Details of the Target

General Information of Target

Target ID LDTP13814
Target Name Phospholipase A-2-activating protein (PLAA)
Gene Name PLAA
Gene ID 9373
Synonyms
PLAP; Phospholipase A-2-activating protein; PLA2P; PLAP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSYPADDYESEAAYDPYAYPSDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIKNFIQYFH
KTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAP
QVGNDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPN
QWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVLHSLVDKSNI
NRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELN
KKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMI
NKQNEQMHALLAIALTMYPMRIDESIHLQLREKYGDKMLRMQKGDPQVYEELFSYSCPKF
LSPVVPNYDNVHPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLD
LTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYG
DFFIRQIHKFEELNRTLKKMGQRP
Target Bioclass
Enzyme
Family
WD repeat PLAP family
Subcellular location
Nucleus
Function
Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis.
Uniprot ID
Q9Y263
Ensemble ID
ENST00000397292.8
HGNC ID
HGNC:9043
ChEMBL ID
CHEMBL6114

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.99  LDD0402  [1]
STPyne
 Probe Info  		K179(6.11); K315(8.00); K529(5.88); K537(1.45)  LDD0277  [2]
Probe 1
 Probe Info  		Y396(15.69); Y477(8.10)  LDD3495  [3]
BTD
 Probe Info  		C263(1.28); C631(1.02)  LDD1700  [4]
EA-probe
 Probe Info  		N.A.  LDD0440  [5]
HHS-465
 Probe Info  		Y477(10.00)  LDD2237  [6]
DBIA
 Probe Info  		C193(1.58)  LDD0078  [7]
ATP probe
 Probe Info  		K315(0.00); K622(0.00)  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C605(0.00); C208(0.00); C263(0.00); C631(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C263(0.00); C584(0.00)  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		C605(0.00); C631(0.00); C584(0.00); C193(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [11]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
TFBX
 Probe Info  		C787(0.00); C664(0.00); C666(0.00); C788(0.00)  LDD0027  [11]
WYneN
 Probe Info  		C787(0.00); C631(0.00)  LDD0021  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
ENE
 Probe Info  		C631(0.00); C787(0.00)  LDD0006  [13]
IPM
 Probe Info  		C631(0.00); C605(0.00); C787(0.00); C788(0.00)  LDD0005  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
Acrolein
 Probe Info  		C193(0.00); C631(0.00); C263(0.00); H260(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [15]
Methacrolein
 Probe Info  		C193(0.00); C263(0.00); C787(0.00); C666(0.00)  LDD0218  [15]
W1
 Probe Info  		N.A.  LDD0236  [16]
AOyne
 Probe Info  		15.00  LDD0443  [17]
NAIA_5
 Probe Info  		C605(0.00); C116(0.00); C208(0.00); C263(0.00)  LDD2223  [12]
HHS-482
 Probe Info  		Y477(1.12)  LDD2239  [6]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C041
 Probe Info  		11.47  LDD1741  [18]
C064
 Probe Info  		7.06  LDD1761  [18]
C147
 Probe Info  		6.96  LDD1829  [18]
C194
 Probe Info  		9.00  LDD1870  [18]
C216
 Probe Info  		5.86  LDD1890  [18]
C243
 Probe Info  		12.30  LDD1916  [18]
C280
 Probe Info  		15.03  LDD1950  [18]
C350
 Probe Info  		22.32  LDD2011  [18]
C363
 Probe Info  		19.70  LDD2024  [18]
C364
 Probe Info  		27.10  LDD2025  [18]
C376
 Probe Info  		6.82  LDD2036  [18]
STS-1
 Probe Info  		N.A.  LDD0136  [19]
STS-2
 Probe Info  		N.A.  LDD0138  [19]
KIRA6 AfBP
 Probe Info  		N.A.  LDD0378  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C787(1.08)  LDD2142  [4]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C631(0.77)  LDD2095  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C631(0.88); C787(0.79); C263(0.40)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C631(1.24); C788(0.95)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C788(1.46)  LDD2103  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C631(0.74); C193(0.52)  LDD2132  [4]
 LDCM0214  AC1 HCT 116 C193(1.22); C263(1.41); C584(0.92); C664(0.87)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C116(1.40); C193(1.17); C26(0.63); C27(0.63)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C193(0.85); C26(0.66); C263(0.56); C27(0.58)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C193(0.92); C26(0.65); C263(0.63); C27(0.52)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C193(0.93); C26(0.64); C263(0.56); C27(0.59)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C193(1.15); C26(0.59); C263(0.62); C27(0.46)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C193(1.04); C26(0.71); C263(0.55); C27(0.68)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C193(0.98); C26(0.55); C263(0.69); C27(0.46)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C193(0.99); C26(0.63); C263(0.75); C27(0.51)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C193(1.07); C26(0.56); C263(0.52); C27(0.48)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C193(0.88); C26(0.68); C263(0.68); C27(0.54)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C193(0.79); C26(0.65); C263(0.80); C27(0.66)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C116(1.34); C193(1.41); C26(0.62); C27(0.62)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C193(0.97); C26(0.62); C263(0.54); C27(0.48)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C193(0.90); C26(0.63); C263(0.52); C27(0.47)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C193(1.09); C26(0.59); C263(0.60); C27(0.49)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C116(1.09); C193(0.96); C26(1.32); C263(1.05)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C116(1.02); C193(1.09); C26(1.03); C263(1.12)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C116(1.01); C193(1.27); C26(0.93); C263(1.06)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C116(1.03); C193(1.23); C26(0.87); C263(1.10)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C116(1.04); C193(1.17); C26(1.03); C263(1.14)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C116(0.93); C193(1.11); C26(0.95); C263(1.39)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C116(1.28); C193(1.15); C26(1.00); C263(1.01)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C116(1.68); C193(1.13); C26(0.81); C27(0.81)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C116(1.12); C193(1.29); C26(1.09); C263(0.72)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C116(1.15); C193(1.08); C26(0.80); C263(1.19)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C116(1.04); C193(1.10); C26(1.05); C263(1.15)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C116(1.33); C193(1.19); C26(0.93); C263(0.98)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C116(1.10); C193(1.01); C26(0.90); C263(1.18)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C116(1.17); C193(0.98); C26(1.10); C263(1.19)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C116(1.09); C193(1.15); C26(0.92); C263(1.16)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C116(0.94); C193(1.17); C26(1.01); C263(1.26)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C116(0.97); C193(1.37); C26(1.20); C27(1.20)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C116(0.89); C193(0.72); C26(1.31); C27(1.31)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C116(0.85); C193(1.04); C26(0.99); C27(0.99)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C116(0.93); C193(0.75); C26(1.44); C27(1.44)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C116(0.85); C193(0.84); C26(1.11); C27(1.11)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C116(0.88); C193(1.03); C26(1.62); C27(1.62)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C116(0.80); C193(1.10); C26(1.21); C27(1.21)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C116(0.87); C193(1.12); C26(1.20); C27(1.20)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C116(0.76); C193(1.23); C26(1.19); C27(1.19)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C116(0.90); C193(1.02); C26(1.22); C27(1.22)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C116(0.68); C193(1.10); C26(1.12); C27(1.12)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C116(0.79); C193(0.88); C26(1.35); C27(1.35)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C116(1.13); C193(1.21); C26(0.67); C27(0.67)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C116(0.76); C193(1.04); C26(1.28); C27(1.28)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C116(0.72); C193(0.99); C26(1.05); C27(1.05)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C116(0.95); C193(0.80); C26(0.99); C27(0.99)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C664(0.91); C27(0.95); C193(1.01); C666(1.03)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C27(0.83); C666(0.95); C664(0.96); C193(1.19)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C27(0.71); C193(1.04); C664(1.05); C666(1.25)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C27(0.68); C664(0.78); C666(0.86); C193(1.18)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C666(0.95); C27(0.95); C664(0.97); C193(1.27)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C664(0.85); C666(1.01); C27(1.06); C193(1.74)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C27(0.87); C664(0.97); C666(1.04); C193(1.29)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C26(0.59); C27(0.59); C666(0.90); C664(0.91)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C27(0.70); C664(0.92); C666(1.00); C193(1.06)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C664(0.86); C666(0.90); C193(1.07); C27(1.12)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C664(0.92); C27(0.99); C666(1.00); C193(1.37)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C27(0.74); C664(0.85); C666(1.04); C193(1.74)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C193(1.18); C27(0.77); C664(1.09); C666(1.19)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C193(1.12); C27(0.99); C664(0.87); C666(1.02)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C193(0.94); C27(0.74); C664(1.07); C666(1.17)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C193(0.79); C27(1.23); C664(1.18); C666(1.37)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C116(0.80); C193(0.97); C666(0.99); C664(1.04)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C666(0.83); C664(0.87); C116(0.91); C193(1.15)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C116(0.83); C666(0.87); C664(0.88); C193(1.00)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C666(0.81); C664(0.85); C263(1.02); C193(1.05)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C666(0.86); C664(0.86); C116(0.94); C193(1.04)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C116(0.91); C664(0.93); C666(0.98); C193(1.06)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