Details of the Target

General Information of Target

Target ID LDTP06220
Target Name LIM and SH3 domain protein 1 (LASP1)
Gene Name LASP1
Gene ID 3927
Synonyms
MLN50; LIM and SH3 domain protein 1; LASP-1; Metastatic lymph node gene 50 protein; MLN 50
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQ
SFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNI
KYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPVA
QSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWM
YGTVERTGDTGMLPANYVEAI
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Cytoplasm, cell cortex
Function
Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
TTD ID
T95992
Uniprot ID
Q14847
DrugMap ID
TTZJA87
Ensemble ID
ENST00000318008.11
HGNC ID
HGNC:6513

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.G201C DBIA    Probe Info 
HGC27 SNV: p.E106Q .
JHH7 SNV: p.A215P .
KMS27 SNV: p.Q172E DBIA    Probe Info 
NCIH1155 SNV: p.A209V .
NCIH661 SNV: p.E48Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.61  LDD0402  [1]
P2
 Probe Info  		2.65  LDD0449  [2]
P3
 Probe Info  		1.87  LDD0450  [2]
P8
 Probe Info  		1.80  LDD0451  [2]
A-EBA
 Probe Info  		3.21  LDD0215  [3]
AZ-9
 Probe Info  		3.03  LDD0393  [4]
CY-1
 Probe Info  		101.35  LDD0243  [5]
CY4
 Probe Info  		100.00  LDD0244  [5]
N1
 Probe Info  		100.00  LDD0242  [5]
ONAyne
 Probe Info  		K112(0.45); K121(3.84); K128(4.06); K75(3.11)  LDD0274  [6]
BTD
 Probe Info  		C29(2.02)  LDD1699  [7]
Probe 1
 Probe Info  		Y13(148.11); Y122(22.57); Y152(15.20)  LDD3495  [8]
AF-1
 Probe Info  		3.34  LDD0421  [9]
DBIA
 Probe Info  		C5(1.40)  LDD3311  [10]
HHS-482
 Probe Info  		Y122(1.05); Y86(1.00)  LDD0285  [11]
HHS-475
 Probe Info  		Y152(0.78); Y122(0.81); Y13(0.86); Y86(1.01)  LDD0264  [12]
HHS-465
 Probe Info  		Y122(10.00); Y86(10.00)  LDD2237  [13]
5E-2FA
 Probe Info  		H31(0.00); H56(0.00); H163(0.00); H162(0.00)  LDD2235  [14]
ATP probe
 Probe Info  		N.A.  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [16]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [17]
Lodoacetamide azide
 Probe Info  		C20(0.00); C29(0.00); C32(0.00); C35(0.00)  LDD0037  [16]
ATP probe
 Probe Info  		K187(0.00); K128(0.00); K45(0.00); K112(0.00)  LDD0035  [18]
NAIA_4
 Probe Info  		N.A.  LDD2226  [19]
WYneN
 Probe Info  		N.A.  LDD0021  [20]
IPM
 Probe Info  		C20(0.00); C53(0.00)  LDD0147  [21]
SF
 Probe Info  		N.A.  LDD0028  [22]
STPyne
 Probe Info  		N.A.  LDD0009  [20]
TFBX
 Probe Info  		C53(0.00); C20(0.00); C35(0.00)  LDD0148  [21]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [23]
Acrolein
 Probe Info  		C20(0.00); C29(0.00); C32(0.00); C35(0.00)  LDD0217  [24]
Methacrolein
 Probe Info  		C29(0.00); C32(0.00); C20(0.00)  LDD0218  [24]
W1
 Probe Info  		N.A.  LDD0236  [25]
NAIA_5
 Probe Info  		C8(0.00); C53(0.00); C20(0.00); C5(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		15.03  LDD1865  [26]
C191
 Probe Info  		20.25  LDD1868  [26]
C193
 Probe Info  		5.10  LDD1869  [26]
VE-P
 Probe Info  		N.A.  LDD0396  [27]
DA-2
 Probe Info  		N.A.  LDD0070  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C29(0.50)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C29(0.85); C20(0.59)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C29(1.06); C20(0.46)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C29(1.48); C20(0.90)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C29(0.97); C20(0.99); C35(1.05); C53(1.14)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C20(1.15); C35(1.03); C53(1.26); C32(1.09)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C29(1.45)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C29(0.93); C20(0.35)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C29(0.77); C20(0.58)  LDD2131  [7]
