Details of the Target

General Information of Target

Target ID LDTP12297
Target Name Thioredoxin reductase 2, mitochondrial (TXNRD2)
Gene Name TXNRD2
Gene ID 10587
Synonyms
KIAA1652; TRXR2; Thioredoxin reductase 2, mitochondrial; EC 1.8.1.9; Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDALEDYVWPRATSELILLPVTGLECVGDRLLAGEGPDVLVYSLDFGGHLRMIKRVQNLL
GHYLIHGFRVRPEPNGDLDLEAMVAVFGSKGLRVVKISWGQGHFWELWRSGLWNMSDWIW
DARWLEGNIALALGHNSVVLYDPVVGCILQEVPCTDRCTLSSACLIGDAWKELTIVAGAV
SNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGD
LRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVWSHEGEILQAFRGHQGRG
IRAIAAHERQAWVITGGDDSGIRLWHLVGRGYRGLGVSALCFKSRSRPGTLKAVTLAGSW
RLLAVTDTGALYLYDVEVKCWEQLLEDKHFQSYCLLEAAPGPEGFGLCAMANGEGRVKVV
PINTPTAAVDQTLFPGKVHSLSWALRGYEELLLLASGPGGVVACLEISAAPSGKAIFVKE
RCRYLLPPSKQRWHTCSAFLPPGDFLVCGDRRGSVLLFPSRPGLLKDPGVGGKARAGAGA
PVVGSGSSGGGNAFTGLGPVSTLPSLHGKQGVTSVTCHGGYVYTTGRDGAYYQLFVRDGQ
LQPVLRQKSCRGMNWLAGLRIVPDGSMVILGFHANEFVVWNPRSHEKLHIVNCGGGHRSW
AFSDTEAAMAFAYLKDGDVMLYRALGGCTRPHVILREGLHGREITCVKRVGTITLGPEYG
VPSFMQPDDLEPGSEGPDLTDIVITCSEDTTVCVLALPTTTGSAHALTAVCNHISSVRAV
AVWGIGTPGGPQDPQPGLTAHVVSAGGRAEMHCFSIMVTPDPSTPSRLACHVMHLSSHRL
DEYWDRQRNRHRMVKVDPETRYMSLAVCELDQPGLGPLVAAACSDGAVRLFLLQDSGRIL
QLLAETFHHKRCVLKVHSFTHEAPNQRRRLLLCSAATDGSLAFWDLTTMLDHDSTVLEPP
VDPGLPYRLGTPSLTLQAHSCGINSLHTLPTREGHHLVASGSEDGSLHVFVLAVEMLQLE
EAVGEAGLVPQLRVLEEYSVPCAHAAHVTGLKILSPSIMVSASIDQRLTFWRLGHGEPTF
MNSTVFHVPDVADMDCWPVSPEFGHRCALGGQGLEVYNWYD
Target Bioclass
Enzyme
Family
Class-I pyridine nucleotide-disulfide oxidoreductase family
Subcellular location
Mitochondrion
Function
Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.
Uniprot ID
Q9NNW7
Ensemble ID
ENST00000400521.7
HGNC ID
HGNC:18155
ChEMBL ID
CHEMBL2403

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.A118P DBIA    Probe Info 
JURKAT SNV: p.R144C; p.Q421Ter Compound 10    Probe Info 
MOLT4 SNV: p.R376M IA-alkyne    Probe Info 
NCIH1993 SNV: p.I246S .
