Details of the Target

General Information of Target

Target ID LDTP00236
Target Name Transcription elongation factor SPT5 (SUPT5H)
Gene Name SUPT5H
Gene ID 6829
Synonyms
SPT5; SPT5H; Transcription elongation factor SPT5; hSPT5; DRB sensitivity-inducing factor 160 kDa subunit; DSIF p160; DRB sensitivity-inducing factor large subunit; DSIF large subunit; Tat-cotransactivator 1 protein; Tat-CT1 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDSEDSNFSEEEDSERSSDGEEAEVDEERRSAAGSEKEEEPEDEEEEEEEEEYDEEEEE
EDDDRPPKKPRHGGFILDEADVDDEYEDEDQWEDGAEDILEKEEIEASNIDNVVLDEDRS
GARRLQNLWRDQREEELGEYYMKKYAKSSVGETVYGGSDELSDDITQQQLLPGVKDPNLW
TVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYIYVEAYKQTHVKQAIE
GVGNLRLGYWNQQMVPIKEMTDVLKVVKEVANLKPKSWVRLKRGIYKDDIAQVDYVEPSQ
NTISLKMIPRIDYDRIKARMSLKDWFAKRKKFKRPPQRLFDAEKIRSLGGDVASDGDFLI
FEGNRYSRKGFLFKSFAMSAVITEGVKPTLSELEKFEDQPEGIDLEVVTESTGKEREHNF
QPGDNVEVCEGELINLQGKILSVDGNKITIMPKHEDLKDMLEFPAQELRKYFKMGDHVKV
IAGRFEGDTGLIVRVEENFVILFSDLTMHELKVLPRDLQLCSETASGVDVGGQHEWGELV
QLDPQTVGVIVRLERETFQVLNMYGKVVTVRHQAVTRKKDNRFAVALDSEQNNIHVKDIV
KVIDGPHSGREGEIRHLFRSFAFLHCKKLVENGGMFVCKTRHLVLAGGSKPRDVTNFTVG
GFAPMSPRISSPMHPSAGGQRGGFGSPGGGSGGMSRGRGRRDNELIGQTVRISQGPYKGY
IGVVKDATESTARVELHSTCQTISVDRQRLTTVGSRRPGGMTSTYGRTPMYGSQTPMYGS
GSRTPMYGSQTPLQDGSRTPHYGSQTPLHDGSRTPAQSGAWDPNNPNTPSRAEEEYEYAF
DDEPTPSPQAYGGTPNPQTPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQG
SYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPGAPSP
GGYNPHTPGSGIEQNSSDWVTTDIQVKVRDTYLDTQVVGQTGVIRSVTGGMCSVYLKDSE
KVVSISSEHLEPITPTKNNKVKVILGEDREATGVLLSIDGEDGIVRMDLDEQLKILNLRF
LGKLLEA
Target Bioclass
Other
Family
SPT5 family
Subcellular location
Nucleus
Function
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
Uniprot ID
O00267
Ensemble ID
ENST00000359191.10
HGNC ID
HGNC:11469

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.G811D; p.P968S DBIA    Probe Info 
AGS SNV: p.K287T DBIA    Probe Info 
COLO678 SNV: p.G811A .
DU145 SNV: p.G21V .
HCT15 SNV: p.G715W .
HS936T Substitution: p.P336L DBIA    Probe Info 
JURKAT SNV: p.R813H Compound 10    Probe Info 
LS180 SNV: p.R280C DBIA    Probe Info 
MELJUSO SNV: p.V980L DBIA    Probe Info 
MOLT4 SNV: p.S158F; p.R283W; p.R315H IA-alkyne    Probe Info 
NCIH358 SNV: p.G1082W .
NCIH716 SNV: p.Q774P .
OVK18 Deletion: p.G350VfsTer32 .
