Details of the Target

General Information of Target

Target ID LDTP13647
Target Name Ras GTPase-activating protein-binding protein 2 (G3BP2)
Gene Name G3BP2
Gene ID 9908
Synonyms
KIAA0660; Ras GTPase-activating protein-binding protein 2; G3BP-2; GAP SH3 domain-binding protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKKQNRKTGNSKTQSASPPPKERSSSPATEQSWMENDFDELREEGFRRSNYSELREDIQ
TKGKEVENFEKNLEECITRITNTEKCLKELMELKTKARELREECRSLRSRCDQLEERVSA
MEDEMNEMKREGKFREKRIKRNEQSLQEIWDYVKRPNLRLIGVPESDVENGTKLENTLQD
IIQENFPNLARQANVQIQEIQRTPQRYSSRRATPRHIIVRFTKVEMKEKMLRAAREKGRV
TLKGKPIRLTADLSAETLQARREWGPIFNILKEKNFQPRISYPAKLSFISEGEIKYFIDK
QMLRDFVTTRPALKELLKEALNMERNNRYQPLQNHAKM
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. Plays an essential role in stress granule formation. Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress. Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations.
Uniprot ID
Q9UN86
Ensemble ID
ENST00000357854.7
HGNC ID
HGNC:30291

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.G475D DBIA    Probe Info 
CAL62 SNV: p.G421A .
CHL1 SNV: p.P162S DBIA    Probe Info 
HCT15 SNV: p.T470A .
HEC1 SNV: p.V358G .
HT115 SNV: p.R78C .
LS180 SNV: p.R13W; p.S173N DBIA    Probe Info 
NCIH2172 Deletion: p.D135MfsTer19 .
OVK18 SNV: p.H331Y .
RL952 SNV: p.R290H DBIA    Probe Info 
SNU1 Insertion: p.T409NfsTer14 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		4.51  LDD0215  [1]
AZ-9
 Probe Info  		10.00  LDD0393  [2]
STPyne
 Probe Info  		K25(7.73); K281(10.00); K365(9.70); K392(2.73)  LDD0277  [3]
BTD
 Probe Info  		C73(1.02)  LDD2090  [4]
HHS-475
 Probe Info  		Y29(0.97)  LDD0264  [5]
DBIA
 Probe Info  		C73(1.20)  LDD0531  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
m-APA
 Probe Info  		H62(0.00); H127(0.00)  LDD2231  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
IPM
 Probe Info  		N.A.  LDD0147  [12]
SF
 Probe Info  		Y29(0.00); K407(0.00)  LDD0028  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
1c-yne
 Probe Info  		K370(0.00); K25(0.00)  LDD0228  [16]
1d-yne
 Probe Info  		K365(0.00); K370(0.00)  LDD0357  [16]
Acrolein
 Probe Info  		H42(0.00); C73(0.00); H62(0.00); H63(0.00)  LDD0217  [17]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
Methacrolein
 Probe Info  		N.A.  LDD0218  [17]
NAIA_5
 Probe Info  		N.A.  LDD2223  [18]
HHS-465
 Probe Info  		K407(0.00); Y29(0.00)  LDD2240  [19]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [20]
FFF probe14
 Probe Info  		20.00  LDD0477  [20]
FFF probe2
 Probe Info  		5.64  LDD0463  [20]
FFF probe3
 Probe Info  		12.96  LDD0464  [20]
STS-2
 Probe Info  		1.00  LDD0139  [21]
VE-P
 Probe Info  		N.A.  LDD0396  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C73(1.02)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C73(1.25)  LDD2152  [4]
 LDCM0214  AC1 HCT 116 C73(1.20)  LDD0531  [6]
 LDCM0215  AC10 HEK-293T C73(0.97)  LDD1508  [23]
 LDCM0216  AC100 HCT 116 C73(0.49)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C73(0.59)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C73(0.55)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C73(0.58)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C73(0.72)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C73(0.53)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C73(0.55)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C73(0.55)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C73(0.65)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C73(0.57)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C73(0.95)  LDD1509  [23]
 LDCM0227  AC110 HCT 116 C73(0.64)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C73(0.69)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C73(0.59)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C73(0.99)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C73(0.81)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C73(0.82)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C73(0.80)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C73(0.91)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C73(0.78)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C73(0.81)  LDD0553  [6]
 LDCM0237  AC12 HEK-293T C73(0.99)  LDD1510  [23]
 LDCM0238  AC120 HCT 116 C73(1.08)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C73(0.92)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C73(0.95)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C73(0.99)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C73(0.85)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C73(0.78)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C73(0.73)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C73(0.84)  LDD0562  [6]
 LDCM0246  AC128 PaTu 8988t C73(1.14)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C73(1.49)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C73(1.32)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C73(1.14)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C73(1.04)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C73(1.30)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C73(1.34)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C73(1.35)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C73(1.43)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C73(1.65)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C73(1.58)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C73(1.25)  LDD1137  [6]
 LDCM0259  AC14 HEK-293T C73(1.08)  LDD1512  [23]
 LDCM0260  AC140 PaTu 8988t C73(1.31)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C73(1.16)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C73(1.31)  LDD1141  [6]
