Details of the Target

General Information of Target

Target ID LDTP01582
Target Name Pre-mRNA-splicing factor SLU7 (SLU7)
Gene Name SLU7
Gene ID 10569
Synonyms
Pre-mRNA-splicing factor SLU7; hSlu7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSATVVDAVNAAPLSGSKEMSLEEPKKMTREDWRKKKELEEQRKLGNAPAEVDEEGKDIN
PHIPQYISSVPWYIDPSKRPTLKHQRPQPEKQKQFSSSGEWYKRGVKENSIITKYRKGAC
ENCGAMTHKKKDCFERPRRVGAKFTGTNIAPDEHVQPQLMFDYDGKRDRWNGYNPEEHMK
IVEEYAKVDLAKRTLKAQKLQEELASGKLVEQANSPKHQWGEEEPNSQMEKDHNSEDEDE
DKYADDIDMPGQNFDSKRRITVRNLRIREDIAKYLRNLDPNSAYYDPKTRAMRENPYANA
GKNPDEVSYAGDNFVRYTGDTISMAQTQLFAWEAYDKGSEVHLQADPTKLELLYKSFKVK
KEDFKEQQKESILEKYGGQEHLDAPPAELLLAQTEDYVEYSRHGTVIKGQERAVACSKYE
EDVKIHNHTHIWGSYWKEGRWGYKCCHSFFKYSYCTGEAGKEIVNSEECIINEITGEESV
KKPQTLMELHQEKLKEEKKKKKKKKKKHRKSSSDSDDEEKKHEKLKKALNAEEARLLHVK
ETMQIDERKRPYNSMYETREPTEEEMEAYRMKRQRPDDPMASFLGQ
Target Bioclass
Other
Family
SLU7 family
Subcellular location
Nucleus
Function
Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
Uniprot ID
O95391
Ensemble ID
ENST00000297151.9
HGNC ID
HGNC:16939

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
Probe 1
 Probe Info  		Y569(126.01)  LDD3495  [2]
Acrolein
 Probe Info  		N.A.  LDD0223  [3]
DBIA
 Probe Info  		C120(1.37); C123(1.37)  LDD0080  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
Phosphinate-6
 Probe Info  		C120(0.00); C133(0.00)  LDD0018  [6]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		12.82  LDD1713  [7]
C004
 Probe Info  		6.02  LDD1714  [7]
C346
 Probe Info  		10.27  LDD2007  [7]
C355
 Probe Info  		23.10  LDD2016  [7]
C361
 Probe Info  		17.75  LDD2022  [7]
C383
 Probe Info  		11.47  LDD2042  [7]
C388
 Probe Info  		42.22  LDD2047  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C120(1.29); C123(1.29); C455(2.26)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C120(1.12); C123(1.12)  LDD0532  [4]
 LDCM0226  AC11 HCT 116 C120(1.10); C123(1.10)  LDD0543  [4]
 LDCM0230  AC113 HCT 116 C445(1.20); C446(1.20)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C445(1.12); C446(1.12)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C445(1.62); C446(1.62)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C445(1.28); C446(1.28)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C445(1.22); C446(1.22)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C445(1.07); C446(1.07)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C445(1.36); C446(1.36)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C120(0.81); C123(0.81)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C445(1.27); C446(1.27)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C445(1.09); C446(1.09)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C445(1.17); C446(1.17)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C445(1.10); C446(1.10)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C445(1.23); C446(1.23)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C445(1.20); C446(1.20)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C445(1.18); C446(1.18)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C445(1.19); C446(1.19)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C445(1.25); C446(1.25)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C445(1.03); C446(1.03)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C445(1.16); C446(1.16)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C445(0.89); C446(0.89)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C445(1.16); C446(1.16)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C445(1.12); C446(1.12)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C445(1.04); C446(1.04)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C445(1.10); C446(1.10)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C445(1.13); C446(1.13)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C445(0.96); C446(0.96)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C445(1.02); C446(1.02)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C445(1.21); C446(1.21)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C120(1.20); C123(1.20)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C445(1.12); C446(1.12)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C445(1.06); C446(1.06)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C445(1.39); C446(1.39)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C120(0.84); C123(0.84)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C120(0.68); C123(0.75)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C120(0.78); C123(0.83)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C123(0.75); C120(0.78)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C123(0.79); C120(0.85)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C123(0.57); C120(0.69)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C123(0.72); C120(0.85)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C120(1.18); C123(1.18)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C123(0.78); C120(0.86)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C123(0.73); C120(0.78)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C123(0.77); C120(0.85)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C123(0.61); C120(0.68)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C120(0.83); C123(0.95)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C120(0.71); C123(0.80)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C120(1.06); C123(0.89)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C120(0.72); C123(0.72)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C455(0.72)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C455(0.74)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C455(0.61)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C455(0.77); C120(1.31); C123(1.31)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C455(0.67)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C455(0.63)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C455(0.71)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C455(0.65)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C455(0.59)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C120(1.29)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C120(1.32)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C120(1.41)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C120(1.06)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C120(1.33)  LDD0887  [4]
 LDCM0290  AC3 HCT 116 C455(1.23); C120(1.47); C123(1.47)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C120(1.32)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C120(1.10)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C120(1.27)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C120(1.25)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C120(1.07)  LDD0893  [4]
