Details of the Target

General Information of Target

Target ID LDTP00957
Target Name Lysine-specific histone demethylase 1A (KDM1A)
Gene Name KDM1A
Gene ID 23028
Synonyms
AOF2; KDM1; KIAA0601; LSD1; Lysine-specific histone demethylase 1A; EC 1.14.99.66; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2; [histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP
RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY
REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ
SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF
GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC
PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN
ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC
EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN
KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI
TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA
TPGVPAQQSPSM
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Flavin monoamine oxidase family
Subcellular location
Nucleus
Function
Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context . Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.
TTD ID
T16739
Uniprot ID
O60341
DrugMap ID
TTNR0UQ
Ensemble ID
ENST00000356634.7
HGNC ID
HGNC:29079
ChEMBL ID
CHEMBL6136

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 2
 Probe Info  		20.00  LDD0389  [1]
TH211
 Probe Info  		Y807(20.00)  LDD0260  [2]
Probe 1
 Probe Info  		Y462(49.83); Y494(12.13); Y520(8.99)  LDD3495  [3]
P11
 Probe Info  		20.00  LDD0201  [4]
Alkylaryl probe 3
 Probe Info  		3.93  LDD0282  [5]
SAHA-CA-4PAP
 Probe Info  		10.70  LDD0269  [6]
BTD
 Probe Info  		C360(0.78)  LDD2091  [7]
HHS-465
 Probe Info  		Y242(2.96)  LDD2237  [8]
DBIA
 Probe Info  		C195(1.03); C573(0.86)  LDD0078  [9]
CY4
 Probe Info  		N.A.  LDD0247  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C360(0.00); C491(0.00); C195(0.00); C573(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C618(0.00); C195(0.00); C573(0.00)  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C360(0.00); C491(0.00); C195(0.00); C573(0.00)  LDD0037  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
TFBX
 Probe Info  		C600(0.00); C360(0.00); C195(0.00)  LDD0027  [13]
Compound 10
 Probe Info  		C360(0.00); C573(0.00)  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
IPM
 Probe Info  		C491(0.00); C360(0.00)  LDD0147  [13]
STPyne
 Probe Info  		N.A.  LDD0009  [15]
Acrolein
 Probe Info  		C195(0.00); C491(0.00); C573(0.00); H802(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		C600(0.00); C195(0.00)  LDD0218  [16]
W1
 Probe Info  		C573(0.00); C665(0.00)  LDD0236  [17]
NAIA_5
 Probe Info  		C360(0.00); C573(0.00)  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C147
 Probe Info  		11.00  LDD1829  [19]
VE-P
 Probe Info  		N.A.  LDD0396  [20]
SAHA-CA-8PAP
 Probe Info  		17.33  LDD0362  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C360(0.94)  LDD2112  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C360(0.98)  LDD2132  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C727(2.26)  LDD0372  [21]
 LDCM0214  AC1 HCT 116 C195(0.88); C360(1.08); C491(1.20); C573(0.98)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C195(0.84); C360(1.08); C491(0.95); C573(0.83)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C195(0.70); C360(0.85); C491(0.98); C600(1.25)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C195(0.73); C360(0.77); C491(1.10); C600(0.92)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C195(0.77); C360(0.78); C491(1.05); C600(1.10)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C195(0.66); C360(0.79); C491(0.88); C600(0.85)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C195(0.70); C360(0.77); C491(0.91); C600(0.97)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C195(0.69); C360(0.83); C491(0.96); C600(1.17)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C195(0.63); C360(0.81); C491(0.88); C600(0.99)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C195(0.75); C360(0.84); C491(0.92); C600(0.91)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C195(0.71); C360(0.84); C491(0.97); C600(1.10)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C195(0.74); C360(0.80); C491(0.94); C600(1.01)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C195(0.82); C360(0.96); C491(0.74); C573(0.88)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C195(0.81); C360(0.82); C491(0.94); C600(0.90)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C195(0.77); C360(0.84); C491(0.89); C600(0.78)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C195(0.82); C360(0.75); C491(1.03); C600(0.68)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C195(1.05); C360(0.98); C491(1.11); C573(1.01)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C195(0.91); C360(0.88); C491(1.13); C573(1.10)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C195(0.93); C360(0.84); C491(1.11); C573(0.97)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C195(0.92); C360(0.85); C491(1.14); C573(1.03)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C195(1.05); C360(0.84); C491(1.10); C573(0.99)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C195(0.94); C360(0.82); C491(1.15); C573(0.99)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C195(0.97); C360(0.89); C491(0.99); C573(1.09)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C195(0.96); C360(1.04); C491(0.88); C573(0.87)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C195(0.95); C360(0.89); C491(0.87); C573