Details of the Target

General Information of Target

Target ID LDTP05736
Target Name Bifunctional coenzyme A synthase (COASY)
Gene Name COASY
Gene ID 80347
Synonyms
Bifunctional coenzyme A synthase; CoA synthase; NBP; POV-2) [Includes: Phosphopantetheine adenylyltransferase; EC 2.7.7.3; Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT; Dephospho-CoA kinase; DPCK; EC 2.7.1.24; Dephosphocoenzyme A kinase; DPCOAK)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVFRSGLLVLTTPLASLAPRLASILTSAARLVNHTLYVHLQPGMSLEGPAQPQSSPVQA
TFEVLDFITHLYAGADVHRHLDVRILLTNIRTKSTFLPPLPTSVQNLAHPPEVVLTDFQT
LDGSQYNPVKQQLVRYATSCYSCCPRLASVLLYSDYGIGEVPVEPLDVPLPSTIRPASPV
AGSPKQPVRGYYRGAVGGTFDRLHNAHKVLLSVACILAQEQLVVGVADKDLLKSKLLPEL
LQPYTERVEHLSEFLVDIKPSLTFDVIPLLDPYGPAGSDPSLEFLVVSEETYRGGMAINR
FRLENDLEELALYQIQLLKDLRHTENEEDKVSSSSFRQRMLGNLLRPPYERPELPTCLYV
IGLTGISGSGKSSIAQRLKGLGAFVIDSDHLGHRAYAPGGPAYQPVVEAFGTDILHKDGI
INRKVLGSRVFGNKKQLKILTDIMWPIIAKLAREEMDRAVAEGKRVCVIDAAVLLEAGWQ
NLVHEVWTAVIPETEAVRRIVERDGLSEAAAQSRLQSQMSGQQLVEQSHVVLSTLWEPHI
TQRQVEKAWALLQKRIPKTHQALD
Target Bioclass
Enzyme
Family
Eukaryotic CoaD family
Subcellular location
Cytoplasm
Function
Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
Uniprot ID
Q13057
Ensemble ID
ENST00000393818.3
HGNC ID
HGNC:29932
ChEMBL ID
CHEMBL4105867

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DETROIT562 SNV: p.A548V .
HCT116 SNV: p.E485D .
HT SNV: p.V486G .
HT115 SNV: p.K558N .
JURKAT SNV: p.R247H; p.A297T .
KO52 SNV: p.Q316R .
LN18 SNV: p.M444I .
LNCaP clone FGC SNV: p.L426I .
MOLT4 SNV: p.A449T IA-alkyne    Probe Info 
NCIH661 SNV: p.I540V .
WM793 Substitution: p.W487Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AZ-9
 Probe Info  		5.60  LDD0393  [2]
TH216
 Probe Info  		Y396(20.00)  LDD0259  [3]
DBIA
 Probe Info  		C244(3.50)  LDD3312  [4]
HHS-482
 Probe Info  		Y396(0.72)  LDD0285  [5]
HHS-475
 Probe Info  		Y396(1.07); Y126(1.08); Y313(1.50)  LDD0264  [6]
HHS-465
 Probe Info  		Y396(3.04)  LDD2237  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
AMP probe
 Probe Info  		N.A.  LDD0200  [9]
ATP probe
 Probe Info  		K235(0.00); K330(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C215(0.00); C357(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C357(0.00); C215(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C215(0.00); C357(0.00)  LDD0037  [10]
JW-RF-010
 Probe Info  		C143(0.00); C144(0.00)  LDD0026  [11]
TFBX
 Probe Info  		C144(0.00); C140(0.00)  LDD0027  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [12]
1d-yne
 Probe Info  		N.A.  LDD0356  [13]
ENE
 Probe Info  		N.A.  LDD0006  [12]
IPM
 Probe Info  		N.A.  LDD0005  [12]
STPyne
 Probe Info  		N.A.  LDD0009  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
W1
 Probe Info  		C143(0.00); C144(0.00)  LDD0236  [16]
AOyne
 Probe Info  		11.90  LDD0443  [17]
NAIA_5
 Probe Info  		N.A.  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C143
 Probe Info  		57.68  LDD1825  [19]
C289
 Probe Info  		32.22  LDD1959  [19]
FFF probe13
 Probe Info  		5.20  LDD0475  [20]
FFF probe3
 Probe Info  		11.82  LDD0465  [20]
STS-1
 Probe Info  		N.A.  LDD0137  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C357(1.04)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C357(1.02); C144(1.16)  LDD1508  [22]
 LDCM0226  AC11 HEK-293T C357(0.95); C144(0.97)  LDD1509  [22]
 LDCM0237  AC12 HEK-293T C357(0.92); C144(1.06)  LDD1510  [22]
 LDCM0259  AC14 HEK-293T C357(0.91); C144(0.90)  LDD1512  [22]
 LDCM0270  AC15 HEK-293T C357(1.02); C144(1.06)  LDD1513  [22]
 LDCM0276  AC17 HEK-293T C357(0.91)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C357(1.01); C144(0.98)  LDD1516  [22]
 LDCM0278  AC19 HEK-293T C357(0.83); C144(0.76)  LDD1517  [22]
