Details of the Target

General Information of Target

Target ID LDTP13462
Target Name ADP-sugar pyrophosphatase (NUDT5)
Gene Name NUDT5
Gene ID 11164
Synonyms
NUDIX5; ADP-sugar pyrophosphatase; EC 3.6.1.13; 8-oxo-dGDP phosphatase; EC 3.6.1.58; Nuclear ATP-synthesis protein NUDIX5; EC 2.7.7.96; Nucleoside diphosphate-linked moiety X motif 5; Nudix motif 5; hNUDT5; YSA1H
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASVDFKTYVDQACRAAEEFVNVYYTTMDKRRRLLSRLYMGTATLVWNGNAVSGQESLSE
FFEMLPSSEFQISVVDCQPVHDEATPSQTTVLVVICGSVKFEGNKQRDFNQNFILTAQAS
PSNTVWKIASDCFRFQDWAS
Target Bioclass
Enzyme
Family
Nudix hydrolase family
Subcellular location
Nucleus
Function
Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
Uniprot ID
Q9UKK9
Ensemble ID
ENST00000491614.6
HGNC ID
HGNC:8052
ChEMBL ID
CHEMBL4105713

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		4.52  LDD0393  [1]
CY4
 Probe Info  		100.00  LDD0244  [2]
TH211
 Probe Info  		Y74(20.00)  LDD0260  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K210(9.74); K218(8.61); K42(3.74)  LDD0277  [5]
Probe 1
 Probe Info  		Y16(42.33); Y36(6.26); Y119(114.58)  LDD3495  [6]
m-APA
 Probe Info  		12.51  LDD0403  [7]
BTD
 Probe Info  		C76(1.48)  LDD2123  [8]
HHS-482
 Probe Info  		Y74(1.54)  LDD0285  [9]
HHS-475
 Probe Info  		Y74(0.92); Y16(0.98)  LDD0264  [10]
HHS-465
 Probe Info  		Y16(10.00); Y74(8.81)  LDD2237  [11]
DBIA
 Probe Info  		C76(1.07)  LDD0080  [12]
5E-2FA
 Probe Info  		N.A.  LDD2235  [13]
ATP probe
 Probe Info  		K210(0.00); K218(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C91(0.00); C76(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C91(0.00); C76(0.00)  LDD0036  [15]
IPIAA_L
 Probe Info  		C91(0.00); C76(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C76(0.00); C91(0.00)  LDD0037  [15]
ATP probe
 Probe Info  		N.A.  LDD0035  [17]
IPM
 Probe Info  		N.A.  LDD0147  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [19]
1c-yne
 Probe Info  		N.A.  LDD0228  [20]
Acrolein
 Probe Info  		H73(0.00); C76(0.00)  LDD0217  [21]
AOyne
 Probe Info  		13.10  LDD0443  [22]
MPP-AC
 Probe Info  		N.A.  LDD0428  [23]
NAIA_5
 Probe Info  		N.A.  LDD2223  [24]
TPP-AC
 Probe Info  		N.A.  LDD0427  [23]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C76(1.20)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C76(1.34)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C76(0.90)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C76(0.95)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C76(0.88)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C76(0.88)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C76(0.82)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C76(0.83)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C76(0.73)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C76(0.78)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C76(0.92)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C76(0.80)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C76(0.77)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C76(0.81)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C76(0.91)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C76(0.87)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C76(0.87)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C76(0.84)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C76(1.03)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C76(1.07)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C76(1.07)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C76(0.84)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C76(1.02)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C76(0.78)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C76(0.89)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C76(0.94)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C76(0.87)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C76(1.02)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C76(1.00)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C76(0.85)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C76(0.80)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C76(1.04)  LDD0562  [12]
 LDCM0246  AC128 HEK-293T C126(1.09)  LDD0844  [12]
 LDCM0247  AC129 HEK-293T C126(1.11)  LDD0845  [12]
 LDCM0249  AC130 HEK-293T C126(1.18)  LDD0847  [12]
 LDCM0250  AC131 HEK-293T C126(1.20)  LDD0848  [12]