NCIH446 SNV: p.P93L DBIA    Probe Info 
OVK18 SNV: p.Y228D DBIA    Probe Info 
SBC5 SNV: p.A226S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.95  LDD0402  [1]
STPyne
 Probe Info  		K153(0.17)  LDD0277  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
THZ1-DTB
 Probe Info  		C86(0.99); C91(1.00)  LDD0460  [4]
BTD
 Probe Info  		C500(2.46)  LDD1700  [5]
Johansson_61
 Probe Info  		_(5.21)  LDD1485  [6]
YY4-yne
 Probe Info  		3.36  LDD0400  [7]
DBIA
 Probe Info  		C522(1.68)  LDD0080  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		K172(0.00); K175(0.00)  LDD0199  [10]
IA-alkyne
 Probe Info  		C86(0.00); C168(0.00); C483(0.00)  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
Acrolein
 Probe Info  		C168(0.00); C86(0.00); C500(0.00); C91(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		C500(0.00); C86(0.00); C91(0.00)  LDD0218  [16]
AOyne
 Probe Info  		10.70  LDD0443  [17]
NAIA_5
 Probe Info  		C168(0.00); C483(0.00); C54(0.00); C279(0.00)  LDD2223  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C168(0.42)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C168(0.74); C500(0.70)  LDD2112  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C500(0.67)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C168(1.14)  LDD2152  [5]
 LDCM0214  AC1 HEK-293T C483(0.88); C168(0.95); C54(1.12); C446(0.92)  LDD1507  [19]
 LDCM0215  AC10 HEK-293T C483(0.97); C168(0.79); C54(1.03); C446(0.97)  LDD1508  [19]
 LDCM0226  AC11 HEK-293T C483(1.05); C168(0.95); C54(1.04); C407(1.05)  LDD1509  [19]
 LDCM0237  AC12 HEK-293T C483(0.90); C168(1.02); C54(0.95); C407(1.50)  LDD1510  [19]
 LDCM0259  AC14 HEK-293T C483(1.19); C168(0.98); C54(0.99); C446(1.01)  LDD1512  [19]
 LDCM0270  AC15 HEK-293T C483(1.00); C500(1.03); C168(1.02); C54(1.02)  LDD1513  [19]
 LDCM0276  AC17 HEK-293T C483(1.01); C168(0.95); C54(1.21); C446(1.08)  LDD1515  [19]
 LDCM0277  AC18 HEK-293T C483(0.87); C168(0.89); C54(1.05); C446(0.96)  LDD1516  [19]
 LDCM0278  AC19 HEK-293T C483(1.07); C168(0.89); C54(1.34); C407(0.84)  LDD1517  [19]
 LDCM0279  AC2 HEK-293T C483(0.92); C168(0.97); C54(0.95); C446(0.91)  LDD1518  [19]
 LDCM0280  AC20 HEK-293T C483(1.01); C168(0.99); C54(0.95); C407(0.88)  LDD1519  [19]
 LDCM0281  AC21 HEK-293T C483(0.88); C168(0.93); C54(0.87); C407(1.25)  LDD1520  [19]
 LDCM0282  AC22 HEK-293T C483(0.84); C168(0.94); C54(1.11); C446(1.02)  LDD1521  [19]
 LDCM0283  AC23 HEK-293T C483(0.85); C500(1.04); C168(1.06); C54(1.00)  LDD1522  [19]
 LDCM0284  AC24 HEK-293T C483(1.05); C168(1.06); C54(1.00); C407(0.98)  LDD1523  [19]
 LDCM0285  AC25 HEK-293T C483(1.01); C168(0.91); C54(1.06); C446(0.99)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C483(0.94); C168(0.97); C54(1.02); C446(0.86)  LDD1525  [19]
 LDCM0287  AC27 HEK-293T C483(1.11); C168(0.96); C54(1.19); C407(1.26)  LDD1526  [19]
 LDCM0288  AC28 HEK-293T C483(1.22); C168(0.96); C54(1.15); C407(0.93)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C483(1.17); C168(1.02); C54(0.91); C407(1.18)  LDD1528  [19]
 LDCM0290  AC3 HEK-293T C483(0.89); C168(1.05); C54(1.09); C407(0.92)  LDD1529  [19]
 LDCM0291  AC30 HEK-293T C483(1.02); C168(0.99); C54(0.98); C446(0.94)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C483(0.78); C500(1.18); C168(1.03); C54(0.89)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C483(1.07); C168(1.13); C54(1.26); C407(1.05)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C483(0.97); C168(0.94); C54(1.16); C446(0.91)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C483(0.96); C168(0.91); C54(1.03); C446(0.98)  LDD1534  [19]
 LDCM0296  AC35 HEK-293T C483(1.16); C168(0.96); C54(0.95); C407(0.87)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C483(0.99); C168(1.03); C54(1.03); C407(0.86)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C483(1.06); C168(1.10); C54(0.84); C407(1.10)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C483(0.98); C168(1.00); C54(0.92); C446(0.96)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C483(0.87); C500(0.97); C168(1.00); C54(1.00)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C483(1.03); C168(1.04); C54(1.16); C407(0.91)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C483(1.00); C168(1.11); C54(1.13); C407(0.79)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C483(0.95); C168(0.94); C54(1.05); C446(1.19)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