Details of the Target

General Information of Target

Target ID LDTP04703
Target Name Tumor protein D52 (TPD52)
Gene Name TPD52
Gene ID 7163
Synonyms
Tumor protein D52; Protein N8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDCREMDLYEDYQSPFDFDAGVNKSYLYLSPSGNSSPPGSPTLQKFGLLRTDPVPEEGED
VAATISATETLSEEEQEELRRELAKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELK
QNIAKGWQDVTATSAYKKTSETLSQAGQKASAAFSSVGSVITKKLEDVKNSPTFKSFEEK
VENLKSKVGGTKPAGGDFGEVLNSAANASATTTEPLPEKTQESL
Target Bioclass
Other
Family
TPD52 family
Uniprot ID
P55327
Ensemble ID
ENST00000379096.9
HGNC ID
HGNC:12005

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		10.00  LDD0393  [1]
TH211
 Probe Info  		Y136(6.22)  LDD0260  [2]
C-Sul
 Probe Info  		6.38  LDD0066  [3]
TH216
 Probe Info  		Y136(16.86)  LDD0259  [2]
Probe 1
 Probe Info  		Y136(140.46)  LDD3495  [4]
HHS-475
 Probe Info  		Y136(0.98)  LDD0264  [5]
HHS-465
 Probe Info  		Y136(10.00)  LDD2237  [6]
Acrolein
 Probe Info  		N.A.  LDD0221  [7]
ATP probe
 Probe Info  		K163(0.00); K164(0.00); K138(0.00); K185(0.00)  LDD0199  [8]
ATP probe
 Probe Info  		K125(0.00); K85(0.00); K169(0.00); K100(0.00)  LDD0035  [9]
NHS
 Probe Info  		K100(0.00); K120(0.00); K138(0.00)  LDD0010  [10]
STPyne
 Probe Info  		K102(0.00); K149(0.00); K120(0.00); K138(0.00)  LDD0009  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [11]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		15.14  LDD1713  [12]
C055
 Probe Info  		15.24  LDD1752  [12]
C056
 Probe Info  		25.46  LDD1753  [12]
C112
 Probe Info  		20.11  LDD1799  [12]
C134
 Probe Info  		24.59  LDD1816  [12]
C143
 Probe Info  		14.72  LDD1825  [12]
C201
 Probe Info  		34.54  LDD1877  [12]
C228
 Probe Info  		15.35  LDD1901  [12]
C264
 Probe Info  		17.27  LDD1935  [12]
C326
 Probe Info  		6.82  LDD1990  [12]
C350
 Probe Info  		22.94  LDD2011  [12]
C362
 Probe Info  		55.72  LDD2023  [12]
C388
 Probe Info  		37.01  LDD2047  [12]
C390
 Probe Info  		22.01  LDD2049  [12]
C426
 Probe Info  		15.67  LDD2081  [12]
DFG-out-4
 Probe Info  		6.30  LDD0075  [13]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0017  DFG-out-2 A431 6.30  LDD0075  [13]
 LDCM0116  HHS-0101 DM93 Y136(0.98)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y136(0.84)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y136(0.90)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y136(0.93)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y136(0.65)  LDD0268  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0109  NEM HeLa N.A.  LDD0224  [7]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Peroxynitrite isomerase THAP4 (THAP4) Nitrobindin family Q8WY91
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitochondrial dynamics protein MIEF1 (MIEF1) SMCR7 family Q9NQG6
Tumor protein D53 (TPD52L1) TPD52 family Q16890
Alpha-tocopherol transfer protein (TTPA) . P49638

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Affinity-based probes based on type II kinase inhibitors. J Am Chem Soc. 2012 Nov 21;134(46):19017-25. doi: 10.1021/ja306035v. Epub 2012 Nov 6.
14 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.