Details of the Target

General Information of Target

Target ID LDTP01197
Target Name Filamin-B (FLNB)
Gene Name FLNB
Gene ID 2317
Synonyms
FLN1L; FLN3; TABP; TAP; Filamin-B; FLN-B; ABP-278; ABP-280 homolog; Actin-binding-like protein; Beta-filamin; Filamin homolog 1; Fh1; Filamin-3; Thyroid autoantigen; Truncated actin-binding protein; Truncated ABP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQK
RMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILH
YSISMPVWEDEGDDDAKKQTPKQRLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAP
GLCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKA
KLKPGAPLKPKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK
EEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAK
GPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCVYKP
MQPGPHVVKIFFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPKGVRIRETTDFKVDTK
AAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSPFE
VQVGPEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQN
DGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKSGC
IVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTIAV
VWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVG
IKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVKVD
PSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDIID
NYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKLNGLENRVEVGK
DQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDVTY
DGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGP
CEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASG
PGLEHGKVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAG
MYTLTMKYGGELVPHFPARVKVEPAVDTSRIKVFGPGIEGKDVFREATTDFTVDSRPLTQ
VGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKV
AVTEGCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDNKD
GSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDPSKVKIAGPGLGSGVRARVL
QSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVKYADE
EIPRSPFKVKVLPTYDASKVTASGPGLSSYGVPASLPVDFAIDARDAGEGLLAVQITDQE
GKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQTGDASKCLAT
GPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAK
PGTYVIYVRFGGVDIPNSPFTVMATDGEVTAVEEAPVNACPPGFRPWVTEEAYVPVSDMN
GLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDNKDGTVTVRYAPTEVGLHEMHI
KYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAGEGGLDLAIEG
PSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKITDDSRRCSQVKL
GSAADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNHIGISFIPREVGEHLVSIKK
NGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVE
GPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKISGEGRVKESIT
RTSRAPSVATVGSICDLNLKIPEINSSDMSAHVTSPSGRVTEAEIVPMGKNSHCVRFVPQ
EMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGVPAEFSIWTRE
AGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDEHIPESPYLVPV
IAPSDDARRLTVMSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSGAVEECHVSELEP
DKYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGTGLEGGTTG
IQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNYLISVKYGGPN
HIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIPKASSDASKVTSKGA
GLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGNQQYNVTYVVKERGD
YVLAVKWGEEHIPGSPFHVTVP
Target Bioclass
Transporter and channel
Family
Filamin family
Subcellular location
Cytoplasm, cytoskeleton, stress fiber; Cytoplasm, cell cortex; Cytoplasm, cytoskeleton
Function
Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
Uniprot ID
O75369
Ensemble ID
ENST00000295956.9
HGNC ID
HGNC:3755
ChEMBL ID
CHEMBL4295677

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.K1745R DBIA    Probe Info 
CORL88 SNV: p.D624G DBIA    Probe Info 
DANG SNV: p.D1738E DBIA    Probe Info 
HCT15 SNV: p.N2259K DBIA    Probe Info 
HT1376 SNV: p.P557L DBIA    Probe Info 
IM95 SNV: p.Y515H DBIA    Probe Info 
IPC298 SNV: p.S1529F DBIA    Probe Info 
JURKAT SNV: p.V103M; p.M270T Compound 10    Probe Info 
LNCaP clone FGC SNV: p.Q2255Ter DBIA    Probe Info 
MDST8 SNV: p.D1706N DBIA    Probe Info 
MFE319 SNV: p.A705T; p.G959E DBIA    Probe Info 
MOLT4 SNV: p.V279L IA-alkyne    Probe Info 
NALM6 SNV: p.P1752L DBIA    Probe Info 
ONS76 SNV: p.P247A DBIA    Probe Info 
PFSK1 SNV: p.Y2260Ter DBIA    Probe Info 
RL952 Deletion: p.A971QfsTer9
SNV: p.R818Ter		 DBIA    Probe Info 
SNGM SNV: p.R553C; p.S1041N DBIA    Probe Info 
SW403 SNV: p.K2006E DBIA    Probe Info 
TE1 SNV: p.Q503E DBIA    Probe Info 
YSCCC SNV: p.D474H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 53 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.72  LDD0402  [1]
P2
 Probe Info  		2.22  LDD0449  [2]
P3
 Probe Info  		4.31  LDD0450  [2]
A-EBA
 Probe Info  		4.21  LDD0215  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
W1
 Probe Info  		10.74  LDD0235  [5]
TH211
