Details of the Target

General Information of Target

Target ID LDTP04622
Target Name Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1)
Gene Name BCAT1
Gene ID 586
Synonyms
BCT1; ECA39; Branched-chain-amino-acid aminotransferase, cytosolic; BCAT(c); EC 2.6.1.42; Protein ECA39
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTV
EWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRM
YRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTK
ALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDN
GCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQ
WGEFKVSERYLTMDDLTTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPK
LASRILSKLTDIQYGREESDWTIVLS
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Class-IV pyridoxal-phosphate-dependent aminotransferase family
Subcellular location
Cytoplasm
Function Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
TTD ID
T92557
Uniprot ID
P54687
DrugMap ID
TTES57P
Ensemble ID
ENST00000261192.12
HGNC ID
HGNC:976
ChEMBL ID
CHEMBL4679

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.P208T .
LNCaP clone FGC SNV: p.L88S .
OVCAR8 Insertion: p.L94WfsTer7; p.P113_P130dup DBIA    Probe Info 
PC14 SNV: p.W267Ter .
TOV21G SNV: p.G16V DBIA    Probe Info 
TYKNU SNV: p.K19R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Alkylaryl probe 2
 Probe Info  		20.00  LDD0391  [2]
DA-P2
 Probe Info  		4.02  LDD0348  [3]
STPyne
 Probe Info  		K346(3.20)  LDD2217  [4]
Alkylaryl probe 1
 Probe Info  		4.00  LDD0388  [2]
Alkylaryl probe 3
 Probe Info  		3.23  LDD0282  [5]
DBIA
 Probe Info  		C233(1.55)  LDD3310  [6]
BTD
 Probe Info  		C221(2.66)  LDD1700  [7]
HHS-465
 Probe Info  		Y161(0.97)  LDD2237  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C140(0.00); C293(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C140(0.00); C293(0.00); C12(0.00); C4(0.00)  LDD0037  [10]
DA-P3
 Probe Info  		N.A.  LDD0178  [3]
Compound 11
 Probe Info  		C4(0.00); C8(0.00)  LDD2213  [13]
IPM
 Probe Info  		C8(0.00); C12(0.00); C335(0.00); C4(0.00)  LDD2156  [14]
SF
 Probe Info  		N.A.  LDD0028  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
AOyne
 Probe Info  		13.50  LDD0443  [17]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C221(0.80)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C221(1.21)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C221(1.37)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C221(1.00)  LDD2152  [7]
 LDCM0214  AC1 HEK-293T C221(1.06); C140(1.00); C338(1.18); C4(1.00)  LDD1507  [19]
 LDCM0215  AC10 HEK-293T C221(1.04); C140(1.10); C338(1.01); C4(0.81)  LDD1508  [19]
 LDCM0226  AC11 HEK-293T C140(1.13); C12(0.89); C338(0.92); C4(1.38)  LDD1509  [19]
 LDCM0237  AC12 HEK-293T C221(1.07); C140(1.08); C293(1.03); C12(0.81)  LDD1510  [19]
 LDCM0259  AC14 HEK-293T C221(0.94); C140(0.94); C338(0.88); C4(0.97)  LDD1512  [19]
 LDCM0270  AC15 HEK-293T C221(0.94); C140(1.00); C338(1.02); C4(1.05)  LDD1513  [19]
 LDCM0276  AC17 HEK-293T C221(0.96); C140(0.95); C338(1.22); C4(0.88)  LDD1515  [19]
 LDCM0277  AC18 HEK-293T C221(0.94); C140(1.06); C338(0.96); C4(0.88)  LDD1516  [19]
 LDCM0278  AC19 HEK-293T C140(0.94); C12(1.01); C338(1.61); C4(0.99)  LDD1517  [19]
 LDCM0279  AC2 HEK-293T C221(1.01); C140(1.13); C338(1.04); C4(0.78)  LDD1518  [19]
 LDCM0280  AC20 HEK-293T C221(1.03); C140(1.01); C293(1.06); C12(1.11)  LDD1519  [19]
 LDCM0281  AC21 HEK-293T C221(0.79); C140(1.05); C293(1.04); C12(0.86)  LDD1520  [19]
 LDCM0282  AC22 HEK-293T C221(1.01); C140(0.94); C338(1.05); C4(0.90)  LDD1521  [19]
 LDCM0283  AC23 HEK-293T C221(1.07); C140(1.00); C338(0.94); C4(1.06)  LDD1522  [19]
 LDCM0284  AC24 HEK-293T C221(0.97); C140(1.07); C338(0.90); C4(0.80)  LDD1523  [19]
 LDCM0285  AC25 HEK-293T C221(0.99); C140(1.10); C338(1.11); C4(0.78)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C221(0.98); C140(1.10); C338(1.00); C4(0.76)  LDD1525  [19]
 LDCM0287  AC27 HEK-293T C140(0.98); C12(0.87); C338(0.93); C4(0.88)  LDD1526  [19]
 LDCM0288  AC28 HEK-293T C221(0.98); C140(0.96); C293(1.01); C12(0.91)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C221(1.05); C140(1.13); C293(0.99); C12(1.22)  LDD1528  [19]
 LDCM0290  AC3 HEK-293T C140(1.32); C12(0.84); C338(0.94); C4(1.39)  LDD1529  [19]
