Details of the Target

General Information of Target

Target ID LDTP05165
Target Name Brain acid soluble protein 1 (BASP1)
Gene Name BASP1
Gene ID 10409
Synonyms
NAP22; Brain acid soluble protein 1; 22 kDa neuronal tissue-enriched acidic protein; Neuronal axonal membrane protein NAP-22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQ
DAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAP
KAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAA
PSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE
Target Bioclass
Transporter and channel
Family
BASP1 family
Subcellular location
Cell membrane
Uniprot ID
P80723
Ensemble ID
ENST00000322611.4
HGNC ID
HGNC:957

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
D283MED SNV: p.A137T .
EFO27 SNV: p.A204S .
HCC44 SNV: p.G35V .
IGROV1 SNV: p.G146E .
LUDLU1 SNV: p.E213D .
MDAMB453 SNV: p.E27K .
MFE319 Deletion: p.S182LfsTer42 .
REH SNV: p.A115V .
RKO SNV: p.A19G; p.A30V .
SKMEL5 SNV: p.A98V .
SW1116 SNV: p.A188T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		12.20  LDD0393  [1]
STPyne
 Probe Info  		K10(0.93)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K149(3.54); K143(3.54)  LDD3494  [3]
Probe 1
 Probe Info  		Y12(178.30)  LDD3495  [4]
ATP probe
 Probe Info  		K184(0.00); K173(0.00); K150(0.00); K18(0.00)  LDD0035  [5]
Acrolein
 Probe Info  		K150(0.00); K143(0.00)  LDD0217  [6]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [7]
STS-2
 Probe Info  		N.A.  LDD0139  [7]
DA-2
 Probe Info  		N.A.  LDD0070  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0230  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
8 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.