SKES1 SNV: p.D456E; p.E556D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.13  LDD0402  [1]
A-EBA
 Probe Info  		2.87  LDD0215  [2]
TH211
 Probe Info  		Y802(15.06)  LDD0257  [3]
ONAyne
 Probe Info  		K344(5.26)  LDD0274  [4]
STPyne
 Probe Info  		K323(3.35); K344(10.00); K369(9.09); K718(7.81)  LDD0277  [4]
Probe 1
 Probe Info  		Y140(78.03); Y141(14.52); Y295(15.06); Y717(38.92)  LDD3495  [5]
Alkylaryl probe 3
 Probe Info  		20.00  LDD0382  [6]
BTD
 Probe Info  		C740(1.18)  LDD1700  [7]
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [8]
AHL-Pu-1
 Probe Info  		C626(3.27); C740(2.56)  LDD0169  [9]
HHS-475
 Probe Info  		Y802(0.25); Y140(0.59); Y771(0.72); Y203(0.79)  LDD0264  [10]
HHS-465
 Probe Info  		Y155(7.52); Y203(10.00); Y771(10.00); Y778(10.00)  LDD2237  [11]
DBIA
 Probe Info  		C626(1.08)  LDD0078  [12]
ATP probe
 Probe Info  		K1037(0.00); K1040(0.00); K639(0.00); K601(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C429(0.00); C638(0.00); C626(0.00); C740(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C638(0.00); C626(0.00); C740(0.00); C429(0.00)  LDD0036  [14]
Lodoacetamide azide
 Probe Info  		C429(0.00); C638(0.00); C626(0.00); C740(0.00)  LDD0037  [14]
ATP probe
 Probe Info  		N.A.  LDD0035  [15]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [16]
NAIA_4
 Probe Info  		N.A.  LDD2226  [17]
WYneN
 Probe Info  		N.A.  LDD0021  [18]
Compound 10
 Probe Info  		N.A.  LDD2216  [19]
Compound 11
 Probe Info  		N.A.  LDD2213  [19]
IPM
 Probe Info  		C740(0.00); C626(0.00)  LDD0005  [18]
SF
 Probe Info  		N.A.  LDD0028  [20]
TFBX
 Probe Info  		C740(0.00); C626(0.00)  LDD0148  [16]
Phosphinate-6
 Probe Info  		C626(0.00); C740(0.00)  LDD0018  [21]
Acrolein
 Probe Info  		C429(0.00); C740(0.00); H801(0.00); C626(0.00)  LDD0217  [22]
Methacrolein
 Probe Info  		C429(0.00); C740(0.00)  LDD0218  [22]
NAIA_5
 Probe Info  		C638(0.00); C740(0.00)  LDD2223  [17]
HHS-482
 Probe Info  		Y249(1.69); Y720(0.82); Y771(0.85); Y778(0.85)  LDD2239  [11]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.34  LDD0472  [23]
FFF probe12
 Probe Info  		12.02  LDD0473  [23]
FFF probe13
 Probe Info  		6.16  LDD0475  [23]
FFF probe2
 Probe Info  		7.92  LDD0463  [23]
FFF probe3
 Probe Info  		7.42  LDD0465  [23]
VE-P
 Probe Info  		N.A.  LDD0396  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C740(0.57)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C740(0.96)  LDD2112  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1012(1.20); C626(0.69); C740(1.12)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C626(0.95); C740(1.23)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C740(0.91)  LDD2103  [7]
 LDCM0025  4SU-RNA HEK-293T C626(2.84)  LDD0172  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C626(3.27); C740(2.56)  LDD0169  [9]
 LDCM0214  AC1 HCT 116 C626(0.99)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C626(2.39)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C626(1.11)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C626(1.13)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C626(1.13)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C626(1.48)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C626(1.23)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C626(1.19)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C626(1.25)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C626(1.42)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C626(0.90)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C626(0.87)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C626(1.22)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C626(0.94)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C626(1.01)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C626(1.17)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C626(1.00)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C626(1.26)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C626(1.32)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C626(1.43)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C626(1.17)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C626(1.07)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C626(1.15)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C626(1.03)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C626(1.48)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C626(1.11)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C626(1.03)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C626(1.30)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C626(1.06)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C626(1.09)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C626(1.37)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C626(1.34)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C626(1.25)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C626(0.88)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C626(1.09)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C626(0.86)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C626(0.99)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C626(1.00)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C626(1.23)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C626(1.16)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C626(1.20)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C626(1.08)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C626(1.33)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C626(1.17)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C626(1.00)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C626(1.30)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C626(1.34)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C626(0.88)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C626(1.19)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C626(1.43)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C626(1.18)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C626(1.30)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C626(1.41)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C626(2.15)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C626(1.55)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C626(1.23)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C626(1.12)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C626(1.07)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C626(1.49)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C626(3.14)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C626(1.34)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C626(1.23)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C626(1.12)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C626(0.98)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C626(0.91)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C626(1.09)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C626(0.92)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C626(0.98)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C626(1.22)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C626(1.05)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C626(1.09)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C626(1.26)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C626(1.01)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C626(0.89)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C626(1.09)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C626(1.10)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C626(1.12)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C626(1.15)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C626(0.95)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C626(1.26)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C626(1.02)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C626(1.36)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C626(1.17)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C626(1.35)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C626(0.99)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C626(1.02)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C626(0.93)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C626(1.03)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C626(1.52)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C626(1.19)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C626(1.60)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C626(1.40)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C626(1.45)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C626(1.42)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C626(1.41)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C626(1.69)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