 LDCM0251  AC132 HEK-293T C126(1.16)  LDD0849  [12]
 LDCM0252  AC133 HEK-293T C126(1.26)  LDD0850  [12]
 LDCM0253  AC134 HEK-293T C126(1.41)  LDD0851  [12]
 LDCM0254  AC135 HEK-293T C126(1.20)  LDD0852  [12]
 LDCM0255  AC136 HEK-293T C126(1.14)  LDD0853  [12]
 LDCM0256  AC137 HEK-293T C126(1.26)  LDD0854  [12]
 LDCM0257  AC138 HEK-293T C126(1.49)  LDD0855  [12]
 LDCM0258  AC139 HEK-293T C126(1.20)  LDD0856  [12]
 LDCM0259  AC14 HCT 116 C76(0.84)  LDD0576  [12]
 LDCM0260  AC140 HEK-293T C126(1.28)  LDD0858  [12]
 LDCM0261  AC141 HEK-293T C126(1.56)  LDD0859  [12]
 LDCM0262  AC142 HEK-293T C126(1.12)  LDD0860  [12]
 LDCM0263  AC143 PaTu 8988t C76(1.34)  LDD1142  [12]
 LDCM0264  AC144 PaTu 8988t C76(1.03)  LDD1143  [12]
 LDCM0265  AC145 PaTu 8988t C76(1.25)  LDD1144  [12]
 LDCM0266  AC146 PaTu 8988t C76(0.96)  LDD1145  [12]
 LDCM0267  AC147 PaTu 8988t C76(1.09)  LDD1146  [12]
 LDCM0268  AC148 PaTu 8988t C76(1.38)  LDD1147  [12]
 LDCM0269  AC149 PaTu 8988t C76(1.43)  LDD1148  [12]
 LDCM0270  AC15 HCT 116 C76(0.90)  LDD0587  [12]
 LDCM0271  AC150 PaTu 8988t C76(0.92)  LDD1150  [12]
 LDCM0272  AC151 PaTu 8988t C76(1.36)  LDD1151  [12]
 LDCM0273  AC152 PaTu 8988t C76(1.17)  LDD1152  [12]
 LDCM0274  AC153 PaTu 8988t C76(1.37)  LDD1153  [12]
 LDCM0621  AC154 PaTu 8988t C76(1.28)  LDD2166  [12]
 LDCM0622  AC155 PaTu 8988t C76(1.06)  LDD2167  [12]
 LDCM0623  AC156 PaTu 8988t C76(1.24)  LDD2168  [12]
 LDCM0624  AC157 PaTu 8988t C76(1.00)  LDD2169  [12]
 LDCM0276  AC17 HCT 116 C76(1.05)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C76(1.02)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C76(0.98)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C76(1.00)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C76(1.03)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C76(0.90)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C76(1.25)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C76(0.95)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C76(1.02)  LDD0601  [12]
 LDCM0285  AC25 HEK-293T C131(0.75); C139(0.75)  LDD0883  [12]
 LDCM0286  AC26 HEK-293T C131(0.87); C139(0.87)  LDD0884  [12]
 LDCM0287  AC27 HEK-293T C131(1.01); C139(1.01)  LDD0885  [12]
 LDCM0288  AC28 HEK-293T C131(1.74); C139(1.74)  LDD0886  [12]
 LDCM0289  AC29 HEK-293T C131(1.05); C139(1.05)  LDD0887  [12]
 LDCM0290  AC3 HCT 116 C76(1.13)  LDD0607  [12]
 LDCM0291  AC30 HEK-293T C131(0.82); C139(0.82)  LDD0889  [12]
 LDCM0292  AC31 HEK-293T C131(1.00); C139(1.00)  LDD0890  [12]
 LDCM0293  AC32 HEK-293T C131(0.88); C139(0.88)  LDD0891  [12]
 LDCM0294  AC33 HEK-293T C131(1.24); C139(1.24)  LDD0892  [12]
 LDCM0295  AC34 HEK-293T C131(0.91); C139(0.91)  LDD0893  [12]
 LDCM0296  AC35 HEK-293T C131(1.33); C139(1.33)  LDD0894  [12]
 LDCM0297  AC36 HEK-293T C131(1.02); C139(1.02)  LDD0895  [12]
 LDCM0298  AC37 HEK-293T C131(0.94); C139(0.94)  LDD0896  [12]
 LDCM0299  AC38 HEK-293T C131(1.05); C139(1.05)  LDD0897  [12]
 LDCM0300  AC39 HEK-293T C131(0.85); C139(0.85)  LDD0898  [12]
 LDCM0301  AC4 HCT 116 C76(1.18)  LDD0618  [12]
 LDCM0302  AC40 HEK-293T C131(0.90); C139(0.90)  LDD0900  [12]
 LDCM0303  AC41 HEK-293T C131(0.65); C139(0.65)  LDD0901  [12]
 LDCM0304  AC42 HEK-293T C131(0.86); C139(0.86)  LDD0902  [12]
 LDCM0305  AC43 HEK-293T C131(0.77); C139(0.77)  LDD0903  [12]
 LDCM0306  AC44 HEK-293T C131(0.81); C139(0.81)  LDD0904  [12]
 LDCM0307  AC45 HEK-293T C131(0.96); C139(0.96)  LDD0905  [12]
 LDCM0308  AC46 PaTu 8988t C76(1.48)  LDD1187  [12]
 LDCM0309  AC47 PaTu 8988t C76(1.06)  LDD1188  [12]
 LDCM0310  AC48 PaTu 8988t C76(1.06)  LDD1189  [12]
 LDCM0311  AC49 PaTu 8988t C76(1.07)  LDD1190  [12]
 LDCM0312  AC5 HCT 116 C76(1.19)  LDD0629  [12]
 LDCM0313  AC50 PaTu 8988t C76(1.21)  LDD1192  [12]
 LDCM0314  AC51 PaTu 8988t C76(1.04)  LDD1193  [12]
 LDCM0315  AC52 PaTu 8988t C76(1.22)  LDD1194  [12]
 LDCM0316  AC53 PaTu 8988t C76(1.07)  LDD1195  [12]
 LDCM0317  AC54 PaTu 8988t C76(1.34)  LDD1196  [12]
 LDCM0318  AC55 PaTu 8988t C76(0.90)  LDD1197  [12]
 LDCM0319  AC56 PaTu 8988t C76(0.92)  LDD1198  [12]
