00); C294(0.00)  LDD0037  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
W1
 Probe Info  		N.A.  LDD0236  [8]
AOyne
 Probe Info  		6.70  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C361
 Probe Info  		17.51  LDD2022  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C258(0.87); C294(0.50); C321(1.05)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C258(0.99); C294(0.89)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C321(0.61)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C321(0.60)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C321(0.49)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C321(0.60)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C321(0.50)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C321(0.61)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C321(0.61)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C321(0.66)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C321(0.62)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C321(0.67)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C258(1.19); C294(0.81)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C321(0.64)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C321(0.65)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C321(0.56)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C258(0.89); C294(1.10); C321(0.98)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C258(0.81); C294(0.94); C321(1.14)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C258(0.92); C294(1.01); C321(1.06)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C258(0.76); C294(1.07); C321(1.22)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C258(0.75); C294(1.10); C321(1.22)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C258(0.90); C294(0.97); C321(1.20)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C258(0.96); C294(1.12); C321(1.30)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C258(0.99); C294(1.02)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C258(1.27); C294(1.09); C321(1.19)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C258(0.64); C294(0.94); C321(1.21)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C258(0.77); C294(1.21); C321(1.27)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C258(0.75); C294(1.10); C321(1.98)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C258(0.72); C294(1.07); C321(1.23)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C258(0.84); C294(0.96); C321(1.18)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C258(0.74); C294(0.87); C321(1.32)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C258(0.80); C294(1.02); C321(1.26)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C321(1.03)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C321(1.07)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C321(0.81)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C321(0.84)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C321(1.19)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C321(1.09)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C321(0.88)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C321(0.94)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C321(0.94)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C321(1.06)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C321(0.88)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C321(1.16)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C258(0.95); C294(0.81)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C321(1.01)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C321(1.01)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C321(2.11)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C258(1.34); C321(1.04)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C321(0.29); C258(1.47)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C321(0.41); C258(1.11)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C321(0.37); C258(1.32)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C321(0.32); C258(1.16)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C321(0.48); C258(1.15)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C321(0.36); C258(1.36)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C294(0.85); C258(0.89)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C321(0.50); C258(1.21)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C321(0.47); C258(1.35)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C321(0.34); C258(1.17)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C321(0.49); C258(1.57)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C258(1.31); C321(0.33)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C258(1.29); C321(0.28)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C258(1.45); C321(0.83)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C258(1.33); C321(0.85)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C294(1.08)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C294(1.05)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C294(1.25)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C294(0.46); C321(0.83); C258(0.84)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C294(1.15)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C294(1.18)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C294(1.17)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C294(1.00)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C294(1.37)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C294(0.76); C321(0.94)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C294(1.00); C321(1.01)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C294(0.92); C321(0.94)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C321(0.86); C294(1.13)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C321(1.13); C294(1.15)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C294(0.50); C258(0.75); C321(0.90)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C321(1.16); C294(1.23)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C321(1.01); C294(1.03)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C321(0.99); C294(1.27)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C294(0.87); C321(0.99)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C294(0.84); C321(0.90)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C321(0.99); C294(1.29)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