 LDCM0214  AC1 HEK-293T C53(0.96); C29(1.00)  LDD1507  [29]
 LDCM0215  AC10 HEK-293T C53(0.88); C29(0.97)  LDD1508  [29]
 LDCM0226  AC11 HEK-293T C53(1.06); C32(0.97)  LDD1509  [29]
 LDCM0237  AC12 HEK-293T C53(0.93); C32(1.06)  LDD1510  [29]
 LDCM0259  AC14 HEK-293T C53(1.05); C32(1.12)  LDD1512  [29]
 LDCM0270  AC15 HEK-293T C53(0.92); C32(0.96)  LDD1513  [29]
 LDCM0276  AC17 HEK-293T C53(1.00); C29(1.07)  LDD1515  [29]
 LDCM0277  AC18 HEK-293T C53(1.04); C29(0.97)  LDD1516  [29]
 LDCM0278  AC19 HEK-293T C53(0.97); C32(0.77)  LDD1517  [29]
 LDCM0279  AC2 HEK-293T C53(1.02); C29(0.95)  LDD1518  [29]
 LDCM0280  AC20 HEK-293T C53(0.98); C32(0.96)  LDD1519  [29]
 LDCM0281  AC21 HEK-293T C53(0.96); C32(0.96)  LDD1520  [29]
 LDCM0282  AC22 HEK-293T C53(0.99); C32(0.99)  LDD1521  [29]
 LDCM0283  AC23 HEK-293T C53(1.07); C32(1.06)  LDD1522  [29]
 LDCM0284  AC24 HEK-293T C53(1.04)  LDD1523  [29]
 LDCM0285  AC25 HEK-293T C53(0.96); C29(1.04)  LDD1524  [29]
 LDCM0286  AC26 HEK-293T C53(0.94); C29(0.99)  LDD1525  [29]
 LDCM0287  AC27 HEK-293T C53(1.02); C32(0.99)  LDD1526  [29]
 LDCM0288  AC28 HEK-293T C53(0.99); C32(1.10)  LDD1527  [29]
 LDCM0289  AC29 HEK-293T C53(0.92); C32(0.93)  LDD1528  [29]
 LDCM0290  AC3 HEK-293T C53(1.03); C32(0.90)  LDD1529  [29]
 LDCM0291  AC30 HEK-293T C53(1.03); C32(1.09)  LDD1530  [29]
 LDCM0292  AC31 HEK-293T C53(0.95); C32(0.88)  LDD1531  [29]
 LDCM0293  AC32 HEK-293T C53(1.09)  LDD1532  [29]
 LDCM0294  AC33 HEK-293T C53(0.96); C29(1.10)  LDD1533  [29]
 LDCM0295  AC34 HEK-293T C53(0.93); C29(1.03)  LDD1534  [29]
 LDCM0296  AC35 HEK-293T C53(1.06); C32(1.08)  LDD1535  [29]
 LDCM0297  AC36 HEK-293T C53(0.96); C32(1.14)  LDD1536  [29]
 LDCM0298  AC37 HEK-293T C53(1.03); C32(1.17)  LDD1537  [29]
 LDCM0299  AC38 HEK-293T C53(1.06); C32(1.11)  LDD1538  [29]
 LDCM0300  AC39 HEK-293T C53(0.94); C32(1.02)  LDD1539  [29]
 LDCM0301  AC4 HEK-293T C53(0.97); C32(0.94)  LDD1540  [29]
 LDCM0302  AC40 HEK-293T C53(1.02)  LDD1541  [29]
 LDCM0303  AC41 HEK-293T C53(0.97); C29(1.02)  LDD1542  [29]
 LDCM0304  AC42 HEK-293T C53(0.87); C29(0.93)  LDD1543  [29]
 LDCM0305  AC43 HEK-293T C53(1.03); C32(1.07)  LDD1544  [29]
 LDCM0306  AC44 HEK-293T C53(0.92); C32(1.02)  LDD1545  [29]
 LDCM0307  AC45 HEK-293T C53(0.99); C32(1.03)  LDD1546  [29]
 LDCM0308  AC46 HEK-293T C53(1.04); C32(1.04)  LDD1547  [29]
 LDCM0309  AC47 HEK-293T C53(0.88); C32(0.86)  LDD1548  [29]
 LDCM0310  AC48 HEK-293T C53(1.02)  LDD1549  [29]
 LDCM0311  AC49 HEK-293T C53(0.95); C29(0.96)  LDD1550  [29]
 LDCM0312  AC5 HEK-293T C53(0.97); C32(0.96)  LDD1551  [29]
 LDCM0313  AC50 HEK-293T C53(0.97); C29(0.86)  LDD1552  [29]
 LDCM0314  AC51 HEK-293T C53(1.04); C32(0.99)  LDD1553  [29]
 LDCM0315  AC52 HEK-293T C53(0.94); C32(1.06)  LDD1554  [29]
 LDCM0316  AC53 HEK-293T C53(1.02); C32(1.01)  LDD1555  [29]
 LDCM0317  AC54 HEK-293T C53(1.04); C32(0.97)  LDD1556  [29]
 LDCM0318  AC55 HEK-293T C53(0.92); C32(0.90)  LDD1557  [29]
 LDCM0319  AC56 HEK-293T C53(1.06)  LDD1558  [29]
 LDCM0320  AC57 HEK-293T C53(1.02); C29(1.06)  LDD1559  [29]
 LDCM0321  AC58 HEK-293T C53(0.92); C29(0.97)  LDD1560  [29]
 LDCM0322  AC59 HEK-293T C53(1.11); C32(1.08)  LDD1561  [29]
 LDCM0323  AC6 HEK-293T C53(1.01); C32(0.99)  LDD1562  [29]
 LDCM0324  AC60 HEK-293T C53(0.92); C32(1.10)  LDD1563  [29]
 LDCM0325  AC61 HEK-293T C53(0.97); C32(1.05)  LDD1564  [29]
 LDCM0326  AC62 HEK-293T C53(1.04); C32(1.00)  LDD1565  [29]
 LDCM0327  AC63 HEK-293T C53(0.91); C32(1.01)  LDD1566  [29]
 LDCM0328  AC64 HEK-293T C53(1.08)  LDD1567  [29]
 LDCM0334  AC7 HEK-293T C53(0.99); C32(1.00)  LDD1568  [29]
