Details of the Target

General Information of Target

Target ID LDTP10621
Target Name Sideroflexin-2 (SFXN2)
Gene Name SFXN2
Gene ID 118980
Synonyms
Sideroflexin-2
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MATVAELKAVLKDTLEKKGVLGHLKARIRAEVFNALDDDREPRPSLSHENLLINELIREY
LEFNKYKYTASVLIAESGQPVVPLDRQFLIHELNAFEESKDNTIPLLYGILAHFLRGTKD
GIQNAFLKGPSLQPSDPSLGRQPSRRKPMDDHLRKEEQKSTNIEDLHVSQAVNR
Target Bioclass
Transporter and channel
Family
Sideroflexin family
Subcellular location
Mitochondrion inner membrane
Function Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria. Involved in mitochondrial iron homeostasis by regulating heme biosynthesis.
Uniprot ID
Q96NB2
Ensemble ID
ENST00000369893.10
HGNC ID
HGNC:16086

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C290(1.08)  LDD0533  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
NPM
 Probe Info  		N.A.  LDD0016  [4]
STPyne
 Probe Info  		N.A.  LDD0009  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
AOyne
 Probe Info  		13.50  LDD0443  [6]
NAIA_5
 Probe Info  		C290(0.00); C205(0.00); C189(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		8.28  LDD1740  [8]
C091
 Probe Info  		10.06  LDD1782  [8]
C092
 Probe Info  		16.68  LDD1783  [8]
C094
 Probe Info  		25.11  LDD1785  [8]
C112
 Probe Info  		19.29  LDD1799  [8]
C177
 Probe Info  		8.17  LDD1856  [8]
C186
 Probe Info  		8.06  LDD1864  [8]
C218
 Probe Info  		12.21  LDD1892  [8]
C231
 Probe Info  		12.91  LDD1904  [8]
C289
 Probe Info  		44.94  LDD1959  [8]
C349
 Probe Info  		9.38  LDD2010  [8]
C350
 Probe Info  		24.25  LDD2011  [8]
C361
 Probe Info  		21.26  LDD2022  [8]
C362
 Probe Info  		28.44  LDD2023  [8]
C407
 Probe Info  		15.24  LDD2064  [8]
FFF probe11
 Probe Info  		20.00  LDD0471  [9]
FFF probe13
 Probe Info  		20.00  LDD0475  [9]
FFF probe2
 Probe Info  		20.00  LDD0463  [9]
FFF probe3
 Probe Info  		20.00  LDD0464  [9]
OEA-DA
 Probe Info  		13.82  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C290(0.99); C189(1.11)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C290(1.05); C189(1.04)  LDD1508  [11]
 LDCM0216  AC100 HCT 116 C290(1.08)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C290(1.03)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C290(0.94)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C290(0.94)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C290(0.97)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C290(1.04)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C290(1.05)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C290(1.05)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C290(0.96)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C290(0.96)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C290(1.12); C189(0.97)  LDD1509  [11]
 LDCM0227  AC110 HCT 116 C290(0.97)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C290(1.07)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C290(0.96)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C290(0.98)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C290(0.87)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C290(0.94)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C290(0.96)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C290(1.21)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C290(1.08)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C290(0.97)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C290(1.02); C189(0.92)  LDD1510  [11]
 LDCM0238  AC120 HCT 116 C290(0.90)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C290(1.57)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C290(1.01)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C290(0.96)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C290(1.32)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C290(0.97)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C290(1.04)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C290(1.13)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C290(1.17)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C290(1.09)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C290(1.08)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C290(1.09)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C290(1.17)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C290(1.10)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C290(1.26)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C290(1.29)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C290(1.18)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C290(1.17)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C290(1.03)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C290(1.13)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C290(0.95); C189(0.97)  LDD1512  [11]
 LDCM0260  AC140 HCT 116 C290(1.17)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C290(1.29)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C290(1.21)  LDD0579  [2]
 LDCM0263  AC143 HEK-293T C290(0.90)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C290(0.99)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C290(0.84)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C290(0.89)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C290(1.17)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C290(0.84)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C290(0.99)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C290(0.99); C189(1.03)  LDD1513  [11]
 LDCM0271  AC150 HEK-293T C290(0.90)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C290(0.93)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C290(0.95)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C290(0.91)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C290(1.05)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C290(0.91)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C290(0.89)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C290(1.02)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C290(0.88)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C290(1.02)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C290(1.09)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C290(1.04); C189(1.09)  LDD1518  [11]
 LDCM0280  AC20 HCT 116 C290(1.00)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C290(0.94)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C290(1.07)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C290(0.96)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C290(0.92)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C290(1.01); C189(1.06)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C290(0.99); C189(1.03)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C290(1.02); C189(1.08)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C290(1.06); C189(1.00)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C290(1.03); C189(0.86)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C290(0.97); C189(0.98)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C290(0.93); C189(0.96)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C290(1.04); C189(0.82)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C290(0.95); C189(0.88)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C290(1.03); C189(1.04)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C290(0.94); C189(1.07)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C290(1.00); C189(1.06)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C290(0.96); C189(0.91)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C290(0.98); C189(0.74)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C290(0.83); C189(0.99)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C290(0.93); C189(0.81)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C290(0.96); C189(0.97)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C290(0.90); C189(0.98)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C290(1.06); C189(1.02)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C290(0.94); C189(1.04)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C290(0.99); C189(0.94)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C290(1.01); C189(0.93)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C290(0.97); C189(0.84)  LDD1546  [11]
