Details of the Target

General Information of Target

Target ID LDTP06301
Target Name Eukaryotic translation initiation factor 4H (EIF4H)
Gene Name EIF4H
Gene ID 7458
Synonyms
KIAA0038; WBSCR1; WSCR1; Eukaryotic translation initiation factor 4H; eIF-4H; Williams-Beuren syndrome chromosomal region 1 protein
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDA
IFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRK
QDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPM
GSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPRE
EVVQKEQE
Target Bioclass
Other
Subcellular location
Cytoplasm, perinuclear region
Function Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
Uniprot ID
Q15056
Ensemble ID
ENST00000265753.13
HGNC ID
HGNC:12741
ChEMBL ID
CHEMBL1293274

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MFE319 SNV: p.G137Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P2
 Probe Info  		4.86  LDD0449  [1]
P3
 Probe Info  		2.82  LDD0450  [1]
P8
 Probe Info  		2.37  LDD0451  [1]
AZ-9
 Probe Info  		2.89  LDD0393  [2]
TH211
 Probe Info  		Y45(10.54); Y42(10.23)  LDD0260  [3]
C-Sul
 Probe Info  		24.00  LDD0066  [4]
FBP2
 Probe Info  		2.05  LDD0323  [5]
ONAyne
 Probe Info  		K123(7.55)  LDD0274  [6]
STPyne
 Probe Info  		K120(7.24); K123(7.20); K76(8.73); K80(8.06)  LDD0277  [6]
Probe 1
 Probe Info  		Y101(79.88)  LDD3495  [7]
HHS-482
 Probe Info  		Y86(0.34)  LDD0286  [8]
HHS-475
 Probe Info  		Y86(0.68); Y12(0.95); Y45(1.06); Y42(1.79)  LDD0264  [9]
HHS-465
 Probe Info  		Y12(8.97); Y45(3.53); Y86(10.00)  LDD2237  [10]
DBIA
 Probe Info  		C85(1.08)  LDD0531  [11]
5E-2FA
 Probe Info  		N.A.  LDD2235  [12]
m-APA
 Probe Info  		N.A.  LDD2231  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [13]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [13]
1d-yne
 Probe Info  		N.A.  LDD0356  [15]
IPM
 Probe Info  		N.A.  LDD2156  [16]
NHS
 Probe Info  		N.A.  LDD0010  [17]
SF
 Probe Info  		Y12(0.00); Y7(0.00)  LDD0028  [18]
1c-yne
 Probe Info  		N.A.  LDD0228  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [19]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		17.63  LDD1865  [20]
C191
 Probe Info  		15.78  LDD1868  [20]
C193
 Probe Info  		6.63  LDD1869  [20]
C210
 Probe Info  		52.71  LDD1884  [20]
C284
 Probe Info  		21.56  LDD1954  [20]
FFF probe11
 Probe Info  		6.85  LDD0472  [21]
FFF probe12
 Probe Info  		20.00  LDD0473  [21]
FFF probe13
 Probe Info  		13.71  LDD0475  [21]
FFF probe2
 Probe Info  		8.00  LDD0463  [21]
FFF probe3
 Probe Info  		11.13  LDD0464  [21]
FFF probe9
 Probe Info  		6.17  LDD0470  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C85(1.08)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C85(1.01)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C85(0.88)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C85(0.90)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C85(0.84)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C85(1.04)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C85(0.91)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C85(0.97)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C85(1.07)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C85(0.96)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C85(0.99)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C85(0.95)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C85(1.06)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C85(0.92)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C85(1.00)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C85(1.07)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C85(0.87)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C85(1.00)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C85(0.94)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C85(0.99)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C85(0.95)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C85(1.03)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C85(0.94)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C85(1.10)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C85(0.90)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C85(0.84)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C85(0.76)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C85(0.74)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C85(0.89)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C85(0.99)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C85(0.95)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C85(0.90)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C85(0.80)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C85(1.20)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C85(1.09)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C85(1.06)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C85(1.16)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C85(1.11)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C85(1.03)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C85(1.09)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C85(1.02)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C85(1.05)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C85(1.00)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C85(1.12)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C85(1.00)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C85(1.14)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C85(1.03)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C85(1.04)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C85(1.07)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C85(0.92)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C85(1.02)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C85(1.01)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C85(0.88)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C85(0.51)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C85(0.89)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C85(1.10)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C85(0.91)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C85(0.96)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C85(0.77)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C85(0.39)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C85(0.90)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C85(0.88)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C85(0.82)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C85(0.84)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C85(0.79)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C85(0.70)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C85(0.84)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C85(1.47)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C85(0.45)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C85(0.60)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C85(0.61)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C85(0.58)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