 LDCM0263  AC143 HCT 116 C73(0.94)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C73(1.11)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C73(1.17)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C73(1.29)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C73(0.99)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C73(1.03)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C73(1.17)  LDD0586  [6]
 LDCM0270  AC15 HEK-293T C73(1.00)  LDD1513  [23]
 LDCM0271  AC150 HCT 116 C73(1.13)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C73(1.23)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C73(1.40)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C73(1.37)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C73(1.34)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C73(1.33)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C73(1.32)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C73(1.30)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C73(0.78)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C73(0.78)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C73(0.65)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C73(1.08)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C73(0.69)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C73(0.70)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C73(0.71)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C73(0.79)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C73(0.64)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C73(1.01)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C73(1.12)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C73(0.99)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C73(1.33)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C73(1.23)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C73(1.17)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C73(1.12)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C73(1.07)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C73(1.29)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C73(0.95)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C73(1.02)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C73(1.14)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C73(0.79)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C73(0.99)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C73(0.91)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C73(0.99)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C73(1.12)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C73(1.06)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C73(0.87)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C73(0.82)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C73(0.77)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C73(1.03)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C73(1.08)  LDD0624  [6]
 LDCM0308  AC46 HEK-293T C73(1.05)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C73(1.12)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C73(0.95)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C73(0.94)  LDD0909  [6]
 LDCM0312  AC5 HCT 116 C73(1.15)  LDD0629  [6]
 LDCM0313  AC50 HEK-293T C73(1.09)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C73(1.17)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C73(0.98)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C73(0.83)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C73(0.97)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C73(1.09)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C73(1.33)  LDD0917  [6]
 LDCM0320  AC57 HCT 116 C73(1.01)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C73(1.08)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C73(1.04)  LDD0639  [6]
 LDCM0323  AC6 HEK-293T C73(0.97)  LDD1562  [23]
 LDCM0324  AC60 HCT 116 C73(1.21)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C73(0.99)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C73(0.94)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C73(0.97)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C73(0.92)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C73(1.16)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C73(1.14)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C73(0.82)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C73(0.87)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C73(0.90)  LDD0650  [6]
 LDCM0334  AC7 HEK-293T C73(1.02)  LDD1568  [23]
 LDCM0335  AC70 HCT 116 C73(0.85)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C73(0.97)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C73(0.96)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C73(1.01)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C73(0.91)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C73(1.06)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C73(0.87)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C73(0.73)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C73(0.78)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C73(0.80)  LDD0661  [6]
 LDCM0345  AC8 HEK-293T C73(0.98)  LDD1569  [23]
