Details of the Target

General Information of Target

Target ID LDTP00862
Target Name Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA)
Gene Name SGTA
Gene ID 6449
Synonyms
SGT; SGT1; Small glutamine-rich tetratricopeptide repeat-containing protein alpha; Alpha-SGT; Vpu-binding protein; UBP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDNKKRLAYAIIQFLHDQLRHGGLSSDAQESLEVAIQCLETAFGVTVEDSDLALPQTLPE
IFEAAATGKEMPQDLRSPARTPPSEEDSAEAERLKTEGNEQMKVENFEAAVHFYGKAIEL
NPANAVYFCNRAAAYSKLGNYAGAVQDCERAICIDPAYSKAYGRMGLALSSLNKHVEAVA
YYKKALELDPDNETYKSNLKIAELKLREAPSPTGGVGSFDIAGLLNNPGFMSMASNLMNN
PQIQQLMSGMISGGNNPLGTPGTSPSQNDLASLIQAGQQFAQQMQQQNPELIEQLRSQIR
SRTPSASNDDQQE
Target Bioclass
Other
Family
SGT family
Subcellular location
Cytoplasm
Function
Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex. Binds directly to HSC70 and HSP70 and regulates their ATPase activity.; (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70.
Uniprot ID
O43765
Ensemble ID
ENST00000221566.7
HGNC ID
HGNC:10819

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AZ-9
 Probe Info  		10.00  LDD0393  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
TH211
 Probe Info  		Y127(20.00); Y141(20.00)  LDD0257  [4]
TH214
 Probe Info  		Y182(18.93)  LDD0258  [4]
TH216
 Probe Info  		Y181(18.57); Y114(9.05)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K137(1.79); K160(7.99)  LDD0277  [6]
Probe 1
 Probe Info  		Y135(181.34); Y195(18.77)  LDD3495  [7]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [8]
AHL-Pu-1
 Probe Info  		C153(2.52)  LDD0168  [9]
HHS-482
 Probe Info  		Y114(0.88); Y135(1.01); Y141(0.91); Y181(0.87)  LDD0285  [10]
HHS-475
 Probe Info  		Y181(0.84); Y141(1.04)  LDD0264  [11]
HHS-465
 Probe Info  		Y114(3.53); Y127(10.00); Y135(1.38); Y181(10.00)  LDD2237  [12]
DBIA
 Probe Info  		C129(0.92)  LDD0078  [13]
5E-2FA
 Probe Info  		H16(0.00); H112(0.00)  LDD2235  [14]
ATP probe
 Probe Info  		K160(0.00); K184(0.00); K95(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C153(0.00); C129(0.00); C148(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C129(0.00); C153(0.00); C148(0.00)  LDD0032  [17]
IPIAA_L
 Probe Info  		C148(0.00); C129(0.00)  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C153(0.00); C129(0.00); C148(0.00)  LDD0037  [16]
BTD
 Probe Info  		N.A.  LDD0004  [19]
IPM
 Probe Info  		C148(0.00); C129(0.00)  LDD0025  [20]
JW-RF-010
 Probe Info  		C153(0.00); C129(0.00)  LDD0026  [20]
NAIA_4
 Probe Info  		C129(0.00); C153(0.00)  LDD2226  [21]
TFBX
 Probe Info  		C129(0.00); C153(0.00)  LDD0027  [20]
WYneN
 Probe Info  		N.A.  LDD0021  [19]
WYneO
 Probe Info  		C153(0.00); C148(0.00)  LDD0022  [19]
Compound 10
 Probe Info  		C129(0.00); C153(0.00)  LDD2216  [22]
Compound 11
 Probe Info  		N.A.  LDD2213  [22]
PF-06672131
 Probe Info  		N.A.  LDD0017  [23]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [24]
1c-yne
 Probe Info  		N.A.  LDD0228  [25]
Acrolein
 Probe Info  		N.A.  LDD0217  [26]
Methacrolein
 Probe Info  		N.A.  LDD0218  [26]
W1
 Probe Info  		C148(0.00); C129(0.00); C153(0.00)  LDD0236  [27]
AOyne
 Probe Info  		15.00  LDD0443  [28]
NAIA_5
 Probe Info  		C153(0.00); C129(0.00); C148(0.00)  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C046
 Probe Info  		5.24  LDD1745  [29]
C313
 Probe Info  		13.00  LDD1980  [29]
FFF probe11
 Probe Info  		5.40  LDD0471  [30]
FFF probe13
 Probe Info  		10.86  LDD0475  [30]
FFF probe14
 Probe Info  		20.00  LDD0477  [30]
FFF probe3
 Probe Info  		9.21  LDD0465  [30]
FFF probe6
 Probe Info  		5.08  LDD0467  [30]
VE-P
 Probe Info  		N.A.  LDD0396  [31]
STS-1
 Probe Info  		N.A.  LDD0068  [32]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C153(0.77)  LDD2142  [33]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C129(0.71)  LDD2112  [33]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C153(0.99)  LDD2095  [33]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C129(0.94)  LDD2130  [33]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C153(1.31); C129(1.11)  LDD2117  [33]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C153(0.66)  LDD2131  [33]
 LDCM0025  4SU-RNA HEK-293T C153(2.52)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C153(3.69)  LDD0169  [9]
 LDCM0214  AC1 HCT 116 C129(0.09); C148(0.98); C153(1.22)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C129(0.50); C148(1.02); C153(1.11)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C129(0.79); C148(0.67); C153(1.24)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C129(0.63); C148(0.58); C153(1.14)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C129(0.73); C148(0.56); C153(1.07)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C129(1.00); C148(0.71); C153(1.25)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C129(0.83); C148(0.45); C153(0.99)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C129(0.80); C148(0.50); C153(1.15)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C129(0.59); C148(0.51); C153(1.22)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C129(0.68); C148(0.54); C153(1.10)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C129(0.72); C148(0.73); C153(1.31)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C129(1.03