C321(1.00); C294(2.23)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C321(0.94); C294(0.98)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C321(0.96); C294(1.03)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C321(1.03); C294(1.19)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C294(0.36); C321(0.67); C258(0.71)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C321(0.96); C294(1.06)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C321(0.92); C294(1.04)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C321(1.01); C294(1.14)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C321(1.00); C294(1.13)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C321(0.96); C294(0.96)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C321(1.10); C294(1.17)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C321(1.09); C294(1.20)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C321(1.14); C294(1.14)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C294(1.27); C321(2.68)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C294(1.19); C321(1.29)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C294(0.37); C258(0.68); C321(0.74)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C321(1.26); C294(1.56)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C294(1.30); C321(1.52)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C321(0.87); C294(1.35)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C294(1.03); C321(1.23)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C321(1.05); C294(1.18)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C294(1.14); C321(1.36)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C321(1.41); C294(1.51)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C258(1.09); C294(1.40)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C258(0.97); C294(1.57)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C258(1.09); C294(1.56)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C294(1.00); C258(1.37)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C258(1.21); C294(1.32)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C258(0.87); C294(3.33)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C258(0.99); C294(2.20)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C258(1.29); C294(2.07)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C258(1.33); C294(1.80)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C294(1.04); C258(1.08)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C258(0.88); C294(1.09)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C258(1.18); C294(1.38)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C258(0.71); C321(1.21)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C321(0.84); C258(0.84)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C294(0.74); C258(1.20)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C321(1.01); C258(1.10)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C321(0.78); C258(0.88)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C258(0.84); C321(0.94)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C321(0.94); C258(1.50)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C321(0.82); C258(1.15)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C321(1.03); C258(1.38)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C321(0.80); C258(1.62)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C321(0.82); C258(1.13)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C321(0.98); C258(0.99)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C321(0.88); C258(0.95)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C294(0.92); C258(1.08)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C321(0.95); C258(1.23)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C258(0.53); C321(1.16)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C321(0.85); C258(1.99)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C294(0.93)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C294(0.89)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C294(1.01)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C294(0.78)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C294(0.64)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C294(0.72)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C294(0.73)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C294(0.59)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C294(0.77)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C294(0.81)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C294(0.81)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C294(1.10)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C294(0.77)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C294(0.99)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C294(0.79)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C321(0.68)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C321(0.72)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C258(1.00); C294(0.92)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C294(0.79); C258(1.17)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C258(0.87); C294(1.05)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C294(1.16)  LDD2171  [2]
 LDCM0367  CL1 HEK-293T C266(1.04); C294(1.15); C321(0.93); C258(0.96)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C266(1.05); C294(1.34); C321(1.38)  LDD1572  [11]
 LDCM0369  CL100 HCT 116 C294(0.30); C321(0.70); C258(1.03)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C258(0.85); C294(0.91)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C294(0.68); C258(0.89)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C258(0.87); C294(0.91)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C294(0.75); C258(0.95)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C294(1.24)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C294(0.85)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C294(1.16)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C294(1.48)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C294(1.27)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C266(1.00); C294(1.11); C321(0.98); C258(0.91)  LDD1583  [11]