 Probe Info  		Y596(20.00); Y2502(16.34); Y2069(10.53)  LDD0257  [6]
TH214
 Probe Info  		Y596(20.00)  LDD0258  [6]
TH216
 Probe Info  		Y2502(20.00); Y596(20.00)  LDD0259  [6]
YN-4
 Probe Info  		100.00  LDD0445  [7]
ONAyne
 Probe Info  		K1005(3.69); K1057(1.02); K1221(2.88); K1241(4.24)  LDD0274  [8]
OPA-S-S-alkyne
 Probe Info  		K1955(1.23); K1241(1.42); K960(1.54); K2470(1.78)  LDD3494  [9]
Probe 1
 Probe Info  		Y66(11.19); Y511(9.64); Y596(5.47); Y904(9.56)  LDD3495  [10]
JZ128-DTB
 Probe Info  		C2248(0.00); C178(0.00)  LDD0462  [11]
DBIA
 Probe Info  		C2556(9.72)  LDD0209  [12]
HHS-475
 Probe Info  		Y902(0.71); Y596(0.85); Y1530(0.98); Y904(1.96)  LDD0264  [13]
HHS-465
 Probe Info  		Y1530(10.00); Y596(10.00); Y904(9.98)  LDD2237  [14]
5E-2FA
 Probe Info  		H2243(0.00); H2550(0.00); H867(0.00); H1046(0.00)  LDD2235  [15]
ATP probe
 Probe Info  		K681(0.00); K2088(0.00); K2170(0.00); K409(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1868(0.00); C2556(0.00); C1280(0.00); C2115(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		C450(0.00); C1617(0.00); C706(0.00); C2537(0.00)  LDD0032  [18]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [19]
Lodoacetamide azide
 Probe Info  		C1868(0.00); C2556(0.00); C1280(0.00); C769(0.00)  LDD0037  [17]
ATP probe
 Probe Info  		K2470(0.00); K16(0.00); K2507(0.00); K60(0.00)  LDD0035  [20]
BTD
 Probe Info  		C2333(0.00); C2115(0.00)  LDD0004  [21]
NAIA_4
 Probe Info  		C706(0.00); C1326(0.00); C1375(0.00); C2115(0.00)  LDD2226  [22]
TFBX
 Probe Info  		C2501(0.00); C450(0.00); C660(0.00); C2537(0.00)  LDD0027  [23]
WYneC
 Probe Info  		C2333(0.00); C1617(0.00); C2431(0.00)  LDD0014  [21]
WYneN
 Probe Info  		C2333(0.00); C706(0.00); C2431(0.00); C660(0.00)  LDD0021  [21]
WYneO
 Probe Info  		C1326(0.00); C2501(0.00); C604(0.00); C2154(0.00)  LDD0022  [21]
DA-P3
 Probe Info  		N.A.  LDD0178  [24]
Compound 10
 Probe Info  		C1617(0.00); C2115(0.00); C2501(0.00); C660(0.00)  LDD2216  [25]
Compound 11
 Probe Info  		C2501(0.00); C660(0.00)  LDD2213  [25]
ENE
 Probe Info  		C1081(0.00); C1868(0.00); C455(0.00); C660(0.00)  LDD0006  [21]
IPM
 Probe Info  		C2501(0.00); C2154(0.00); C1326(0.00)  LDD0005  [21]
NHS
 Probe Info  		K1221(0.00); K838(0.00); K681(0.00); K1510(0.00)  LDD0010  [21]
PF-06672131
 Probe Info  		N.A.  LDD0017  [26]
PPMS
 Probe Info  		C2501(0.00); C1081(0.00)  LDD0008  [21]
SF
 Probe Info  		Y904(0.00); K6(0.00); Y902(0.00)  LDD0028  [27]
STPyne
 Probe Info  		K681(0.00); K838(0.00); K2428(0.00)  LDD0009  [21]
VSF
 Probe Info  		C1617(0.00); C450(0.00); C660(0.00); C455(0.00)  LDD0007  [21]
YN-1
 Probe Info  		D505(0.00); E498(0.00)  LDD0447  [7]
Phosphinate-6
 Probe Info  		C1915(0.00); C1326(0.00); C1617(0.00); C2501(0.00)  LDD0018  [28]
1c-yne
 Probe Info  		K2576(0.00); K1232(0.00); K2244(0.00); K877(0.00)  LDD0228  [29]
1d-yne
 Probe Info  		K504(0.00); K822(0.00)  LDD0357  [29]
Acrolein
 Probe Info  		C1280(0.00); H2132(0.00); C2115(0.00); C660(0.00)  LDD0217  [30]
Cinnamaldehyde
 Probe Info  		C1326(0.00); C991(0.00); C2537(0.00)  LDD0220  [30]
Crotonaldehyde
 Probe Info  		H560(0.00); C1326(0.00); C604(0.00); C991(0.00)  LDD0219  [30]
Methacrolein
 Probe Info  		C2556(0.00); C450(0.00); C660(0.00); C2057(0.00)  LDD0218  [30]
NAIA_5
 Probe Info  		C2556(0.00); C1081(0.00); C2115(0.00); C1617(0.00)  LDD2223  [22]
HHS-482
 Probe Info  		Y1530(1.38); Y155(1.04); Y1818(0.79); Y2343(1.31)  LDD2239  [14]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		6.50  LDD0138  [31]
Staurosporine capture compound
 Probe Info  		2.00  LDD0083  [32]
Photocelecoxib
 Probe Info  		N.A.  LDD0153  [33]
DA-2
 Probe Info  		N.A.  LDD0071  [34]
STS-1
 Probe Info  		N.A.  LDD0069  [35]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1868(1.06); C2501(0.84); C450(0.55); C2431(0.45)  LDD2142  [36]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1868(0.76); C450(0.59); C2431(0.89); C2333(0.70)  LDD2112  [36]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C1868(1.13); C2501(0.68); C450(0.67); C2556(0.59)  LDD2095  [36]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C2501(0.83); C2431(0.61); C2333(0.86); C2115(0.84)  LDD2130  [36]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1868(1.07); C2501(0.92); C450(0.69); C2556(1.50)  LDD2117  [36]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1868(0.87); C2501(0.99); C450(1.15); C2431(1.48)  LDD2152  [36]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1868(0.98); C2501(1.08); C450(0.96); C2333(2.12)  LDD2103  [36]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C2501(0.59); C450(0.66); C416(0.52); C2537(0.48)  LDD2132  [36]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C1868(1.04); C2501(0.71); C2333(0.89); C1952(0.49)  LDD2131  [36]