); C148(0.63); C153(1.02)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C129(0.49); C148(0.79); C153(1.18)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C129(0.92); C148(0.50); C153(1.23)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C129(1.14); C148(0.56); C153(1.25)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C129(0.80); C148(0.57); C153(1.32)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C129(1.04); C148(1.30); C153(1.01)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C129(0.94); C148(1.23); C153(1.16)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C129(0.94); C148(1.14); C153(1.22)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C129(0.80); C148(1.15); C153(1.21)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C129(0.79); C148(1.48); C153(1.09)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C129(0.68); C148(1.63); C153(1.06)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C129(0.67); C148(1.40); C153(1.20)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C129(0.61); C148(1.18); C153(1.05)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C129(7.80); C148(1.05); C153(1.30)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C129(2.38); C148(1.41); C153(1.04)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C129(1.44); C148(1.37); C153(1.19)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C129(5.91); C148(1.83); C153(1.08)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C129(0.97); C148(1.39); C153(1.13)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C129(1.79); C148(1.42); C153(1.20)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C129(1.42); C148(1.26); C153(1.22)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C129(1.14); C148(1.46); C153(1.20)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C148(1.05)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C148(1.69)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C148(1.05)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C148(1.45)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C148(1.21)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C148(1.02)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C148(0.95)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C148(0.93)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C148(0.98)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C148(1.63)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C148(0.77)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C148(0.95)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C129(0.80); C148(0.96); C153(1.14)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C148(0.80)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C148(0.95)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C148(2.38)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C129(1.07); C148(1.00); C153(1.08)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C148(0.42); C153(1.32); C129(1.46)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C148(0.66); C153(1.18); C129(1.31)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C148(0.61); C129(1.01); C153(1.22)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C148(0.56); C153(1.35); C129(1.45)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C148(0.56); C129(1.01); C153(1.77)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C148(0.53); C129(1.07); C153(1.43)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C148(0.84); C129(1.12); C153(1.14)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C129(0.99); C153(1.32); C148(1.42)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C129(1.12); C153(1.14); C148(1.26)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C148(0.67); C129(1.30); C153(1.40)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C148(0.39); C129(1.17); C153(1.90)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C129(1.23); C148(0.60); C153(1.21)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C129(1.20); C148(0.76); C153(1.25)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C129(1.41); C148(0.81); C153(1.01)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C129(2.31); C148(0.68); C153(0.96)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C148(0.69); C153(1.10); C129(1.90)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C148(0.79); C129(1.29); C153(1.37)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C153(0.96); C148(0.99); C129(1.75)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C129(0.15); C148(1.09); C153(1.17)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C148(0.68); C153(1.00); C129(1.73)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C148(0.67); C153(1.07); C129(1.42)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C148(0.81); C153(0.96); C129(1.35)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C148(0.73); C153(1.19); C129(1.59)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C148(0.75); C153(1.01); C129(1.49)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C148(0.76); C153(0.93); C129(0.99)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C148(0.72); C129(0.77); C153(1.32)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C148(0.70); C153(1.08); C129(1.11)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C148(0.72); C129(0.89); C153(1.14)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C148(0.62); C129(1.40); C153(1.48)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C129(0.05); C148(0.97); C153(1.08)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C148(0.63); C129(1.39); C153(1.53)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C148(0.63); C129(1.10); C153(1.33)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C148(0.55); C129(0.92); C153(1.38)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C148(0.59); C153(1.10); C129(1.31)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C148(0.49); C153(1.11); C129(2.53)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C129(0.82); C153(0.93); C148(1.48)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C129(0.95); C153(0.99); C148(1.12)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C153(0.99); C129(1.16); C148(1.21)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C153(0.95); C148(1.10); C129(1.52)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C129(0.65); C148(1.01); C153(1.17)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C129(0.04); C148(0.88); C153(1.26)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C148(0.84); C153(1.19); C129(1.46)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C148(0.92); C153(1.03); C129(1.86)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C148(1.04); C153(1.10); C129(2.40)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C148(1.04); C153(1.17); C129(1.48)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C148(1.00); C153(1.06); C129(2.68)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C148(0.88); C153(1.38); C129(1.80)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C153(1.02); C148(1.05); C129(1.05)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C129(0.75); C148(0.86); C153(1.08)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C129(0.74); C153(1.09); C148(1.20)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C148(0.51); C129(1.01); C153(1.42)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C129(0.04); C148(1.07); C153(1.21)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C148(0.59); C153(1.28); C129(1.90)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C153(0.85); C129(1.40); C148(2.34)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C148(0.86); C129(0.97); C153(1.07)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C148(0.65); C153(1.17); C129(1.64)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C148(0.77); C153(1.11); C129(1.39)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C148(0.51); C129(1.05); C153(1.39)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C148(0.42); C129(1.55); C153(1.68)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C129(0.65); C148(0.74); C153(1.31)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C148(0.76); C153(1.37); C129(1.70)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C148(0.66); C129(0.70); C153(1.41)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C148(0.74); C129(0.75); C153(1.22)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C148(0.73); C129(0.74); C153(1.37)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C129(0.63); C148(0.97); C153(1.46)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C148(0.61); C129(0.70); C153(1.51)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C148(0.70); C129(0.83); C153(1.35)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C148(0.56); C129(0.67); C153(1.70)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C129(0.50); C148(0.63); C153(1.58)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C148(0.81); C129(0.94); C153(1.67)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C129(0.53); C148(0.55); C153(1.98)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C148(0.85); C129(1.03); C153(1.05)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C148(0.80); C153(1.06); C129(1.18)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C129(0.82); C148(1.05); C153(1.09)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C129(0.49); C148(0.82); C153(1.21)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C129(0.65); C153(0.93); C148(1.08)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C148(0.71); C129(1.01); C153(1.07)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C148(0.57); C129(0.82); C153(1.35)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C148(0.58); C129(0.78); C153(1.27)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C148(0.56); C129(0.74); C153(1.51)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C148(0.66); C129(0.86); C153(1.04)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C148(0.65); C153(1.10); C129(1.45)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C148(0.89); C129(0.96); C153(1.04)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C129(0.68); C148(0.82); C153(1.05)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C148(0.85); C129(0.95); C153(1.18)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C148(0.76); C129(0.79); C153(1.03)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C129