Details of the Target

General Information of Target

Target ID LDTP06030
Target Name Cytochrome c oxidase copper chaperone (COX17)
Gene Name COX17
Gene ID 10063
Synonyms
Cytochrome c oxidase copper chaperone
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPGLVDSNPAPPESQEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALG
FKI
Target Type
Literature-reported
Target Bioclass
Other
Family
COX17 family
Subcellular location
Mitochondrion intermembrane space
Function
Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
TTD ID
T03409
Uniprot ID
Q14061
DrugMap ID
TT0F26C
Ensemble ID
ENST00000261070.7
HGNC ID
HGNC:2264

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY4
 Probe Info  		100.00  LDD0244  [1]
C-Sul
 Probe Info  		6.60  LDD0066  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
AZ-9
 Probe Info  		E16(10.00)  LDD2209  [4]
IPM
 Probe Info  		C24(0.00); C23(0.00)  LDD0241  [5]
Alkylaryl probe 3
 Probe Info  		3.15  LDD0282  [6]
Johansson_61
 Probe Info  		_(10.82)  LDD1486  [7]
Acrolein
 Probe Info  		H47(0.00); H44(0.00)  LDD0221  [8]
DBIA
 Probe Info  		C23(3.33); C26(3.33); C24(3.33)  LDD0080  [9]
W1
 Probe Info  		C23(2.58)  LDD0239  [5]
5E-2FA
 Probe Info  		H47(0.00); H44(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		K18(0.00); K21(0.00)  LDD0199  [11]
m-APA
 Probe Info  		H44(0.00); H47(0.00)  LDD2231  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [13]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [12]
JW-RF-010
 Probe Info  		C23(0.00); C24(0.00); C26(0.00)  LDD0026  [14]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
Compound 11
 Probe Info  		N.A.  LDD2213  [15]
Phosphinate-6
 Probe Info  		C23(0.00); C24(0.00); C26(0.00)  LDD0018  [16]
NAIA_5
 Probe Info  		C36(0.00); C55(0.00); C45(0.00)  LDD2223  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C23(1.45)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C23(1.00)  LDD1508  [18]
 LDCM0259  AC14 HEK-293T C23(1.22)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C23(1.49)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C23(1.78)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C23(1.36)  LDD1516  [18]
 LDCM0279  AC2 HEK-293T C23(0.81)  LDD1518  [18]
 LDCM0281  AC21 HEK-293T C23(1.15)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C23(1.27)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C23(1.71)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C23(1.62)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C23(1.88)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C23(0.94)  LDD1525  [18]
 LDCM0289  AC29 HEK-293T C23(1.03)  LDD1528  [18]
 LDCM0291  AC30 HEK-293T C23(1.09)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C23(1.34)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C23(1.41)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C23(1.88)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C23(1.09)  LDD1534  [18]
 LDCM0298  AC37 HEK-293T C23(1.29)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C23(1.47)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C23(1.68)  LDD1539  [18]
 LDCM0302  AC40 HEK-293T C23(1.32)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C23(2.04)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C23(0.98)  LDD1543  [18]
 LDCM0307  AC45 HEK-293T C23(1.43)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C23(1.32)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C23(1.70)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C23(1.55)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C23(1.85)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C23(1.06)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C23(0.89)  LDD1552  [18]
 LDCM0316  AC53 HEK-293T C23(1.40)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C23(1.11)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C23(1.64)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C23(1.56)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C23(1.73)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C23(0.97)  LDD1560  [18]
 LDCM0323  AC6 HEK-293T C23(1.00)  LDD1562  [18]
 LDCM0325  AC61 HEK-293T C23(1.21)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C23(1.43)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C23(1.58)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C23(1.44)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C23(1.31)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C23(1.06)  LDD1569  [18]
 LDCM0248  AKOS034007472 HEK-293T C23(1.25)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C23(1.57)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C23(1.26)  LDD1514  [18]
 LDCM0108  Chloroacetamide HeLa H44(0.00); H47(0.00)  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C23(0.86)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C23(0.71)  LDD1572  [18]
 LDCM0370  CL101 HEK-293T C23(1.01)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C23(1.17)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C23(1.40)  LDD1576  [18]
 LDCM0374  CL105 HEK-293T C23(0.85)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C23(1.32)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C23(1.77)  LDD1580  [18]
 LDCM0378  CL109 HEK-293T C23(1.23)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C23(1.17)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C23(1.19)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C23(1.64)  LDD1585  [18]
 LDCM0383  CL113 HEK-293T C23(1.27)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C23(1.42)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C23(1.54)  LDD1589  [18]