C193(0.95); C116(1.04); C666(1.05); C664(1.06)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C116(0.76); C193(0.95); C666(0.96); C664(0.98)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C193(0.90); C116(0.91); C666(0.99); C664(1.12)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C116(0.78); C193(0.94); C26(0.99); C664(1.09)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C116(0.83); C26(0.93); C664(0.95); C666(0.97)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C116(0.73); C664(0.89); C666(0.90); C26(0.96)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C116(0.79); C26(0.90); C664(0.95); C666(1.02)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C116(0.81); C664(0.82); C666(0.91); C193(1.04)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C666(0.88); C664(0.92); C193(1.11); C584(1.14)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C666(0.71); C664(0.77); C116(0.83); C26(1.09)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C116(0.87); C193(1.08); C26(1.14); C664(1.20)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C116(0.71); C666(0.73); C664(0.82); C584(1.19)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C116(0.72); C666(0.79); C664(0.83); C584(1.08)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C116(0.72); C664(0.85); C666(0.89); C584(1.05)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C193(0.86); C664(1.01); C26(1.02); C666(1.03)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C193(0.86); C664(0.92); C666(0.95); C27(0.98)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C193(0.85); C664(0.87); C666(0.92); C27(0.96)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C193(0.88); C27(0.92); C664(0.94); C666(0.98)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C27(0.85); C26(0.93); C664(0.96); C666(0.97)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C666(0.93); C664(0.97); C584(1.09); C193(1.16)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C27(0.83); C664(0.89); C666(0.91); C193(1.00)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C193(0.91); C664(0.92); C666(0.96); C27(1.00)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C27(0.87); C193(0.90); C666(0.92); C664(0.93)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C27(0.80); C666(0.84); C664(0.86); C193(0.91)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C27(0.90); C664(0.94); C26(0.94); C666(0.95)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C664(0.88); C666(0.90); C27(0.92); C26(0.99)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C116(0.81); C26(0.93); C27(0.94); C666(0.94)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C116(0.70); C27(0.77); C26(0.81); C584(0.94)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C27(0.82); C26(0.84); C666(0.85); C664(0.86)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C116(0.71); C27(0.77); C666(0.88); C664(0.88)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C666(0.90); C664(0.93); C584(1.10); C193(1.18)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C116(0.73); C27(0.83); C26(0.84); C666(0.86)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C193(0.86); C584(0.87); C27(0.98); C26(0.99)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C27(0.77); C26(0.78); C116(0.84); C584(0.97)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C116(0.71); C584(0.76); C27(0.83); C26(0.83)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C116(0.76); C26(0.84); C27(0.92); C584(0.95)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C27(0.75); C26(0.79); C116(0.83); C584(0.87)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C116(0.59); C27(0.67); C26(0.70); C584(0.76)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C666(0.77); C664(0.77); C26(0.90); C27(0.90)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C666(0.72); C664(0.76); C26(0.80); C27(0.80)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C666(0.74); C664(0.75); C116(0.92); C26(1.00)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C666(0.76); C664(0.77); C26(0.79); C27(0.79)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C664(0.62); C666(0.64); C116(0.85); C26(0.96)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C664(0.71); C666(0.73); C26(0.91); C27(0.91)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C666(0.70); C664(0.71); C26(0.96); C27(0.96)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C666(0.67); C664(0.67); C116(0.89); C26(1.00)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C664(0.72); C666(0.73); C116(1.05); C26(1.09)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C664(0.71); C666(0.72); C26(0.87); C27(0.87)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C664(0.77); C666(0.78); C584(0.88); C26(0.93)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C664(0.63); C666(0.65); C26(0.84); C27(0.84)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C666(0.87); C584(0.88); C664(0.89); C26(0.96)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C584(0.81); C26(0.89); C27(0.89); C666(0.89)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C26(0.85); C27(0.85); C666(0.89); C664(0.91)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C26(0.62); C27(0.62); C666(0.80); C664(0.83)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C26(0.91); C27(0.91); C193(0.91); C666(0.95)