 LDCM0346  AC80 HCT 116 C73(1.01)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C73(1.04)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C73(1.20)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C73(1.08)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C73(1.20)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C73(0.98)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C73(0.93)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C73(1.05)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C73(0.87)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C73(0.97)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C73(0.99)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C73(1.00)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C73(0.89)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C73(1.03)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C73(1.15)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C73(1.00)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C73(0.88)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C73(1.00)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C73(0.59)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C73(0.57)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C73(0.67)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C73(0.84)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C73(0.94)  LDD1511  [23]
 LDCM0356  AKOS034007680 HEK-293T C73(1.00)  LDD1570  [23]
 LDCM0275  AKOS034007705 HEK-293T C73(1.01)  LDD1514  [23]
 LDCM0108  Chloroacetamide HeLa C73(0.00); H62(0.00); H331(0.00); H63(0.00)  LDD0222  [17]
 LDCM0367  CL1 PaTu 8988t C73(1.04)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C73(0.85)  LDD1247  [6]
 LDCM0369  CL100 HCT 116 C73(1.08)  LDD0686  [6]
 LDCM0370  CL101 HEK-293T C73(0.98)  LDD1574  [23]
 LDCM0371  CL102 HEK-293T C73(0.96)  LDD1575  [23]
 LDCM0372  CL103 HEK-293T C73(1.02)  LDD1576  [23]
 LDCM0373  CL104 HEK-293T C73(0.99)  LDD1577  [23]
 LDCM0374  CL105 HCT 116 C73(0.92)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C73(0.79)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C73(0.85)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C73(0.82)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C73(0.81)  LDD0695  [6]
 LDCM0379  CL11 PaTu 8988t C73(0.89)  LDD1258  [6]
 LDCM0380  CL110 HCT 116 C73(0.80)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C73(0.63)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C73(1.01)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C73(1.08)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C73(1.14)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C73(0.98)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C73(0.96)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C73(1.00)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C73(0.85)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C73(0.83)  LDD0706  [6]
 LDCM0390  CL12 PaTu 8988t C73(0.94)  LDD1269  [6]
 LDCM0391  CL120 HCT 116 C73(0.75)  LDD0708  [6]
 LDCM0392  CL121 HEK-293T C73(1.21)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C73(1.07)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C73(1.27)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C73(1.10)  LDD0993  [6]
 LDCM0396  CL125 HCT 116 C73(1.00)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C73(1.06)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C73(1.18)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C73(1.08)  LDD0716  [6]
 LDCM0400  CL13 PaTu 8988t C73(1.12)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C73(1.03)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C73(0.93)  LDD1281  [6]
 LDCM0403  CL16 HEK-293T C73(0.97)  LDD1607  [23]
 LDCM0404  CL17 HEK-293T C73(0.95)  LDD1608  [23]
 LDCM0405  CL18 HEK-293T C73(1.02)  LDD1609  [23]
 LDCM0406  CL19 HEK-293T C73(0.85)  LDD1610  [23]
 LDCM0407  CL2 PaTu 8988t C73(0.88)  LDD1286  [6]
 LDCM0408  CL20 HEK-293T C73(1.06)  LDD1612  [23]
 LDCM0409  CL21 HEK-293T C73(1.08)  LDD1613  [23]
 LDCM0410  CL22 HEK-293T C73(1.00)  LDD1614  [23]
 LDCM0411  CL23 HEK-293T C73(1.09)  LDD1615  [23]
 LDCM0412  CL24 HEK-293T C73(1.00)  LDD1616  [23]
 LDCM0413  CL25 HEK-293T C73(0.97)  LDD1617  [23]
 LDCM0414  CL26 HEK-293T C73(1.02)  LDD1618  [23]
 LDCM0415  CL27 HEK-293T C73(0.98)  LDD1619  [23]
 LDCM0416  CL28 HEK-293T C73(0.94)  LDD1620  [23]
 LDCM0417  CL29 HEK-293T C73(0.95)  LDD1621  [23]
 LDCM0418  CL3 PaTu 8988t C73(0.88)  LDD1297  [6]
 LDCM0419  CL30 HEK-293T C73(0.98)  LDD1623  [23]
 LDCM0420  CL31 HCT 116 C73(0.89)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C73(0.69)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C73(0.63)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C73(0.66)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C73(0.89)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C73(0.70)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C73(1.04)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C73(0.87)  LDD0745  [6]
 LDCM0429  CL4 PaTu 8988t C73(1.00)  LDD1308  [6]
 LDCM0430  CL40 HCT 116 C73(0.68)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C73(0.83)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C73(0.76)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C73(0.71)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C73(0.83)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C73(0.58)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C73(0.98)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C73(0.95)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C73(0.81)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C73(1.11)  LDD0756  [6]
 LDCM0440  CL5 PaTu 8988t C73(1.02)  LDD1319  [6]
 LDCM0441  CL50 HCT 116 C73(0.84)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C73(0.88)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C73(0.84)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C73(0.89)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C73(0.93)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C73(0.86)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C73(0.99)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C73(0.85)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C73(0.88)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C73(1.09)  LDD0767  [6]
 LDCM0451  CL6 PaTu 8988t C73(0.93)  LDD1330  [6]