 LDCM0320  AC57 HCT 116 C76(0.92)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C76(0.96)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C76(0.97)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C76(1.09)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C76(0.97)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C76(1.07)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C76(1.10)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C76(0.95)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C76(0.99)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C76(1.09)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C76(0.98)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C76(1.01)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C139(0.71); C76(0.95)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C139(0.53); C76(0.93)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C76(0.95)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C139(0.85); C76(1.05)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C139(0.54); C76(1.04)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C139(0.73); C76(0.95)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C139(0.80); C76(1.02)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C139(0.69); C76(0.94)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C139(0.76); C76(0.95)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C139(0.54); C76(0.94)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C139(0.93); C76(0.96)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C139(0.57); C76(1.00)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C139(0.82); C76(0.96)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C76(1.10)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C139(0.57); C76(1.07)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C139(0.72); C76(0.98)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C76(1.05); C139(1.12)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C76(0.96)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C76(0.81)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C76(0.93)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C76(0.94)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C76(0.84)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C76(0.81)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C76(0.92)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C76(0.94)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C76(0.75)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C76(0.86)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C76(0.94)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C76(0.87)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C76(0.77)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C76(0.83)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C76(0.88)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C76(1.05)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C76(0.91)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C76(0.79)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C76(0.79)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C76(1.00)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 12.51  LDD0403  [7]
 LDCM0020  ARS-1620 HCC44 C76(0.88)  LDD2171  [12]
 LDCM0108  Chloroacetamide HeLa C91(0.00); H190(0.00); C76(0.00); H73(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C76(0.84)  LDD2227  [24]
 LDCM0367  CL1 HEK-293T C76(1.01); C91(1.06); C139(0.92)  LDD1571  [26]
 LDCM0368  CL10 HEK-293T C76(2.48); C91(0.78); C139(1.14)  LDD1572  [26]
 LDCM0369  CL100 HCT 116 C76(1.11)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C76(0.94)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C76(0.85)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C76(0.68)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C76(0.91)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C76(0.90)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C76(0.91)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C76(1.08)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C76(0.99)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C76(0.91)  LDD0695  [12]
 LDCM0379  CL11 HEK-293T C76(0.91); C91(1.26); C139(1.36)  LDD1583  [26]
 LDCM0380  CL110 HCT 116 C76(0.88)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C76(1.14)  LDD0698  [12]
 LDCM0382  CL112 HEK-293T C131(0.78); C139(0.78)  LDD0980  [12]
 LDCM0383  CL113 HEK-293T C131(1.09); C139(1.09)  LDD0981  [12]
 LDCM0384  CL114 HEK-293T C131(0.99); C139(0.99)  LDD0982  [12]
 LDCM0385  CL115 HEK-293T C131(0.77); C139(0.77)  LDD0983  [12]
 LDCM0386  CL116 HEK-293T C131(0.73); C139(0.73)  LDD0984  [12]
 LDCM0387  CL117 HEK-293T C131(1.34); C139(1.34)  LDD0985  [12]