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C666(0.82); C664(0.90); C584(0.99); C26(0.99)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C26(0.69); C27(0.69); C666(0.76); C664(0.81)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C26(0.81); C27(0.81); C666(0.83); C664(0.88)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C26(0.55); C27(0.55); C666(0.79); C664(0.85)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C26(0.87); C27(0.87); C666(0.89); C664(0.93)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C26(0.75); C27(0.75); C666(0.81); C664(0.84)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C666(0.85); C664(0.88); C584(0.97); C26(0.97)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C666(0.90); C26(0.94); C27(0.94); C664(0.96)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C26(0.79); C27(0.79); C666(0.83); C664(0.84)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C26(0.87); C27(0.87); C666(0.89); C664(0.96)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C26(0.80); C27(0.80); C666(0.96); C584(0.97)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C26(0.33); C27(0.33); C666(0.92); C664(0.97)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C666(0.68); C664(0.72); C26(1.31); C193(1.46)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C666(0.65); C664(0.68); C26(1.45); C193(1.61)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C666(0.65); C664(0.71); C193(1.27); C26(1.34)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C664(0.74); C666(0.75); C193(1.14); C26(1.25)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C666(0.84); C664(0.85); C193(1.04); C26(1.20)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C666(0.84); C664(0.84); C193(1.05); C26(1.05)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C664(0.73); C666(0.74); C193(1.19); C26(1.24)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C193(0.91); C26(0.94); C666(1.01); C664(1.02)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C664(0.75); C666(0.76); C26(1.15); C193(1.37)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C666(0.78); C664(0.80); C26(0.87); C193(1.28)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C666(0.85); C664(0.86); C26(0.93); C193(1.21)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C664(0.91); C666(0.94); C193(1.18); C26(1.37)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C664(0.73); C666(0.75); C193(1.00); C26(1.35)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C664(0.84); C666(0.89); C26(1.08); C193(1.11)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C664(0.73); C666(0.73); C193(1.31); C26(1.46)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C263(0.28); C27(0.28); C26(0.41); C666(0.52)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C27(0.55); C263(0.60); C26(0.67); C666(0.70)  LDD0683  [7]
 LDCM0545  Acetamide MDA-MB-231 C193(0.67); C788(1.02)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C263(0.82)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C116(1.28); C193(1.00); C26(0.84); C27(0.84)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C26(0.60); C27(0.60); C664(0.85); C666(0.85)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C26(0.59); C27(0.59); C664(0.76); C666(0.78)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C193(1.58)  LDD0078  [7]
 LDCM0498  BS-3668 MDA-MB-231 C631(0.53); C788(1.44)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C193(0.00); C631(0.00); C263(0.00); H342(0.00)  LDD0222  [15]
 LDCM0367  CL1 HCT 116 C26(1.09); C193(1.10); C664(1.10); C666(1.17)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C664(0.92); C666(0.92); C193(1.16); C26(1.65)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C666(0.85); C664(0.86); C584(0.99); C193(1.04)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C26(0.59); C27(0.59); C666(0.83); C664(0.88)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C26(0.80); C27(0.80); C666(0.90); C664(0.94)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C26(0.85); C27(0.85); C193(0.96); C666(0.98)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C26(0.83); C27(0.83); C664(0.85); C666(0.86)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C116(0.84); C664(0.88); C666(0.89); C193(1.10)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C666(0.74); C116(0.76); C664(0.77); C193(1.38)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C664(0.77); C666(0.77); C116(0.89); C193(1.35)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C116(0.91); C666(0.91); C664(1.00); C193(1.35)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C116(0.81); C664(0.82); C666(0.83); C193(1.02)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C193(0.91); C26(0.92); C664(0.95); C666(0.96)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C116(0.73); C666(0.98); C664(1.02); C193(1.11)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C116(0.76); C666(0.85); C664(0.92); C193(1.12)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C116(0.77); C193(1.03); C584(1.04); C26(1.04)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C116(0.78); C666(0.87); C664(0.94); C584(1.03)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C666(0.74); C664(0.82); C116(0.88); C584(1.00)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C666(0.78); C664(0.85); C116(0.93); C584(1.09)