 LDCM0296  AC35 HCT 116 C445(1.32); C446(1.32)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C445(1.22); C446(1.22)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C445(1.52); C446(1.52)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C445(1.20); C446(1.20)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C445(1.10); C446(1.10)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C455(1.26); C120(1.66); C123(1.66)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C445(1.38); C446(1.38)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C445(1.42); C446(1.42)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C445(1.23); C446(1.23)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C445(1.65); C446(1.65)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C445(1.43); C446(1.43)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C445(1.70); C446(1.70)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C455(1.14)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C455(0.97)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C455(1.16)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C455(1.08)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C455(0.92); C120(1.55); C123(1.55)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C455(0.77)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C455(1.21)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C455(0.81)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C455(1.01)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C455(0.79)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C455(0.88)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C455(1.29)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C445(1.01); C446(1.01)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C445(0.92); C446(0.92)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C445(1.10); C446(1.10)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C120(1.22); C123(1.22)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C445(1.22); C446(1.22)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C445(1.09); C446(1.09)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C445(1.17); C446(1.17)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C445(1.00); C446(1.00)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C445(1.21); C446(1.21)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C445(1.10); C446(1.10)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C445(0.97); C446(0.97)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C445(1.17); C446(1.17)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C455(1.22)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C455(1.24)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C120(1.07); C123(1.07)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C455(0.99)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C455(1.22)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C455(1.05)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C455(1.20)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C455(1.38)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C455(1.30)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C455(1.05)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C455(1.18)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C455(1.41)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C455(1.16)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C120(1.19); C123(1.19)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C455(1.07)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C455(1.39)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C455(1.25)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C455(0.67)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C455(0.50)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C455(0.63)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C455(0.36)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C455(0.60)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C455(0.50)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C455(0.44)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C455(0.58)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C455(0.40)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C455(0.38)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C455(0.40)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C455(0.46)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C455(1.52)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C455(0.40)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C455(0.37)  LDD0681  [4]
 LDCM0248  AKOS034007472 HCT 116 C120(1.25); C123(1.25)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C120(1.25); C123(1.25)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C120(1.45); C123(1.45)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C120(1.41); C123(1.41)  LDD2171  [4]
 LDCM0367  CL1 HCT 116 C455(0.61)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C455(0.71)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C455(1.17); C120(1.41); C123(1.41)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C120(2.04); C123(2.04)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C120(1.24); C123(1.24)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C120(1.40); C123(1.40)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C120(1.06); C123(1.06)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C455(0.64)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C455(0.67)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C455(0.58)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C455(0.77)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C455(0.60)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C455(0.88)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C455(0.51)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C455(0.61)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C120(1.59)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C120(1.20)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C120(1.65)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C120(1.43)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C120(1.66)  LDD0984  [4]
 LDCM0387  CL117 HCT 116 C445(1.44); C446(1.44)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C445(1.47); C446(1.47)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C445(1.39); C446(1.39)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C455(0.64)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C445(1.30); C446(1.30)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C455(0.78)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C455(1.13)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C455(0.76)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C455(0.94)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C445(1.00); C446(1.00)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C445(1.02); C446(1.02)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C445(0.92); C446(0.92)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C445(0.98); C446(0.98)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C455(0.90)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C455(0.57)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C455(0.81)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C455(0.72)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C455(0.93)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C455(1.73)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C455(0.87)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C455(0.90)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C455(0.84)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C455(0.79)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C455(0.95)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C455(0.74)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C455(0.98)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C455(0.77)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C455(0.90)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C