 LDCM0025  4SU-RNA HEK-293T C26(3.09)  LDD0371  [37]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1617(6.66)  LDD0372  [37]
 LDCM0214  AC1 HEK-293T C1326(0.86); C2501(1.07); C706(1.07); C1952(0.85)  LDD1507  [38]
 LDCM0215  AC10 HEK-293T C1326(0.96); C2501(1.01); C706(0.95); C1952(0.84)  LDD1508  [38]
 LDCM0226  AC11 HEK-293T C1326(0.90); C2501(1.07); C706(1.01); C1952(0.94)  LDD1509  [38]
 LDCM0237  AC12 HEK-293T C1326(0.98); C2501(1.03); C706(0.92); C1952(0.92)  LDD1510  [38]
 LDCM0259  AC14 HEK-293T C1326(0.92); C2501(0.98); C706(0.95); C1952(0.95)  LDD1512  [38]
 LDCM0270  AC15 HEK-293T C1326(0.89); C2501(0.96); C706(1.13); C1952(0.96)  LDD1513  [38]
 LDCM0276  AC17 HEK-293T C1326(0.92); C2501(1.08); C706(1.09); C1952(0.90)  LDD1515  [38]
 LDCM0277  AC18 HEK-293T C1326(1.02); C2501(1.02); C706(1.00); C1952(0.90)  LDD1516  [38]
 LDCM0278  AC19 HEK-293T C1326(0.78); C2501(1.03); C706(1.05); C1952(0.92)  LDD1517  [38]
 LDCM0279  AC2 HEK-293T C1326(1.05); C2501(0.97); C706(1.04); C1952(0.97)  LDD1518  [38]
 LDCM0280  AC20 HEK-293T C1326(1.04); C2501(1.01); C706(1.00); C1952(0.92)  LDD1519  [38]
 LDCM0281  AC21 HEK-293T C1326(0.97); C2501(1.07); C706(0.97); C1952(0.92)  LDD1520  [38]
 LDCM0282  AC22 HEK-293T C1326(0.99); C2501(0.97); C706(1.01); C1952(0.87)  LDD1521  [38]
 LDCM0283  AC23 HEK-293T C1326(0.95); C2501(0.97); C706(1.04); C1952(0.94)  LDD1522  [38]
 LDCM0284  AC24 HEK-293T C1326(0.95); C2501(0.97); C706(0.98); C1952(0.98)  LDD1523  [38]
 LDCM0285  AC25 HEK-293T C1326(0.94); C2501(1.06); C706(1.05); C1952(0.85)  LDD1524  [38]
 LDCM0286  AC26 HEK-293T C1326(1.02); C2501(1.00); C706(0.96); C1952(0.87)  LDD1525  [38]
 LDCM0287  AC27 HEK-293T C1326(0.95); C2501(1.01); C706(0.98); C1952(0.95)  LDD1526  [38]
 LDCM0288  AC28 HEK-293T C1326(0.95); C2501(0.96); C706(1.00); C1952(0.83)  LDD1527  [38]
 LDCM0289  AC29 HEK-293T C1326(1.01); C2501(1.11); C706(0.98); C1952(1.00)  LDD1528  [38]
 LDCM0290  AC3 HEK-293T C1326(0.83); C2501(1.03); C706(1.05); C1952(0.96)  LDD1529  [38]
 LDCM0291  AC30 HEK-293T C1326(1.02); C2501(0.99); C706(0.97); C1952(0.99)  LDD1530  [38]
 LDCM0292  AC31 HEK-293T C1326(0.94); C2501(0.96); C706(1.06); C1952(0.95)  LDD1531  [38]
 LDCM0293  AC32 HEK-293T C1326(0.95); C2501(0.98); C706(0.96); C1952(0.93)  LDD1532  [38]
 LDCM0294  AC33 HEK-293T C1326(0.90); C2501(0.96); C706(0.99); C1952(0.82)  LDD1533  [38]
 LDCM0295  AC34 HEK-293T C1326(0.99); C2501(0.97); C706(1.02); C1952(0.81)  LDD1534  [38]
 LDCM0296  AC35 HEK-293T C1326(0.87); C2501(1.06); C706(0.97); C1952(0.93)  LDD1535  [38]
 LDCM0297  AC36 HEK-293T C1326(0.92); C2501(0.96); C706(0.97); C1952(0.89)  LDD1536  [38]
 LDCM0298  AC37 HEK-293T C1326(1.01); C2501(0.94); C706(1.05); C1952(1.01)  LDD1537  [38]
 LDCM0299  AC38 HEK-293T C1326(0.93); C2501(0.99); C706(0.93); C1952(0.91)  LDD1538  [38]
 LDCM0300  AC39 HEK-293T C1326(0.98); C2501(0.95); C706(1.14); C1952(0.96)  LDD1539  [38]
 LDCM0301  AC4 HEK-293T C1326(0.93); C2501(1.04); C706(0.91); C1952(0.95)  LDD1540  [38]
 LDCM0302  AC40 HEK-293T C1326(1.01); C2501(0.96); C706(0.93); C1952(0.93)  LDD1541  [38]
 LDCM0303  AC41 HEK-293T C1326(0.86); C2501(0.98); C706(1.03); C1952(0.91)  LDD1542  [38]
 LDCM0304  AC42 HEK-293T C1326(1.00); C2501(1.00); C706(1.02); C1952(0.85)  LDD1543  [38]
 LDCM0305  AC43 HEK-293T C1326(0.98); C2501(1.07); C706(1.01); C1952(0.88)  LDD1544  [38]
 LDCM0306  AC44 HEK-293T C1326(0.98); C2501(0.96); C706(0.92); C1952(0.89)  LDD1545  [38]
 LDCM0307  AC45 HEK-293T C1326(1.14); C2501(1.04); C706(0.99); C1952(0.94)  LDD1546  [38]
 LDCM0308  AC46 HEK-293T C1326(1.05); C2501(0.93); C706(1.02); C1952(0.92)  LDD1547  [38]
 LDCM0309  AC47 HEK-293T C1326(0.99); C2501(0.88); C706(1.05); C1952(0.96)  LDD1548  [38]
 LDCM0310  AC48 HEK-293T C1326(0.97); C2501(1.03); C706(0.97); C1952(0.94)  LDD1549  [38]
 LDCM0311  AC49 HEK-293T C1326(0.92); C2501(0.99); C706(1.05); C1952(0.83)  LDD1550  [38]
 LDCM0312  AC5 HEK-293T C1326(1.13); C2501(1.11); C706(0.95); C1952(1.01)  LDD1551  [38]
 LDCM0313  AC50 HEK-293T C1326(0.97); C2501(0.98); C706(0.98); C1952(0.85)  LDD1552  [38]
 LDCM0314  AC51 HEK-293T C1326(0.89); C2501(1.02); C706(0.99); C1952(0.89)  LDD1553  [38]
 LDCM0315  AC52 HEK-293T C1326(1.01); C2501(0.98); C706(0.98); C1952(0.85)  LDD1554  [38]
 LDCM0316  AC53 HEK-293T C1326(1.11); C2501(0.96); C706(0.97); C1952(0.91)  LDD1555  [38]
 LDCM0317  AC54 HEK-293T C1326(0.99); C2501(0.94); C706(1.01); C1952(0.91)  LDD1556  [38]
 LDCM0318  AC55 HEK-293T C1326(0.91); C2501(0.91); C706(1.10); C1952(0.99)  LDD1557  [38]
 LDCM0319  AC56 HEK-293T C1326(0.93); C2501(0.97); C706(0.91); C1952(0.91)  LDD1558  [38]
 LDCM0320  AC57 HEK-293T C1326(0.82); C2501(1.00); C706(1.09); C1952(0.78)  LDD1559  [38]