C85(0.80)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C85(1.08)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C85(0.86)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C85(1.06)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C85(0.81)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C85(1.19)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C85(1.39)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C85(1.26)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C85(1.06)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C85(1.14)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C85(1.06)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C85(0.80)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C85(1.22)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C85(1.41)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C85(0.91)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C85(1.03)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C85(1.03)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C85(1.38)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C85(0.74)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C85(0.94)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C85(0.93)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C85(1.25)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C85(0.78)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C85(0.88)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C85(0.91)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C85(0.96)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C85(1.09)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C85(0.68)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C85(1.93)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C85(0.80)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C85(1.00)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C85(0.98)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C85(0.84)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C85(0.94)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C85(0.75)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C85(0.43)  LDD0636  [11]
 LDCM0320  AC57 HEK-293T C85(0.95)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C85(1.02)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C85(1.18)  LDD1561  [22]
 LDCM0323  AC6 HCT 116 C85(1.09)  LDD0640  [11]
 LDCM0324  AC60 HEK-293T C85(1.07)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C85(1.04)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C85(1.04)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C85(1.04)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C85(1.14)  LDD1567  [22]
 LDCM0332  AC68 HCT 116 C85(0.95)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C85(1.23)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C85(1.14)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C85(1.02)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C85(1.42)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C85(1.85)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C85(0.84)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C85(0.84)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C85(0.84)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C85(0.86)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C85(0.96)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C85(1.00)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C85(1.29)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C85(0.99)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C85(1.47)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C85(1.07)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C85(0.92)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C85(0.93)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C85(1.18)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C85(1.22)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C85(1.23)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C85(1.25)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C85(1.18)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C85(1.31)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C85(1.29)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C85(1.16)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C85(0.59)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C85(0.79)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C85(1.12)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C85(1.28)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C85(0.98)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C85(1.29)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C85(0.96)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C85(0.85)  LDD0683  [11]
 LDCM0248  AKOS034007472 HCT 116 C85(1.23)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C85(1.35)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C85(0.99)  LDD0592  [11]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [19]
 LDCM0367  CL1 HCT 116 C85(0.73)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C85(0.81)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C85(0.97)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C85(1.13)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C85(1.05)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C85(1.09)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C85(1.08)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C85(0.65)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C85(0.56)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C85(0.76)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C85(0.69)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C85(0.68)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C85(0.79)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C85(0.60)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C85(0.75)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C85(0.71)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C85(1.14)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C85(1.02)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C85(0.96)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C85(0.89)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C85(0.61)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C85(1.04)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C85(0.97)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C85(0.84)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C85(1.12)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C85(1.15)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C85(0.97)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C85(0.89)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C85(0.75)  LDD0712  [11]
 LDCM0396  CL125 HEK-293T C85(1.05)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C85(0.98)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C85(1.10)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C85(1.06)  LDD1603  [22]