 LDCM0308  AC46 HCT 116 C290(0.84)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C290(0.96)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C290(0.97)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C290(0.93)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C290(0.99); C189(0.81)  LDD1551  [11]
 LDCM0313  AC50 HCT 116 C290(0.95)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C290(0.93)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C290(0.86)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C290(0.90)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C290(1.07)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C290(0.74)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C290(0.70)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C290(1.09)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C290(0.98)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C290(1.25)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C290(0.92); C189(1.04)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C290(0.96)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C290(1.15)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C290(0.99)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C290(1.02)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C290(0.98)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C290(0.92)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C290(1.17)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C290(1.11)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C290(1.14)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C290(1.32)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C290(0.95); C189(0.80)  LDD1568  [11]
 LDCM0335  AC70 HCT 116 C290(1.05)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C290(1.15)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C290(1.05)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C290(1.00)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C290(1.08)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C290(1.06)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C290(1.16)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C290(1.12)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C290(0.96)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C290(1.03)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C290(1.06); C189(1.05)  LDD1569  [11]
 LDCM0346  AC80 HCT 116 C290(0.95)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C290(1.31)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C290(1.04)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C290(0.89)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C290(0.90)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C290(0.86)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C290(0.87)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C290(0.75)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C290(0.91)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C290(0.89)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C290(1.00)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C290(0.80)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C290(0.86)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C290(0.89)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C290(0.73)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C290(0.82)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C290(0.90)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C290(0.81)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C290(0.97)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C290(0.98)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C290(1.01); C189(0.87)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C290(0.98); C189(1.05)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C290(1.00); C189(1.01)  LDD1514  [11]
 LDCM0367  CL1 HCT 116 C290(0.97)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C290(0.88)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C290(0.98); C189(0.95)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C290(0.98); C189(0.92)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C290(0.98); C189(0.93)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C290(1.05); C189(0.93)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C290(0.94); C189(0.89)  LDD1577  [11]
 LDCM0374  CL105 HCT 116 C290(0.91)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C290(0.96)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C290(0.93)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C290(0.96)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C290(1.01)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C290(0.90)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C290(1.01)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C290(0.91)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C290(0.93); C189(0.91)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C290(0.94); C189(0.91)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C290(0.99); C189(0.97)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C290(0.99); C189(0.98)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C290(0.96); C189(1.01)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C290(0.96); C189(0.97)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C290(1.02); C189(0.92)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C290(1.01); C189(0.92)  LDD1593  [11]
 LDCM0390  CL12 HCT 116 C290(0.98)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C290(1.02); C189(1.00)  LDD1595  [11]
 LDCM0392  CL121 HCT 116 C290(0.73)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C290(0.72)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C290(0.95)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C290(0.72)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C290(1.04)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C290(0.82)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C290(0.89)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C290(0.99)  LDD0997  [2]
 LDCM0400  CL13 HCT 116 C290(0.94)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C290(0.93)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C290(1.12)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C290(1.14)  LDD1001  [2]