 LDCM0321  AC58 HEK-293T C1326(0.93); C2501(0.98); C706(0.98); C1952(0.78)  LDD1560  [38]
 LDCM0322  AC59 HEK-293T C1326(0.92); C2501(1.03); C706(0.99); C1952(0.90)  LDD1561  [38]
 LDCM0323  AC6 HEK-293T C1326(0.97); C2501(1.03); C706(0.98); C1952(0.86)  LDD1562  [38]
 LDCM0324  AC60 HEK-293T C1326(0.89); C2501(0.96); C706(0.96); C1952(0.75)  LDD1563  [38]
 LDCM0325  AC61 HEK-293T C1326(0.99); C2501(1.04); C706(1.03); C1952(0.79)  LDD1564  [38]
 LDCM0326  AC62 HEK-293T C1326(0.97); C2501(0.95); C706(0.96); C1952(0.74)  LDD1565  [38]
 LDCM0327  AC63 HEK-293T C1326(0.94); C2501(0.96); C706(0.98); C1952(0.81)  LDD1566  [38]
 LDCM0328  AC64 HEK-293T C1326(1.08); C2501(0.96); C706(0.96); C1952(0.88)  LDD1567  [38]
 LDCM0334  AC7 HEK-293T C1326(0.96); C2501(1.01); C706(1.13); C1952(1.01)  LDD1568  [38]
 LDCM0345  AC8 HEK-293T C1326(0.98); C2501(1.02); C706(0.96); C1952(1.09)  LDD1569  [38]
 LDCM0545  Acetamide MDA-MB-231 C416(0.91); C2333(0.69); C1952(0.79); C2115(0.87)  LDD2138  [36]
 LDCM0520  AKOS000195272 MDA-MB-231 C1868(0.65); C2501(0.69); C450(0.70); C2431(0.58)  LDD2113  [36]
 LDCM0248  AKOS034007472 HEK-293T C1326(1.09); C2501(1.02); C706(1.01); C1952(0.95)  LDD1511  [38]
 LDCM0356  AKOS034007680 HEK-293T C1326(0.90); C2501(1.04); C706(1.02); C1952(0.91)  LDD1570  [38]
 LDCM0275  AKOS034007705 HEK-293T C1326(0.97); C2501(0.97); C706(0.93); C1952(0.95)  LDD1514  [38]
 LDCM0156  Aniline NCI-H1299 C706(0.00); C1326(0.00)  LDD0404  [1]
 LDCM0498  BS-3668 MDA-MB-231 C1868(1.31); C450(1.24); C416(0.91); C2537(1.08)  LDD2091  [36]
 LDCM0630  CCW28-3 231MFP C1095(1.22); C1087(1.03)  LDD2214  [39]
 LDCM0108  Chloroacetamide HeLa C1280(0.00); C2556(0.00); H2132(0.00); C2115(0.00)  LDD0222  [30]
 LDCM0632  CL-Sc Hep-G2 C2115(2.20); C660(1.53); C2115(1.45); C2556(1.35)  LDD2227  [22]
 LDCM0367  CL1 HEK-293T C1326(1.02); C2501(1.00); C706(0.93); C1952(0.96)  LDD1571  [38]
 LDCM0368  CL10 HEK-293T C1326(0.81); C2501(0.90); C706(1.05); C1952(0.97)  LDD1572  [38]
 LDCM0369  CL100 HEK-293T C1326(1.00); C2501(1.03); C706(0.94); C1952(0.87)  LDD1573  [38]
 LDCM0370  CL101 HEK-293T C1326(1.01); C2501(1.00); C706(1.01); C1952(1.00)  LDD1574  [38]
 LDCM0371  CL102 HEK-293T C1326(1.09); C2501(0.94); C706(1.02); C1952(0.84)  LDD1575  [38]
 LDCM0372  CL103 HEK-293T C1326(0.99); C2501(0.95); C706(1.01); C1952(0.99)  LDD1576  [38]
 LDCM0373  CL104 HEK-293T C1326(0.94); C2501(0.98); C706(0.95); C1952(1.00)  LDD1577  [38]
 LDCM0374  CL105 HEK-293T C1326(1.04); C2501(0.97); C706(1.00); C1952(0.92)  LDD1578  [38]
 LDCM0375  CL106 HEK-293T C1326(0.94); C2501(0.99); C706(0.91); C1952(0.91)  LDD1579  [38]
 LDCM0376  CL107 HEK-293T C1326(0.97); C2501(0.89); C706(0.99); C1952(0.95)  LDD1580  [38]
 LDCM0377  CL108 HEK-293T C1326(0.88); C2501(1.00); C706(0.95); C1952(0.88)  LDD1581  [38]
 LDCM0378  CL109 HEK-293T C1326(1.06); C2501(1.03); C706(1.04); C1952(0.92)  LDD1582  [38]
 LDCM0379  CL11 HEK-293T C1326(0.90); C2501(0.94); C706(1.05); C1952(1.28)  LDD1583  [38]
 LDCM0380  CL110 HEK-293T C1326(1.03); C2501(0.92); C706(1.07); C1952(0.84)  LDD1584  [38]
 LDCM0381  CL111 HEK-293T C1326(1.12); C2501(0.95); C706(1.03); C1952(1.03)  LDD1585  [38]
 LDCM0382  CL112 HEK-293T C1326(0.96); C2501(1.08); C706(1.02); C1952(0.93)  LDD1586  [38]
 LDCM0383  CL113 HEK-293T C1326(0.98); C2501(1.04); C706(0.97); C1952(0.94)  LDD1587  [38]
 LDCM0384  CL114 HEK-293T C1326(1.09); C2501(0.88); C706(1.01); C1952(0.92)  LDD1588  [38]
 LDCM0385  CL115 HEK-293T C1326(0.97); C2501(0.98); C706(0.99); C1952(0.98)  LDD1589  [38]
 LDCM0386  CL116 HEK-293T C1326(0.97); C2501(1.00); C706(0.91); C1952(0.96)  LDD1590  [38]
 LDCM0387  CL117 HEK-293T C1326(0.96); C2501(1.02); C706(0.92); C1952(1.00)  LDD1591  [38]
 LDCM0388  CL118 HEK-293T C1326(1.02); C2501(0.90); C706(0.99); C1952(0.87)  LDD1592  [38]
 LDCM0389  CL119 HEK-293T C1326(1.02); C2501(0.94); C706(1.05); C1952(1.02)  LDD1593  [38]
 LDCM0390  CL12 HEK-293T C1326(0.85); C2501(0.99); C706(1.02); C1952(1.23)  LDD1594  [38]
 LDCM0391  CL120 HEK-293T C1326(0.92); C2501(1.01); C706(1.01); C1952(0.93)  LDD1595  [38]
 LDCM0392  CL121 HEK-293T C1326(1.01); C2501(0.99); C706(1.04); C1952(0.94)  LDD1596  [38]
 LDCM0393  CL122 HEK-293T C1326(1.02); C2501(0.85); C706(0.97); C1952(0.90)  LDD1597  [38]
 LDCM0394  CL123 HEK-293T C1326(0.87); C2501(0.86); C706(0.99); C1952(0.84)  LDD1598  [38]
 LDCM0395  CL124 HEK-293T C1326(0.94); C2501(1.03); C706(1.08); C1952(0.89)  LDD1599  [38]
 LDCM0396  CL125 HEK-293T C1326(1.06); C2501(0.92); C706(1.06); C1952(0.86)  LDD1600  [38]
 LDCM0397  CL126 HEK-293T C1326(1.10); C2501(0.90); C706(0.99); C1952(0.82)  LDD1601  [38]
 LDCM0398  CL127 HEK-293T C1326(1.12); C2501(0.92); C706(1.04); C1952(0.86)  LDD1602  [38]