(1.04)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C195(1.06); C360(0.93); C491(1.07); C573(1.01)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C195(1.02); C360(0.84); C491(1.03); C573(1.06)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C195(0.95); C360(1.02); C491(1.02); C573(1.01)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C195(1.08); C360(0.91); C491(1.20); C573(1.11)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C195(0.91); C360(0.93); C491(1.01); C573(1.13)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C195(0.97); C360(0.88); C491(1.07); C573(1.00)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C195(1.00); C360(0.87); C491(1.05); C573(1.02)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C195(1.48); C360(1.52); C573(1.04); C600(1.39)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C195(1.17); C360(1.42); C573(1.12); C600(1.27)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C195(0.97); C360(1.32); C573(0.94); C600(1.22)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C195(0.91); C360(1.13); C573(1.12); C600(1.04)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C195(1.05); C360(1.16); C573(1.14); C600(1.08)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C195(1.22); C360(1.17); C573(0.97); C600(1.18)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C195(0.87); C360(1.15); C573(0.93); C600(1.10)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C195(0.95); C360(1.26); C573(1.11); C600(1.03)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C195(1.10); C360(1.24); C573(0.91); C600(0.95)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C195(1.20); C360(1.27); C573(1.01); C600(1.07)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C195(0.95); C360(1.38); C573(1.01); C600(0.85)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C195(1.07); C360(1.16); C573(1.07); C600(1.06)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C195(0.86); C360(0.89); C491(0.80); C573(0.86)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C195(1.07); C360(1.36); C573(1.10); C600(0.92)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C195(1.12); C360(1.36); C573(1.05); C600(1.00)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C195(1.03); C360(1.23); C573(0.96); C600(1.02)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C665(0.65); C618(0.76); C623(0.76); C600(0.81)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C618(0.42); C623(0.42); C491(0.87); C665(0.88)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C618(0.59); C623(0.59); C195(0.96); C665(0.99)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C618(0.44); C623(0.44); C665(0.68); C360(0.97)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C618(0.44); C623(0.44); C360(0.84); C600(0.87)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C618(0.48); C623(0.48); C665(0.89); C600(0.90)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C618(0.42); C623(0.42); C665(0.85); C360(0.89)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C618(0.67); C623(0.67); C491(0.82); C573(0.88)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C618(0.63); C623(0.63); C600(0.87); C665(0.91)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C618(0.64); C623(0.64); C665(0.73); C360(0.78)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C618(0.43); C623(0.43); C665(0.75); C360(0.84)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C618(0.52); C623(0.52); C665(0.63); C360(1.08)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C195(0.95); C360(0.88); C491(1.07); C600(1.01)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C195(0.95); C360(0.89); C491(1.06); C600(1.44)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C195(1.19); C360(1.00); C491(1.06); C600(1.15)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C195(1.13); C360(0.89); C491(1.03); C600(1.05)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C618(0.75); C623(0.75); C573(0.82); C195(0.96)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C618(0.60); C623(0.60); C573(0.85); C195(0.88)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C618(0.76); C623(0.76); C573(0.81); C360(0.90)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C618(0.80); C623(0.80); C360(0.89); C573(0.94)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C618(0.77); C623(0.77); C195(0.91); C573(0.92)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C618(0.63); C623(0.63); C573(0.85); C195(0.85)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C618(0.80); C623(0.80); C195(0.92); C573(0.93)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C195(0.77); C618(0.80); C623(0.80); C573(0.84)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C618(0.91); C623(0.91); C573(0.93); C360(1.00)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C618(0.73); C623(0.73); C573(0.89); C360(0.91)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C618(0.60); C623(0.60); C600(0.64); C360(0.84)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C618(0.59); C623(0.59); C360(0.70); C195(0.79)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C618(0.55); C623(0.55); C360(0.79); C195(0.82)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C600(0.58); C618(0.64); C623(0.64); C360(0.74)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C618(0.79); C623(0.79); C360(0.98); C195(0.98)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C600(0.61); C360(0.66); C618(0.73); C623(0.73)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C618