 LDCM0388  CL118 HEK-293T C131(0.65); C139(0.65)  LDD0986  [12]
 LDCM0389  CL119 HEK-293T C131(0.89); C139(0.89)  LDD0987  [12]
 LDCM0390  CL12 HEK-293T C76(0.96); C91(1.32); C139(1.65)  LDD1594  [26]
 LDCM0391  CL120 HEK-293T C131(0.69); C139(0.69)  LDD0989  [12]
 LDCM0392  CL121 PaTu 8988t C76(0.99)  LDD1271  [12]
 LDCM0393  CL122 PaTu 8988t C76(0.85)  LDD1272  [12]
 LDCM0394  CL123 PaTu 8988t C76(1.25)  LDD1273  [12]
 LDCM0395  CL124 PaTu 8988t C76(1.31)  LDD1274  [12]
 LDCM0396  CL125 HCT 116 C76(1.01)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C76(1.07)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C76(1.02)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C76(0.98)  LDD0716  [12]
 LDCM0400  CL13 HEK-293T C76(0.86); C91(1.16); C139(0.85)  LDD1604  [26]
 LDCM0401  CL14 HEK-293T C76(1.00); C91(1.03); C139(1.07)  LDD1605  [26]
 LDCM0402  CL15 HEK-293T C76(0.80); C91(0.81); C139(0.95)  LDD1606  [26]
 LDCM0403  CL16 HEK-293T C76(0.98); C91(0.40); C139(1.01)  LDD1607  [26]
 LDCM0404  CL17 HCT 116 C76(1.11)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C76(1.10)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C76(0.98)  LDD0723  [12]
 LDCM0407  CL2 HEK-293T C76(0.98); C91(0.98); C139(0.93)  LDD1611  [26]
 LDCM0408  CL20 HCT 116 C76(1.10)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C76(1.02)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C76(1.27)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C76(1.26)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C76(1.13)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C76(0.97)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C76(1.21)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C76(1.09)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C76(1.07)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C76(1.20)  LDD0734  [12]
 LDCM0418  CL3 HEK-293T C76(0.96); C91(0.90); C139(1.19)  LDD1622  [26]
 LDCM0419  CL30 HCT 116 C76(1.07)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C139(0.77); C76(1.13)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C139(0.69); C76(1.08)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C139(0.69); C76(1.92)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C139(1.59); C76(1.47)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C139(0.98); C76(1.26)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C139(0.81); C76(1.10)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C139(1.18); C76(1.15)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C139(0.89); C76(1.13)  LDD0745  [12]
 LDCM0429  CL4 HEK-293T C76(0.96); C91(1.14); C139(0.91)  LDD1633  [26]
 LDCM0430  CL40 HCT 116 C139(0.67); C76(1.49)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C139(1.25); C76(1.11)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C139(1.04); C76(1.12)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C139(1.28); C76(1.07)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C139(0.96); C76(1.47)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C139(0.67); C76(1.64)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C76(0.95)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C76(1.03)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C76(0.94)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C76(0.86)  LDD0756  [12]
 LDCM0440  CL5 HEK-293T C76(0.96); C91(1.02); C139(1.05); C131(1.07)  LDD1644  [26]
 LDCM0441  CL50 HCT 116 C76(0.81)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C76(0.76)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C76(0.90)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C76(1.04)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C76(1.04)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C76(1.03)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C76(1.06)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C76(0.87)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C76(0.96)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C76(0.92)  LDD0767  [12]
 LDCM0451  CL6 HEK-293T C76(0.94); C91(0.91); C139(0.84)  LDD1654  [26]