 LDCM0279  AC2 HEK-293T C357(1.01); C144(1.09)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C357(0.92); C144(1.07)  LDD1519  [22]
 LDCM0281  AC21 HEK-293T C357(0.97)  LDD1520  [22]
 LDCM0282  AC22 HEK-293T C357(0.97); C144(1.02)  LDD1521  [22]
 LDCM0283  AC23 HEK-293T C357(0.98); C144(1.08)  LDD1522  [22]
 LDCM0284  AC24 HEK-293T C357(1.03); C144(1.12)  LDD1523  [22]
 LDCM0285  AC25 HEK-293T C357(0.99)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C357(0.96); C144(1.01)  LDD1525  [22]
 LDCM0287  AC27 HEK-293T C357(0.95); C144(0.99)  LDD1526  [22]
 LDCM0288  AC28 HEK-293T C357(1.09); C144(1.12)  LDD1527  [22]
 LDCM0289  AC29 HEK-293T C357(0.93)  LDD1528  [22]
 LDCM0290  AC3 HEK-293T C357(0.99); C144(0.97)  LDD1529  [22]
 LDCM0291  AC30 HEK-293T C357(0.97); C144(0.87)  LDD1530  [22]
 LDCM0292  AC31 HEK-293T C357(1.09); C144(0.98)  LDD1531  [22]
 LDCM0293  AC32 HEK-293T C357(1.06); C144(1.02)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C357(1.08)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C357(0.99); C144(1.22)  LDD1534  [22]
 LDCM0296  AC35 HEK-293T C357(1.01); C144(1.13)  LDD1535  [22]
 LDCM0297  AC36 HEK-293T C357(1.13); C144(1.12)  LDD1536  [22]
 LDCM0298  AC37 HEK-293T C357(1.01)  LDD1537  [22]
 LDCM0299  AC38 HEK-293T C357(1.01); C144(0.89)  LDD1538  [22]
 LDCM0300  AC39 HEK-293T C357(1.13); C144(0.88)  LDD1539  [22]
 LDCM0301  AC4 HEK-293T C357(1.04); C144(0.93)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C357(1.01); C144(0.98)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C357(1.03)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C357(1.00); C144(1.04)  LDD1543  [22]
 LDCM0305  AC43 HEK-293T C357(0.99); C144(0.90)  LDD1544  [22]
 LDCM0306  AC44 HEK-293T C357(1.01); C144(1.00)  LDD1545  [22]
 LDCM0307  AC45 HEK-293T C357(1.01)  LDD1546  [22]
 LDCM0308  AC46 HEK-293T C357(1.04); C144(1.00)  LDD1547  [22]
 LDCM0309  AC47 HEK-293T C357(1.02); C144(0.93)  LDD1548  [22]
 LDCM0310  AC48 HEK-293T C357(1.01); C144(1.04)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C357(0.99)  LDD1550  [22]
 LDCM0312  AC5 HEK-293T C357(1.07)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C357(1.03); C144(0.93)  LDD1552  [22]
 LDCM0314  AC51 HEK-293T C357(1.04); C144(0.94)  LDD1553  [22]
 LDCM0315  AC52 HEK-293T C357(0.98); C144(0.98)  LDD1554  [22]
 LDCM0316  AC53 HEK-293T C357(1.00)  LDD1555  [22]
 LDCM0317  AC54 HEK-293T C357(0.93); C144(0.81)  LDD1556  [22]
 LDCM0318  AC55 HEK-293T C357(0.95); C144(1.01)  LDD1557  [22]
 LDCM0319  AC56 HEK-293T C357(0.99); C144(1.05)  LDD1558  [22]
 LDCM0320  AC57 HEK-293T C357(1.00)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C357(1.08); C144(1.00)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C357(0.89); C144(0.97)  LDD1561  [22]
 LDCM0323  AC6 HEK-293T C357(1.02); C144(1.02)  LDD1562  [22]
 LDCM0324  AC60 HEK-293T C357(1.01); C144(0.97)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C357(0.99)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C357(1.20); C144(1.12)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C357(1.04); C144(1.00)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C357(0.95); C144(1.07)  LDD1567  [22]
 LDCM0334  AC7 HEK-293T C357(1.08); C144(0.89)  LDD1568  [22]
 LDCM0345  AC8 HEK-293T C357(1.08); C144(0.66)  LDD1569  [22]
 LDCM0248  AKOS034007472 HEK-293T C357(0.99)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C357(0.93)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C357(1.02); C144(1.00)  LDD1514  [22]
 LDCM0156  Aniline NCI-H1299 12.99  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa H323(0.00); H390(0.00); H416(0.00)  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C357(0.16)  LDD2227  [18]