(0.54); C623(0.54); C360(0.77); C600(0.81)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C618(0.49); C623(0.49); C600(0.51); C360(0.73)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C618(0.53); C623(0.53); C600(0.68); C360(0.71)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C618(0.46); C623(0.46); C600(0.65); C360(0.70)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C618(0.87); C623(0.87); C491(0.87); C665(1.02)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C491(0.80); C665(0.89); C195(1.01); C360(1.08)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C491(0.82); C665(0.88); C195(0.97); C360(1.11)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C491(0.83); C665(0.89); C195(0.99); C360(1.00)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C491(0.85); C195(0.89); C665(0.89); C618(1.00)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C618(0.60); C623(0.60); C195(0.90); C360(1.03)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C491(0.76); C665(0.89); C195(0.95); C600(0.98)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C665(0.90); C195(0.93); C491(0.94); C360(1.05)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C491(0.86); C195(0.92); C600(0.98); C665(1.03)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C491(0.92); C360(0.93); C665(1.00); C195(1.03)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C491(0.88); C665(0.91); C195(0.93); C618(1.09)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C491(0.87); C665(0.89); C195(1.04); C618(1.08)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C600(0.82); C360(0.88); C665(0.89); C573(0.96)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C600(0.82); C665(0.91); C573(0.93); C618(0.94)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C573(0.84); C665(0.97); C618(0.97); C623(0.97)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C665(0.80); C360(0.91); C600(0.93); C618(1.03)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C618(0.65); C623(0.65); C195(0.99); C573(1.02)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C665(0.87); C618(0.92); C623(0.92); C573(0.98)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C665(0.82); C573(0.85); C360(1.00); C195(1.15)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C665(0.86); C600(0.87); C195(0.95); C573(0.95)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C600(0.76); C665(0.84); C618(0.87); C623(0.87)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C573(0.92); C618(0.93); C623(0.93); C195(1.01)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C600(0.75); C665(0.91); C618(1.00); C623(1.00)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C665(0.84); C600(0.91); C573(0.92); C360(0.96)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C618(0.50); C623(0.50); C491(0.94); C360(0.99)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C618(0.50); C623(0.50); C360(0.91); C195(0.91)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C618(0.60); C623(0.60); C360(0.89); C195(0.89)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C618(0.62); C623(0.62); C491(0.74); C573(0.81)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C618(0.53); C623(0.53); C600(0.78); C195(0.88)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C618(0.52); C623(0.52); C360(0.87); C665(0.90)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C618(0.50); C623(0.50); C195(0.85); C491(0.87)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C618(0.54); C623(0.54); C195(0.82); C573(0.83)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C618(0.54); C623(0.54); C195(0.89); C600(0.92)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C618(0.64); C623(0.64); C360(0.93); C491(0.95)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C618(0.64); C623(0.64); C360(0.93); C600(0.96)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C618(0.62); C623(0.62); C600(0.90); C573(0.90)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C618(0.80); C623(0.80); C491(0.94); C195(1.03)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C618(0.72); C623(0.72); C195(1.04); C491(1.05)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C491(0.69); C618(0.73); C623(0.73); C195(0.82)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C618(0.58); C623(0.58); C195(0.89); C665(0.99)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C618(0.79); C623(0.79); C491(0.96); C195(1.10)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C618(0.72); C623(0.72); C195(0.92); C491(1.00)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C618(0.84); C623(0.84); C665(0.86); C491(0.98)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C618(0.84); C623(0.84); C491(1.03); C600(1.03)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C491(0.97); C665(0.98); C618(0.99); C623(0.99)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C618(0.71); C623(0.71); C491(0.95); C195(1.00)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C618(0.66); C623(0.66); C491(0.91); C195(0.92)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C618(0.68); C623(0.68); C665(0.93); C600(0.99)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C618(0.72); C623(0.72); C665(0.95); C491(1.02)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C618(0.63); C623(0.63); C195(0.86); C665(0.87)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C618(0.73); C623(0.73); C600(1.01); C491(1.02)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C618(0.83); C623(0.83); C491(1.00); C195(1.08)