Details of the Target

General Information of Target

Target ID LDTP11207
Target Name Acidic leucine-rich nuclear phosphoprotein 32 family member E (ANP32E)
Gene Name ANP32E
Gene ID 81611
Synonyms
Acidic leucine-rich nuclear phosphoprotein 32 family member E; LANP-like protein; LANP-L
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKNPPDDTGPVHVPLGHIVANEKWRGSQLAQEMQGKIKLIFEDGLTPDFYLSNRCCILY
VTEADLVAGNGYRKRLVRVRNSNNLKGIVVVEKTRMSEQYFPALQKFTVLDLGMVLLPVA
SQMEASCLVIQLVQEQTKEPSKNPLLGKKRALLLSEPSLLRTVQQIPGVGKVKAPLLLQK
FPSIQQLSNASIGELEQVVGQAVAQQIHAFFTQPR
Target Bioclass
Other
Family
ANP32 family
Subcellular location
Cytoplasm
Function
Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.
Uniprot ID
Q9BTT0
Ensemble ID
ENST00000436748.6
HGNC ID
HGNC:16673

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.11  LDD0402  [1]
AZ-9
 Probe Info  		4.66  LDD0393  [2]
TH211
 Probe Info  		Y92(11.60)  LDD0260  [3]
STPyne
 Probe Info  		K113(10.00)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
HHS-465
 Probe Info  		Y92(6.51)  LDD2237  [5]
DBIA
 Probe Info  		C123(1.14); C87(1.39)  LDD0531  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
1d-yne
 Probe Info  		N.A.  LDD0358  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C87(0.00); C123(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C123(0.00); C87(0.00)  LDD0032  [10]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [11]
IPIAA_L
 Probe Info  		C87(0.00); C123(0.00)  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C87(0.00); C123(0.00)  LDD0037  [9]
ATP probe
 Probe Info  		N.A.  LDD0035  [12]
IPM
 Probe Info  		N.A.  LDD0025  [13]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [14]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
Compound 11
 Probe Info  		N.A.  LDD2213  [15]
NHS
 Probe Info  		K113(0.00); K101(0.00)  LDD0010  [14]
NPM
 Probe Info  		N.A.  LDD0016  [14]
1c-yne
 Probe Info  		K86(0.00); K68(0.00)  LDD0228  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
W1
 Probe Info  		N.A.  LDD0236  [17]
NAIA_5
 Probe Info  		N.A.  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe12
 Probe Info  		12.10  LDD0473  [19]
FFF probe13
 Probe Info  		6.46  LDD0475  [19]
FFF probe3
 Probe Info  		6.74  LDD0465  [19]
FFF probe9
 Probe Info  		12.86  LDD0470  [19]
VE-P
 Probe Info  		N.A.  LDD0396  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C123(1.14); C87(1.39)  LDD0531  [6]
 LDCM0215  AC10 HEK-293T C123(1.06); C27(0.99)  LDD0813  [6]
 LDCM0216  AC100 HCT 116 C87(0.82)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C87(0.73)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C87(0.77)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C87(0.61)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C87(0.81)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C87(0.65)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C87(0.57)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C87(0.59)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C87(0.72)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C87(0.89)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C123(1.01); C27(0.93)  LDD0824  [6]
 LDCM0227  AC110 HCT 116 C87(0.71)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C87(0.66)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C87(0.64)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C87(0.98)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C87(0.85)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C87(1.73)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C87(1.01)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C87(0.89)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C87(0.85)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C87(1.01)  LDD0553  [6]
 LDCM0237  AC12 HEK-293T C123(1.02); C27(1.04)  LDD0835  [6]
 LDCM0238  AC120 HCT 116 C87(1.09)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C87(1.05)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C87(1.09)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C87(0.70)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C87(0.75)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C87(1.32)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C87(0.98)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C87(0.81)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C123(0.59); C87(0.67)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C123(0.91); C87(1.25)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C123(1.01); C87(0.94)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C123(1.27); C87(1.36)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C123(1.20); C87(1.47)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C123(0.83); C87(1.11)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C123(0.93); C87(0.85)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C123(0.95); C87(1.10)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C123(0.95); C87(1.29)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C123(1.19); C87(1.26)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C123(1.14); C87(1.22)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C123(1.31); C87(1.26)  LDD0575  [6]
 LDCM0259  AC14 HEK-293T C123(1.01); C27(0.99)  LDD0857  [6]
 LDCM0260  AC140 HCT 116 C123(1.02); C87(1.09)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C123(0.97); C87(1.19)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C123(1.19); C87(1.70)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C123(0.89)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C123(0.65)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C123(0.73)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C123(1.06)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C123(0.74)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C123(0.49)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C123(0.67)  LDD0586  [6]
 LDCM0270  AC15 HEK-293T C123(1.04); C27(1.00)  LDD0868  [6]
 LDCM0271  AC150 HCT 116 C123(1.10)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C123(0.89)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C123(0.73)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C123(0.44)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C123(0.76)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C123(0.87)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C123(0.87)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C123(0.71)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C123(0.72); C87(0.96)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C123(0.31); C87(0.63)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C123(0.77); C87(0.94)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C87(0.92); C123(1.25)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C123(0.60); C87(0.96)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C123(0.59); C87(0.99)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C123(0.59); C87(1.07)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C123(0.75); C87(0.89)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C123(0.82); C87(1.04)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C87(0.93)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C87(0.57)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C87(0.69)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C87(0.58)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C87(0.51)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C123(1.11); C87(1.22)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C87(0.55)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C87(0.56)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C87(0.52)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C87(0.87