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C666(0.74); C664(0.78); C116(0.87); C584(1.08)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C27(0.75); C666(0.92); C116(0.93); C26(0.93)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C664(0.86); C666(0.89); C27(0.89); C26(0.95)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C664(0.93); C666(0.97); C27(0.98); C193(1.05)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C666(0.96); C664(0.98); C26(0.98); C193(1.05)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C193(0.88); C664(0.89); C666(0.92); C27(1.05)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C116(0.55); C584(0.86); C193(1.10); C26(1.18)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C27(0.66); C116(0.73); C584(0.75); C26(0.80)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C116(0.64); C27(0.66); C26(0.71); C584(0.83)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C27(0.82); C116(0.84); C664(0.87); C26(0.88)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C666(0.82); C664(0.85); C26(0.89); C27(0.89)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C666(0.77); C664(0.77); C116(0.88); C26(0.93)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C666(0.77); C664(0.78); C116(0.94); C584(0.97)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C664(0.76); C666(0.76); C26(0.99); C27(0.99)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C666(0.84); C664(0.87); C193(0.95); C26(0.96)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C666(0.89); C664(0.89); C193(0.99); C26(1.06)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C26(0.79); C193(0.83); C666(0.89); C664(0.92)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C666(0.87); C664(0.87); C26(0.92); C27(0.93)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C263(0.80); C26(0.90); C666(0.96); C664(0.98)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C666(0.77); C664(0.77); C263(0.91); C26(0.95)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C263(0.86); C664(0.92); C666(0.93); C193(0.95)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C26(0.94); C193(0.96); C664(0.99); C666(1.01)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C263(0.75); C664(0.80); C666(0.82); C193(1.08)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C26(0.78); C263(0.78); C664(0.85); C666(0.87)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C584(0.81); C664(0.84); C263(0.87); C666(0.89)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C584(0.75); C664(0.77); C666(0.79); C263(0.84)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C666(0.84); C664(0.86); C26(0.86); C584(0.99)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C193(0.93); C26(0.97); C263(1.32); C584(0.95)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C193(1.12); C26(0.89); C263(0.93); C584(1.03)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C193(1.05); C26(0.87); C263(0.91); C584(1.04)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C193(1.04); C26(1.00); C263(0.88); C584(1.28)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C193(1.00); C26(1.01); C263(0.73); C584(1.05)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C193(0.94); C26(1.10); C664(1.12); C666(1.12)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C193(1.12); C26(0.83); C263(1.45); C584(1.28)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C116(0.91); C193(1.05); C26(1.01); C263(0.86)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C116(1.08); C193(1.19); C263(0.97); C27(0.92)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C116(0.90); C193(1.04); C263(0.75); C27(1.07)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C116(0.78); C193(1.38); C263(1.04); C27(1.53)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C116(0.78); C193(1.33); C263(0.88); C27(1.18)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C116(0.80); C193(1.27); C263(0.69); C27(1.05)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C116(0.90); C193(1.37); C263(1.08); C27(0.93)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C116(0.87); C193(1.43); C263(0.94); C27(0.91)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C193(1.00); C26(0.96); C664(0.99); C666(1.00)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C116(0.75); C193(1.18); C263(0.81); C27(0.90)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C116(1.11); C193(1.21); C263(0.81); C27(0.98)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C116(0.81); C193(1.95); C263(0.97); C27(0.91)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C116(0.86); C193(1.46); C263(1.01); C27(0.87)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C116(0.82); C193(1.18); C263(0.82); C27(0.85)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C116(0.87); C193(1.41); C263(0.97); C27(1.02)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C193(0.65); C26(1.39); C27(1.39); C584(1.32)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C193(0.83); C26(1.24); C27(1.24); C584(1.05)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C193(0.74); C26(1.27); C27(1.27); C584(1.09)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C193(0.67); C26(1.33); C27(1.33); C584(1.37)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C193(0.86); C26(0.85); C664(1.06); C666(1.04)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C193(0.74); C26(1.22); C27(1.22