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C491(1.01); C665(1.10); C618(1.10); C623(1.10)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C618(0.64); C623(0.64); C195(0.88); C665(0.88)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C618(0.64); C623(0.64); C195(0.72); C665(0.81)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C618(0.63); C623(0.63); C665(0.75); C195(0.82)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C618(0.70); C623(0.70); C665(0.85); C360(0.89)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C665(0.85); C618(0.95); C623(0.95); C491(1.01)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C618(0.75); C623(0.75); C665(0.92); C195(0.97)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C618(0.69); C623(0.69); C195(0.82); C360(0.88)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C360(0.96); C491(1.11); C600(1.13); C195(1.18)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C618(0.64); C623(0.64); C195(0.82); C491(0.85)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C618(0.64); C623(0.64); C195(0.77); C665(0.81)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C600(0.83); C618(0.84); C623(0.84); C665(0.84)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C618(0.77); C623(0.77); C491(0.77); C195(0.84)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C665(0.73); C618(0.76); C623(0.76); C195(0.88)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C618(0.63); C623(0.63); C491(0.82); C665(0.86)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C618(0.61); C623(0.61); C665(0.82); C360(0.83)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C618(0.36); C623(0.36); C195(0.74); C600(0.80)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C618(0.55); C623(0.55); C195(0.78); C360(0.87)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C195(0.92); C360(1.00); C491(0.88); C573(0.98)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C491(0.71); C618(0.72); C623(0.72); C360(0.85)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C618(0.59); C623(0.59); C491(0.83); C195(0.84)  LDD0592  [9]
 LDCM0020  ARS-1620 HCC44 C195(1.03); C573(0.86)  LDD0078  [9]
 LDCM0498  BS-3668 MDA-MB-231 C360(0.78)  LDD2091  [7]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [4]
 LDCM0108  Chloroacetamide HeLa C195(0.00); C600(0.00); H802(0.00); H253(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C573(1.32)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C665(0.91); C600(0.94); C573(0.96); C491(0.96)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C195(0.80); C618(0.80); C623(0.80); C600(0.83)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C618(0.65); C623(0.65); C195(0.92); C573(1.01)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C618(0.65); C623(0.65); C195(0.80); C491(0.83)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C491(0.67); C618(0.83); C623(0.83); C665(0.86)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C491(0.75); C618(0.84); C623(0.84); C573(0.85)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C491(0.75); C618(0.85); C623(0.85); C360(0.87)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C618(0.64); C623(0.64); C573(0.81); C360(0.93)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C618(0.52); C623(0.52); C573(0.84); C195(0.94)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C618(0.52); C623(0.52); C573(0.88); C195(0.88)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C618(0.55); C623(0.55); C573(0.93); C195(0.95)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C618(0.65); C623(0.65); C360(0.84); C573(0.87)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C600(0.80); C195(0.85); C618(0.86); C623(0.86)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C618(0.61); C623(0.61); C573(0.84); C360(0.88)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C618(0.66); C623(0.66); C573(0.89); C360(0.91)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C618(0.71); C623(0.71); C600(0.73); C360(0.91)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C618(0.49); C623(0.49); C600(0.64); C360(0.76)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C618(0.58); C623(0.58); C360(0.78); C195(0.80)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C618(0.59); C623(0.59); C600(0.64); C360(0.74)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C600(0.67); C618(0.68); C623(0.68); C360(0.77)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C491(0.88); C665(0.88); C600(0.96); C360(1.10)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C491(0.90); C665(0.96); C618(0.98); C623(0.98)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C491(0.90); C618(0.90); C623(0.90); C195(0.94)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C618(0.83); C623(0.83); C665(0.89); C195(0.91)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C665(0.87); C618(0.94); C623(0.94); C491(0.97)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C360(0.82); C665(0.89); C573(0.99); C195(1.02)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C665(0.82); C600(0.86); C360(0.92); C573(0.93)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C600(0.80); C573(0.85); C618(0.98); C623(0.98)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C600(0.90); C360(0.90); C665(0.92); C618(0.99)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C618(0.86); C623(0.86); C360(0.87); C573(0.87)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C618(0.69); C623(0.69); C360(0.76); C195(0.79)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