 LDCM0399  CL128 HEK-293T C1326(0.91); C2501(0.96); C706(0.96); C1952(0.82)  LDD1603  [38]
 LDCM0400  CL13 HEK-293T C1326(1.01); C2501(1.03); C706(1.03); C1952(0.99)  LDD1604  [38]
 LDCM0401  CL14 HEK-293T C1326(1.00); C2501(1.01); C706(1.03); C1952(1.04)  LDD1605  [38]
 LDCM0402  CL15 HEK-293T C1326(0.87); C2501(0.89); C706(1.02); C1952(1.00)  LDD1606  [38]
 LDCM0403  CL16 HEK-293T C1326(0.97); C2501(1.06); C706(1.00); C1952(0.95)  LDD1607  [38]
 LDCM0404  CL17 HEK-293T C1326(0.85); C2501(1.09); C706(1.03); C1952(0.93)  LDD1608  [38]
 LDCM0405  CL18 HEK-293T C1326(0.93); C2501(1.04); C706(0.99); C1952(0.86)  LDD1609  [38]
 LDCM0406  CL19 HEK-293T C1326(0.90); C2501(1.12); C706(1.06); C1952(1.17)  LDD1610  [38]
 LDCM0407  CL2 HEK-293T C1326(0.98); C2501(1.10); C706(0.99); C1952(1.02)  LDD1611  [38]
 LDCM0408  CL20 HEK-293T C1326(0.96); C2501(1.09); C706(0.97); C1952(1.15)  LDD1612  [38]
 LDCM0409  CL21 HEK-293T C1326(1.10); C2501(1.09); C706(1.00); C1952(0.96)  LDD1613  [38]
 LDCM0410  CL22 HEK-293T C1326(0.90); C2501(1.07); C706(1.11); C1952(1.20)  LDD1614  [38]
 LDCM0411  CL23 HEK-293T C1326(1.02); C2501(1.00); C706(1.38); C1952(1.23)  LDD1615  [38]
 LDCM0412  CL24 HEK-293T C1326(0.94); C2501(1.05); C706(1.03); C1952(1.20)  LDD1616  [38]
 LDCM0413  CL25 HEK-293T C1326(1.09); C2501(0.97); C706(0.93); C1952(0.94)  LDD1617  [38]
 LDCM0414  CL26 HEK-293T C1326(1.02); C2501(0.92); C706(0.97); C1952(1.01)  LDD1618  [38]
 LDCM0415  CL27 HEK-293T C1326(1.04); C2501(0.96); C706(1.00); C1952(1.08)  LDD1619  [38]
 LDCM0416  CL28 HEK-293T C1326(0.95); C2501(0.96); C706(1.08); C1952(1.08)  LDD1620  [38]
 LDCM0417  CL29 HEK-293T C1326(0.99); C2501(1.00); C706(1.05); C1952(1.01)  LDD1621  [38]
 LDCM0418  CL3 HEK-293T C1326(0.94); C2501(1.06); C706(1.09); C1952(1.00)  LDD1622  [38]
 LDCM0419  CL30 HEK-293T C1326(1.04); C2501(1.01); C706(0.94); C1952(0.91)  LDD1623  [38]
 LDCM0420  CL31 HEK-293T C1326(0.88); C2501(1.09); C706(0.99); C1952(1.02)  LDD1624  [38]
 LDCM0421  CL32 HEK-293T C1326(1.05); C2501(1.11); C706(0.96); C1952(1.03)  LDD1625  [38]
 LDCM0422  CL33 HEK-293T C1326(0.84); C2501(0.92); C706(1.00); C1952(0.86)  LDD1626  [38]
 LDCM0423  CL34 HEK-293T C1326(0.85); C2501(1.01); C706(1.00); C1952(1.16)  LDD1627  [38]
 LDCM0424  CL35 HEK-293T C1326(0.96); C2501(1.11); C706(1.30); C1952(1.17)  LDD1628  [38]
 LDCM0425  CL36 HEK-293T C1326(1.00); C2501(0.98); C706(0.92); C1952(1.07)  LDD1629  [38]
 LDCM0426  CL37 HEK-293T C1326(1.04); C2501(0.98); C706(0.91); C1952(0.94)  LDD1630  [38]
 LDCM0428  CL39 HEK-293T C1326(0.91); C2501(0.87); C706(1.04); C1952(0.96)  LDD1632  [38]
 LDCM0429  CL4 HEK-293T C1326(0.83); C2501(1.01); C706(0.96); C1952(1.06)  LDD1633  [38]
 LDCM0430  CL40 HEK-293T C1326(1.03); C2501(0.95); C706(1.09); C1952(1.10)  LDD1634  [38]
 LDCM0431  CL41 HEK-293T C1326(0.96); C2501(1.00); C706(1.11); C1952(0.87)  LDD1635  [38]
 LDCM0432  CL42 HEK-293T C1326(1.04); C2501(1.02); C706(0.99); C1952(0.92)  LDD1636  [38]
 LDCM0433  CL43 HEK-293T C1326(0.93); C2501(0.99); C706(1.01); C1952(1.02)  LDD1637  [38]
 LDCM0434  CL44 HEK-293T C1326(1.06); C2501(1.08); C706(0.90); C1952(0.98)  LDD1638  [38]
 LDCM0435  CL45 HEK-293T C1326(0.96); C2501(1.10); C706(0.94); C1952(1.03)  LDD1639  [38]
 LDCM0436  CL46 HEK-293T C1326(0.89); C2501(1.08); C706(1.20); C1952(1.12)  LDD1640  [38]
 LDCM0437  CL47 HEK-293T C1326(0.91); C2501(0.98); C706(1.07); C1952(1.13)  LDD1641  [38]
 LDCM0438  CL48 HEK-293T C1326(1.02); C2501(1.00); C706(0.93); C1952(1.06)  LDD1642  [38]
 LDCM0439  CL49 HEK-293T C1326(1.01); C2501(0.88); C706(1.07); C1952(0.94)  LDD1643  [38]
 LDCM0440  CL5 HEK-293T C1326(0.90); C2501(1.12); C706(1.09); C1952(1.11)  LDD1644  [38]
 LDCM0441  CL50 HEK-293T C1326(1.06); C2501(0.96); C706(0.95); C1952(0.91)  LDD1645  [38]
 LDCM0443  CL52 HEK-293T C1326(0.98); C2501(0.96); C706(1.00); C1952(0.99)  LDD1646  [38]
 LDCM0444  CL53 HEK-293T C1326(0.94); C2501(0.97); C706(0.99); C1952(0.85)  LDD1647  [38]
 LDCM0445  CL54 HEK-293T C1326(0.86); C2501(0.91); C706(0.84); C1952(0.81)  LDD1648  [38]
 LDCM0446  CL55 HEK-293T C1326(0.93); C2501(1.06); C706(0.99); C1952(1.09)  LDD1649  [38]
 LDCM0447  CL56 HEK-293T C1326(1.00); C2501(1.02); C706(0.87); C1952(1.03)  LDD1650  [38]
 LDCM0448  CL57 HEK-293T C1326(0.92); C2501(0.98); C706(1.02); C1952(1.00)  LDD1651  [38]
 LDCM0449  CL58 HEK-293T C1326(0.90); C2501(0.91); C706(0.96); C1952(1.06)  LDD1652  [38]
 LDCM0450  CL59 HEK-293T C1326(0.85); C2501(0.98); C706(1.02); C1952(1.15)  LDD1653  [38]
 LDCM0451  CL6 HEK-293T C1326(0.88); C2501(0.96); C706(0.99); C1952(0.86)  LDD1654  [38]
 LDCM0452  CL60 HEK-293T C1326(0.91); C2501(0.94); C706(0.99); C1952(1.12)  LDD1655  [38]
 LDCM0453  CL61 HEK-293T C1326(1.01); C2501(0.92); C706(1.05); C1952(1.01)  LDD1656  [38]