 LDCM0345  AC8 HEK-293T C53(1.09)  LDD1569  [29]
 LDCM0545  Acetamide MDA-MB-231 C20(0.85); C53(0.50)  LDD2138  [7]
 LDCM0166  Afatinib A431 3.34  LDD0421  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C29(0.92); C20(0.75); C35(1.00); C53(0.73)  LDD2113  [7]
 LDCM0248  AKOS034007472 HEK-293T C53(0.97); C32(1.08)  LDD1511  [29]
 LDCM0356  AKOS034007680 HEK-293T C53(0.98); C29(0.99)  LDD1570  [29]
 LDCM0275  AKOS034007705 HEK-293T C53(1.03)  LDD1514  [29]
 LDCM0156  Aniline NCI-H1299 11.27  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C53(0.92)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C20(0.00); H123(0.00); C29(0.00); C32(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C53(20.00); C53(0.60); C20(0.56)  LDD2227  [19]
 LDCM0367  CL1 HEK-293T C53(0.93); C29(0.90)  LDD1571  [29]
 LDCM0368  CL10 HEK-293T C53(1.01); C32(0.97)  LDD1572  [29]
 LDCM0369  CL100 HEK-293T C53(0.95); C29(0.93)  LDD1573  [29]
 LDCM0370  CL101 HEK-293T C53(0.97); C29(0.96)  LDD1574  [29]
 LDCM0371  CL102 HEK-293T C53(0.88); C29(1.02); C32(0.96)  LDD1575  [29]
 LDCM0372  CL103 HEK-293T C53(0.90); C29(0.99)  LDD1576  [29]
 LDCM0373  CL104 HEK-293T C53(0.94); C29(0.95)  LDD1577  [29]
 LDCM0374  CL105 HEK-293T C53(0.98); C29(1.00)  LDD1578  [29]
 LDCM0375  CL106 HEK-293T C53(0.94); C29(0.94); C32(0.86)  LDD1579  [29]
 LDCM0376  CL107 HEK-293T C53(0.95); C29(0.99)  LDD1580  [29]
 LDCM0377  CL108 HEK-293T C53(1.01); C29(0.93)  LDD1581  [29]
 LDCM0378  CL109 HEK-293T C53(0.98); C29(0.93)  LDD1582  [29]
 LDCM0379  CL11 HEK-293T C53(0.81); C32(0.90)  LDD1583  [29]
 LDCM0380  CL110 HEK-293T C53(0.88); C29(0.94); C32(0.83)  LDD1584  [29]
 LDCM0381  CL111 HEK-293T C53(0.93); C29(0.96)  LDD1585  [29]
 LDCM0382  CL112 HEK-293T C53(0.97); C29(0.86)  LDD1586  [29]
 LDCM0383  CL113 HEK-293T C53(1.00); C29(1.00)  LDD1587  [29]
 LDCM0384  CL114 HEK-293T C53(0.88); C29(0.97); C32(0.78)  LDD1588  [29]
 LDCM0385  CL115 HEK-293T C53(0.97); C29(1.08)  LDD1589  [29]
 LDCM0386  CL116 HEK-293T C53(1.00); C29(0.97)  LDD1590  [29]
 LDCM0387  CL117 HEK-293T C53(1.00); C29(1.03)  LDD1591  [29]
 LDCM0388  CL118 HEK-293T C53(0.96); C29(1.06); C32(0.91)  LDD1592  [29]
 LDCM0389  CL119 HEK-293T C53(1.00); C29(1.09)  LDD1593  [29]
 LDCM0390  CL12 HEK-293T C53(1.03)  LDD1594  [29]
 LDCM0391  CL120 HEK-293T C53(0.97); C29(0.92)  LDD1595  [29]
 LDCM0392  CL121 HEK-293T C53(1.00); C29(0.93)  LDD1596  [29]
 LDCM0393  CL122 HEK-293T C53(1.00); C29(0.88); C32(0.73)  LDD1597  [29]
 LDCM0394  CL123 HEK-293T C53(0.82); C29(0.89)  LDD1598  [29]
 LDCM0395  CL124 HEK-293T C53(0.92); C29(0.74)  LDD1599  [29]
 LDCM0396  CL125 HEK-293T C53(1.01); C29(1.01)  LDD1600  [29]
 LDCM0397  CL126 HEK-293T C53(0.96); C29(1.09); C32(0.97)  LDD1601  [29]
 LDCM0398  CL127 HEK-293T C53(1.00); C29(1.00)  LDD1602  [29]
 LDCM0399  CL128 HEK-293T C53(0.99); C29(1.04)  LDD1603  [29]
 LDCM0400  CL13 HEK-293T C53(0.97); C29(0.94)  LDD1604  [29]
 LDCM0401  CL14 HEK-293T C53(0.95); C29(1.04); C32(0.83)  LDD1605  [29]
 LDCM0402  CL15 HEK-293T C53(0.81); C29(0.96)  LDD1606  [29]
 LDCM0403  CL16 HEK-293T C53(0.98); C29(1.01)  LDD1607  [29]
 LDCM0404  CL17 HEK-293T C53(0.89); C29(1.23)  LDD1608  [29]
 LDCM0405  CL18 HEK-293T C53(0.87); C29(1.09)  LDD1609  [29]
 LDCM0406  CL19 HEK-293T C53(0.90); C32(0.94)  LDD1610  [29]
 LDCM0407  CL2 HEK-293T C53(0.91); C29(1.02); C32(0.73)  LDD1611  [29]
 LDCM0408  CL20 HEK-293T C53(0.81); C32(1.16)  LDD1612  [29]
 LDCM0409  CL21 HEK-293T C53(0.87); C32(1.11)  LDD1613  [29]
 LDCM0410  CL22 HEK-293T C53(1.10); C32(1.25)  LDD1614  [29]
 LDCM0411  CL23 HEK-293T C53(0.83); C32(0.91)  LDD1615  [29]
 LDCM0412  CL24 HEK-293T C53(1.07)  LDD1616  [29]