 LDCM0400  CL13 HCT 116 C85(0.89)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C85(0.86)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C85(0.16)  LDD0719  [11]
 LDCM0403  CL16 HEK-293T C85(1.26)  LDD1001  [11]
 LDCM0404  CL17 HEK-293T C85(0.99)  LDD1002  [11]
 LDCM0405  CL18 HEK-293T C85(0.90)  LDD1003  [11]
 LDCM0406  CL19 HEK-293T C85(1.01)  LDD1004  [11]
 LDCM0407  CL2 HCT 116 C85(0.82)  LDD0724  [11]
 LDCM0408  CL20 HEK-293T C85(0.86)  LDD1006  [11]
 LDCM0409  CL21 HEK-293T C85(0.62)  LDD1007  [11]
 LDCM0410  CL22 HEK-293T C85(0.77)  LDD1008  [11]
 LDCM0411  CL23 HEK-293T C85(1.14)  LDD1009  [11]
 LDCM0412  CL24 HEK-293T C85(0.87)  LDD1010  [11]
 LDCM0413  CL25 HEK-293T C85(0.72)  LDD1011  [11]
 LDCM0414  CL26 HEK-293T C85(1.07)  LDD1012  [11]
 LDCM0415  CL27 HEK-293T C85(1.11)  LDD1013  [11]
 LDCM0416  CL28 HEK-293T C85(1.06)  LDD1014  [11]
 LDCM0417  CL29 HEK-293T C85(0.81)  LDD1015  [11]
 LDCM0418  CL3 HCT 116 C85(0.94)  LDD0735  [11]
 LDCM0419  CL30 HEK-293T C85(0.72)  LDD1017  [11]
 LDCM0420  CL31 HCT 116 C85(0.99)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C85(1.00)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C85(0.86)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C85(0.82)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C85(0.86)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C85(0.94)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C85(0.77)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C85(0.94)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C85(0.98)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C85(1.11)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C85(1.09)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C85(0.57)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C85(0.71)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C85(0.95)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C85(0.83)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C85(1.01)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C85(1.15)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C85(1.23)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C85(1.13)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C85(1.00)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C85(1.28)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C85(1.13)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C85(0.99)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C85(0.89)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C85(0.79)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C85(1.10)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C85(0.77)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C85(0.93)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C85(1.26)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C85(1.04)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C85(1.01)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C85(1.17)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C85(1.04)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C85(1.10)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C85(1.10)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C85(1.08)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C85(1.02)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C85(1.46)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C85(1.01)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C85(0.90)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C85(0.92)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C85(0.98)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C85(1.02)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C85(0.79)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C85(0.84)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C85(0.93)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C85(0.92)  LDD0784  [11]
 LDCM0469  CL76 HEK-293T C85(1.00)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C85(0.96)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C85(1.00)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C85(1.16)  LDD1675  [22]
 LDCM0473  CL8 HCT 116 C85(0.66)  LDD0790  [11]
 LDCM0474  CL80 HEK-293T C85(1.17)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C85(1.14)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C85(1.19)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C85(1.13)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C85(1.06)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C85(1.02)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C85(0.98)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C85(1.11)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C85(1.05)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C85(1.02)  LDD1686  [22]
 LDCM0484  CL9 HCT 116 C85(0.90)  LDD0801  [11]
 LDCM0485  CL90 HEK-293T C85(0.94)  LDD1688  [22]
 LDCM0486  CL91 HCT 116 C85(0.89)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C85(1.30)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C85(1.67)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C85(1.38)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C85(1.27)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C85(1.73)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C85(1.62)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C85(1.08)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C85(1.09)  LDD0811  [11]
 LDCM0191  Compound 21 HEK-293T 4.17  LDD0508  [21]
 LDCM0192  Compound 35 HEK-293T 3.14  LDD0509  [21]
 LDCM0495  E2913 HEK-293T C85(1.00)  LDD1698  [22]
 LDCM0468  Fragment33 HCT 116 C85(1.06)  LDD0785  [11]
 LDCM0427  Fragment51 HCT 116 C85(0.62)  LDD0744  [11]
 LDCM0116  HHS-0101 DM93 Y86(0.68); Y12(0.95); Y45(1.06); Y42(1.79)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y86(0.68); Y12(0.80); Y45(1.14); Y42(2.07)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y86(0.67); Y12(0.85); Y45(0.93); Y42(2.00)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y12(0.84); Y86(0.93); Y42(1.34); Y45(1.40)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y86(0.74); Y12(0.79); Y45(1.14); Y42(1.78)  LDD0268  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [19]
 LDCM0124  JWB142 DM93 Y86(0.34)  LDD0286  [8]
 LDCM0125  JWB146 DM93 Y86(0.36)  LDD0287  [8]
 LDCM0126  JWB150 DM93 Y86(0.42)  LDD0288  [8]
 LDCM0127  JWB152 DM93 Y86(2.22)  LDD0289  [8]
 LDCM0130  JWB211 DM93 Y86(0.36)  LDD0292  [8]
 LDCM0022  KB02 HEK-293T C85(0.94)  LDD1492  [22]
 LDCM0023  KB03 HEK-293T C85(0.95)  LDD1497  [22]
 LDCM0024  KB05 IGR37 C85(1.38)  LDD3314  [23]
 LDCM0131  RA190 MM1.R C85(1.32)  LDD0304  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Eukaryotic initiation factor 4A-I (EIF4A1) DEAD box helicase family P60842
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
F-box only protein 17 (FBXO17) . Q96EF6
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Disks large homolog 3 (DLG3) MAGUK family Q92796
UPF0696 protein C11orf68 (C11orf68) UPF0696 family Q9H3H3
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.