 LDCM0454  CL62 HEK-293T C1326(1.01); C2501(0.92); C706(0.98); C1952(0.95)  LDD1657  [38]
 LDCM0455  CL63 HEK-293T C1326(0.97); C2501(0.94); C706(0.98); C1952(1.00)  LDD1658  [38]
 LDCM0456  CL64 HEK-293T C1326(0.79); C2501(0.98); C706(1.20); C1952(0.85)  LDD1659  [38]
 LDCM0457  CL65 HEK-293T C1326(0.94); C2501(1.02); C706(1.02); C1952(0.90)  LDD1660  [38]
 LDCM0458  CL66 HEK-293T C1326(1.05); C2501(0.99); C706(0.95); C1952(0.83)  LDD1661  [38]
 LDCM0459  CL67 HEK-293T C1326(0.98); C2501(1.09); C706(1.05); C1952(1.02)  LDD1662  [38]
 LDCM0460  CL68 HEK-293T C1326(1.02); C2501(0.93); C706(0.90); C1952(1.02)  LDD1663  [38]
 LDCM0461  CL69 HEK-293T C1326(1.09); C2501(1.01); C706(1.01); C1952(1.00)  LDD1664  [38]
 LDCM0462  CL7 HEK-293T C1326(0.85); C2501(1.11); C706(1.03); C1952(1.12)  LDD1665  [38]
 LDCM0463  CL70 HEK-293T C1326(0.88); C2501(1.01); C706(0.94); C1952(0.98)  LDD1666  [38]
 LDCM0464  CL71 HEK-293T C1326(0.97); C2501(0.96); C706(1.30); C1952(1.07)  LDD1667  [38]
 LDCM0465  CL72 HEK-293T C1326(0.96); C2501(1.04); C706(0.98); C1952(1.01)  LDD1668  [38]
 LDCM0466  CL73 HEK-293T C1326(1.05); C2501(0.86); C706(1.03); C1952(0.95)  LDD1669  [38]
 LDCM0467  CL74 HEK-293T C1326(1.02); C2501(0.89); C706(1.03); C1952(0.90)  LDD1670  [38]
 LDCM0469  CL76 HEK-293T C1326(0.99); C2501(1.03); C706(1.04); C1952(0.97)  LDD1672  [38]
 LDCM0470  CL77 HEK-293T C1326(0.85); C2501(0.96); C706(0.96); C1952(0.86)  LDD1673  [38]
 LDCM0471  CL78 HEK-293T C1326(1.04); C2501(1.04); C706(0.94); C1952(0.93)  LDD1674  [38]
 LDCM0472  CL79 HEK-293T C1326(0.92); C2501(1.11); C706(0.98); C1952(1.10)  LDD1675  [38]
 LDCM0473  CL8 HEK-293T C1326(0.88); C2501(0.83); C706(0.98); C1952(0.63)  LDD1676  [38]
 LDCM0474  CL80 HEK-293T C1326(0.99); C2501(0.95); C706(0.93); C1952(1.05)  LDD1677  [38]
 LDCM0475  CL81 HEK-293T C1326(1.01); C2501(0.98); C706(1.04); C1952(1.08)  LDD1678  [38]
 LDCM0476  CL82 HEK-293T C1326(0.87); C2501(0.98); C706(1.04); C1952(1.02)  LDD1679  [38]
 LDCM0477  CL83 HEK-293T C1326(1.06); C2501(0.96); C706(1.09); C1952(1.03)  LDD1680  [38]
 LDCM0478  CL84 HEK-293T C1326(0.90); C2501(0.99); C706(0.94); C1952(0.98)  LDD1681  [38]
 LDCM0479  CL85 HEK-293T C1326(1.10); C2501(0.91); C706(0.89); C1952(0.98)  LDD1682  [38]
 LDCM0480  CL86 HEK-293T C1326(1.07); C2501(0.91); C706(0.98); C1952(0.89)  LDD1683  [38]
 LDCM0481  CL87 HEK-293T C1326(1.00); C2501(0.84); C706(0.94); C1952(0.90)  LDD1684  [38]
 LDCM0482  CL88 HEK-293T C1326(0.90); C2501(1.01); C706(0.97); C1952(0.90)  LDD1685  [38]
 LDCM0483  CL89 HEK-293T C1326(0.97); C2501(0.94); C706(0.99); C1952(0.86)  LDD1686  [38]
 LDCM0484  CL9 HEK-293T C1326(1.09); C2501(1.04); C706(1.05); C1952(1.06)  LDD1687  [38]
 LDCM0485  CL90 HEK-293T C1326(0.68); C2501(0.78); C706(0.94); C1952(0.62)  LDD1688  [38]
 LDCM0486  CL91 HEK-293T C1326(1.01); C2501(1.04); C706(1.03); C1952(0.96)  LDD1689  [38]
 LDCM0487  CL92 HEK-293T C1326(1.01); C2501(0.95); C706(0.95); C1952(0.85)  LDD1690  [38]
 LDCM0488  CL93 HEK-293T C1326(1.03); C2501(0.94); C706(1.03); C1952(0.88)  LDD1691  [38]
 LDCM0489  CL94 HEK-293T C1326(0.93); C2501(1.00); C706(0.96); C1952(0.95)  LDD1692  [38]
 LDCM0490  CL95 HEK-293T C1326(0.77); C2501(0.89); C706(1.21); C1952(0.85)  LDD1693  [38]
 LDCM0491  CL96 HEK-293T C1326(0.94); C2501(0.83); C706(0.92); C1952(0.91)  LDD1694  [38]
 LDCM0492  CL97 HEK-293T C1326(1.03); C2501(0.92); C706(1.03); C1952(0.95)  LDD1695  [38]
 LDCM0493  CL98 HEK-293T C1326(1.01); C2501(0.92); C706(0.92); C1952(0.99)  LDD1696  [38]
 LDCM0494  CL99 HEK-293T C1326(0.85); C2501(1.03); C706(1.17); C1952(0.94)  LDD1697  [38]
 LDCM0634  CY-0357 Hep-G2 C1868(1.53); C2501(0.91)  LDD2228  [22]
 LDCM0495  E2913 HEK-293T C1326(0.98); C2501(0.97); C706(0.96); C1952(1.03)  LDD1698  [38]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C706(1.12); C2501(1.12); C2556(0.99); C2115(0.86)  LDD1702  [36]
 LDCM0625  F8 Ramos C2501(1.48); C2556(1.14)  LDD2187  [40]
 LDCM0572  Fragment10 Ramos C2501(1.32); C2556(0.78)  LDD2189  [40]
 LDCM0573  Fragment11 Ramos C2501(1.67); C2556(2.29)  LDD2190  [40]
 LDCM0574  Fragment12 Ramos C2501(0.69); C2556(0.78)  LDD2191  [40]
 LDCM0575  Fragment13 Ramos C2501(1.03); C2556(1.13)  LDD2192  [40]
 LDCM0576  Fragment14 Ramos C2501(0.98); C2556(1.71)  LDD2193  [40]
 LDCM0579  Fragment20 Ramos C2501(0.65); C2556(0.72)  LDD2194  [40]
 LDCM0580  Fragment21 Ramos C2501(1.00); C2556(2.82)  LDD2195  [40]
 LDCM0582  Fragment23 Ramos C2501(1.03)  LDD2196  [40]
 LDCM0578  Fragment27 Ramos C2501(0.96); C2556(1.00)  LDD2197  [40]
 LDCM0586  Fragment28 Ramos C2501(0.85); C2556(1.51)  LDD2198  [40]
 LDCM0588  Fragment30 Ramos C2501(1.09); C2556(0.83)  LDD2199  [40]
 LDCM0589  Fragment31 Ramos C2501(0.91)  LDD2200  [40]