(0.65); C148(0.96); C153(0.99)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C129(0.58); C148(0.59); C153(1.58)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C148(0.61); C129(1.25); C153(1.65)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C148(0.69); C129(1.34); C153(1.71)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C148(0.75); C129(0.96); C153(1.55)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C148(0.78); C129(1.15); C153(1.19)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C153(1.08); C129(1.15); C148(1.45)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C148(0.87); C153(1.08); C129(1.61)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C148(0.78); C153(1.37); C129(2.11)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C148(1.01); C153(1.03); C129(1.46)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C148(0.74); C129(1.54); C153(1.79)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C148(0.68); C129(1.52); C153(1.65)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C148(0.98); C129(1.46); C153(1.48)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C148(0.79); C153(1.33); C129(1.66)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C148(0.98); C153(1.13); C129(1.64)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C148(0.83); C153(1.37); C129(1.46)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C148(0.67); C153(1.58); C129(1.64)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C148(0.28); C129(0.43); C153(1.26)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C148(0.57); C129(0.86); C153(1.19)  LDD0683  [13]
 LDCM0545  Acetamide MDA-MB-231 C153(0.64)  LDD2138  [33]
 LDCM0520  AKOS000195272 MDA-MB-231 C153(0.80)  LDD2113  [33]
 LDCM0248  AKOS034007472 HCT 116 C129(0.52); C148(1.18); C153(1.08)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C129(0.55); C148(1.06); C153(1.15)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C148(0.54); C129(0.84); C153(1.47)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 13.01  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C129(0.92)  LDD0078  [13]
 LDCM0498  BS-3668 MDA-MB-231 C153(0.55)  LDD2091  [33]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C129(20.00); C153(1.23)  LDD2227  [21]
 LDCM0367  CL1 HCT 116 C129(0.83); C153(0.98); C148(1.19)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C129(0.90); C148(0.96); C153(1.70)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C129(0.39); C148(0.71); C153(1.25)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C129(0.70); C148(0.76); C153(1.23)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C129(0.43); C148(0.90); C153(0.96)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C129(0.61); C153(0.94); C148(1.45)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C129(0.85); C148(0.88); C153(1.01)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C148(0.59); C153(1.21); C129(1.26)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C148(0.82); C153(1.25); C129(1.27)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C148(0.64); C129(1.21); C153(1.30)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C148(0.84); C153(1.24); C129(1.53)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C148(0.76); C153(1.24); C129(1.68)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C148(0.79); C129(0.97); C153(1.96)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C148(0.54); C129(1.10); C153(1.26)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C148(0.80); C153(1.27); C129(1.57)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C129(0.64); C148(0.89); C153(1.04)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C148(0.55); C129(1.41); C153(1.43)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C148(0.66); C129(1.43); C153(1.78)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C148(0.65); C129(1.12); C153(1.28)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C148(0.78); C129(0.87); C153(1.15)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C148(0.56); C153(1.77); C129(4.37)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C129(0.80); C148(0.89); C153(1.12)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C148(0.86); C129(1.05); C153(1.26)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C148(0.75); C129(1.00); C153(1.92)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C148(0.88); C129(1.04); C153(1.08)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C148(0.89); C129(1.05); C153(1.17)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C148(0.84); C129(0.99); C153(1.13)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C148(0.55); C153(1.22); C129(1.27)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C148(0.56); C129(1.05); C153(1.31)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C129(0.60); C153(1.09); C148(1.33)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C129(0.72); C148(0.98); C153(1.23)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C148(0.84); C129(0.89); C153(1.23)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C148(0.67); C129(0.74); C153(1.31)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C148(0.97); C129(1.22); C153(1.52)