 LDCM0367  CL1 HEK-293T C357(1.04); C467(0.88); C144(0.90)  LDD1571  [22]
 LDCM0368  CL10 HEK-293T C357(0.77); C144(0.92)  LDD1572  [22]
 LDCM0369  CL100 HEK-293T C357(1.01); C144(0.92)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C357(1.04); C467(0.63); C144(0.92)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C357(0.95)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C357(0.87); C144(0.82)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C357(1.00); C144(0.82)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C357(0.98); C467(0.62); C144(0.85)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C357(0.93)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C357(0.93); C144(0.69)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C357(0.95); C144(0.88)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C357(1.01); C467(0.65); C144(0.89)  LDD1582  [22]
 LDCM0379  CL11 HEK-293T C357(0.91); C144(1.05)  LDD1583  [22]
 LDCM0380  CL110 HEK-293T C357(0.92)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C357(0.92); C144(0.80)  LDD1585  [22]
 LDCM0382  CL112 HEK-293T C357(0.94); C144(1.00)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C357(1.02); C467(0.78); C144(0.90)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C357(1.03)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C357(1.12); C144(0.94)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C357(1.01); C144(0.94)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C357(1.07); C467(0.81); C144(0.84)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C357(1.01)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C357(1.00); C144(0.74)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C357(0.92); C144(0.89)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C357(0.95); C144(0.88)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C357(1.02); C467(0.79); C144(0.90)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C357(0.99)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C357(0.88); C144(0.90)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C357(0.90); C144(0.93)  LDD1599  [22]
 LDCM0396  CL125 HEK-293T C357(1.12); C467(0.75); C144(0.92)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C357(1.03)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C357(1.10); C144(0.86)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C357(1.02); C144(1.00)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C357(1.08); C467(0.91); C144(0.81)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C357(1.00)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C357(0.94); C144(0.68)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C357(1.02); C144(0.97)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C357(0.90)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C357(0.95); C144(0.97)  LDD1609  [22]
 LDCM0406  CL19 HEK-293T C357(0.84); C144(0.85)  LDD1610  [22]
 LDCM0407  CL2 HEK-293T C357(1.07)  LDD1611  [22]
 LDCM0408  CL20 HEK-293T C357(0.98); C144(1.07)  LDD1612  [22]
 LDCM0409  CL21 HEK-293T C357(0.82)  LDD1613  [22]
 LDCM0410  CL22 HEK-293T C357(0.91); C144(0.90)  LDD1614  [22]
 LDCM0411  CL23 HEK-293T C357(1.02); C144(0.94)  LDD1615  [22]
 LDCM0412  CL24 HEK-293T C357(1.03); C144(1.04)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C357(1.03); C467(0.61); C144(0.76)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C357(0.97)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C357(1.05); C144(0.87)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C357(0.97); C144(0.93)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C357(0.93)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C357(1.01); C144(1.00)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C357(0.99); C144(0.93)  LDD1623  [22]