 LDCM0291  AC30 HEK-293T C221(0.97); C140(0.98); C338(1.03); C4(0.92)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C221(0.89); C140(0.98); C338(0.95); C4(1.00)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C221(1.00); C140(1.05); C338(1.06); C4(1.08)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C221(0.87); C140(1.01); C338(1.31); C4(0.99)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C221(1.03); C140(1.22); C338(1.03); C4(1.06)  LDD1534  [19]
 LDCM0296  AC35 HEK-293T C140(1.29); C12(0.75); C338(0.94); C4(1.14)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C221(0.96); C140(1.10); C293(1.02); C12(0.96)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C221(0.92); C140(1.11); C293(1.07); C12(1.15)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C221(0.93); C140(1.02); C338(0.92); C4(0.78)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C221(0.91); C140(1.03); C338(0.89); C4(1.04)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C221(0.99); C140(1.01); C293(0.99); C12(1.06)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C221(0.98); C140(0.98); C338(0.94); C4(1.00)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C221(1.04); C140(0.97); C338(1.12); C4(0.90)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C221(1.12); C140(1.20); C338(1.03); C4(1.19)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C140(1.11); C12(0.68); C338(0.95); C4(0.88)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C221(0.94); C140(0.97); C293(1.06); C12(0.76)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C221(0.90); C140(1.10); C293(1.05); C12(1.06)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C221(0.99); C140(0.94); C338(0.66); C4(1.13)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C221(1.05); C140(1.01); C338(0.85); C4(0.95)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C221(1.00); C140(1.04); C338(1.03); C4(0.89)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C221(0.94); C140(1.03); C338(1.02); C4(0.93)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C221(0.90); C140(1.04); C293(0.97); C12(0.95)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C221(1.01); C140(1.14); C338(1.01); C4(0.83)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C140(1.00); C12(0.66); C338(0.92); C4(1.21)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C221(0.97); C140(1.14); C293(1.03); C12(1.04)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C221(0.96); C140(1.14); C293(1.03); C12(1.28)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C221(1.01); C140(0.93); C338(0.72); C4(1.05)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C221(0.93); C140(0.90); C338(0.86); C4(1.11)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C221(0.97); C140(1.05); C338(1.04); C4(0.95)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C221(1.03); C140(1.03); C338(1.15); C4(0.85)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C221(0.96); C140(1.17); C338(0.95); C4(0.91)  LDD1560  [19]
 LDCM0322  AC59 HEK-293T C140(1.08); C12(0.96); C338(1.03); C4(0.91)  LDD1561  [19]
 LDCM0323  AC6 HEK-293T C221(1.05); C140(1.03); C338(0.80); C4(1.14)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C221(0.99); C140(1.04); C293(1.09); C12(1.06)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C221(0.81); C140(1.08); C293(0.97); C12(1.07)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C221(0.94); C140(0.94); C338(1.02); C4(1.20)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C221(1.02); C140(0.98); C338(0.96); C4(0.90)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C221(1.00); C140(0.97); C338(1.00); C4(0.83)  LDD1567  [19]
 LDCM0334  AC7 HEK-293T C221(0.87); C140(1.04); C338(0.85); C4(1.10)  LDD1568  [19]
 LDCM0345  AC8 HEK-293T C221(0.96); C140(1.10); C338(0.93); C4(1.00)  LDD1569  [19]
 LDCM0545  Acetamide MDA-MB-231 C221(0.40)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C221(0.63)  LDD2113  [7]
 LDCM0248  AKOS034007472 HEK-293T C221(0.92); C140(1.07); C293(1.05); C12(0.99)  LDD1511  [19]
 LDCM0356  AKOS034007680 HEK-293T C221(1.01); C140(0.93); C338(1.09); C4(0.96)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C221(0.95); C140(0.96); C338(1.04); C4(0.98)  LDD1514  [19]
