Details of the Target

General Information of Target

Target ID LDTP18547
Target Name Protein CDV3 homolog (CDV3)
Gene Name CDV3
Gene ID 55573
Synonyms
H41; Protein CDV3 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEIHTPYSSLKKLLSLLNGFVAVSGIILVGLGIGGKCGGASLTNVLGLSSAYLLHVGNL
CLVMGCITVLLGCAGWYGATKESRGTLLFCILSMVIVLIMEVTAATVVLLFFPIVGDVAL
EHTFVTLRKNYRGYNEPDDYSTQWNLVMEKLKCCGVNNYTDFSGSSFEMTTGHTYPRSCC
KSIGSVSCDGRDVSPNVIHQKGCFHKLLKITKTQSFTLSGSSLGAAVIQRWGSRYVAQAG
LELLA
Target Bioclass
Other
Family
CDV3 family
Subcellular location
Cytoplasm
Uniprot ID
Q9UKY7
Ensemble ID
ENST00000264993.8
HGNC ID
HGNC:26928

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.E212D .
NCIH1993 SNV: p.E6G; p.N11H ATP probe    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		10.00  LDD0393  [1]
STPyne
 Probe Info  		K15(10.00); K181(6.20); K203(4.60); K232(7.69)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K15(2.40)  LDD3494  [3]
Probe 1
 Probe Info  		Y95(14.30); Y190(82.20)  LDD3495  [4]
HHS-475
 Probe Info  		Y244(0.87); Y190(0.95); Y169(1.52)  LDD0264  [5]
ATP probe
 Probe Info  		K181(0.00); K15(0.00)  LDD0199  [6]
ATP probe
 Probe Info  		N.A.  LDD0035  [7]
SF
 Probe Info  		Y190(0.00); Y95(0.00)  LDD0028  [8]
Ox-W18
 Probe Info  		N.A.  LDD2175  [9]
1c-yne
 Probe Info  		N.A.  LDD0228  [10]
1d-yne
 Probe Info  		N.A.  LDD0357  [10]
HHS-465
 Probe Info  		Y169(0.00); Y190(0.00); Y244(0.00)  LDD2240  [11]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C361
 Probe Info  		17.88  LDD2022  [12]
VE-P
 Probe Info  		N.A.  LDD0396  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y244(0.87); Y190(0.95); Y169(1.52)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y244(0.98); Y169(1.11); Y190(1.18)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y169(0.85); Y244(0.97); Y190(1.80)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y244(0.92); Y169(1.00); Y190(1.46)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y190(0.46); Y244(0.79); Y169(1.11)  LDD0268  [5]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
8 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
9 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
10 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
11 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.