)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C87(0.79)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C87(1.41)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C87(1.42)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C87(1.38)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C87(1.57)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C87(1.19)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C123(1.11); C87(1.42)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C87(0.87)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C87(1.37)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C87(1.04)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C87(1.27)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C87(1.06)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C87(0.97)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C123(0.93); C87(1.10)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C123(0.98); C87(1.20)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C123(1.07); C87(1.70)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C123(0.68); C87(0.70)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C123(1.06); C87(1.30)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C87(0.64); C123(0.65)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C123(0.90); C87(1.47)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C123(0.84); C87(1.16)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C87(0.86); C123(0.86)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C123(0.71); C87(0.86)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C87(0.59); C123(0.77)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C87(0.43); C123(0.51)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C87(0.78)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C87(0.76)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C87(0.68)  LDD0639  [6]
 LDCM0323  AC6 HEK-293T C123(1.00); C27(0.93)  LDD0921  [6]
 LDCM0324  AC60 HCT 116 C87(0.90)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C87(1.07)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C87(0.59)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C87(0.89)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C87(0.52)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C87(0.70)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C87(0.92)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C87(0.42)  LDD0648  [6]
 LDCM0332  AC68 HEK-293T C123(0.77); C27(1.21); C87(0.96)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C123(1.06); C27(1.23); C87(0.93)  LDD0931  [6]
 LDCM0334  AC7 HEK-293T C123(1.08); C27(1.09)  LDD0932  [6]
 LDCM0335  AC70 HEK-293T C123(0.84); C27(1.13); C87(0.75)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C123(0.88); C27(1.14); C87(0.83)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C123(0.88); C27(1.39); C87(0.84)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C123(0.81); C27(1.06); C87(0.68)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C123(0.95); C27(1.06); C87(0.85)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C123(1.00); C27(1.27); C87(1.01)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C123(1.02); C27(1.53); C87(0.99)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C123(0.97); C27(1.59); C87(0.90)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C123(1.01); C27(1.30); C87(0.86)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C123(1.14); C27(1.14); C87(0.94)  LDD0942  [6]
 LDCM0345  AC8 HEK-293T C123(1.05); C27(1.14)  LDD0943  [6]
 LDCM0346  AC80 HEK-293T C123(0.94); C27(1.38); C87(0.77)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C123(0.98); C27(1.21); C87(0.84)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C123(0.84); C27(1.30); C87(0.52)  LDD0946  [6]
 LDCM0349  AC83 HEK-293T C27(0.97)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C27(0.96)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C27(0.89)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C27(1.07)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C27(1.08)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C27(1.27)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C27(1.19)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C27(1.50)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C27(1.01)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C27(1.11)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C27(1.37)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C27(1.62)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C27(1.18)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C27(1.34)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C27(1.11)  LDD0962  [6]
 LDCM0365  AC98 HCT 116 C87(0.39)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C87(0.87)  LDD0683  [6]
 LDCM0248  AKOS034007472 HEK-293T C123(1.01); C27(1.03)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C123(1.12); C27(1.02)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C123(1.05); C27(1.05)  LDD0873  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0367  CL1 HCT 116 C123(0.91)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C123(0.55)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C123(1.06); C87(1.16)  LDD0686  [6]
 LDCM0370  CL101 HEK-293T C123(0.95); C27(1.05)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C123(1.05); C27(0.95)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C123(1.02); C27(1.11)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C123(1.27); C27(1.31)  LDD0971  [6]
 LDCM0374  CL105 HCT 116 C123(0.56); C87(0.79)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C123(0.42); C87(0.56)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C87(0.56); C123(0.56)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C87(0.53); C123(0.54)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C123(0.81); C87(0.84)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C123(0.42)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C123(0.59); C87(0.77)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C123(0.69); C87(0.95)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C87(0.72)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C87(0.61)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C87(0.55)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C87(0.58)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C87(0.82)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C87(0.64)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C87(1.18)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C87(1.00)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C123(0.46)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C87(1.26)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C123(0.79); C87(0.79)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C123(0.87); C87(1.18)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C123(0.64); C87(0.72)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C123(0.67); C87(0.76)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C87(1.25)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C87(1.23)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C87(1.26)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C87(0.76)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C123(0.69)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C123(0.94)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C123(0.54)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C123(0.96)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C123(0.95)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C123(0.89)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C123(0.91)