 LDCM0156  Aniline NCI-H1299 10.95  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C221(0.64)  LDD2091  [7]
 LDCM0367  CL1 HEK-293T C221(0.91); C140(0.86); C338(0.76); C335(0.94)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C221(1.15); C140(0.89); C338(0.81); C4(0.85)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C221(1.12); C140(1.03); C293(1.08); C12(0.82)  LDD1573  [19]
 LDCM0370  CL101 HEK-293T C221(0.96); C140(0.91); C338(0.76); C335(1.02)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C221(0.91); C140(0.90); C12(0.87); C338(0.86)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C221(1.00); C140(0.83); C338(0.89); C4(0.95)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C221(1.04); C140(0.91); C293(0.96); C12(0.81)  LDD1577  [19]
 LDCM0374  CL105 HEK-293T C221(0.91); C140(0.89); C338(0.78); C335(0.90)  LDD1578  [19]
 LDCM0375  CL106 HEK-293T C221(0.94); C140(1.00); C12(0.84); C338(0.81)  LDD1579  [19]
 LDCM0376  CL107 HEK-293T C221(1.01); C140(0.96); C338(0.91); C4(0.93)  LDD1580  [19]
 LDCM0377  CL108 HEK-293T C221(0.93); C140(1.01); C293(1.05); C12(1.06)  LDD1581  [19]
 LDCM0378  CL109 HEK-293T C221(0.97); C140(0.93); C338(0.85); C335(0.92)  LDD1582  [19]
 LDCM0379  CL11 HEK-293T C221(1.15); C140(0.98); C338(0.77); C4(0.86)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C221(0.87); C140(0.93); C12(1.01); C338(0.76)  LDD1584  [19]
 LDCM0381  CL111 HEK-293T C221(1.13); C140(0.97); C338(0.91); C4(0.95)  LDD1585  [19]
 LDCM0382  CL112 HEK-293T C221(1.03); C140(0.95); C293(0.99); C12(0.94)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C221(0.94); C140(1.11); C338(0.93); C335(0.92)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C221(0.90); C140(0.98); C12(0.62); C338(0.91)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C221(0.95); C140(0.94); C338(0.82); C4(0.91)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C221(0.85); C140(0.97); C293(0.95); C12(0.88)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C221(0.97); C140(0.95); C338(0.93); C335(0.94)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C221(0.77); C140(1.08); C12(0.71); C338(0.98)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C221(1.02); C140(0.87); C338(0.90); C4(0.79)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C221(1.02); C140(0.89); C338(0.96); C4(0.77)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C221(0.86); C140(0.99); C293(1.16); C12(0.74)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C221(0.95); C140(0.87); C338(0.83); C335(0.94)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C221(0.89); C140(1.04); C12(0.73); C338(0.91)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C221(1.02); C140(0.86); C338(0.91); C4(0.89)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C221(1.10); C140(1.07); C293(1.03); C12(1.02)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C221(0.97); C140(0.94); C338(0.87); C335(1.01)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C221(0.81); C140(1.00); C12(0.91); C338(0.92)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C221(0.92); C140(0.77); C338(1.04); C4(0.87)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C221(1.10); C140(1.10); C293(1.04); C12(0.89)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C221(0.89); C140(0.89); C338(0.67); C335(0.89)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C221(0.81); C140(1.03); C12(0.68); C338(0.80)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C221(0.95); C140(0.88); C338(0.82); C4(0.73)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C221(0.99); C140(0.98); C293(1.13); C12(0.72)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C221(1.13); C140(0.77); C338(1.24); C4(0.90)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C221(1.00); C140(1.10); C338(1.13); C4(0.75)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C140(1.26); C12(0.77); C338(1.05); C4(1.01)  LDD1610  [19]