 LDCM0380  CL110 HCT 116 C294(0.79)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C294(0.99)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C294(0.79); C321(0.85)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C321(0.90); C294(1.01)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C294(1.16); C321(1.22)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C294(0.89); C321(0.92)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C294(0.84); C321(0.94)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C294(1.18); C321(1.30)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C321(0.92); C294(0.98)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C321(1.01); C294(1.09)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C266(1.07); C294(1.03); C321(1.09); C258(0.93)  LDD1594  [11]
 LDCM0391  CL120 HCT 116 C294(0.86); C321(0.98)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C321(0.68); C294(1.10)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C294(0.99); C321(1.25)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C294(0.95); C321(1.28)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C294(1.18); C321(1.35)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C258(1.02); C294(1.34)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C258(0.98); C294(1.29)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C258(0.97); C294(1.62)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C258(0.96); C294(1.50)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C266(1.19); C294(1.37); C321(0.96); C258(1.01)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C266(0.95); C294(1.34); C321(0.93); C416(1.01)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C266(1.13); C294(1.14); C321(0.97); C258(0.91)  LDD1606  [11]
 LDCM0403  CL16 HCT 116 C294(0.76)  LDD0720  [2]
 LDCM0404  CL17 HEK-293T C266(1.22); C294(1.14); C321(0.82); C258(0.97)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C266(1.03); C294(0.95); C321(0.98); C258(1.05)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C294(1.08); C321(0.92); C258(0.97); C416(0.77)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C266(0.99); C294(1.21); C321(1.03); C416(0.80)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C266(1.00); C294(1.06); C321(0.91); C258(1.04)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C266(1.16); C294(1.16); C321(0.99); C258(1.06)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C266(1.04); C294(1.00); C321(1.08)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C266(1.02); C294(1.12); C321(1.01); C258(0.95)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C266(1.00); C294(1.10); C321(1.10); C258(1.11)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C266(0.96); C294(1.13); C321(0.98); C258(0.82)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C266(1.09); C294(1.05); C321(1.12); C416(0.91)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C266(1.12); C294(0.98); C321(1.01); C258(0.90)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C266(1.05); C294(1.00); C321(0.99); C258(0.94)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C266(1.03); C294(1.14); C321(1.16); C258(1.06)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C266(0.96); C294(1.07); C321(0.96); C258(0.77)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C266(1.08); C294(1.05); C321(1.02); C258(0.93)  LDD1623  [11]
 LDCM0420  CL31 HCT 116 C321(0.37)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C294(0.85); C321(1.00)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C294(0.66); C321(0.57)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C294(0.84); C321(0.44)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C294(0.92); C321(0.45)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C294(0.79); C321(0.44)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C294(0.87); C321(0.46)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C294(0.92); C321(0.51)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C266(1.02); C294(1.01); C321(1.00); C258(0.95)  LDD1633  [11]
 LDCM0430  CL40 HCT 116 C294(0.65); C321(0.36)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C294(0.85); C321(0.39)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C294(0.65); C321(0.61)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C294(0.87); C321(0.46)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C294(0.95); C321(0.56)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C294(0.91); C321(0.52)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C294(1.57)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C294(1.37)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C294(1.05)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C294(0.68)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C266(1.11); C294(1.09); C321(0.90); C258(0.93)  LDD1644  [11]
 LDCM0441  CL50 HCT 116 C294(1.13)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C294(1.03)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C294(1.09)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C294(0.97)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C294(0.88)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C294(1.02)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C294(0.80)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C294(1.30)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C294(1.31)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C294(0.85)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C266(1.09); C294(1.05); C321(0.90); C258(0.97)  LDD1654  [11]
 LDCM0452  CL60 HCT 116 C294(0.84)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C294(0.81)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C294(0.85)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C294(0.62)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C294(0.62)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C294(0.80)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C294(0.69)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C294(0.59)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C294(0.71)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C294(1.21)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C294(1.15); C321(0.91); C258(0.97); C416(0.71)  LDD1665  [11]
 LDCM0463  CL70 HCT 116 C294(0.86)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C294(0.61)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C294(0.91)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C294(0.57)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C294(0.59)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C321(1.03)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C321(0.62)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C321(0.43)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C321(0.49)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C266(1.10); C294(0.96); C321(0.82); C258(0.87)  LDD1676  [11]