 LDCM0387  CL117 HEK-293T C23(1.08)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C23(1.11)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C23(1.47)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C23(1.09)  LDD1594  [18]
 LDCM0392  CL121 HEK-293T C23(0.97)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C23(1.10)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C23(1.41)  LDD1598  [18]
 LDCM0396  CL125 HEK-293T C23(1.01)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C23(1.35)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C23(1.59)  LDD1602  [18]
 LDCM0400  CL13 HEK-293T C23(0.77)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C23(1.28)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C23(1.38)  LDD1606  [18]
 LDCM0404  CL17 HEK-293T C23(1.42)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C23(1.43)  LDD1609  [18]
 LDCM0407  CL2 HEK-293T C23(1.40)  LDD1611  [18]
 LDCM0409  CL21 HEK-293T C23(1.08)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C23(0.97)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C23(1.36)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C23(1.15)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C23(0.97)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C23(1.44)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C23(1.33)  LDD1619  [18]
 LDCM0417  CL29 HEK-293T C23(1.63)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C23(1.38)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C23(1.10)  LDD1623  [18]
 LDCM0422  CL33 HEK-293T C23(0.78)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C23(0.97)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C23(1.39)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C23(1.16)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C23(1.19)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C23(1.46)  LDD1632  [18]
 LDCM0431  CL41 HEK-293T C23(1.78)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C23(1.69)  LDD1636  [18]
 LDCM0435  CL45 HEK-293T C23(0.95)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C23(1.05)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C23(1.28)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C23(1.16)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C23(0.78)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C23(1.19)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C23(1.56)  LDD1645  [18]
 LDCM0444  CL53 HEK-293T C23(1.56)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C23(1.27)  LDD1648  [18]
 LDCM0448  CL57 HEK-293T C23(0.62)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C23(1.01)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C23(1.50)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C23(1.06)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C23(1.19)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C23(1.06)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C23(1.41)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C23(1.59)  LDD1658  [18]
 LDCM0457  CL65 HEK-293T C23(1.90)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C23(1.33)  LDD1661  [18]
 LDCM0461  CL69 HEK-293T C23(1.07)  LDD1664  [18]
 LDCM0463  CL70 HEK-293T C23(1.06)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C23(1.38)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C23(1.37)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C23(0.92)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C23(1.43)  LDD1670  [18]
 LDCM0470  CL77 HEK-293T C23(1.22)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C23(1.11)  LDD1674  [18]
 LDCM0475  CL81 HEK-293T C23(1.25)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C23(1.01)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C23(1.35)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C23(1.18)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C23(1.35)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C23(1.45)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C23(1.38)  LDD1684  [18]
 LDCM0483  CL89 HEK-293T C23(1.90)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C23(0.76)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C23(1.10)  LDD1688  [18]
 LDCM0488  CL93 HEK-293T C23(1.16)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C23(1.34)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C23(1.10)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C23(1.22)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C23(0.94)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C23(1.23)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C23(1.49)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C23(1.77)  LDD1698  [18]
 LDCM0468  Fragment33 HEK-293T C23(1.34)  LDD1671  [18]
 LDCM0427  Fragment51 HEK-293T C23(1.46)  LDD1631  [18]
 LDCM0569  Fragment7 Jurkat _(10.82)  LDD1486  [7]
 LDCM0107  IAA HeLa H47(0.00); H44(0.00)  LDD0221  [8]
 LDCM0022  KB02 HCT 116 C23(3.33); C26(3.33); C24(3.33)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C23(1.39); C26(1.39); C24(1.39)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C23(2.85); C26(2.85); C24(2.85)  LDD0082  [9]
 LDCM0099  Phenelzine HEK-293T 3.15  LDD0282  [6]
 LDCM0112  W16 Hep-G2 C23(2.58)  LDD0239  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1) AAA ATPase family Q9BW62
Protein SCO1 homolog, mitochondrial (SCO1) SCO1/2 family O75880
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Copper . DB09130

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets. ACS Cent Sci. 2021 Sep 22;7(9):1524-1534. doi: 10.1021/acscentsci.1c00616. Epub 2021 Aug 19.
7 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402