C483(1.08); C168(0.85); C54(1.07); C446(0.92)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C483(1.23); C168(0.96); C54(1.04); C407(0.99)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C483(1.03); C168(1.02); C54(0.97); C407(1.39)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C483(0.98); C168(1.00); C54(0.88); C407(0.99)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C483(1.09); C168(0.98); C54(1.07); C446(1.03)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C483(0.86); C500(1.03); C168(1.07); C54(1.00)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C483(1.16); C168(1.06); C54(1.06); C407(0.96)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C483(0.96); C168(0.85); C54(1.05); C446(1.18)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C483(1.08); C168(1.07); C54(0.90); C407(1.15)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C483(1.14); C168(0.92); C54(0.98); C446(0.93)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C483(1.19); C168(0.98); C54(1.09); C407(0.95)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C483(1.00); C168(1.03); C54(0.95); C407(0.86)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C483(0.95); C168(1.02); C54(0.81); C407(1.37)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C483(1.12); C168(0.97); C54(1.03); C446(1.04)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C483(0.82); C500(0.99); C168(0.92); C54(1.00)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C483(1.09); C168(1.02); C54(1.12); C407(0.70)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C483(0.81); C168(0.97); C54(1.09); C446(0.96)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C483(1.00); C168(0.96); C54(1.08); C446(1.23)  LDD1560  [19]
 LDCM0322  AC59 HEK-293T C483(0.96); C168(1.02); C54(1.07); C407(1.19)  LDD1561  [19]
 LDCM0323  AC6 HEK-293T C483(0.94); C168(1.04); C54(0.99); C446(0.94)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C483(0.97); C168(1.05); C54(1.14); C407(1.10)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C483(1.01); C168(0.99); C54(0.92); C407(1.20)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C483(0.90); C168(0.99); C54(0.94); C446(0.94)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C483(0.89); C500(0.96); C168(0.99); C54(1.03)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C483(1.08); C168(1.02); C54(1.01); C407(0.89)  LDD1567  [19]
 LDCM0334  AC7 HEK-293T C483(0.84); C500(0.94); C168(1.05); C54(0.96)  LDD1568  [19]
 LDCM0345  AC8 HEK-293T C483(1.13); C168(1.17); C54(0.98); C407(0.89)  LDD1569  [19]
 LDCM0248  AKOS034007472 HEK-293T C483(1.00); C168(1.02); C54(0.88); C407(0.93)  LDD1511  [19]
 LDCM0356  AKOS034007680 HEK-293T C483(0.95); C168(0.97); C54(1.14); C446(0.78)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C483(1.18); C168(1.08); C54(1.07); C407(0.84)  LDD1514  [19]
 LDCM0156  Aniline NCI-H1299 12.01  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C168(0.00); C86(0.00); C500(0.00); C54(0.00)  LDD0222  [16]
 LDCM0367  CL1 HEK-293T C483(1.25); C500(0.98); C168(0.96); C54(1.18)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C483(1.26); C168(1.21); C54(1.04); C446(0.90)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C483(1.18); C500(0.95); C168(0.96); C54(0.91)  LDD1573  [19]
 LDCM0370  CL101 HEK-293T C483(0.98); C500(0.83); C168(0.93); C54(1.01)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C483(1.03); C168(0.99); C54(0.97); C407(1.22)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C483(1.09); C168(0.93); C446(1.11)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C483(0.96); C500(0.94); C168(0.94); C54(0.96)  LDD1577  [19]
 LDCM0374  CL105 HEK-293T C483(1.05); C500(0.95); C168(0.90); C54(1.02)  LDD1578  [19]
 LDCM0375  CL106 HEK-293T C483(0.94); C168(0.98); C54(0.98); C407(0.84)  LDD1579  [19]
 LDCM0376  CL107 HEK-293T C483(0.87); C168(0.97); C446(1.00)  LDD1580  [19]
 LDCM0377  CL108 HEK-293T C483(0.98); C500(0.86); C168(0.95); C54(0.87)  LDD1581  [19]
 LDCM0378  CL109 HEK-293T C483(1.01); C500(0.91); C168(1.00); C54(1.01)  LDD1582  [19]
 LDCM0379  CL11 HEK-293T C483(0.81); C500(1.05); C168(1.14); C54(0.95)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C483(0.98); C168(1.02); C54(0.96); C407(1.05)  LDD1584  [19]
 LDCM0381  CL111 HEK-293T C483(0.94); C168(0.92); C446(0.89)  LDD1585  [19]