 LDCM0404  CL17 HCT 116 C290(0.71)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C290(0.82)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C290(0.96)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C290(0.88)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C290(0.71)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C290(0.70)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C290(0.81)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C290(0.78)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C290(0.85)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C290(0.86)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C290(0.77)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C290(0.79)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C290(0.80)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C290(0.76)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C290(1.05)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C290(0.96)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C290(1.09)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C290(1.17)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C290(0.90)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C290(1.26)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C290(1.02)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C290(1.22)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C290(1.36)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C290(1.22)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C290(0.90)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C290(1.17)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C290(1.20)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C290(1.09)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C290(1.37)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C290(1.18)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C290(1.13)  LDD0752  [2]
 LDCM0436  CL46 HEK-293T C290(0.97); C189(0.93)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C290(0.96); C189(0.80)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C290(1.05); C189(0.91)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C290(0.90); C189(1.00)  LDD1643  [11]
 LDCM0440  CL5 HCT 116 C290(1.09)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C290(0.96); C189(0.77)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C290(0.93); C189(0.99)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C290(0.93); C189(0.96)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C290(1.04); C189(0.86)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C290(1.11); C189(0.99)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C290(0.99); C189(0.93)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C290(1.12); C189(0.74)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C290(0.53); C189(0.84)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C290(1.00); C189(0.76)  LDD1653  [11]
 LDCM0451  CL6 HCT 116 C290(0.91)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C290(1.02); C189(0.95)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C290(0.92); C189(1.07)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C290(1.02); C189(0.98)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C290(0.98); C189(0.95)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C290(0.99); C189(0.84)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C290(1.00); C189(1.04)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C290(1.06); C189(1.08)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C290(1.02); C189(0.93)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C290(1.02); C189(0.92)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C290(1.04); C189(0.88)  LDD1664  [11]
 LDCM0462  CL7 HCT 116 C290(0.92)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C290(1.00); C189(0.95)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C290(1.00); C189(0.79)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C290(1.04); C189(0.94)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C290(0.95); C189(0.92)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C290(0.99); C189(0.93)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C290(1.06); C189(0.94)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C290(1.16); C189(0.99)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C290(1.00); C189(1.08)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C290(1.11); C189(1.02)  LDD1675  [11]
 LDCM0473  CL8 HCT 116 C290(0.90)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C290(1.02); C189(0.99)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C290(1.03); C189(0.90)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C290(0.87); C189(0.90)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C290(1.14); C189(0.77)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C290(1.00); C189(0.87)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C290(0.95); C189(0.85)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C290(0.99); C189(0.94)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C290(0.96); C189(1.08)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C290(0.97); C189(1.07)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C290(0.90); C189(1.04)  LDD1686  [11]
 LDCM0484  CL9 HCT 116 C290(0.82)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C290(1.18); C189(1.04)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C290(0.96); C189(0.99)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C290(1.02); C189(0.84)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C290(1.12); C189(0.85)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C290(0.84); C189(0.89)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C290(1.33); C189(0.81)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C290(1.08); C189(0.90)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C290(0.98); C189(0.92)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C290(1.03); C189(0.92)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C290(0.91); C189(0.96)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C290(0.74); C189(0.92)  LDD1698  [11]
 LDCM0575  Fragment13 Ramos C290(0.95)  LDD2192  [12]
 LDCM0580  Fragment21 Ramos C290(0.94)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C290(0.65)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C290(0.85)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C290(0.94)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C290(0.92)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C290(1.36)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C290(1.03)  LDD2201  [12]
 LDCM0468  Fragment33 HEK-293T C290(1.03); C189(0.98)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos C290(1.00)  LDD2203  [12]
 LDCM0427  Fragment51 HCT 116 C290(1.14)  LDD0744  [2]
 LDCM0614  Fragment56 Ramos C290(0.87)  LDD2205  [12]
 LDCM0022  KB02 HEK-293T C290(0.91); C189(0.92)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C290(1.04); C189(1.16)  LDD1497  [11]
 LDCM0024  KB05 OAW-42 C189(3.62)  LDD3369  [13]
 LDCM0628  OTUB2-COV-1 HEK-293T C189(1.09)  LDD2207  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.