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C129(1.03); C153(1.07); C148(1.12)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C148(0.81); C129(0.85); C153(1.45)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C148(0.63); C129(1.04); C153(1.15)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C129(0.71); C148(0.80); C153(1.11)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C153(1.12); C148(1.19); C129(1.48)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C148(0.71); C129(0.91); C153(1.12)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C129(0.79); C153(1.08); C148(1.27)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C148(0.59); C153(1.34); C129(1.36)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C148(0.51); C129(1.11); C153(1.40)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C148(0.57); C153(2.15); C129(3.84)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C148(0.64); C153(1.27); C129(3.02)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C129(1.39); C148(0.58); C153(1.58)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C129(1.06); C148(0.53); C153(1.53)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C129(1.19); C148(0.64); C153(1.32)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C129(0.92); C148(0.77); C153(1.22)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C129(1.22); C148(0.56); C153(1.32)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C129(1.63); C148(0.63); C153(1.34)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C129(1.01); C148(1.13); C153(1.13)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C129(1.47); C148(0.83); C153(1.09)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C129(0.53); C148(0.77); C153(1.12)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C148(0.77); C153(1.26)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C148(0.62); C153(1.07)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C148(0.52); C153(1.31)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C148(0.57); C153(1.57)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C148(0.57); C153(1.30)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C148(0.54); C153(1.38)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C148(0.56); C153(1.41)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C129(0.95); C148(0.98); C153(1.12)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C148(0.54); C153(1.35)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C148(0.65); C153(1.19)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C148(0.56); C153(2.00)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C148(0.59); C153(1.56)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C148(0.72); C153(1.41)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C148(0.54); C153(1.58)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C129(0.73); C148(1.59); C153(0.94)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C129(1.00); C148(1.42); C153(0.97)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C129(0.86); C148(1.69); C153(0.93)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C129(0.74); C148(1.12); C153(0.99)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C129(0.89); C148(1.16); C153(1.23)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C129(0.86); C148(1.43); C153(0.89)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C129(0.71); C148(1.56); C153(0.92)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C129(0.86); C148(1.27); C153(0.95)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C129(3.36); C148(1.12); C153(0.91)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C129(1.28); C148(1.17); C153(0.92)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C129(1.13); C148(1.37); C153(0.89)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C129(2.07); C148(1.16); C153(1.05)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C129(1.55); C148(1.16); C153(0.88)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C129(1.73); C148(1.41); C153(0.90)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C129(1.08); C148(1.13); C153(0.93)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C129(0.69); C148(1.10); C153(1.31)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C129(0.95); C148(1.35); C153(1.03)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C129(0.85); C148(0.91); C153(1.04)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C129(0.72); C148(0.95); C153(1.12)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C129(1.21); C148(0.90); C153(1.26)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C129(0.66); C148(0.78); C153(1.28)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C129(1.11); C148(0.65); C153(1.19)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C129(0.94); C148(1.24); C153(1.47)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C129(1.37); C148(1.16); C153(1.38)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C129(1.75); C148(1.01); C153(1.31)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C129(1.25); C148(1.23); C153(1.08)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C129(0.68); C148(0.81); C153(1.53)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C129(1.21); C148(0.99); C153