 LDCM0382  CL112 HEK-293T C483(0.97); C500(0.84); C168(0.83); C54(1.03)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C483(1.08); C500(0.89); C168(1.04); C54(1.15)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C483(0.98); C168(0.98); C54(1.06); C407(1.12)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C483(0.80); C168(0.92); C446(0.90)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C483(0.99); C500(1.04); C168(0.96); C54(0.96)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C483(0.99); C500(1.00); C168(0.95); C54(1.03)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C483(1.01); C168(1.07); C54(1.12); C407(1.24)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C483(0.98); C168(0.94); C446(0.87)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C483(1.04); C168(1.23); C54(1.27); C407(0.76)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C483(1.11); C500(1.02); C168(0.97); C54(0.81)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C483(0.98); C500(0.85); C168(0.94); C54(1.00)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C483(1.01); C168(1.00); C54(0.90); C407(1.01)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C483(1.01); C168(0.90); C446(1.05)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C483(1.24); C500(1.13); C168(0.77); C54(0.77)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C483(0.96); C500(0.63); C168(1.04); C54(1.07)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C483(0.94); C168(1.02); C54(1.08); C407(1.13)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C483(0.82); C168(0.96); C446(0.98)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C483(1.09); C500(0.94); C168(0.99); C54(0.88)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C483(1.05); C500(0.86); C168(1.02); C54(1.14)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C483(1.01); C168(1.12); C54(0.95); C407(0.98)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C483(0.87); C168(0.93); C446(0.96)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C483(0.99); C500(1.03); C168(0.94); C54(0.81)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C483(0.89); C168(0.99); C54(1.43); C446(0.84)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C483(0.95); C168(0.96); C54(1.23); C446(1.05)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C483(1.32); C168(0.94); C54(0.99); C407(1.32)  LDD1610  [19]
 LDCM0407  CL2 HEK-293T C483(0.95); C168(1.14); C54(0.92); C407(1.33)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C483(1.06); C168(1.10); C54(1.05); C407(0.88)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C483(1.11); C168(1.17); C54(0.83); C407(1.00)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C483(1.13); C168(1.12); C54(0.87); C446(0.99)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C483(0.74); C500(0.99); C168(1.22); C54(0.97)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C483(1.09); C168(1.27); C54(1.02); C407(1.02)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C483(0.93); C500(0.77); C168(1.09); C54(1.09)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C483(1.25); C168(1.09); C54(0.83); C407(0.96)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C483(0.94); C168(0.93); C446(1.22)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C483(1.14); C500(1.04); C168(0.93); C54(0.83)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C483(1.02); C168(0.97); C54(1.00); C446(1.18)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C483(1.04); C168(1.01); C446(0.91)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C483(1.12); C168(0.91); C54(1.06); C446(1.19)  LDD1623  [19]
 LDCM0420  CL31 HEK-293T C483(1.06); C168(0.89); C54(1.10); C407(0.72)  LDD1624  [19]
 LDCM0421  CL32 HEK-293T C483(1.15); C168(1.06); C54(0.95); C407(0.73)  LDD1625  [19]
 LDCM0422  CL33 HEK-293T C483(1.35); C168(1.05); C54(0.84); C407(1.28)  LDD1626  [19]
 LDCM0423  CL34 HEK-293T C483(0.99); C168(1.08); C54(0.96); C446(1.07)  LDD1627  [19]
 LDCM0424  CL35 HEK-293T C483(0.81); C500(1.17); C168(1.10); C54(1.07)  LDD1628  [19]
 LDCM0425  CL36 HEK-293T C483(1.02); C168(1.13); C54(1.12); C407(1.08)  LDD1629  [19]
 LDCM0426  CL37 HEK-293T C483(1.01); C500(0.80); C168(1.01); C54(1.02)  LDD1630  [19]
 LDCM0428  CL39 HEK-293T C483(0.98); C168(0.97); C446(0.92)  LDD1632  [19]
 LDCM0429  CL4 HEK-293T C483(1.01); C500(1.01); C168(1.05); C54(0.94)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C483(1.11); C500(1.26); C168(0.98); C54(0.90)  LDD1634  [19]