 LDCM0420  CL31 HEK-293T C357(0.89); C144(1.01)  LDD1624  [22]
 LDCM0421  CL32 HEK-293T C357(0.91); C144(1.22)  LDD1625  [22]
 LDCM0422  CL33 HEK-293T C357(0.70)  LDD1626  [22]
 LDCM0423  CL34 HEK-293T C357(0.81); C144(1.11)  LDD1627  [22]
 LDCM0424  CL35 HEK-293T C357(0.85); C144(0.85)  LDD1628  [22]
 LDCM0425  CL36 HEK-293T C357(0.84); C144(0.96)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C357(1.09); C467(0.53); C144(0.75)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C357(1.08); C144(0.84)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C357(0.95); C144(0.87)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C357(0.95); C144(0.84)  LDD1634  [22]
 LDCM0431  CL41 HEK-293T C357(0.98)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C357(1.08); C144(0.88)  LDD1636  [22]
 LDCM0433  CL43 HEK-293T C357(0.91); C144(0.76)  LDD1637  [22]
 LDCM0434  CL44 HEK-293T C357(0.94); C144(1.08)  LDD1638  [22]
 LDCM0435  CL45 HEK-293T C357(0.85)  LDD1639  [22]
 LDCM0436  CL46 HEK-293T C357(0.86); C144(1.02)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C357(0.86); C144(1.11)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C357(0.95); C144(0.97)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C357(1.21); C467(0.88); C144(0.70)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C357(1.00)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C357(1.00)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C357(0.95); C144(0.89)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C357(0.94)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C357(0.90); C144(0.92)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C357(0.81); C144(0.91)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C357(0.98); C144(1.05)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C357(0.79)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C357(0.84); C144(0.84)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C357(0.89); C144(0.97)  LDD1653  [22]
 LDCM0451  CL6 HEK-293T C357(0.86); C144(0.99)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C357(0.86); C144(0.90)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C357(1.14); C467(0.81); C144(0.79)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C357(1.05)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C357(1.10); C144(0.87)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C357(0.96); C144(1.03)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C357(0.97)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C357(0.95); C144(1.16)  LDD1661  [22]
 LDCM0459  CL67 HEK-293T C357(0.91); C144(0.98)  LDD1662  [22]
 LDCM0460  CL68 HEK-293T C357(0.92); C144(1.04)  LDD1663  [22]
 LDCM0461  CL69 HEK-293T C357(0.85)  LDD1664  [22]
 LDCM0462  CL7 HEK-293T C357(0.90); C144(0.97)  LDD1665  [22]
 LDCM0463  CL70 HEK-293T C357(0.90); C144(0.97)  LDD1666  [22]
 LDCM0464  CL71 HEK-293T C357(0.97); C144(0.95)  LDD1667  [22]
 LDCM0465  CL72 HEK-293T C357(0.84); C144(0.98)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C357(1.05); C467(0.79); C144(0.95)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C357(1.04)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C357(1.08); C144(0.89)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C357(0.85)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C357(0.98); C144(1.15)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C357(1.01); C144(0.91)  LDD1675  [22]
 LDCM0473  CL8 HEK-293T C357(0.81); C144(1.04)  LDD1676  [22]