 LDCM0413  CL25 HEK-293T C53(0.98); C29(1.01)  LDD1617  [29]
 LDCM0414  CL26 HEK-293T C53(0.93); C29(0.97); C32(0.95)  LDD1618  [29]
 LDCM0415  CL27 HEK-293T C53(0.93); C29(1.01)  LDD1619  [29]
 LDCM0416  CL28 HEK-293T C53(1.00); C29(0.93)  LDD1620  [29]
 LDCM0417  CL29 HEK-293T C53(0.94); C29(1.02)  LDD1621  [29]
 LDCM0418  CL3 HEK-293T C53(0.90); C29(1.08)  LDD1622  [29]
 LDCM0419  CL30 HEK-293T C53(0.98); C29(1.07)  LDD1623  [29]
 LDCM0420  CL31 HEK-293T C53(0.96); C32(1.03)  LDD1624  [29]
 LDCM0421  CL32 HEK-293T C53(0.93); C32(1.05)  LDD1625  [29]
 LDCM0422  CL33 HEK-293T C53(0.86); C32(0.98)  LDD1626  [29]
 LDCM0423  CL34 HEK-293T C53(1.15); C32(1.12)  LDD1627  [29]
 LDCM0424  CL35 HEK-293T C53(0.88); C32(0.98)  LDD1628  [29]
 LDCM0425  CL36 HEK-293T C53(1.10)  LDD1629  [29]
 LDCM0426  CL37 HEK-293T C53(1.03); C29(0.99)  LDD1630  [29]
 LDCM0428  CL39 HEK-293T C53(1.14); C29(1.04)  LDD1632  [29]
 LDCM0429  CL4 HEK-293T C53(0.89); C29(0.93)  LDD1633  [29]
 LDCM0430  CL40 HEK-293T C53(0.99); C29(0.92)  LDD1634  [29]
 LDCM0431  CL41 HEK-293T C53(0.89); C29(1.15)  LDD1635  [29]
 LDCM0432  CL42 HEK-293T C53(0.93); C29(1.17)  LDD1636  [29]
 LDCM0433  CL43 HEK-293T C53(1.01); C32(1.14)  LDD1637  [29]
 LDCM0434  CL44 HEK-293T C53(0.91); C32(1.14)  LDD1638  [29]
 LDCM0435  CL45 HEK-293T C53(0.90); C32(1.00)  LDD1639  [29]
 LDCM0436  CL46 HEK-293T C53(1.15); C32(1.28)  LDD1640  [29]
 LDCM0437  CL47 HEK-293T C53(0.87); C32(1.04)  LDD1641  [29]
 LDCM0438  CL48 HEK-293T C53(1.04)  LDD1642  [29]
 LDCM0439  CL49 HEK-293T C53(1.01); C29(1.06)  LDD1643  [29]
 LDCM0440  CL5 HEK-293T C53(0.96); C29(1.12)  LDD1644  [29]
 LDCM0441  CL50 HEK-293T C53(0.91); C29(1.01); C32(0.86)  LDD1645  [29]
 LDCM0443  CL52 HEK-293T C53(0.92); C29(1.08)  LDD1646  [29]
 LDCM0444  CL53 HEK-293T C53(0.92); C29(1.12)  LDD1647  [29]
 LDCM0445  CL54 HEK-293T C53(0.78); C29(1.14)  LDD1648  [29]
 LDCM0446  CL55 HEK-293T C53(1.02); C32(1.10)  LDD1649  [29]
 LDCM0447  CL56 HEK-293T C53(0.89); C32(1.20)  LDD1650  [29]
 LDCM0448  CL57 HEK-293T C53(0.87); C32(1.00)  LDD1651  [29]
 LDCM0449  CL58 HEK-293T C53(1.10); C32(1.21)  LDD1652  [29]
 LDCM0450  CL59 HEK-293T C53(0.88); C32(1.00)  LDD1653  [29]
 LDCM0451  CL6 HEK-293T C53(0.84); C29(0.99)  LDD1654  [29]
 LDCM0452  CL60 HEK-293T C53(1.02)  LDD1655  [29]
 LDCM0453  CL61 HEK-293T C53(0.99); C29(1.14)  LDD1656  [29]
 LDCM0454  CL62 HEK-293T C53(0.97); C29(0.93); C32(0.76)  LDD1657  [29]
 LDCM0455  CL63 HEK-293T C53(0.97); C29(1.12)  LDD1658  [29]
 LDCM0456  CL64 HEK-293T C53(0.92); C29(1.01)  LDD1659  [29]
 LDCM0457  CL65 HEK-293T C53(0.97); C29(1.15)  LDD1660  [29]
 LDCM0458  CL66 HEK-293T C53(0.87); C29(1.08)  LDD1661  [29]
 LDCM0459  CL67 HEK-293T C53(0.97); C32(1.09)  LDD1662  [29]
 LDCM0460  CL68 HEK-293T C53(0.90); C32(1.30)  LDD1663  [29]
 LDCM0461  CL69 HEK-293T C53(0.90); C32(1.30)  LDD1664  [29]
 LDCM0462  CL7 HEK-293T C53(0.92); C32(0.91)  LDD1665  [29]
 LDCM0463  CL70 HEK-293T C53(1.14); C32(1.25)  LDD1666  [29]
 LDCM0464  CL71 HEK-293T C53(0.82); C32(1.02)  LDD1667  [29]
 LDCM0465  CL72 HEK-293T C53(1.14)  LDD1668  [29]
 LDCM0466  CL73 HEK-293T C53(0.95); C29(1.04)  LDD1669  [29]
 LDCM0467  CL74 HEK-293T C53(0.99); C29(1.23); C32(0.91)  LDD1670  [29]
 LDCM0469  CL76 HEK-293T C53(1.01); C29(0.94)  LDD1672  [29]
 LDCM0470  CL77 HEK-293T C53(0.94); C29(1.11)  LDD1673  [29]
 LDCM0471  CL78 HEK-293T C53(0.95); C29(1.09)  LDD1674  [29]
 LDCM0472  CL79 HEK-293T C53(0.97); C32(1.14)  LDD1675  [29]
 LDCM0473  CL8 HEK-293T C53(0.75); C32(0.97)  LDD1676  [29]
 LDCM0474  CL80 HEK-293T C53(0.95); C32(1.14)  LDD1677  [29]
 LDCM0475  CL81 HEK-293T C53(0.94); C32(1.08)  LDD1678  [29]