C618(0.77); C623(0.77); C573(0.86); C360(0.95)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C618(0.57); C623(0.57); C360(0.92); C491(0.99)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C618(0.80); C623(0.80); C195(0.81); C600(0.88)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C618(0.79); C623(0.79); C195(0.85); C600(0.89)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C195(0.86); C573(0.87); C618(0.89); C623(0.89)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C360(0.80); C623(0.85); C573(0.87); C618(0.91)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C623(0.80); C195(0.87); C618(0.90); C573(0.99)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C623(0.65); C618(0.66); C195(0.80); C360(0.84)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C623(0.74); C618(0.75); C600(0.76); C360(0.87)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C665(0.75); C195(0.91); C573(0.92); C360(0.96)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C623(0.71); C195(0.72); C618(0.77); C360(0.85)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C623(0.68); C618(0.84); C195(0.88); C600(0.90)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C665(0.90); C623(0.98); C360(1.04); C195(1.06)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C623(0.74); C360(0.75); C618(0.79); C665(0.79)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C600(0.77); C623(0.78); C618(0.80); C360(0.80)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C195(0.98); C360(0.81); C573(0.98); C600(0.94)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C195(0.93); C360(0.88); C573(1.06); C600(1.10)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C195(0.90); C360(0.83); C573(0.96); C600(1.16)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C195(0.86); C360(0.76); C573(0.93); C600(1.14)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C195(0.80); C360(0.78); C573(1.06); C600(0.88)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C195(0.79); C360(1.04); C491(1.03); C573(0.84)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C195(0.96); C360(0.85); C573(1.03); C600(0.94)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C195(0.90); C360(0.92); C491(1.09); C573(0.93)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C195(0.87); C360(0.86); C491(1.03); C573(0.78)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C195(0.72); C360(0.86); C491(0.92); C573(0.80)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C195(0.88); C360(0.89); C491(1.04); C573(1.03)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C195(0.96); C360(0.83); C491(0.94); C573(0.85)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C195(0.87); C360(0.86); C491(0.94); C573(1.02)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C195(0.82); C360(0.93); C491(0.93); C573(1.03)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C195(0.79); C360(0.93); C491(0.94); C573(1.01)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C195(0.82); C360(0.99); C491(1.06); C573(0.82)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C195(0.77); C360(0.90); C491(0.91); C573(0.98)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C195(0.94); C360(0.86); C491(0.96); C573(1.05)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C195(0.71); C360(1.14); C491(0.92); C573(1.01)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C195(0.91); C360(0.93); C491(0.90); C573(1.06)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C195(0.96); C360(0.87); C491(0.92); C573(0.93)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C195(0.98); C360(0.92); C491(1.03); C573(0.97)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C195(0.86); C360(1.03); C491(1.00); C573(0.91)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C195(0.92); C360(1.05); C491(1.07); C573(0.83)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C195(0.89); C360(1.08); C491(1.13); C573(0.88)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C195(1.10); C360(0.93); C491(1.16); C573(0.96)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C195(0.92); C360(1.00); C491(1.07); C573(0.89)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C195(0.95); C360(1.01); C491(1.05); C573(1.01)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C195(1.00); C360(1.00); C491(1.13); C573(1.00)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C195(0.92); C360(0.91); C491(1.05); C573(0.98)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C195(0.84); C360(0.98); C491(0.97); C573(0.89)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C195(0.92); C360(1.00); C491(1.01); C573(0.94)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C195(0.94); C360(1.06); C491(1.05); C573(0.93)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C195(0.92); C360(0.94); C491(1.09); C573(0.87)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C195(0.95); C360(0.96); C491(1.14); C573(0.92)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C195(0.89); C360(0.95); C491(1.09); C573(0.98)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C195(1.12); C360(0.96); C491(1.07); C573(0.91)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C195(0.78); C360(0.87); C491(0.94); C573(0.89)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C195(0.91); C360(0.92); C491(1.12); C573(0.83)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C195(0.90); C360(0.98); C573(1.05); C600(0.89)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C195(0.93); C360(0.97); C573(0.90); C600(0.88)