 LDCM0590  Fragment32 Ramos C2501(1.37); C2556(0.85)  LDD2201  [40]
 LDCM0468  Fragment33 HEK-293T C1326(0.98); C2501(0.87); C706(1.04); C1952(0.98)  LDD1671  [38]
 LDCM0596  Fragment38 Ramos C2501(0.75)  LDD2203  [40]
 LDCM0566  Fragment4 Ramos C2501(0.86); C2556(0.90)  LDD2184  [40]
 LDCM0427  Fragment51 HEK-293T C1326(1.10); C2501(1.05); C706(0.97); C1952(0.92)  LDD1631  [38]
 LDCM0610  Fragment52 Ramos C2501(1.25); C2556(0.86)  LDD2204  [40]
 LDCM0614  Fragment56 Ramos C2501(1.22)  LDD2205  [40]
 LDCM0569  Fragment7 Ramos C2501(0.86); C2556(0.50)  LDD2186  [40]
 LDCM0571  Fragment9 Ramos C2501(1.01); C2556(0.54)  LDD2188  [40]
 LDCM0116  HHS-0101 DM93 Y902(0.71); Y596(0.85); Y1530(0.98); Y904(1.96)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y596(0.71); Y1530(1.16); Y904(1.71)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y596(0.77); Y904(1.18); Y1530(1.48)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y596(0.81); Y904(1.24); Y1530(1.65); Y902(2.98)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y904(1.02); Y596(1.47); Y902(1.84); Y1530(1.91)  LDD0268  [13]
 LDCM0107  IAA HeLa C1280(0.00); H2132(0.00); C2115(0.00); H906(0.00)  LDD0221  [30]
 LDCM0179  JZ128 PC-3 C2248(0.00); C178(0.00)  LDD0462  [11]
 LDCM0022  KB02 HEK-293T C1326(1.02); C604(0.93); C2501(1.04); C1868(1.10)  LDD1492  [38]
 LDCM0023  KB03 Jurkat C2556(9.72)  LDD0209  [12]
 LDCM0024  KB05 G361 C1648(2.34); C991(1.42); C2568(1.66); C2532(1.56)  LDD3311  [41]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1868(0.91); C2501(1.00); C450(1.08); C2333(0.99)  LDD2102  [36]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C2501(0.63); C416(1.11); C2333(1.14); C1952(0.78)  LDD2121  [36]
 LDCM0109  NEM HeLa H2132(0.00); C1280(0.00); H906(0.00); H1046(0.00)  LDD0223  [30]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C1868(0.74); C2501(0.64); C450(1.50); C416(1.03)  LDD2089  [36]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C2501(1.18); C450(1.00); C1952(1.57); C2115(1.29)  LDD2090  [36]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1868(0.91); C450(1.12); C2333(1.53); C1952(1.16)  LDD2092  [36]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1868(0.86); C2501(1.03); C450(0.88); C2537(1.20)  LDD2093  [36]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1868(1.37); C2333(1.79); C2115(2.01); C2154(3.54)  LDD2094  [36]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C450(0.60); C2333(0.12); C2154(0.23); C991(0.30)  LDD2096  [36]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C1868(0.77); C2501(0.77); C450(1.08); C2431(0.88)  LDD2097  [36]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1868(0.78); C2501(0.86); C450(0.87); C2333(1.29)  LDD2098  [36]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1868(1.27); C2501(0.82); C416(1.27); C2537(1.53)  LDD2099  [36]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C2501(1.07); C450(0.65); C2431(0.36); C2333(0.46)  LDD2100  [36]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1868(0.69); C2501(0.78); C450(0.98); C2537(2.17)  LDD2101  [36]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1868(0.70); C2501(1.10); C2333(0.29); C1952(0.30)  LDD2104  [36]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1868(1.18); C2501(1.07); C450(1.94); C2431(1.08)  LDD2105  [36]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C1868(0.64); C2501(0.93); C450(0.33); C416(0.26)  LDD2106  [36]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C2501(0.81); C450(0.93); C416(0.86); C2537(1.17)  LDD2107  [36]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1868(0.63); C2501(0.65); C2333(0.61); C1952(0.32)  LDD2108  [36]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C2501(0.71); C450(0.55); C416(0.95); C2431(0.63)  LDD2109  [36]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C1868(1.09); C450(0.35); C2333(0.39); C1952(0.28)  LDD2110  [36]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1868(1.24); C2501(0.86); C450(0.87); C2431(1.17)  LDD2111  [36]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1868(1.06); C2501(0.88); C450(0.48); C2431(0.35)  LDD2114  [36]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C2501(0.48); C450(0.34); C2333(0.40); C2115(0.36)  LDD2115  [36]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C1868(1.43); C450(0.88); C416(1.06); C2431(0.31)  LDD2116  [36]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C2501(0.74); C2537(0.61); C2154(0.30); C1326(0.37)  LDD2118  [36]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C2501(2.52); C2537(1.80); C2431(2.20); C2333(1.95)  LDD2119  [36]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C2501(0.98); C450(0.70); C416(0.84); C2333(0.61)  LDD2120  [36]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1868(1.23); C2501(0.62); C450(0.61); C2537(0.32)  