 LDCM0476  CL82 HEK-293T C53(1.18); C32(1.20)  LDD1679  [29]
 LDCM0477  CL83 HEK-293T C53(0.86); C32(1.01)  LDD1680  [29]
 LDCM0478  CL84 HEK-293T C53(0.90)  LDD1681  [29]
 LDCM0479  CL85 HEK-293T C53(1.11); C29(1.02)  LDD1682  [29]
 LDCM0480  CL86 HEK-293T C53(0.95); C29(1.12); C32(0.91)  LDD1683  [29]
 LDCM0481  CL87 HEK-293T C53(0.92); C29(1.09)  LDD1684  [29]
 LDCM0482  CL88 HEK-293T C53(0.98); C29(1.10)  LDD1685  [29]
 LDCM0483  CL89 HEK-293T C53(1.01); C29(1.13)  LDD1686  [29]
 LDCM0484  CL9 HEK-293T C53(0.91); C32(0.83)  LDD1687  [29]
 LDCM0485  CL90 HEK-293T C53(0.83); C29(1.06)  LDD1688  [29]
 LDCM0486  CL91 HEK-293T C53(1.03); C32(1.07)  LDD1689  [29]
 LDCM0487  CL92 HEK-293T C53(0.86); C32(1.22)  LDD1690  [29]
 LDCM0488  CL93 HEK-293T C53(0.89); C32(1.17)  LDD1691  [29]
 LDCM0489  CL94 HEK-293T C53(1.09); C32(1.28)  LDD1692  [29]
 LDCM0490  CL95 HEK-293T C53(0.81); C32(0.94)  LDD1693  [29]
 LDCM0491  CL96 HEK-293T C53(0.91)  LDD1694  [29]
 LDCM0492  CL97 HEK-293T C53(0.98); C29(0.99)  LDD1695  [29]
 LDCM0493  CL98 HEK-293T C53(0.97); C29(0.90); C32(0.84)  LDD1696  [29]
 LDCM0494  CL99 HEK-293T C53(0.95); C29(0.93)  LDD1697  [29]
 LDCM0495  E2913 HEK-293T C53(0.89); C29(1.11)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C53(1.57); C35(1.26); C32(1.23)  LDD1702  [7]
 LDCM0625  F8 Ramos C20(2.05); C53(4.27)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C20(0.62); C53(0.59)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C20(6.82); C53(0.27)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C20(0.48); C53(0.46)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C20(0.39); C53(0.46)  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C20(0.60); C53(0.66)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C20(0.54); C53(0.61)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C20(0.51); C53(0.51)  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C20(1.38); C53(1.71)  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C20(0.98); C53(0.91)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C20(0.53); C53(0.61)  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C20(0.70); C53(0.59)  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C20(0.63); C53(1.07)  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C20(0.65); C53(0.64)  LDD2201  [30]
 LDCM0468  Fragment33 HEK-293T C53(0.90); C29(1.11)  LDD1671  [29]
 LDCM0596  Fragment38 Ramos C20(1.91); C53(1.07)  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C20(0.69); C53(0.81)  LDD2184  [30]
 LDCM0427  Fragment51 HEK-293T C53(0.95); C29(0.99); C32(0.96)  LDD1631  [29]
 LDCM0610  Fragment52 Ramos C20(1.95); C53(0.73)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C20(0.57); C53(0.37)  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C20(0.52); C53(0.55)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C20(0.49); C53(0.20)  LDD2188  [30]
 LDCM0116  HHS-0101 DM93 Y152(0.78); Y122(0.81); Y13(0.86); Y86(1.01)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y152(0.72); Y122(0.78); Y86(0.81); Y13(0.82)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y122(0.79); Y86(0.86); Y152(1.00); Y13(1.45)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y86(0.81); Y122(0.82); Y13(0.83); Y57(0.96)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y13(0.40); Y122(0.73); Y86(0.83); Y152(1.01)  LDD0268  [12]
 LDCM0107  IAA HeLa H123(0.00); C32(0.00); H31(0.00); C35(0.00)  LDD0221  [24]
 LDCM0123  JWB131 DM93 Y122(1.05); Y86(1.00)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y122(0.92); Y86(0.97)  LDD0286  [11]