455(0.89)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C455(0.74)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C455(0.72)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C455(0.66)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C455(1.14)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C455(0.65)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C455(1.27)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C455(0.64)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C455(0.81)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C455(0.69)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C455(0.75)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C455(0.70)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C455(0.74)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C455(0.59)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C455(0.69)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C455(0.65)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C455(0.87)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C455(0.84)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C455(1.14)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C455(1.18)  LDD0752  [4]
 LDCM0436  CL46 PaTu 8988t C445(0.91); C446(0.91); C455(1.03)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C445(0.99); C446(0.99); C455(0.93)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C445(0.84); C446(0.84); C455(1.04)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C445(0.93); C446(0.93); C455(0.94)  LDD1318  [4]
 LDCM0440  CL5 HCT 116 C455(0.68)  LDD0757  [4]
 LDCM0441  CL50 PaTu 8988t C445(1.32); C446(1.32); C455(1.28)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C445(0.82); C446(0.82); C455(1.21)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C445(0.92); C446(0.92); C455(1.10)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C445(1.00); C446(1.00); C455(1.35)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C445(1.10); C446(1.10); C455(1.34)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C445(1.02); C446(1.02); C455(1.28)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C445(0.68); C446(0.68); C455(0.65)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C445(1.00); C446(1.00); C455(0.90)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C445(1.08); C446(1.08); C455(1.03)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C445(1.15); C446(1.15); C455(0.96)  LDD1329  [4]
 LDCM0451  CL6 HCT 116 C455(1.09)  LDD0768  [4]
 LDCM0452  CL60 PaTu 8988t C445(0.96); C446(0.96); C455(0.88)  LDD1331  [4]
 LDCM0453  CL61 HCT 116 C120(1.25); C123(1.25)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C120(1.44); C123(1.44)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C120(0.97); C123(0.97)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C120(1.25); C123(1.25)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C120(0.86); C123(0.86)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C120(1.01); C123(1.01)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C120(0.94); C123(0.94)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C120(0.90); C123(0.90)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C120(1.02); C123(1.02)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C455(0.80)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C120(0.96); C123(0.96)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C120(0.99); C123(0.99)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C120(1.14); C123(1.14)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C120(0.97); C123(0.97)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C120(1.01); C123(1.01)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C445(1.15); C446(1.15); C455(1.48)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C445(0.84); C446(0.84); C455(0.76)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C445(0.90); C446(0.90); C455(0.85)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C445(1.01); C446(1.01); C455(0.81)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C455(0.63)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C445(1.46); C446(1.46); C455(1.98)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C445(0.83); C446(0.83); C455(0.96)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C445(1.15); C446(1.15); C455(1.15)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C445(1.03); C446(1.03); C455(1.06)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C445(1.04); C446(1.04); C455(1.12)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C445(0.76); C446(0.76); C455(1.20)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C445(0.80); C446(0.80); C455(0.92)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C445(0.94); C446(0.94); C455(0.76)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C445(1.05); C446(1.05); C455(0.92)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C445(1.45); C446(1.45); C455(1.54)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C455(0.70)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C445(0.86); C446(0.86); C455(1.06)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C120(0.98); C123(0.98); C455(0.87)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C120(1.21); C123(1.21); C455(1.67)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C120(1.40); C123(1.40); C455(1.20)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C120(1.33); C123(1.33); C455(0.63)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C120(1.41); C123(1.41); C455(1.66)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C120(1.98); C123(1.98); C455(0.84)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C120(1.47); C123(1.47); C455(0.94)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C120(1.10); C123(1.10); C455(0.95)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C120(1.34); C123(1.34); C455(0.95)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C455(0.99); C469(1.00)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C445(4.52); C455(1.43)  LDD1702  [9]
 LDCM0468  Fragment33 HCT 116 C120(0.91); C123(0.91)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C455(0.79)  LDD0744  [4]
 LDCM0022  KB02 HCT 116 C120(1.37); C123(1.37)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C120(1.32); C123(1.32)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C120(1.83); C123(1.83)  LDD0082  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]
 LDCM0021  THZ1 HCT 116 C120(1.41); C123(1.41)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase NSD3 (NSD3) Histone-lysine methyltransferase family Q9BZ95
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Peptidyl-prolyl cis-trans isomerase-like 3 (PPIL3) Cyclophilin-type PPIase family Q9H2H8
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-10 (ATXN10) Ataxin-10 family Q9UBB4
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Colorectal mutant cancer protein (MCC) MCC family P23508
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) . Q13155
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Differentially expressed in FDCP 6 homolog (DEF6) . Q9H4E7
Four and a half LIM domains protein 3 (FHL3) . Q13643
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
Pre-mRNA-processing-splicing factor 8 (PRPF8) . Q6P2Q9
Splicing factor 3B subunit 2 (SF3B2) . Q13435
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) . O43395

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761