 LDCM0407  CL2 HEK-293T C221(0.93); C140(1.13); C12(0.62); C338(0.97)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C221(1.11); C140(0.92); C293(1.33); C12(1.24)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C221(1.20); C140(0.88); C293(1.38); C12(0.90)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C221(0.93); C140(1.02); C338(1.06); C4(0.97)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C221(1.22); C140(0.91); C338(1.04); C4(1.13)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C221(1.02); C140(0.83); C338(0.99); C4(0.83)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C221(0.90); C140(0.81); C338(0.78); C335(0.91)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C221(0.89); C140(1.09); C12(0.96); C338(0.92)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C221(0.98); C140(1.07); C338(1.06); C4(0.95)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C221(0.88); C140(1.01); C293(1.09); C12(1.23)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C221(1.00); C140(0.83); C338(1.45); C4(0.89)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C221(0.97); C140(0.95); C338(0.96); C4(0.78)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C221(0.97); C140(1.19); C338(0.96); C4(0.95)  LDD1623  [19]
 LDCM0420  CL31 HEK-293T C140(1.08); C12(1.08); C338(0.98); C4(0.90)  LDD1624  [19]
 LDCM0421  CL32 HEK-293T C221(0.98); C140(0.82); C293(1.18); C12(1.01)  LDD1625  [19]
 LDCM0422  CL33 HEK-293T C221(1.03); C140(0.74); C293(1.22); C12(0.74)  LDD1626  [19]
 LDCM0423  CL34 HEK-293T C221(1.06); C140(1.03); C338(0.76); C4(0.75)  LDD1627  [19]
 LDCM0424  CL35 HEK-293T C221(1.24); C140(0.77); C338(0.93); C4(1.06)  LDD1628  [19]
 LDCM0425  CL36 HEK-293T C221(1.10); C140(0.90); C338(1.13); C4(0.72)  LDD1629  [19]
 LDCM0426  CL37 HEK-293T C221(0.89); C140(0.89); C338(0.89); C335(1.02)  LDD1630  [19]
 LDCM0428  CL39 HEK-293T C221(1.22); C140(0.78); C338(0.86); C4(0.93)  LDD1632  [19]
 LDCM0429  CL4 HEK-293T C221(1.23); C140(0.90); C293(1.07); C12(0.98)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C221(1.04); C140(0.90); C293(1.07); C12(0.91)  LDD1634  [19]
 LDCM0431  CL41 HEK-293T C221(1.10); C140(0.85); C338(1.09); C4(1.17)  LDD1635  [19]
 LDCM0432  CL42 HEK-293T C221(1.05); C140(0.97); C338(0.86); C4(1.13)  LDD1636  [19]
 LDCM0433  CL43 HEK-293T C140(1.21); C12(0.83); C338(0.97); C4(1.00)  LDD1637  [19]
 LDCM0434  CL44 HEK-293T C221(1.00); C140(0.85); C293(1.14); C12(0.66)  LDD1638  [19]
 LDCM0435  CL45 HEK-293T C221(1.12); C140(0.87); C293(1.09); C12(0.97)  LDD1639  [19]
 LDCM0436  CL46 HEK-293T C221(1.12); C140(1.09); C338(0.86); C4(1.06)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C221(1.37); C140(0.89); C338(1.04); C4(1.07)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C221(1.07); C140(0.78); C338(0.82); C4(0.90)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C221(0.94); C140(0.98); C338(1.00); C335(1.02)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C221(0.91); C140(0.96); C338(0.91); C4(0.85)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C221(0.81); C140(1.05); C12(0.55); C338(0.92)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C221(0.93); C140(0.92); C293(1.13); C12(1.11)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C221(1.04); C140(0.81); C338(0.99); C4(0.84)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C221(1.11); C140(0.76); C338(0.75); C4(0.83)  LDD1648  [19]
 LDCM0446  CL55 HEK-293T C140(1.12); C12(0.73); C338(0.91); C4(0.83)  LDD1649  [19]
 LDCM0447  CL56 HEK-293T C221(1.06); C140(0.79); C293(1.26); C12(0.93)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C221(1.25); C140(0.94); C293(1.27); C12(0.96)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C221(0.97); C140(0.95); C338(1.00); C4(0.93)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C221(1.13); C140(0.85); C338(0.92); C4(0.94)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C221(1.14); C140(0.96); C338(1.13); C4(0.66)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C221(1.04); C140(0.76); C338(1.01); C4(1.08)  LDD1655  [19]
 LDCM0453  CL61 HEK-293T C221(0.91); C140(0.96); C338(0.88); C335(0.93)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C221(0.74); C140(1.00); C12(0.73); C338(0.87)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C221(0.94); C140(0.90); C338(0.87); C4(1.17)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C221(0.98); C140(0.93); C293(1.15); C12(0.91)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C221(1.11); C140(0.89); C338(0.97); C4(0.89)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C221(1.05); C140(1.08); C338(1.04); C4(1.14)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C140(0.89); C12(1.05); C338(0.77); C4(1.07)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C221(1.00); C140(0.85); C293(1.17); C12(0.89)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C221(1.05); C140(0.97); C293(1.31); C12(1.05)  LDD1664  [19]