 LDCM0125  JWB146 DM93 Y122(1.07); Y86(1.12)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y122(3.65); Y86(3.88)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y122(2.23); Y86(2.57)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y122(1.60); Y86(1.59)  LDD0290  [11]
 LDCM0129  JWB202 DM93 Y122(0.81); Y86(0.94)  LDD0291  [11]
 LDCM0130  JWB211 DM93 Y122(1.19); Y86(1.12)  LDD0292  [11]
 LDCM0022  KB02 HEK-293T C53(0.97); C35(0.96); C32(0.99); C32(0.95)  LDD1492  [29]
 LDCM0023  KB03 HEK-293T C53(0.93); C35(1.02); C32(0.95); C32(1.10)  LDD1497  [29]
 LDCM0024  KB05 G361 C5(1.40)  LDD3311  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C29(1.29)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C20(0.74)  LDD2121  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C20(0.68); C53(0.95)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C29(0.98)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C29(1.40)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C20(1.10); C35(1.46); C53(1.11); C5(0.95)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C29(1.81); C53(1.12)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C29(0.49); C53(0.93)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C20(0.74); C35(1.00); C53(1.13); C32(0.87)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C29(2.86)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C29(1.53); C20(0.99); C35(1.60); C53(0.92)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C29(0.83); C20(0.41); C5(0.92)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C29(0.75); C20(1.38); C35(1.84); C32(1.21)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C29(0.66)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C29(1.55)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C29(0.58)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C29(0.79); C20(0.88); C53(1.02); C32(1.16)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C29(0.78)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C35(0.95); C53(0.93); C5(0.49)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C53(0.55)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C29(0.93); C20(0.96); C35(1.26); C53(0.54)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C29(0.56)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C29(0.53); C20(0.64); C35(1.02); C53(0.56)  LDD2115  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C29(1.10); C53(0.97)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C29(1.12)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C29(1.25); C20(2.14); C35(1.34); C53(1.28)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C29(0.52); C20(0.61); C35(0.72); C53(0.76)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C29(0.71); C53(1.09)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C29(0.91); C20(0.76); C35(0.89); C53(1.02)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C29(0.92); C53(1.07)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C29(1.08); C20(0.90); C35(0.97); C53(0.99)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C29(0.94); C20(0.92); C53(1.02)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C29(0.86); C20(0.99); C35(0.82); C53(1.04)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C29(0.53); C20(0.70); C35(0.60); C53(0.76)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C29(0.84); C20(0.97); C35(0.90); C53(0.88)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C29(1.01); C20(0.89); C35(0.52); C53(0.61)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C29(0.94); C20(0.55); C53(0.89); C32(0.64)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C29(0.68); C20(0.99); C53(1.18); C32(0.82)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C29(1.87); C20(1.02); C35(1.86); C53(1.17)