 LDCM0452  CL60 HCT 116 C76(0.93)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C139(0.95); C76(1.17)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C139(0.70); C76(1.08)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C139(0.95); C76(1.01)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C139(0.89); C76(1.27)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C139(0.83); C76(1.01)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C139(0.71); C76(1.40)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C139(0.88); C76(1.12)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C139(0.95); C76(0.88)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C139(0.86); C76(1.09)  LDD0778  [12]
 LDCM0462  CL7 HEK-293T C76(0.93); C91(1.03); C139(1.07)  LDD1665  [26]
 LDCM0463  CL70 HCT 116 C139(0.76); C76(1.07)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C139(0.88); C76(0.98)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C139(1.16); C76(1.04)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C139(0.85); C76(1.10)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C139(0.99); C76(1.03)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C139(0.78)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C139(0.35)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C139(0.67)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C139(0.90)  LDD0789  [12]
 LDCM0473  CL8 HEK-293T C76(0.66); C91(0.68); C139(0.76)  LDD1676  [26]
 LDCM0474  CL80 HCT 116 C139(0.85)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C139(0.78)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C139(0.95)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C139(0.65)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C139(0.69)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C139(0.66)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C139(0.62)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C139(0.66)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C139(0.63)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C139(0.65)  LDD0800  [12]
 LDCM0484  CL9 HEK-293T C76(0.89); C91(0.84); C139(1.32)  LDD1687  [26]
 LDCM0485  CL90 HCT 116 C139(0.61)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C76(1.12)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C76(1.03)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C76(1.06)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C76(1.33)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C76(1.30)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C76(1.17)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C76(1.10)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C76(1.19)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C76(2.30)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C76(0.98); C91(0.94); C139(1.01)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C76(1.13)  LDD1702  [8]
 LDCM0468  Fragment33 HCT 116 C139(0.89); C76(1.26)  LDD0785  [12]
 LDCM0427  Fragment51 HCT 116 C139(0.86); C76(1.09)  LDD0744  [12]
 LDCM0116  HHS-0101 DM93 Y74(0.92); Y16(0.98)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y16(0.86); Y74(0.87)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y74(0.92); Y16(1.10)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y16(0.73); Y74(0.87)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y16(0.92); Y74(0.92)  LDD0268  [10]
 LDCM0107  IAA HeLa H190(0.00); H73(0.00)  LDD0221  [21]
 LDCM0123  JWB131 DM93 Y74(1.54)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y74(1.35)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y74(1.17)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y74(4.66)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y74(2.41)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y74(0.81)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y74(0.74)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y74(1.48)  LDD0292  [9]
 LDCM0022  KB02 HCT 116 C76(1.07)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C76(1.02)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C76(1.11)  LDD0082  [12]
 LDCM0109  NEM HeLa H190(0.00); H73(0.00); H206(0.00)  LDD0223  [21]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C76(1.48)  LDD2123  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C76(0.95)  LDD2134  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C76(0.63)  LDD2148  [8]
 LDCM0021  THZ1 HCT 116 C76(0.88)  LDD2173  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-sugar pyrophosphatase (NUDT5) Nudix hydrolase family Q9UKK9
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) Cytochrome c oxidase subunit 5B family P10606
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402