 LDCM0462  CL7 HEK-293T C140(1.11); C12(0.85); C338(1.00); C4(0.91)  LDD1665  [19]
 LDCM0463  CL70 HEK-293T C221(0.98); C140(1.04); C338(0.98); C4(0.92)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C221(1.34); C140(0.83); C338(0.91); C4(0.81)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C221(1.02); C140(0.98); C338(1.26); C4(1.07)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C221(0.95); C140(0.95); C338(0.85); C335(0.91)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C221(0.82); C140(1.03); C12(0.72); C338(0.86)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C221(0.93); C140(1.07); C293(0.91); C12(1.22)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C221(1.05); C140(0.91); C338(1.04); C4(0.82)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C221(1.04); C140(1.09); C338(1.03); C4(0.89)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C140(1.07); C12(0.87); C338(0.91); C4(0.91)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C221(1.06); C140(0.88); C293(1.31); C12(0.71)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C221(1.08); C140(0.97); C293(1.17); C12(1.26)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C221(1.03); C140(1.03); C293(1.19); C12(0.95)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C221(0.94); C140(1.10); C338(0.93); C4(0.85)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C221(1.19); C140(0.86); C338(1.26); C4(0.97)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C221(1.14); C140(0.92); C338(0.97); C4(0.77)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C221(0.90); C140(0.86); C338(0.89); C335(1.12)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C221(0.84); C140(1.08); C12(0.94); C338(0.87)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C221(0.96); C140(0.87); C338(0.95); C4(0.86)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C221(1.09); C140(0.92); C293(1.04); C12(1.23)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C221(0.93); C140(1.06); C338(1.09); C4(0.81)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C221(1.01); C140(0.96); C293(1.22); C12(1.04)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C221(1.25); C140(0.89); C338(1.02); C4(0.69)  LDD1688  [19]
 LDCM0486  CL91 HEK-293T C140(1.16); C12(0.73); C338(0.94); C4(1.16)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C221(0.99); C140(0.88); C293(1.14); C12(1.08)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C221(0.96); C140(0.96); C293(1.15); C12(0.89)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C221(1.07); C140(0.91); C338(0.87); C4(1.01)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C221(1.11); C140(0.81); C338(0.86); C4(0.90)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C221(1.04); C140(0.76); C338(0.94); C4(0.83)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C221(0.87); C140(0.90); C338(0.68); C335(1.01)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C221(0.88); C140(1.00); C12(0.79); C338(0.81)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C221(1.09); C140(0.88); C338(0.94); C4(0.90)  LDD1697  [19]
 LDCM0495  E2913 HEK-293T C221(1.00); C140(0.85); C338(0.87); C4(0.81)  LDD1698  [19]
 LDCM0625  F8 Ramos C293(0.68); C221(0.83); C140(0.62); C4(1.34)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C293(0.82); C221(0.61); C140(0.26)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C293(0.26); C221(0.52); C140(3.69)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C293(1.27); C221(0.47); C140(0.27)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C293(1.86); C221(0.55); C140(0.77)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C293(0.77); C221(1.69); C140(0.71)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C293(1.40); C221(0.55); C140(0.21)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C293(1.35); C221(0.50); C140(0.81)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C293(1.05); C221(0.39)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C293(0.91); C221(0.53)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C293(0.73); C221(0.58); C140(0.52); C4(0.33)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C293(1.56); C221(0.49); C140(0.29)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C293(1.05); C221(0.51); C140(0.84)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C293(0.82); C221(0.44); C140(0.33)  LDD2201  [20]