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C123(0.98)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C123(0.76)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C123(0.53)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C123(0.27)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C123(0.62)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C123(0.48)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C123(0.53)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C123(0.72)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C123(0.82)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C123(0.72)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C123(0.77)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C123(0.81)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C123(1.01)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C123(0.84); C87(0.68)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C123(1.01); C87(0.74)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C123(0.67); C87(0.54)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C123(0.43); C87(0.44)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C123(0.42); C87(0.51)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C123(0.50); C87(0.54)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C123(0.39); C87(0.57)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C123(0.43); C87(0.59)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C123(0.91)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C123(0.58); C87(0.44)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C123(0.61); C87(0.69)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C123(0.27); C87(0.55)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C123(0.32); C87(0.56)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C123(0.58); C87(0.58)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C123(0.43); C87(0.40)  LDD0752  [6]
 LDCM0436  CL46 HEK-293T C87(0.78)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C87(0.98)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C87(1.00)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C87(1.05)  LDD1037  [6]
 LDCM0440  CL5 HCT 116 C123(0.90)  LDD0757  [6]
 LDCM0441  CL50 HEK-293T C87(0.64)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C87(0.79)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C87(1.16)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C87(1.04)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C87(0.84)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C87(0.99)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C87(1.01)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C87(0.96)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C87(1.07)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C87(0.81)  LDD1048  [6]
 LDCM0451  CL6 HCT 116 C123(0.81)  LDD0768  [6]
 LDCM0452  CL60 HEK-293T C87(0.72)  LDD1050  [6]
 LDCM0453  CL61 HCT 116 C123(0.98); C87(1.06)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C123(1.07); C87(1.23)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C123(0.96); C87(1.00)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C123(0.81); C87(1.29)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C123(0.92); C87(0.99)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C123(0.50); C87(1.01)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C123(0.78); C87(0.67)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C123(1.00); C87(0.61)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C123(0.99); C87(0.76)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C123(0.57)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C123(0.99); C87(1.01)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C123(0.86); C87(0.96)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C123(1.19); C87(0.78)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C123(0.87); C87(0.78)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C123(1.02); C87(0.82)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C123(0.97)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C123(0.83)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C123(0.99)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C123(0.61)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C123(0.35)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C123(1.05)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C123(0.80)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C123(0.37)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C123(0.55)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C123(0.29)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C123(0.98)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C123(1.14)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C123(1.06)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C123(0.60)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C123(0.25)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C123(0.70)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C123(0.98)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C123(1.01); C87(0.96)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C123(0.95); C87(1.20)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C123(1.02); C87(1.22)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C123(0.88); C87(1.51)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C123(1.00); C87(1.23)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C123(1.01); C87(1.17)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C123(0.99); C87(0.95)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C123(1.04); C87(1.08)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C123(1.08); C87(1.14)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C87(0.91); C123(1.08); C29(0.93)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C87(1.72)  LDD1702  [22]
 LDCM0625  F8 Ramos C87(0.83)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C87(0.79)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C87(0.16)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C87(1.02)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C87(1.25)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C87(0.79)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C87(0.93)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C87(1.12)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C87(0.88)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C87(1.21)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C87(0.73)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C87(1.33)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C87(1.48)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C87(0.75)  LDD2201  [23]
 LDCM0468  Fragment33 HCT 116 C123(0.98); C87(1.18)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C87(1.31)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C87(0.85)  LDD2184  [23]
 LDCM0427  Fragment51 HCT 116 C123(0.25); C87(0.22)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C87(1.56)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C87(1.34)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C87(0.84)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C87(0.78)  LDD2188  [23]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0022  KB02 HEK-293T C87(1.00); C123(1.16)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C87(1.03); C123(1.13)  LDD1497  [21]
 LDCM0024  KB05 HMCB C82(1.49)  LDD3312  [24]
 LDCM0131  RA190 MM1.R C123(1.34); C87(1.00)  LDD0304  [25]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MRG/MORF4L-binding protein (MRGBP) EAF7 family Q9NV56

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
25 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.