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C195(0.88); C360(1.02); C573(0.97); C600(0.73)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C195(0.93); C360(0.85); C573(1.01); C600(0.72)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C195(1.04); C360(1.03); C573(0.98); C600(0.83)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C195(0.99); C360(0.99); C573(1.12); C600(0.68)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C195(0.87); C360(0.91); C573(0.86); C600(0.77)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C195(0.86); C360(0.90); C573(0.95); C600(0.68)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C195(1.02); C360(0.88); C573(0.88); C600(0.80)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C195(0.86); C360(1.01); C491(0.97); C573(0.92)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C195(0.91); C360(0.95); C573(0.92); C600(0.71)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C195(0.89); C360(1.07); C573(0.90); C600(0.63)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C195(1.08); C360(0.93); C573(1.01); C600(0.79)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C195(0.89); C360(0.92); C573(0.87); C600(0.68)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C195(0.78); C360(0.93); C573(0.98); C600(0.73)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C195(0.80); C360(1.05); C491(0.89); C573(1.09)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C195(0.80); C360(1.19); C491(1.13); C573(1.07)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C195(0.90); C360(1.16); C491(0.98); C573(1.06)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C195(0.89); C360(1.11); C491(1.02); C573(0.89)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C195(0.82); C360(1.09); C491(1.01); C573(0.97)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C195(0.85); C360(1.02); C491(1.18); C573(1.05)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C195(0.92); C360(1.14); C491(1.07); C573(0.94)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C195(0.97); C360(1.17); C491(1.02); C573(1.00)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C195(0.90); C360(1.13); C491(1.04); C573(0.91)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C195(1.03); C360(1.05); C491(1.13); C573(0.96)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C195(0.81); C360(1.00); C491(0.98); C573(0.97)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C195(0.82); C360(1.03); C491(1.05); C573(0.90)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C195(0.91); C360(0.99); C491(0.93); C573(0.95)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C195(0.99); C360(1.27); C491(0.94); C573(0.90)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C195(1.14); C360(1.06); C491(1.00); C573(1.18)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C195(0.81); C360(0.91); C491(1.03); C573(0.87)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C195(0.86); C360(1.28); C491(0.98); C573(1.02)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C195(0.92); C360(0.89); C491(1.12); C573(0.94)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C195(1.00); C360(0.98); C491(1.01); C573(1.04)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C195(0.95); C360(1.14); C491(0.88); C573(0.94)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C195(0.93); C360(0.88); C491(0.89); C573(1.04)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C195(0.91); C360(0.98); C491(1.13); C573(0.95)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C195(0.93); C360(0.90); C491(1.08); C573(1.04)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C195(0.93); C360(0.86); C491(1.18); C573(1.05)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C195(0.82); C360(0.85); C491(1.15); C573(0.94)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C195(1.12); C360(0.95); C491(1.26); C573(0.95)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C360(1.11); C665(0.91); C573(1.12); C195(1.05)  LDD1698  [22]
 LDCM0625  F8 Ramos C665(0.57)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C665(0.71)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C665(1.13)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C665(0.63)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C665(0.83)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C665(0.60)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C665(0.54)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C665(0.80)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C665(1.22)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C665(0.84)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C665(0.81)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C665(1.00)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C665(1.19)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C665(0.51)  LDD2201  [23]
 LDCM0468  Fragment33 HCT 116 C195(0.86); C360(0.85); C573(0.89); C600(0.69)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C665(0.87)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C665(0.75)  LDD2184  [23]
 LDCM0427  Fragment51 HCT 116 C195(0.84); C360(1.01); C491(0.80); C573(0.99)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C665(1.18)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C665(1.07)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C665(0.78)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C665(0.61)  LDD2188  [23]
 LDCM0107  IAA HeLa H459(0.00); C623(0.00); C600(0.00); H802(0.00)  LDD0221  [16]