C626(1.02)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C626(1.04)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C626(0.99)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C626(1.56)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C626(1.20)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C626(1.18)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C626(0.84)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C626(0.96)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C626(1.15)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C626(1.13)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C626(1.19)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C626(1.48)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C626(0.97)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C626(1.17)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C626(0.99)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C626(1.71)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C626(1.16)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C626(0.88)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C626(0.94)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C626(1.06)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C626(0.90)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C626(0.92)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C626(0.87)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C626(0.96)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C626(1.40)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C626(1.44)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C626(1.19)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C626(1.88)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C626(1.24)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C626(1.42)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C626(2.35)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C626(2.37)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C626(2.40)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C626(1.79)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C626(1.33)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C626(1.14)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C626(1.27)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C626(2.97)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C626(1.34)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C626(0.97)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C626(2.18)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C626(1.96)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C626(1.76)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C626(1.37)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C626(1.41)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C626(1.08)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C626(1.20)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C626(1.29)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C626(0.95)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C626(1.72)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C626(1.54)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C626(1.16)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C626(1.21)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C626(1.03)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C626(1.37)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C626(1.62)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C626(1.74)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C626(1.14)  LDD0683  [12]
 LDCM0545  Acetamide MDA-MB-231 C740(0.50)  LDD2138  [7]
 LDCM0248  AKOS034007472 HCT 116 C626(0.96)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C626(1.56)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C626(1.77)  LDD0592  [12]
 LDCM0020  ARS-1620 HCC44 C626(1.08)  LDD0078  [12]
 LDCM0498  BS-3668 MDA-MB-231 C626(0.80); C740(0.58)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C429(0.00); C740(0.00); H801(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C626(20.00)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C626(11.72)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C626(3.19)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C626(1.31)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C626(1.87)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C626(1.29)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C626(2.14)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C626(1.16)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C626(1.73)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C626(1.32)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C626(0.99)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C626(1.63)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C626(1.37)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C626(14.58)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C626(1.60)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C626(2.11)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C626(1.62)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C626(1.27)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C626(2.64)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C626(3.23)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C626(1.46)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C626(9.53)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C626(1.67)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C626(1.22)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C626(0.99)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C626(1.28)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C626(0.95)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C626(1.55)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C626(6.81)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C626(1.58)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C626(1.37)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C626(4.41)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C626(1.70)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C626(1.02)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C626(4.34)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C626(9.66)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C626(4.92)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C626(1.49)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C626(2.38)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C626(1.07)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C626(1.29)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C626(5.83)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C626(1.40)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C626(7.00)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C626(3.16)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C626(1.20)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C626(1.34)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C626(1.91)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C626(1.31)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C626(1.41)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C626(2.21)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C626(1.12)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C626(0.97)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C626(0.98)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C626(5.71)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C626(4.15)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C626(9.13)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C626(3.81)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C626(2.04)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C626(4.14)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C626(2.10)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C626(5.01)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C626(2.43)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C626(2.35)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C626(2.21)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C626(3.59)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C626(2.99)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C626(4.05)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C626(3.34)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C626(2.91)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C626(7.24)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C626(1.47)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C626(0.66)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C626(0.67)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C626(1.59)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C626(1.50)