 LDCM0474  CL80 HCT 116 C321(1.40)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C321(0.47)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C321(0.57)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C321(0.59)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C321(0.66)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C321(0.44)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C321(0.59)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C321(0.47)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C321(0.55)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C321(0.80)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C266(1.20); C294(1.15); C321(0.89); C258(1.07)  LDD1687  [11]
 LDCM0485  CL90 HCT 116 C321(0.86)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C258(0.93); C294(0.67); C321(0.74)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C258(0.99); C294(0.58); C321(0.79)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C258(0.76); C294(0.64); C321(0.88)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C258(0.86); C294(0.71); C321(0.72)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C258(0.84); C294(0.40); C321(0.65)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C258(0.84); C294(0.41); C321(0.76)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C258(0.88); C294(0.39); C321(0.73)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C258(1.13); C294(0.37); C321(0.68)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C258(0.91); C294(0.32); C321(0.72)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C266(1.12); C294(1.06); C321(0.97); C258(0.96)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C576(2.73); C321(2.59); C266(1.21)  LDD1702  [1]
 LDCM0625  F8 Ramos C266(1.12); C321(1.45); C576(2.18); C294(0.64)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C266(0.40); C321(0.61)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C266(1.89); C321(20.00); C576(3.89); C294(20.00)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C266(0.23); C321(0.99); C294(0.73)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C266(0.39); C321(1.13)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C266(0.35); C321(0.81); C576(1.37)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C266(0.37)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C266(0.40); C576(0.75); C294(1.10)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C266(1.83); C321(1.05)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C266(0.58); C321(0.42)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C266(0.32); C321(0.40); C576(0.49); C294(0.51)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C266(0.52); C321(0.65); C576(1.05); C294(1.19)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C266(0.48); C321(0.89); C294(1.26)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C266(0.34); C321(0.49); C294(0.92)  LDD2201  [12]
 LDCM0468  Fragment33 HCT 116 C294(0.58)  LDD0785  [2]
 LDCM0596  Fragment38 Ramos C266(0.27); C321(0.39)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C321(1.13)  LDD2184  [12]
 LDCM0427  Fragment51 HCT 116 C294(0.81); C321(0.45)  LDD0744  [2]
 LDCM0610  Fragment52 Ramos C266(0.81); C576(1.23)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C266(0.53); C321(0.84)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C294(1.28)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C266(0.54); C321(0.77)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C258(0.97); C266(1.01); C294(1.24); C416(1.35)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C258(0.97); C266(1.06); C294(0.86); C416(1.33)  LDD1497  [11]
 LDCM0024  KB05 HMCB C321(3.30)  LDD3312  [13]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C321(0.96)  LDD2137  [1]
 LDCM0021  THZ1 HCT 116 C294(1.16)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
2'-5'-oligoadenylate synthase 2 (OAS2) 2-5A synthase family P29728
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
SRSF protein kinase 2 (SRPK2) CMGC Ser/Thr protein kinase family P78362
Dual specificity protein kinase CLK2 (CLK2) CMGC Ser/Thr protein kinase family P49760
Dual specificity protein kinase CLK3 (CLK3) CMGC Ser/Thr protein kinase family P49761
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
RNA-binding protein with serine-rich domain 1 (RNPS1) Splicing factor SR family Q15287
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B6 (HOXB6) Antp homeobox family P17509
Homeobox protein Hox-B7 (HOXB7) Antp homeobox family P09629
Homeobox protein Hox-C4 (HOXC4) Antp homeobox family P09017
Zinc finger protein 263 (ZNF263) Krueppel C2H2-type zinc-finger protein family O14978
Zinc finger protein 473 (ZNF473) Krueppel C2H2-type zinc-finger protein family Q8WTR7
Zinc finger protein 777 (ZNF777) Krueppel C2H2-type zinc-finger protein family Q9ULD5
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
S-arrestin (SAG) Arrestin family P10523
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Protein INCA1 (INCA1) INCA family Q0VD86
NKAP-like protein (NKAPL) NKAP family Q5M9Q1
Arginine/serine-rich protein 1 (RSRP1) RSRP family Q9BUV0
CLK4-associating serine/arginine rich protein (CLASRP) Splicing factor SR family Q8N2M8
Serine/arginine-rich splicing factor 10 (SRSF10) Splicing factor SR family O75494
Serine/arginine-rich splicing factor 3 (SRSF3) Splicing factor SR family P84103
Transformer-2 protein homolog beta (TRA2B) Splicing factor SR family P62995
Calcium homeostasis endoplasmic reticulum protein (CHERP) . Q8IWX8
RNA-binding motif protein, X chromosome (RBMX) . P38159
RNA-binding motif protein, Y chromosome, family 1 member A1 (RBMY1A1) . P0DJD3
RNA-binding motif protein, Y chromosome, family 1 member F/J (RBMY1F; RBMY1J) . Q15415
Smad nuclear-interacting protein 1 (SNIP1) . Q8TAD8
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ethyl 3-[(E)-2-amino-1-cyanoethenyl]-67-dichloro-1-methyl-1h-indole-2-carboxylate Small molecular drug DB08691
K-00546 Small molecular drug DB07664
Kh-cb19 Small molecular drug D00BAJ
Leucettine L41 Small molecular drug D04IMY

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840