LDD2122  [36]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1868(0.88); C2501(0.79); C450(0.68); C2556(1.52)  LDD2123  [36]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1868(1.44); C2501(0.76); C450(0.88); C2537(0.39)  LDD2124  [36]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C2501(0.76); C450(0.62); C2537(0.90); C2431(0.93)  LDD2125  [36]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C1868(1.44); C2501(0.68); C450(0.65); C2431(1.56)  LDD2126  [36]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1868(0.98); C2501(0.83); C450(0.60); C2556(1.48)  LDD2127  [36]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1868(0.95); C2501(0.81); C450(0.80); C2333(1.18)  LDD2128  [36]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C450(0.79); C2537(1.42); C2431(1.42); C2333(1.88)  LDD2129  [36]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1868(0.49); C2501(0.67); C450(0.76); C2115(0.44)  LDD2133  [36]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1868(0.29); C2501(0.48); C450(0.70); C2537(0.58)  LDD2134  [36]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C2501(0.80); C450(0.74); C2537(1.57); C2431(1.53)  LDD2135  [36]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1868(1.00); C450(1.28); C2556(1.12); C2537(1.36)  LDD2136  [36]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1868(0.98); C2501(0.79); C450(0.58); C2556(1.09)  LDD2137  [36]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C2333(3.40); C2537(3.36); C1952(2.26); C1617(2.17)  LDD1700  [36]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1868(1.03); C2501(0.67); C450(0.98); C2537(1.10)  LDD2140  [36]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1868(0.74); C2501(0.60); C2431(0.81); C2333(0.70)  LDD2141  [36]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C2501(1.12); C2537(0.74); C2333(0.94); C1952(0.57)  LDD2143  [36]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C2501(3.26); C2537(1.91); C2431(2.61); C2333(1.84)  LDD2144  [36]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C1868(1.81); C2501(3.70); C450(0.45); C2333(0.06)  LDD2145  [36]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1868(0.83); C450(0.74); C2556(1.02); C2333(1.24)  LDD2146  [36]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C2501(2.60); C2333(1.35); C2154(2.04); C1326(3.45)  LDD2147  [36]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C2501(0.47); C450(0.47); C2537(0.60); C2431(0.35)  LDD2148  [36]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C1868(1.46); C2501(0.62); C450(0.79); C2154(0.21)  LDD2149  [36]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1868(0.83); C2501(0.41); C2556(0.98); C416(0.96)  LDD2150  [36]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C1868(1.44); C2154(0.39)  LDD2151  [36]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C1868(1.27); C2501(1.06); C450(2.86); C1952(1.38)  LDD2153  [36]
 LDCM0627  NUDT7-COV-1 HEK-293T C2501(0.85)  LDD2206  [42]
 LDCM0628  OTUB2-COV-1 HEK-293T C2501(0.65)  LDD2207  [42]
 LDCM0019  Staurosporine Hep-G2 2.00  LDD0083  [32]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) STE Ser/Thr protein kinase family Q13233
Mitogen-activated protein kinase kinase kinase 4 (MAP3K4) STE Ser/Thr protein kinase family Q9Y6R4
Ras-related C3 botulinum toxin substrate 1 (RAC1) Rho family P63000
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Filamin-A (FLNA) Filamin family P21333
Filamin-B (FLNB) Filamin family O75369
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
SH2/SH3 adapter protein NCK1 (NCK1) . P16333
Ubiquitin-like protein ISG15 (ISG15) . P05161

References

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2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
12 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
20 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
24 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
25 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
26 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
27 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
28 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
29 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
30 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
31 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
32 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
33 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
34 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
35 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
36 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
37 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD044402
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