 LDCM0468  Fragment33 HEK-293T C221(1.03); C140(0.94); C338(0.87); C4(1.23)  LDD1671  [19]
 LDCM0596  Fragment38 Ramos C293(1.61); C221(0.35); C140(0.95)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C293(0.61); C221(0.65); C140(0.46)  LDD2184  [20]
 LDCM0427  Fragment51 HEK-293T C221(0.97); C140(1.06); C12(0.92); C338(1.06)  LDD1631  [19]
 LDCM0610  Fragment52 Ramos C293(1.30); C221(0.69); C140(0.76)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C293(1.05); C221(0.89); C140(0.36)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C293(0.39); C221(0.43); C140(0.44); C4(0.69)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C293(0.73); C221(0.51); C140(0.21)  LDD2188  [20]
 LDCM0022  KB02 HEK-293T C140(0.98); C338(0.95); C335(1.07)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C140(0.85); C338(0.97); C335(1.03)  LDD1497  [19]
 LDCM0024  KB05 COLO792 C233(1.55)  LDD3310  [6]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C221(0.62)  LDD2089  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C221(0.69)  LDD2093  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C221(0.68)  LDD2097  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C221(1.16)  LDD2099  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C221(0.91)  LDD2101  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C221(0.92)  LDD2107  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C221(0.94)  LDD2111  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C221(0.44)  LDD2115  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C221(1.52)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C221(0.95)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C221(0.76)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C221(0.95)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C221(0.90)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C221(1.34)  LDD2127  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C221(0.70)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C221(0.44)  LDD2133  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C221(0.80)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C221(1.06)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C221(1.13)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C221(2.66)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C221(0.67)  LDD2140  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C221(0.62)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C221(2.96)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C221(0.32)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C221(0.77)  LDD2146  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C221(0.45)  LDD2148  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C221(0.50)  LDD2150  [7]
 LDCM0099  Phenelzine HEK-293T 3.23  LDD0282  [5]
 LDCM0170  Structure8 Ramos 13.11  LDD0433  [21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Axonemal dynein light intermediate polypeptide 1 (DNALI1) Inner dynein arm light chain family O14645
Gelsolin (GSN) Villin/gelsolin family P06396

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gabapentin Small molecular drug DB00996
Glutamic Acid Small molecular drug DB00142
Pyridoxal Phosphate Small molecular drug DB00114
Valine Small molecular drug DB00161
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isoleucine Small molecular drug DB00167
Leucine Small molecular drug DB00149
N'-(5-chlorobenzofuran-2-carbonyl)-2-(Trifluoromethyl)Benzenesulfonohydrazide . DB07544

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
5 Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets. ACS Cent Sci. 2021 Sep 22;7(9):1524-1534. doi: 10.1021/acscentsci.1c00616. Epub 2021 Aug 19.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.