 LDCM0431  CL41 HEK-293T C483(0.97); C168(1.01); C54(1.09); C446(0.84)  LDD1635  [19]
 LDCM0432  CL42 HEK-293T C483(0.98); C168(0.93); C54(1.04); C446(0.97)  LDD1636  [19]
 LDCM0433  CL43 HEK-293T C483(1.11); C168(1.07); C54(0.97); C407(1.26)  LDD1637  [19]
 LDCM0434  CL44 HEK-293T C483(0.92); C168(1.04); C54(0.99); C407(0.91)  LDD1638  [19]
 LDCM0435  CL45 HEK-293T C483(1.53); C168(0.96); C54(0.89); C407(1.29)  LDD1639  [19]
 LDCM0436  CL46 HEK-293T C483(1.27); C168(1.04); C54(0.99); C446(1.01)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C483(0.66); C500(1.14); C168(1.10); C54(1.03)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C483(1.11); C168(1.09); C54(0.99); C407(0.82)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C483(0.97); C500(0.80); C168(1.11); C54(1.02)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C483(0.96); C168(1.06); C54(1.23); C446(0.92)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C483(1.30); C168(1.08); C54(1.01); C407(1.09)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C483(1.38); C500(1.25); C168(0.99); C54(1.02)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C483(0.91); C168(0.94); C54(1.07); C446(1.00)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C483(1.11); C168(0.76); C54(0.96); C446(0.97)  LDD1648  [19]
 LDCM0446  CL55 HEK-293T C483(0.96); C168(1.02); C54(1.05); C407(1.05)  LDD1649  [19]
 LDCM0447  CL56 HEK-293T C483(0.96); C168(1.12); C54(1.02); C407(0.87)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C483(1.19); C168(1.02); C54(0.82); C407(0.84)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C483(1.02); C168(0.98); C54(1.05); C446(1.11)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C483(0.71); C500(1.03); C168(1.16); C54(0.94)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C483(1.08); C168(1.12); C54(1.19); C446(1.03)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C483(1.17); C168(1.16); C54(1.03); C407(0.91)  LDD1655  [19]
 LDCM0453  CL61 HEK-293T C483(0.99); C500(0.82); C168(1.01); C54(1.07)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C483(1.07); C168(1.04); C54(1.08); C407(1.11)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C483(0.88); C168(0.97); C446(1.02)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C483(1.10); C500(1.01); C168(0.97); C54(0.92)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C483(1.09); C168(0.91); C54(1.10); C446(1.05)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C483(0.94); C168(0.93); C54(1.00); C446(0.90)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C483(1.21); C168(0.98); C54(0.94); C407(1.57)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C483(1.02); C168(1.13); C54(1.09); C407(1.00)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C483(1.16); C168(0.94); C54(0.90); C407(0.99)  LDD1664  [19]
 LDCM0462  CL7 HEK-293T C483(1.01); C168(1.08); C54(1.15); C407(1.28)  LDD1665  [19]
 LDCM0463  CL70 HEK-293T C483(1.11); C168(1.06); C54(1.07); C446(1.01)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C483(0.80); C500(1.01); C168(1.04); C54(1.03)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C483(1.16); C168(1.28); C54(1.00); C407(0.83)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C483(0.93); C500(0.74); C168(0.98); C54(0.99)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C483(1.01); C168(1.04); C54(1.00); C407(1.26)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C483(0.95); C500(1.03); C168(0.99); C54(1.06)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C483(0.95); C168(0.89); C54(1.14); C446(1.12)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C483(0.96); C168(0.90); C54(1.08); C446(1.06)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C483(1.19); C168(0.95); C54(1.02); C407(0.93)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C483(0.89); C168(1.03); C54(0.94); C407(1.07)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C483(1.07); C168(1.13); C54(1.05); C407(0.91)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C483(1.16); C168(0.98); C54(0.93); C407(1.14)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C483(1.19); C168(1.04); C54(1.05); C446(0.97)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C483(0.78); C500(1.03); C168(1.02); C54(1.07)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C483(1.00); C168(1.11); C54(1.16); C407(1.01)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C483(0.91); C500(0.84); C168(1.03); C54(1.02)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C483(0.93); C168(1.19); C54(0.98); C407(1.42)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C483(0.77); C168(1.02); C446(1.09)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C483(0.96); C500(0.94); C168(1.01); C54(0.89)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C483(1.14); C168(1.03); C54(1.25); C446(1.08)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C483(1.14); C168(1.03); C54(0.89); C407(1.00)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C483(0.97); C168(0.85); C54(1.28); C446(1.39)  