(1.36)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C129(1.33); C148(1.08); C153(1.33)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C129(1.58); C148(0.87); C153(1.27)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C129(1.48); C148(1.17); C153(1.23)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C129(1.51); C148(1.14); C153(1.19)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C129(1.16); C148(0.49); C153(1.14)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C129(1.69); C148(0.54); C153(0.96)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C129(0.95); C148(0.65); C153(1.11)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C129(1.07); C148(0.51); C153(1.29)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C129(1.02); C148(0.63); C153(1.82)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C129(0.80); C148(0.85); C153(1.06)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C129(0.75); C148(0.68); C153(1.10)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C129(0.74); C148(0.54); C153(1.43)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C129(0.96); C148(0.54); C153(1.30)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C129(1.00); C148(0.47); C153(1.91)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C129(1.22); C148(0.49); C153(1.32)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C129(1.08); C148(0.72); C153(1.14)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C129(1.00); C148(0.67); C153(1.45)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C129(2.00); C148(0.59); C153(1.49)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C129(1.12); C148(0.56); C153(1.95)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C129(0.98); C148(0.90); C153(1.31)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C129(1.30); C148(0.78); C153(1.01)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C129(0.31); C148(1.05); C153(1.10)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C129(0.87); C148(0.89); C153(1.05)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C129(0.68); C148(1.04); C153(1.07)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C129(0.68); C148(0.89); C153(1.23)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C129(0.79); C148(0.90); C153(1.21)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C129(0.13); C148(1.19); C153(1.28)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C129(0.16); C148(1.03); C153(1.20)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C129(0.04); C148(0.78); C153(1.24)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C129(0.05); C148(0.80); C153(1.32)  LDD0811  [13]
 LDCM0495  E2913 HEK-293T C148(0.98); C153(1.35); C129(1.26)  LDD1698  [34]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C153(0.85)  LDD1702  [33]
 LDCM0625  F8 Ramos C153(1.41); C148(1.12); C129(0.85)  LDD2187  [35]
 LDCM0572  Fragment10 Ramos C153(1.05); C148(0.96); C129(1.04)  LDD2189  [35]
 LDCM0573  Fragment11 Ramos C153(0.11); C148(1.28); C129(0.46)  LDD2190  [35]
 LDCM0574  Fragment12 Ramos C153(0.94); C148(0.95); C129(1.10)  LDD2191  [35]
 LDCM0575  Fragment13 Ramos C153(1.43); C148(1.60); C129(1.47)  LDD2192  [35]
 LDCM0576  Fragment14 Ramos C153(0.70); C148(0.78); C129(0.65)  LDD2193  [35]
 LDCM0579  Fragment20 Ramos C153(0.85); C148(0.89); C129(1.06)  LDD2194  [35]
 LDCM0580  Fragment21 Ramos C153(1.74); C148(1.54); C129(1.37)  LDD2195  [35]
 LDCM0582  Fragment23 Ramos C153(1.68); C148(1.70); C129(1.01)  LDD2196  [35]
 LDCM0578  Fragment27 Ramos C153(1.77); C148(1.65); C129(1.48)  LDD2197  [35]
 LDCM0586  Fragment28 Ramos C153(0.73); C148(0.50); C129(1.03)  LDD2198  [35]
 LDCM0588  Fragment30 Ramos C153(2.16); C148(2.08); C129(1.55)  LDD2199  [35]
 LDCM0589  Fragment31 Ramos C153(1.64); C148(1.69); C129(1.61)  LDD2200  [35]
 LDCM0590  Fragment32 Ramos C153(0.89); C148(1.01); C129(0.98)  LDD2201  [35]
 LDCM0468  Fragment33 HCT 116 C129(1.18); C148(0.91); C153(1.20)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C153(1.19); C148(1.57); C129(1.46)  LDD2203  [35]
 LDCM0566  Fragment4 Ramos C153(0.64); C148(0.65); C129(0.78)  LDD2184  [35]
 LDCM0427  Fragment51 HCT 116 C148(0.35); C153(1.74)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C153(1.77); C148(1.80); C129(1.65)  LDD2204  [35]
 LDCM0614  Fragment56 Ramos C153(2.50); C148(2.02); C129(1.75)  LDD2205  [35]
 LDCM0569  Fragment7 Ramos C153(0.99); C148(0.64); C129(0.57)  LDD2186  [35]
 LDCM0571  Fragment9 Ramos C153(1.08); C148(0.98); C129(1.03)  LDD2188  [35]
 LDCM0116  HHS-0101 DM93 Y181(0.84); Y141(1.04)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y181(0.84); Y141(1.51)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y141(0.57); Y181(0.76)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y141(0.35); Y181(0.79)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y181(0.77); Y141(1.44)  LDD0268  [11]
 LDCM0107  IAA HeLa N.A.  LDD0221  [26]
