Details of the Target

General Information of Target

Target ID LDTP04979
Target Name U6 snRNA-associated Sm-like protein LSm3 (LSM3)
Gene Name LSM3
Gene ID 27258
Synonyms
U6 snRNA-associated Sm-like protein LSm3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADDVDQQQTTNTVEEPLDLIRLSLDERIYVKMRNDRELRGRLHAYDQHLNMILGDVEET
VTTIEIDEETYEEIYKSTKRNIPMLFVRGDGVVLVAPPLRVG
Target Bioclass
Other
Family
SnRNP Sm proteins family
Subcellular location
Nucleus
Function
Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Uniprot ID
P62310
Ensemble ID
ENST00000306024.4
HGNC ID
HGNC:17874

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		3.16  LDD0066  [1]
TH211
 Probe Info  		Y46(20.00)  LDD0257  [2]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C063
 Probe Info  		10.93  LDD1760  [3]
C091
 Probe Info  		10.20  LDD1782  [3]
C173
 Probe Info  		5.58  LDD1853  [3]
C177
 Probe Info  		10.70  LDD1856  [3]
C287
 Probe Info  		11.55  LDD1957  [3]
C293
 Probe Info  		19.84  LDD1963  [3]
C310
 Probe Info  		10.34  LDD1977  [3]
C313
 Probe Info  		25.28  LDD1980  [3]
C361
 Probe Info  		17.63  LDD2022  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Methylosome subunit pICln (CLNS1A) PICln (TC 1.A.47) family P54105
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Y-box-binding protein 1 (YBX1) YBX1 family P67809
Nucleus accumbens-associated protein 1 (NACC1) . Q96RE7
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Protein INCA1 (INCA1) INCA family Q0VD86
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
Protein LSM12 (LSM12) LSM12 family Q3MHD2
Small nuclear ribonucleoprotein Sm D3 (SNRPD3) SnRNP core protein family P62318
U6 snRNA-associated Sm-like protein LSm1 (LSM1) SnRNP Sm proteins family O15116
U6 snRNA-associated Sm-like protein LSm2 (LSM2) SnRNP Sm proteins family Q9Y333
U6 snRNA-associated Sm-like protein LSm5 (LSM5) SnRNP Sm proteins family Q9Y4Y9
U6 snRNA-associated Sm-like protein LSm7 (LSM7) SnRNP Sm proteins family Q9UK45
U6 snRNA-associated Sm-like protein LSm8 (LSM8) SnRNP Sm proteins family O95777
U7 snRNA-associated Sm-like protein LSm10 (LSM10) SnRNP Sm proteins family Q969L4
Small nuclear ribonucleoprotein F (SNRPF) SnRNP Sm proteins family P62306
U6 snRNA-associated Sm-like protein LSm6 (LSM6) SnRNP Sm proteins family P62312
T-cell leukemia/lymphoma protein 1A (TCL1A) TCL1 family P56279

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587