 LDCM0022  KB02 HCT 116 C195(1.08)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C195(1.11)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C195(1.17)  LDD0082  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C360(0.43)  LDD2121  [7]
 LDCM0109  NEM HeLa H802(0.00); H459(0.00); H551(0.00)  LDD0223  [16]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C360(0.74)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C491(1.14)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C360(1.01)  LDD2094  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C360(0.95)  LDD2098  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C360(1.24)  LDD2105  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C491(1.76)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C360(1.09)  LDD2114  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C360(0.57)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C360(0.66)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C491(2.42)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C360(0.75)  LDD2120  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C665(1.07)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C491(0.97)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C360(1.07)  LDD2128  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C491(1.06); C665(1.83)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C665(1.14)  LDD2136  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C491(0.97)  LDD2146  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C360(0.27)  LDD2150  [7]
 LDCM0099  Phenelzine HEK-293T 3.93  LDD0282  [5]
 LDCM0096  SAHA K562 10.70  LDD0269  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome regulatory subunit 4 (PSMC1) AAA ATPase family P62191
Histone-lysine N-methyltransferase EHMT2 (EHMT2) Histone-lysine methyltransferase family Q96KQ7
Histone deacetylase 3 (HDAC3) Histone deacetylase family O15379
Baculoviral IAP repeat-containing protein 2 (BIRC2) IAP family Q13490
Lysyl oxidase homolog 4 (LOXL4) Lysyl oxidase family Q96JB6
Angiotensin-converting enzyme 2 (ACE2) Peptidase M2 family Q9BYF1
Chromodomain-helicase-DNA-binding protein 1 (CHD1) SNF2/RAD54 helicase family O14646
Chromodomain-helicase-DNA-binding protein 3 (CHD3) SNF2/RAD54 helicase family Q12873
SPRY domain-containing SOCS box protein 1 (SPSB1) SPSB family Q96BD6
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
GTP-binding protein 2 (GTPBP2) Classic translation factor GTPase family Q9BX10
E3 SUMO-protein ligase ZBED1 (ZBED1) . O96006
Secretion-regulating guanine nucleotide exchange factor (SERGEF) . Q9UGK8
Ubiquitin-associated and SH3 domain-containing protein B (UBASH3B) . Q8TF42
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
MICOS complex subunit MIC60 (IMMT) MICOS complex subunit Mic60 family Q16891
Neurogenic locus notch homolog protein 1 (NOTCH1) NOTCH family P46531
Oxysterols receptor LXR-alpha (NR1H3) Nuclear hormone receptor family Q13133
Cellular tumor antigen p53 (TP53) P53 family P04637
Syntaxin-19 (STX19) Syntaxin family Q8N4C7
FYVE and coiled-coil domain-containing protein 1 (FYCO1) . Q9BQS8
Transcription factor
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox expressed in ES cells 1 (HESX1) ANF homeobox family Q9UBX0
Nuclear factor erythroid 2-related factor 2 (NFE2L2) BZIP family Q16236
Cell division cycle 5-like protein (CDC5L) CEF1 family Q99459
REST corepressor 1 (RCOR1) CoREST family Q9UKL0
REST corepressor 2 (RCOR2) CoREST family Q8IZ40
Mothers against decapentaplegic homolog 9 (SMAD9) Dwarfin/SMAD family O15198
Zinc finger and BTB domain-containing protein 39 (ZBTB39) Krueppel C2H2-type zinc-finger protein family O15060
Zinc finger protein 516 (ZNF516) Krueppel C2H2-type zinc-finger protein family Q92618
Peroxisome proliferator-activated receptor delta (PPARD) Nuclear hormone receptor family Q03181
PHD finger protein 19 (PHF19) Polycomblike family Q5T6S3
Zinc finger protein SNAI1 (SNAI1) Snail C2H2-type zinc-finger protein family O95863
Recombining binding protein suppressor of hairless (RBPJ) Su(H) family Q06330
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
Myc proto-oncogene protein (MYC) . P01106
T-cell acute lymphocytic leukemia protein 1 (TAL1) . P17542
Other
Click To Hide/Show 46 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Coilin (COIL) Coilin family P38432
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6A (GOLGA6A) GOLGA6 family Q9NYA3
Glutathione S-transferase C-terminal domain-containing protein (GSTCD) GSTCD family Q8NEC7
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Histone H3.1t (H3-4) Histone H3 family Q16695
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 39 (KRT39) Intermediate filament family Q6A163
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Neuroblastoma breakpoint family member 1 (NBPF1) NBPF family Q3BBV0
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) RIX1/PELP1 family Q8IZL8
Vacuolar-sorting protein SNF8 (SNF8) SNF8 family Q96H20
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Vacuolar protein sorting-associated protein 37B (VPS37B) VPS37 family Q9H9H4
A-kinase anchor protein 9 (AKAP9) . Q99996
Ankyrin repeat domain-containing protein 23 (ANKRD23) . Q86SG2
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Cell division cycle-associated protein 4 (CDCA4) . Q9BXL8
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
DnaJ homolog subfamily A member 3, mitochondrial (DNAJA3) . Q96EY1
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
Kelch domain-containing protein 4 (KLHDC4) . Q8TBB5