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C29(0.61); C20(0.75); C53(0.84); C32(0.72)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C29(1.93); C20(1.57)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C35(2.23); C5(0.65)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C29(0.54)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C29(0.50); C20(0.65); C35(0.83); C53(0.76)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C29(1.66); C20(3.12); C35(0.98); C32(1.19)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C29(5.84)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C29(1.44); C20(0.84); C35(0.99); C53(0.78)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C29(0.95); C20(1.11); C53(1.94)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C29(0.44); C20(0.51); C35(0.53); C53(0.58)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C29(0.86); C53(1.21)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C20(0.58); C53(0.67)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C29(0.65); C53(0.64)  LDD2151  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C29(2.68)  LDD2153  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
60 kDa heat shock protein, mitochondrial (HSPD1) Chaperonin (HSP60) family P10809
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Palmitoyltransferase ZDHHC17 (ZDHHC17) DHHC palmitoyltransferase family Q8IUH5
DNA polymerase delta catalytic subunit (POLD1) DNA polymerase type-B family P28340
Inactive glycosyltransferase 25 family member 3 (CERCAM) Glycosyltransferase 25 family Q5T4B2
Integrator complex subunit 11 (INTS11) RNA-metabolizing metallo-beta-lactamase-like family Q5TA45
Beta-secretase 2 (BACE2) Peptidase A1 family Q9Y5Z0
Inactive Ufm1-specific protease 1 (UFSP1) Peptidase C78 family Q6NVU6
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Proteasome subunit alpha type-3 (PSMA3) Peptidase T1A family P25788
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Serine/threonine-protein kinase PAK 1 (PAK1) STE Ser/Thr protein kinase family Q13153
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
Tensin-2 (TNS2) PTEN phosphatase protein family Q63HR2
GTPase HRas (HRAS) Ras family P01112
Neuronal-specific septin-3 (SEPTIN3) Septin GTPase family Q9UH03
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 ubiquitin-protein ligase RNF38 (RNF38) . Q9H0F5
F-box only protein 17 (FBXO17) . Q96EF6
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
MyoD family inhibitor (MDFI) MDFI family Q99750
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Optineurin (OPTN) . Q96CV9
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Doublesex- and mab-3-related transcription factor 3 (DMRT3) DMRT family Q9NQL9
Homeobox even-skipped homolog protein 2 (EVX2) Even-skipped homeobox family Q03828
Vascular endothelial zinc finger 1 (VEZF1) Krueppel C2H2-type zinc-finger protein family Q14119
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
Pituitary homeobox 1 (PITX1) Paired homeobox family P78337
Rhox homeobox family member 2 (RHOXF2) Paired-like homeobox family Q9BQY4
Pituitary-specific positive transcription factor 1 (POU1F1) POU transcription factor family P28069
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Zinc finger C2HC domain-containing protein 1A (ZC2HC1A) ZC2HC1 family Q96GY0
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Chorion-specific transcription factor GCMb (GCM2) . O75603
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Forkhead box protein H1 (FOXH1) . O75593
Proto-oncogene c-Rel (REL) . Q04864
T-cell leukemia homeobox protein 3 (TLX3) . O43711
Transcription factor 4 (TCF4) . P15884