 LDCM0452  CL60 HCT 116 C73(1.00)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C73(1.05)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C73(1.04)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C73(0.95)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C73(1.00)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C73(1.11)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C73(1.08)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C73(1.01)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C73(1.03)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C73(1.01)  LDD0778  [6]
 LDCM0462  CL7 PaTu 8988t C73(1.00)  LDD1341  [6]
 LDCM0463  CL70 HCT 116 C73(1.00)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C73(1.05)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C73(1.12)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C73(0.98)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C73(1.07)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C73(0.97)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C73(0.91)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C73(1.00)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C73(0.86)  LDD0789  [6]
 LDCM0473  CL8 PaTu 8988t C73(0.85)  LDD1352  [6]
 LDCM0474  CL80 HCT 116 C73(0.91)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C73(0.98)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C73(0.98)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C73(0.88)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C73(0.93)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C73(0.83)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C73(0.97)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C73(0.87)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C73(0.92)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C73(0.97)  LDD0800  [6]
 LDCM0484  CL9 PaTu 8988t C73(1.00)  LDD1363  [6]
 LDCM0485  CL90 HCT 116 C73(0.79)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C73(0.70)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C73(1.25)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C73(1.03)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C73(1.15)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C73(1.02)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C73(1.14)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C73(1.24)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C73(1.12)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C73(1.17)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C73(1.09)  LDD1698  [23]
 LDCM0625  F8 Ramos C73(0.55)  LDD2187  [24]
 LDCM0573  Fragment11 Ramos C73(5.80)  LDD2190  [24]
 LDCM0576  Fragment14 Ramos C73(0.90)  LDD2193  [24]
 LDCM0586  Fragment28 Ramos C73(1.24)  LDD2198  [24]
 LDCM0468  Fragment33 HCT 116 C73(1.04)  LDD0785  [6]
 LDCM0566  Fragment4 Ramos C73(0.50)  LDD2184  [24]
 LDCM0427  Fragment51 HCT 116 C73(0.87)  LDD0744  [6]
 LDCM0569  Fragment7 Ramos C73(0.61)  LDD2186  [24]
 LDCM0116  HHS-0101 DM93 Y29(0.97)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y29(1.03)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y29(0.31)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y29(0.62)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y29(0.91)  LDD0268  [5]
 LDCM0107  IAA HeLa C73(0.00); H331(0.00); H127(0.00); H62(0.00)  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C73(0.92)  LDD1492  [23]
 LDCM0023  KB03 HEK-293T C73(0.88)  LDD1497  [23]
 LDCM0024  KB05 HMCB C73(1.88)  LDD3312  [25]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C73(1.40)  LDD2102  [4]
 LDCM0109  NEM HeLa H331(0.00); H62(0.00); H127(0.00); H31(0.00)  LDD0223  [17]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C73(1.02)  LDD2090  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C73(0.90)  LDD2097  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C73(1.22)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C73(0.97)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C73(0.63)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C73(0.92)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C73(1.08)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C73(0.56)  LDD2115  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C73(1.87)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C73(0.88)  LDD2120  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C73(0.98)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C73(0.89)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C73(0.79)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C73(0.59)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C73(1.34)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C73(0.57)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C73(1.39)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C73(1.52)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C73(0.98)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C73(0.80)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C73(0.53)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C73(0.86)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C73(1.88)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C73(0.90)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C73(1.02)  LDD2146  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C73(0.47)  LDD2148  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 10 (USP10) Peptidase C19 family Q14694
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 618 (ZNF618) Krueppel C2H2-type zinc-finger protein family Q5T7W0
Twist-related protein 1 (TWIST1) . Q15672
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
FMR1-interacting protein NUFIP2 (NUFIP2) . Q7Z417

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
22 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840