 LDCM0474  CL80 HEK-293T C357(1.05); C144(0.87)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C357(0.83)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C357(0.91); C144(0.92)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C357(0.84); C144(1.02)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C357(0.83); C144(0.97)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C357(1.25); C467(0.75); C144(0.97)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C357(1.13)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C357(1.10); C144(1.03)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C357(1.04); C144(0.92)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C357(1.01)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C357(0.89)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C357(0.83); C144(0.98)  LDD1688  [22]
 LDCM0486  CL91 HEK-293T C357(1.00); C144(0.78)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C357(0.92); C144(1.12)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C357(0.79)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C357(0.97); C144(1.27)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C357(0.71); C144(0.92)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C357(0.94); C144(0.88)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C357(1.00); C467(0.51); C144(0.88)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C357(0.99)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C357(0.95); C144(0.94)  LDD1697  [22]
 LDCM0495  E2913 HEK-293T C357(1.03); C144(0.96)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C144(3.45)  LDD1702  [23]
 LDCM0468  Fragment33 HEK-293T C357(1.13); C144(0.94)  LDD1671  [22]
 LDCM0427  Fragment51 HEK-293T C357(1.04)  LDD1631  [22]
 LDCM0116  HHS-0101 DM93 Y396(1.07); Y126(1.08); Y313(1.50)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y126(0.18); Y396(1.13); Y313(1.38)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y396(1.04); Y313(1.18); Y126(6.05)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y396(1.30); Y313(1.51); Y126(4.48)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y396(1.13); Y313(1.29); Y126(4.77)  LDD0268  [6]
 LDCM0107  IAA HeLa H323(0.00); H390(0.00); H416(0.00)  LDD0221  [15]
 LDCM0123  JWB131 DM93 Y396(0.72)  LDD0285  [5]
 LDCM0124  JWB142 DM93 Y396(0.69)  LDD0286  [5]
 LDCM0125  JWB146 DM93 Y396(1.10)  LDD0287  [5]
 LDCM0126  JWB150 DM93 Y396(2.04)  LDD0288  [5]
 LDCM0127  JWB152 DM93 Y396(2.47)  LDD0289  [5]
 LDCM0128  JWB198 DM93 Y396(1.31)  LDD0290  [5]
 LDCM0129  JWB202 DM93 Y396(0.67)  LDD0291  [5]
 LDCM0130  JWB211 DM93 Y396(0.84)  LDD0292  [5]
 LDCM0022  KB02 HEK-293T C357(1.08); C140(0.73); C144(1.25)  LDD1492  [22]
 LDCM0023  KB03 HEK-293T C357(0.99); C140(0.58); C144(1.08)  LDD1497  [22]
 LDCM0024  KB05 HMCB C244(3.50)  LDD3312  [4]
 LDCM0109  NEM HeLa H390(0.00); H416(0.00); H323(0.00); H393(0.00)  LDD0223  [15]
 LDCM0628  OTUB2-COV-1 HEK-293T C144(0.66); C357(0.48)  LDD2207  [24]
 LDCM0131  RA190 MM1.R C140(1.14); C144(1.14)  LDD0304  [25]
 LDCM0170  Structure8 Ramos 16.84  LDD0433  [26]
 LDCM0112  W16 Hep-G2 C144(0.66)  LDD0239  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Enhancer of mRNA-decapping protein 4 (EDC4) WD repeat EDC4 family Q6P2E9
Centrobin (CNTROB) . Q8N137
Uncharacterized protein KIAA1958 (KIAA1958) . Q8N8K9

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-methyl-2,4-pentanediol Small molecular drug D06GOK
4'-phosphopantetheine Small molecular drug D09HSI
Coenzyme A Small molecular drug D0W3NA
Dephospho Coenzyme A Small molecular drug D0SK8U
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ptx-007011 . D03CIN

References

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2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
24 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
25 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
26 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.