Transcriptional regulator QRICH1 (QRICH1) . Q2TAL8
Zinc finger and BTB domain-containing protein 9 (ZBTB9) . Q96C00
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oxoeicosanoid receptor 1 (OXER1) G-protein coupled receptor 1 family Q8TDS5
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet endothelial cell adhesion molecule (PECAM1) . P16284
Other
Click To Hide/Show 54 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Beta-crystallin A2 (CRYBA2) Beta/gamma-crystallin family P53672
Beta-crystallin A3 (CRYBA1) Beta/gamma-crystallin family P05813
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Docking protein 6 (DOK6) DOK family, Type B subfamily Q6PKX4
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Progranulin (GRN) Granulin family P28799
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Vimentin (VIM) Intermediate filament family P08670
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 12-4 (KRTAP12-4) KRTAP type 12 family P60329
Keratin-associated protein 19-3 (KRTAP19-3) KRTAP type 19 family Q7Z4W3
Keratin-associated protein 19-4 (KRTAP19-4) KRTAP type 19 family Q3LI73
Keratin-associated protein 19-6 (KRTAP19-6) KRTAP type 19 family Q3LI70
Keratin-associated protein 3-2 (KRTAP3-2) KRTAP type 3 family Q9BYR7
Keratin-associated protein 3-3 (KRTAP3-3) KRTAP type 3 family Q9BYR6
Keratin-associated protein 4-2 (KRTAP4-2) KRTAP type 4 family Q9BYR5
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Tight junction protein ZO-2 (TJP2) MAGUK family Q9UDY2
Mediator of RNA polymerase II transcription subunit 25 (MED25) Mediator complex subunit 25 family Q71SY5
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Protein sprouty homolog 2 (SPRY2) Sprouty family O43597
Tektin-3 (TEKT3) Tektin family Q9BXF9
Tektin-4 (TEKT4) Tektin family Q8WW24
Tektin-5 (TEKT5) Tektin family Q96M29
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6
Gelsolin (GSN) Villin/gelsolin family P06396
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
YTH domain-containing family protein 1 (YTHDF1) YTHDF family Q9BYJ9
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
Calcium homeostasis endoplasmic reticulum protein (CHERP) . Q8IWX8
Cleavage stimulation factor subunit 2 tau variant (CSTF2T) . Q9H0L4
DAZ-associated protein 2 (DAZAP2) . Q15038
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) . P52597
Leukocyte receptor cluster member 8 (LENG8) . Q96PV6
LIM domain transcription factor LMO4 (LMO4) . P61968
Nuclear transport factor 2 (NUTF2) . P61970
Proline-rich protein 35 (PRR35) . P0CG20
Protein TFG (TFG) . Q92734
Rho guanine nucleotide exchange factor 16 (ARHGEF16) . Q5VV41
RING finger protein 11 (RNF11) . Q9Y3C5
RNA-binding protein with multiple splicing 2 (RBPMS2) . Q6ZRY4
SH2 domain-containing protein 2A (SH2D2A) . Q9NP31
Ubiquilin-2 (UBQLN2) . Q9UHD9
Uncharacterized protein C14orf119 (C14orf119) . Q9NWQ9
Zinc finger CCCH domain-containing protein 10 (ZC3H10) . Q96K80

References

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3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
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Mass spectrometry data entry: PXD028270
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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Mass spectrometry data entry: PXD047840
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
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14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
23 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
26 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
27 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
28 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578