); C584(1.12)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C193(0.75); C26(1.31); C27(1.31); C584(1.18)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C193(0.77); C26(1.19); C27(1.19); C584(1.41)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C193(1.08); C26(1.40); C27(1.40); C584(0.97)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C193(0.77); C26(0.98); C27(0.98); C584(1.20)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C193(0.73); C26(1.24); C27(1.24); C584(1.25)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C193(0.96); C26(1.12); C27(1.12); C584(0.94)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C193(0.81); C26(1.02); C27(1.02); C584(1.15)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C193(0.76); C26(1.23); C27(1.23); C584(1.44)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C193(0.93); C26(1.08); C27(1.08); C584(1.21)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C193(0.92); C26(0.88); C664(0.83); C666(0.80)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C193(0.76); C26(1.24); C27(1.24); C584(1.23)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C116(1.00); C193(0.98); C26(1.19); C664(0.83)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C116(1.29); C193(0.96); C26(1.16); C664(0.92)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C116(1.22); C193(1.12); C26(1.11); C664(0.83)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C116(0.93); C193(1.05); C26(1.10); C664(0.79)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C116(0.84); C193(1.09); C26(1.29); C664(0.97)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C116(1.10); C193(1.36); C26(1.37); C664(0.87)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C116(1.03); C193(1.20); C26(1.08); C664(0.90)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C116(1.18); C193(1.31); C26(1.70); C664(0.76)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C116(1.65); C193(1.09); C26(1.27); C664(0.75)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C193(0.99); C26(0.80); C664(0.96); C666(0.95)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C116(0.97); C193(1.14); C26(1.09); C664(0.84)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C116(0.92); C193(1.18); C26(1.10); C664(0.88)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C116(1.33); C193(1.21); C26(1.22); C664(0.85)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C116(1.11); C193(1.14); C26(1.24); C664(0.85)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C116(1.20); C193(1.16); C26(1.06); C664(0.85)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C116(0.78); C193(1.08); C26(0.97); C27(0.88)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C116(0.66); C193(0.96); C26(0.92); C27(0.76)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C116(0.79); C193(1.11); C26(0.91); C27(0.87)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C116(0.75); C193(1.16); C26(1.05); C27(0.96)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C193(0.95); C26(0.78); C664(0.84); C666(0.81)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C116(0.90); C193(1.07); C26(1.02); C27(1.03)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C116(0.76); C193(1.04); C26(0.92); C27(0.86)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C116(0.79); C193(1.32); C26(0.96); C27(0.75)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C116(0.87); C193(1.26); C26(0.88); C27(0.82)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C116(0.78); C193(1.42); C26(0.92); C27(0.82)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C116(1.04); C193(1.17); C26(0.93); C27(0.95)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C116(0.81); C193(1.04); C26(0.95); C27(0.90)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C116(0.88); C193(1.07); C26(0.97); C27(0.85)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C116(0.85); C193(1.21); C26(0.83); C27(0.79)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C116(0.68); C193(1.66); C26(0.97); C27(0.79)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C193(1.04); C26(1.02); C664(0.89); C666(0.87)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C116(0.91); C193(0.89); C26(0.96); C27(1.02)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C193(1.04); C263(0.76); C584(1.07); C664(0.86)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C193(1.02); C263(0.76); C584(0.94); C664(0.89)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C193(1.00); C263(1.12); C584(1.01); C664(0.96)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C193(1.10); C263(1.05); C584(0.95); C664(0.82)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C193(1.14); C263(0.85); C584(0.94); C664(0.82)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C193(1.10); C263(0.83); C584(0.98); C664(0.90)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C193(1.14); C263(0.87); C584(1.09); C664(0.81)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C193(1.13); C263(1.31); C584(1.14); C664(0.75)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C193(1.17); C263(1.36); C584(1.08); C664(0.85)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C193(0.99); C631(1.03); C584(0.89); C208(1.03)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C631(7.37); C263(1.05)  LDD1702  [4]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [5]
