Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Johansson_61  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Fragment7  Competitor Info 
Competitor Concentration 7.5 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Bone marrow
Disease Model T acute lymphoblastic leukemia [ICD-11:2A90]
Model Name Human T acute lymphoblastic leukemia cell lysate (Jurkat)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 14 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00394  Chromodomain-helicase-DNA-binding protein 1 (CHD1) 20.0
 LDTP02622  Creatine kinase U-type, mitochondrial (CKMT1A; CKMT1B) 20.0
 LDTP19892  DGAT1/2-independent enzyme synthesizing storage lipids (TMEM68) 20.0
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 20.0
 LDTP11294  Protein adenylyltransferase SelO, mitochondrial (SELENOO) 20.0
 LDTP04988  Thioredoxin reductase-like selenoprotein T (SELENOT) 20.0
 LDTP03904  Ubiquitin carboxyl-terminal hydrolase 8 (USP8) 20.0
 LDTP03163  Sterol carrier protein 2 (SCP2) 13.2
 LDTP12297  Thioredoxin reductase 2, mitochondrial (TXNRD2) 12.8
 LDTP02852  Methylated-DNA--protein-cysteine methyltransferase (MGMT) 9.4
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 5.9
 LDTP09904  Caspase-10 (CASP10) 5.2
 LDTP06658  Thioredoxin reductase 1, cytoplasmic (TXNRD1) 5.2
 LDTP12835  Large ribosomal subunit protein mL39 (MRPL39) 4.4
Other
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06804  Girdin (CCDC88A) 20.0
 LDTP12432  Inner centromere protein (INCENP) 20.0
 LDTP07272  Keratin, type II cytoskeletal 79 (KRT79) 20.0
 LDTP11075  Selenoprotein S (SELENOS) 20.0
 LDTP04290  YLP motif-containing protein 1 (YLPM1) 20.0
 LDTP06030  Cytochrome c oxidase copper chaperone (COX17) 10.8

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.