Details of the Target

General Information of Target

Target ID LDTP16193
Target Name Craniofacial development protein 1 (CFDP1)
Gene Name CFDP1
Gene ID 10428
Synonyms
BCNT; CENP-29; Craniofacial development protein 1; Bucentaur
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEPQPRGAERDLYRDTWVRYLGYANEVGEAFRSLVPAAVVWLSYGVASSYVLADAIDKG
KKAGEVPSPEAGRSARVTVAVVDTFVWQALASVAIPGFTINRVCAASLYVLGTATRWPLA
VRKWTTTALGLLTIPIIIHPIDRSVDFLLDSSLRKLYPTVGKPSSS
Target Bioclass
Other
Subcellular location
Chromosome, centromere, kinetochore
Function May play a role during embryogenesis.
Uniprot ID
Q9UEE9
Ensemble ID
ENST00000283882.4
HGNC ID
HGNC:1873

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CASKI SNV: p.E83K .
HDMYZ Deletion: p.S143VfsTer7 .
OVTOKO SNV: p.G99S .
SNU1 Insertion: p.K230EfsTer13 .
SUPT1 SNV: p.E155G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K268(6.24)  LDD0277  [1]
Probe 1
 Probe Info  		Y271(36.71)  LDD3495  [2]
Alkylaryl probe 3
 Probe Info  		20.00  LDD0382  [3]
HHS-465
 Probe Info  		Y271(10.00)  LDD2237  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
Ox-W18
 Probe Info  		W114(0.00); W248(0.00)  LDD2175  [6]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		14.62  LDD1713  [7]
C313
 Probe Info  		15.45  LDD1980  [7]
C348
 Probe Info  		13.93  LDD2009  [7]
C349
 Probe Info  		10.85  LDD2010  [7]
C350
 Probe Info  		29.86  LDD2011  [7]
C351
 Probe Info  		5.54  LDD2012  [7]
C353
 Probe Info  		7.84  LDD2014  [7]
C354
 Probe Info  		12.21  LDD2015  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0099  Phenelzine HEK-293T 20.00  LDD0382  [3]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587