 LDCM0625  F8 Ramos C193(1.35); 1.07; C631(1.20)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C193(0.90); C263(0.23); 6.43  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C193(0.11); C263(5.52); 3.94; C631(2.39)  LDD2190  [22]
 LDCM0574  Fragment12 Ramos C193(0.71); C263(0.28); C605(1.42)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C193(1.13); C263(0.78); 0.93; C605(0.50)  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C193(0.66); 6.17; C631(1.51); C605(1.82)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C193(0.57); C263(0.19)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C193(0.97); C263(0.58); 0.79; C605(0.54)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C193(0.82); C263(0.21); 1.71; C605(1.23)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C193(1.10); C263(0.67); 0.71; C605(0.57)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C193(0.71); C263(0.28); 0.92; C631(0.55)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C193(1.43); 0.98; C605(0.61)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C193(0.96); C263(0.63); 2.62; C605(0.67)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C193(0.87); C263(0.41); 5.40  LDD2201  [22]
 LDCM0468  Fragment33 HCT 116 C116(0.93); C193(1.21); C26(1.30); C664(0.80)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C193(0.92); 0.70; C605(0.38)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C193(0.96); C263(1.07); 7.86  LDD2184  [22]
 LDCM0427  Fragment51 HCT 116 C116(0.88); C193(1.61); C263(0.78); C27(0.84)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C193(1.23); C263(1.08); 2.11; C605(0.91)  LDD2204  [22]
 LDCM0614  Fragment56 Ramos C193(1.45); C263(1.36); 2.15; C605(1.07)  LDD2205  [22]
 LDCM0569  Fragment7 Ramos C193(0.55); C263(0.52); 9.56; C631(0.52)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C193(0.65); C263(0.25)  LDD2188  [22]
 LDCM0107  IAA HeLa H260(0.00); C263(0.00); H17(0.00); H342(0.00)  LDD0221  [15]
 LDCM0022  KB02 HCT 116 C584(1.57); C26(1.10); C193(1.04); C27(1.52)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C584(1.45); C26(1.15); C193(0.95); C27(1.91)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C584(2.39); C26(1.08); C193(1.04); C27(0.85)  LDD0082  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C631(0.64); C193(0.86)  LDD2121  [4]
 LDCM0109  NEM HeLa H342(0.00); H260(0.00); H17(0.00)  LDD0223  [15]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C631(0.46); C193(0.86)  LDD2089  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C263(1.25)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C631(0.90)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C263(1.51)  LDD2094  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C263(1.22)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C116(0.98); C193(1.03); C263(0.83)  LDD2099  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C788(0.85)  LDD2101  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C787(1.80); C263(1.22)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C116(1.01); C193(1.25); C263(0.65)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C116(0.73); C263(0.39)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C631(1.11); C193(1.97)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C788(0.47); C263(0.93)  LDD2115  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C631(1.63)  LDD2118  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C263(0.88)  LDD2120  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C631(0.90); C263(0.59)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C631(1.76)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C631(1.07); C116(0.88); C193(1.11); C788(0.95)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C116(0.91); C193(1.67); C788(0.99); C263(0.77)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C631(1.10)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C631(1.14); C116(1.01)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C788(0.67); C263(0.60)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C631(1.37); C263(0.41)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C631(1.20); C116(1.04); C193(2.17); C787(1.06)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C116(1.07); C787(0.62); C263(1.13)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C263(1.28); C631(1.02)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C631(0.85); C116(0.46); C193(1.05)  LDD2140  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C631(1.29)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C631(1.91); C193(1.90)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C631(0.87); C116(1.04); C263(0.65)  LDD2146  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C631(0.39)  LDD2150  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C664(0.62)  LDD2206  [23]
 LDCM0628  OTUB2-COV-1 HEK-293T C664(0.83)  LDD2207  [23]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin subunit alpha-3 (KPNA4) Importin alpha family O00629
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
UBX domain-containing protein 1 (UBXN1) . Q04323

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor. ACS Chem Biol. 2020 Dec 18;15(12):3106-3111. doi: 10.1021/acschembio.0c00802. Epub 2020 Dec 8.
Mass spectrometry data entry: PXD022628
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.