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C626(0.99)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C626(1.61)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C626(2.67)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C626(0.87)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C626(8.93)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C626(9.92)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C626(0.71)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C626(1.39)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C626(1.99)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C626(3.04)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C626(1.40)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C626(3.79)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C626(2.83)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C626(2.42)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C626(1.85)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C626(10.06)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C626(1.86)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C626(7.39)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C626(5.71)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C626(0.62)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C626(1.28)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C626(1.64)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C626(1.29)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C626(2.56)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C626(1.62)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C626(1.48)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C626(3.11)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C626(1.40)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C626(1.54)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C626(12.85)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C626(1.14)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C626(1.44)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C626(1.44)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C626(1.61)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C626(1.80)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C626(1.32)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C626(1.37)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C626(2.60)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C626(1.36)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C626(1.78)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C626(2.73)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C626(2.95)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C626(2.35)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C626(2.16)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C626(2.17)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C626(3.48)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C626(3.41)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C626(1.64)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C626(1.67)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C626(3.93)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C626(4.90)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C740(1.00); C626(6.58); C521(1.04); C429(1.01)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C626(1.23)  LDD1702  [7]
 LDCM0625  F8 Ramos C740(1.31); C626(0.88)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C740(0.84)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C740(0.45)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C740(1.10)  LDD2191  [26]
 LDCM0575  Fragment13 Ramos C740(1.18)  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C740(0.76); C626(0.88)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C740(0.94)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos C740(1.31); C626(1.53)  LDD2195  [26]
 LDCM0582  Fragment23 Ramos C740(1.22); C626(0.62)  LDD2196  [26]
 LDCM0578  Fragment27 Ramos C740(1.11); C626(1.54)  LDD2197  [26]
 LDCM0586  Fragment28 Ramos C740(1.27)  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C740(1.07)  LDD2199  [26]
 LDCM0589  Fragment31 Ramos C740(1.15); C626(0.50)  LDD2200  [26]
 LDCM0590  Fragment32 Ramos C740(0.96)  LDD2201  [26]
 LDCM0468  Fragment33 HCT 116 C626(5.37)  LDD0785  [12]
 LDCM0596  Fragment38 Ramos C740(0.84); C626(0.81)  LDD2203  [26]
 LDCM0566  Fragment4 Ramos C740(0.94); C626(4.33)  LDD2184  [26]
 LDCM0427  Fragment51 HCT 116 C626(7.07)  LDD0744  [12]
 LDCM0610  Fragment52 Ramos C740(0.87); C626(1.76)  LDD2204  [26]
 LDCM0614  Fragment56 Ramos C740(1.14); C626(0.46)  LDD2205  [26]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [8]
 LDCM0571  Fragment9 Ramos C740(0.85)  LDD2188  [26]
 LDCM0116  HHS-0101 DM93 Y802(0.25); Y140(0.59); Y771(0.72); Y203(0.79)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y140(0.48); Y802(0.68); Y203(0.76); Y778(0.77)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y802(0.15); Y140(0.40); Y155(0.52); Y771(0.66)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y802(0.47); Y140(0.50); Y203(0.71); Y771(0.86)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y787(0.69); Y140(0.74); Y203(0.74); Y720(0.81)  LDD0268  [10]
 LDCM0107  IAA HeLa C429(0.00); H801(0.00); H809(0.00); H642(0.00)  LDD0221  [22]
 LDCM0022  KB02 HCT 116 C626(20.00)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C626(16.10)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C626(1.43)  LDD0082  [12]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C740(0.89)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C740(0.64)  LDD2121  [7]
 LDCM0109  NEM HeLa H809(0.00); H642(0.00); H801(0.00)  LDD0223  [22]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C740(0.93)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C740(0.90)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C626(1.36); C740(0.95)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C740(1.06)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1012(0.31); C740(0.41)  LDD2096  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C740(0.72)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1012(1.77); C626(0.97); C740(0.97)  LDD2099  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C740(0.52)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C626(1.02); C740(1.06)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C740(1.04)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1012(0.95); C626(1.00); C740(0.87)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C740(1.05)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1012(1.25); C626(0.99)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C740(0.72)  LDD2114  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C626(1.62); C740(1.92)  LDD2119  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1012(1.46); C626(0.73); C740(0.88)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C740(0.46)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1012(1.46); C626(0.87)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C626(0.91); C740(1.00)  LDD2127  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1012(1.07); C626(1.03); C740(0.81)  LDD2129  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1012(0.73)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C626(0.92)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C626(1.30); C740(1.04)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1012(1.43); C626(1.00); C740(0.83)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C740(1.18)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1012(1.22); C626(1.07); C740(0.75)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C740(0.67)  LDD2141  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1012(1.53); C626(1.46)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C626(0.93); C740(1.01)  LDD2146  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C740(0.72)  LDD2151  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C740(1.34)  LDD2153  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C740(0.93)  LDD2206  [27]
 LDCM0628  OTUB2-COV-1 HEK-293T C740(0.81)  LDD2207  [27]
 LDCM0099  Phenelzine HEK-293T 20.00  LDD0382  [6]
 LDCM0131  RA190 MM1.R C740(1.20)  LDD0304  [28]
 LDCM0021  THZ1 HCT 116 C626(1.09)  LDD2173  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase A (PPIA) Cyclophilin-type PPIase family P62937
Cyclin-dependent kinase 7 (CDK7) CMGC Ser/Thr protein kinase family P50613
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) RNA polymerase beta' chain family P24928
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription elongation factor SPT4 (SUPT4H1) SPT4 family P63272
Telomeric repeat-binding factor 1 (TERF1) . P54274

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
28 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.