LDD1688  [19]
 LDCM0486  CL91 HEK-293T C483(1.12); C168(0.98); C54(1.09); C407(0.98)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C483(1.15); C168(1.10); C54(1.20); C407(0.81)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C483(1.06); C168(0.96); C54(0.91); C407(1.39)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C483(1.25); C168(1.08); C54(1.10); C446(0.95)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C483(0.84); C500(0.79); C168(1.07); C54(1.01)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C483(0.99); C168(1.04); C54(1.07); C407(0.94)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C483(0.97); C500(0.92); C168(1.07); C54(1.09)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C483(0.97); C168(1.11); C54(1.03); C407(1.49)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C483(0.82); C168(0.95); C446(0.99)  LDD1697  [19]
 LDCM0495  E2913 HEK-293T C483(0.84); C168(0.95); C446(0.90)  LDD1698  [19]
 LDCM0468  Fragment33 HEK-293T C483(0.88); C168(0.91); C446(1.14)  LDD1671  [19]
 LDCM0427  Fragment51 HEK-293T C483(0.89); C168(1.05); C54(1.00); C407(0.96)  LDD1631  [19]
 LDCM0616  Fragment61 Jurkat _(5.30)  LDD1489  [6]
 LDCM0569  Fragment7 Jurkat _(5.21)  LDD1485  [6]
 LDCM0107  IAA HeLa C168(0.00); H165(0.00); C500(0.00); C91(0.00)  LDD0221  [16]
 LDCM0022  KB02 HCT 116 C522(1.68)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C522(1.54)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C522(1.52)  LDD0082  [8]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C168(1.07)  LDD2102  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [16]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C168(0.73)  LDD2096  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C500(0.27)  LDD2104  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C168(0.33)  LDD2106  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C168(0.50)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C500(0.98)  LDD2109  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C500(0.37)  LDD2114  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C168(0.89)  LDD2118  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C500(2.19)  LDD2119  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C500(0.76)  LDD2120  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C168(1.12)  LDD2122  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C168(0.68)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C500(0.90)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C168(0.93)  LDD2126  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C168(0.91); C500(0.81)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C168(1.03)  LDD2129  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C168(0.60)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C168(0.84)  LDD2135  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C500(2.46)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C500(0.76)  LDD2140  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C168(1.02); C500(0.69)  LDD2143  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C500(0.25)  LDD2145  [5]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C168(0.75)  LDD2149  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C168(0.45)  LDD2150  [5]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C168(0.96)  LDD2151  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C168(2.65)  LDD2153  [5]
 LDCM0021  THZ1 HeLa S3 C86(0.99); C91(1.00)  LDD0460  [4]
 LDCM0154  YY4 T cell 3.36  LDD0400  [7]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Motexafin Gadolinium Small molecular drug DB05428

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
7 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402