Details of the Target

General Information of Target

Target ID LDTP19007
Target Name Small acidic protein (SMAP)
Gene Name SMAP
Gene ID 10944
Synonyms
C11orf58; Small acidic protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPCPRPFWLRHSRAPQGSGPSSPGSLSAPRSPSRGEDQEEEEEEEGDGSPGSGPILPPAS
PVECLICVSSFDGVFKLPKRLDCGHVFCLECLARLSLATAGGGNAVACPVCRAPTRLAPR
RGLPALPTQSGLLPRDARAPPSRQGSVRFDRRRGLLYLRPPPPPPGPRKARAPPPPPPLR
LGRPLSRRLSLASPAWVFNAAVALAVLVAAGLVVSGVYIFFLIPHATSSGPPRPQLVALA
PAPGFSWFPPRPPPGSPWAPAWTPRPTGPDLDTALPGTAEDALEPEAGPEDPAEAERTLD
RRSDGTWGTEAGPGWAPWPRGARRLWGSQ
Target Bioclass
Other
Family
SMAP family
Uniprot ID
O00193
Ensemble ID
ENST00000228136.9
HGNC ID
HGNC:16990

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
C-Sul
 Probe Info  		3.90  LDD0066  [2]
TH211
 Probe Info  		Y84(20.00)  LDD0257  [3]
STPyne
 Probe Info  		K13(10.00); K170(0.58); K174(5.40); K49(2.70)  LDD0277  [4]
ONAyne
 Probe Info  		K13(0.00); K62(0.00)  LDD0273  [4]
Probe 1
 Probe Info  		Y84(31.57)  LDD3495  [5]
Alkylaryl probe 3
 Probe Info  		15.68  LDD0382  [6]
HHS-482
 Probe Info  		Y84(0.65)  LDD0286  [7]
HHS-475
 Probe Info  		Y84(0.80)  LDD0264  [8]
ATP probe
 Probe Info  		K62(0.00); K91(0.00); K75(0.00)  LDD0199  [9]
CY-1
 Probe Info  		D89(0.00); E81(0.00); M88(0.00); S82(0.00)  LDD0246  [10]
ATP probe
 Probe Info  		N.A.  LDD0035  [11]
NHS
 Probe Info  		N.A.  LDD0010  [12]
SF
 Probe Info  		N.A.  LDD0028  [13]
Ox-W18
 Probe Info  		N.A.  LDD2175  [14]
1c-yne
 Probe Info  		K75(0.00); K91(0.00)  LDD0228  [15]
1d-yne
 Probe Info  		N.A.  LDD0357  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
AOyne
 Probe Info  		15.00  LDD0443  [17]
HHS-465
 Probe Info  		K91(0.00); Y84(0.00); K50(0.00)  LDD2240  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 14.74  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0116  HHS-0101 DM93 Y84(0.80)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y84(0.81)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y84(0.74)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y84(0.96)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y84(0.97)  LDD0268  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0124  JWB142 DM93 Y84(0.65)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y84(1.26)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y84(3.57)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y84(2.34)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y84(1.85)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y84(0.55)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y84(1.17)  LDD0292  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [16]
 LDCM0099  Phenelzine HEK-293T 15.68  LDD0382  [6]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
11 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010