Merlin (NF2) . P35240
Methyl-CpG-binding domain protein 3 (MBD3) . O95983
Nuclear receptor-binding factor 2 (NRBF2) . Q96F24
Orofacial cleft 1 candidate gene 1 protein (OFCC1) . Q8IZS5
Outer dynein arm-docking complex subunit 3 (ODAD3) . A5D8V7
Protein FAM204A (FAM204A) . Q9H8W3
Ras association domain-containing protein 1 (RASSF1) . Q9NS23
Ras association domain-containing protein 2 (RASSF2) . P50749
Ras association domain-containing protein 3 (RASSF3) . Q86WH2
Spindle and centriole-associated protein 1 (SPICE1) . Q8N0Z3
Splicing factor 3B subunit 2 (SF3B2) . Q13435
Sterile alpha motif domain-containing protein 3 (SAMD3) . Q8N6K7
Testis-expressed protein 9 (TEX9) . Q8N6V9
Transmembrane protein 266 (TMEM266) . Q2M3C6
Uncharacterized protein C8orf74 (C8orf74) . Q6P047

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cc-90011 Small molecular drug DB5UA2
Img-7289 . D03EOZ
Incb59872 . D0R7CD
Phase 1
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Seclidemstat Small molecular drug DCWT40
Tas-1440 Small molecular drug DI17KH
Gsk2879552 . D0I4ZN
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gsk-lsd1 Small molecular drug D0EV7U
Ncl-1 Small molecular drug D0L6TQ
Og-l002 Small molecular drug D0C8SX
Vafidemstat . DB16446
Patented
Click To Hide/Show 69 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cyclic Peptide Derivative 1 Peptide D04OEV
Aryl Cyclopropylamine Derivative 3 Small molecular drug D0JE6I
Aryl Cyclopropylamine Derivative 4 Small molecular drug D0C1TH
Aryl Cyclopropylamine Derivative 5 Small molecular drug D07IAO
Benzenamine Derivative 1 Small molecular drug D0U1DY
Benzenamine Derivative 2 Small molecular drug D05HBM
Benzenamine Derivative 3 Small molecular drug D08WMK
Benzenamine Derivative 4 Small molecular drug D0KR0I
Cyclopropylamine Derivative 1 Small molecular drug D0B6GK
Cyclopropylamine Derivative 10 Small molecular drug D0W9VF
Cyclopropylamine Derivative 11 Small molecular drug D02CIX
Cyclopropylamine Derivative 12 Small molecular drug D0R2YA
Cyclopropylamine Derivative 13 Small molecular drug D07DIJ
Cyclopropylamine Derivative 3 Small molecular drug D0NJ6B
Cyclopropylamine Derivative 4 Small molecular drug D0F1CT
Cyclopropylamine Derivative 5 Small molecular drug D0LR6D
Cyclopropylamine Derivative 6 Small molecular drug D0KZ5T
Cyclopropylamine Derivative 7 Small molecular drug D0C0PK
Cyclopropylamine Derivative 8 Small molecular drug D0R7RY
Cyclopropylamine Derivative 9 Small molecular drug D04PWX
Heteroaryl-cyclopropylamine Derivative 1 Small molecular drug D07NTA
Heteroaryl-cyclopropylamine Derivative 2 Small molecular drug D0LK8A
Heteroaryl-cyclopropylamine Derivative 3 Small molecular drug D06VMN
Heteroaryl-cyclopropylamine Derivative 4 Small molecular drug D01CIK
N-(2-phenylcyclopropyl) Amino Acid Derivative 1 Small molecular drug D0UL9U
N-(2-phenylcyclopropyl) Amino Acid Derivative 2 Small molecular drug D0XH9M
N-(2-phenylcyclopropyl) Amino Acid Derivative 3 Small molecular drug D08IOP
N6-cyclopropyllydine Derivative 1 Small molecular drug D0BE4Z
Pmid27019002-compound-13 Small molecular drug D0DD4I
Pmid27019002-compound-16 Small molecular drug D02YGX
Pmid27019002-compound-17 Small molecular drug D0WT1Z
Pmid27019002-compound-20a Small molecular drug D03MPD
Pmid27019002-compound-20b Small molecular drug D0O2WW
Pmid27019002-compound-21a Small molecular drug D0YI0V
Pmid27019002-compound-21b Small molecular drug D07MQD
Pmid27019002-compound-21c Small molecular drug D0UE4K
Pmid27019002-compound-28 Small molecular drug D0L4OH
Pmid27019002-compound-28a Small molecular drug D06XEU
Pmid27019002-compound-31a Small molecular drug D0I9QC
Pmid27019002-compound-31b Small molecular drug D08FVR
Pmid27019002-compound-37a Small molecular drug D0VB7F
Pmid27019002-compound-37b Small molecular drug D0YX4R
Pmid27019002-compound-41 Small molecular drug D05FVW
Pmid27019002-compound-42a Small molecular drug D0UG5Q
Pmid27019002-compound-42b Small molecular drug D0GA7D
Pmid27019002-compound-43a Small molecular drug D0RC0G
Pmid27019002-compound-43b Small molecular drug D0MO5Y
Pmid27019002-compound-43c Small molecular drug D0J1HQ
Pmid27019002-compound-44 Small molecular drug D0W8XM
Pmid27019002-compound-45 Small molecular drug D0D9CK
Pmid27019002-compound-46 Small molecular drug D0Z7HE
Pmid27019002-compound-47 Small molecular drug D0WO5W
Pmid27019002-compound-48 Small molecular drug D09OMM
Pmid27019002-compound-49 Small molecular drug D0DL5J
Pmid27019002-compound-50 Small molecular drug D0P4NF
Pmid27019002-compound-7 Small molecular drug D0U4DT
Pyrimidine Derivative 16 Small molecular drug D0L0DT
Pyrimidine Derivative 17 Small molecular drug D07LKA
Pyrimidine Derivative 18 Small molecular drug D0N2QZ
Tarnylcypromine Derivative 1 Small molecular drug D0BG7B
Tarnylcypromine Derivative 2 Small molecular drug D04OHC
Tarnylcypromine Derivative 3 Small molecular drug D0O7IH
Pmid25399762-compound-table 6-10 . D0AI6J
Pmid25399762-compound-table 6-11 . D02WXS
Pmid25399762-compound-table 6-12 . D0E7SF
Pmid25399762-compound-table 6-13 . D06KBT
Pmid25399762-compound-table 6-14 . D0PM2S
Pmid25399762-compound-table 6-15 . D0Q1EG
Pmid25399762-compound-table 6-9 . D0IO2A

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
5 Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets. ACS Cent Sci. 2021 Sep 22;7(9):1524-1534. doi: 10.1021/acscentsci.1c00616. Epub 2021 Aug 19.
6 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
21 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578