 LDCM0123  JWB131 DM93 Y114(0.88); Y135(1.01); Y141(0.91); Y181(0.87)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y114(0.90); Y127(0.37); Y135(0.73); Y141(0.95)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y114(0.91); Y127(0.38); Y135(0.85); Y141(0.73)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y114(0.34); Y127(4.80); Y135(1.75); Y141(4.15)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y114(0.99); Y127(1.62); Y135(1.11); Y141(2.55)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y114(0.45); Y127(1.27); Y135(1.13); Y141(1.19)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y127(0.47); Y141(0.57); Y181(0.65)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y114(1.05); Y127(0.79); Y135(1.14); Y141(0.56)  LDD0292  [10]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [8]
 LDCM0022  KB02 HCT 116 C153(1.31)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C153(1.17)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C153(1.38)  LDD0082  [13]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C153(1.04)  LDD2102  [33]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C153(0.77)  LDD2121  [33]
 LDCM0109  NEM HeLa H16(0.00); H175(0.00); H112(0.00)  LDD0223  [26]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C153(0.70)  LDD2089  [33]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C153(1.43)  LDD2093  [33]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C153(1.19); C129(0.91); C148(0.96)  LDD2099  [33]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C153(0.80)  LDD2100  [33]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C129(0.65)  LDD2104  [33]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C153(1.11); C129(1.61)  LDD2105  [33]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C129(0.48)  LDD2106  [33]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C148(1.08)  LDD2107  [33]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C153(1.03)  LDD2108  [33]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C129(0.55)  LDD2109  [33]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C153(0.57); C129(0.71)  LDD2114  [33]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C153(0.55)  LDD2115  [33]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C153(1.11); C129(0.80)  LDD2123  [33]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C153(1.30)  LDD2124  [33]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C129(0.79); C148(0.80)  LDD2125  [33]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C153(1.58)  LDD2129  [33]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C148(1.02)  LDD2134  [33]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C129(1.08)  LDD2135  [33]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C153(2.35); C129(0.95)  LDD2136  [33]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C129(0.73); C148(1.04)  LDD2137  [33]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C153(1.10)  LDD2140  [33]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C153(0.63)  LDD2141  [33]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C153(2.92)  LDD2144  [33]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C153(1.05)  LDD2146  [33]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C153(0.65)  LDD2150  [33]
 LDCM0627  NUDT7-COV-1 HEK-293T C129(0.48)  LDD2206  [36]
 LDCM0628  OTUB2-COV-1 HEK-293T C153(0.74)  LDD2207  [36]
 LDCM0131  RA190 MM1.R C153(1.26); C129(1.16); C148(1.13)  LDD0304  [37]
 LDCM0021  THZ1 HCT 116 C153(1.12)  LDD2173  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Anterior gradient protein 3 (AGR3) AGR family Q8TD06
Ethanolamine kinase 1 (ETNK1) Choline/ethanolamine kinase family Q9HBU6
Amine oxidase [copper-containing] 3 (AOC3) Copper/topaquinone oxidase family Q16853
Extracellular superoxide dismutase [Cu-Zn] (SOD3) Cu-Zn superoxide dismutase family P08294
Peptidyl-prolyl cis-trans isomerase C (PPIC) Cyclophilin-type PPIase family P45877
Peptidyl-prolyl cis-trans isomerase B (PPIB) Cyclophilin-type PPIase family P23284
NADH-cytochrome b5 reductase 1 (CYB5R1) Flavoprotein pyridine nucleotide cytochrome reductase family Q9UHQ9
Glutathione peroxidase 7 (GPX7) Glutathione peroxidase family Q96SL4
Phospholipase A and acyltransferase 4 (PLAAT4) H-rev107 family Q9UL19
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 (ITPRIPL1) ITPRIP family Q6GPH6
Nucleoside diphosphate kinase 3 (NME3) NDK family Q13232
ATP-dependent (S)-NAD(P)H-hydrate dehydratase (NAXD) NnrD/CARKD family Q8IW45
Inactive ribonuclease-like protein 10 (RNASE10) Pancreatic ribonuclease family Q5GAN6
Signal peptide peptidase-like 2A (SPPL2A) Peptidase A22B family Q8TCT8
Procathepsin L (CTSL) Peptidase C1 family P07711
Transmembrane protease serine 11D (TMPRSS11D) Peptidase S1 family O60235
Endoplasmic reticulum resident protein 27 (ERP27) Protein disulfide isomerase family Q96DN0
E3 ubiquitin-protein ligase RNF144A (RNF144A) RBR family P50876
Disintegrin and metalloproteinase domain-containing protein 21 (ADAM21) . Q9UKJ8
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Sulfite oxidase, mitochondrial (SUOX) . P51687
Thioredoxin domain-containing protein 12 (TXNDC12) . O95881
Transporter and channel
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
FXYD domain-containing ion transport regulator 7 (FXYD7) FXYD family P58549
Glycophorin-A (GYPA) Glycophorin A family P02724
Membrane-spanning 4-domains subfamily A member 3 (MS4A3) MS4A family Q96HJ5
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) OST1 family P04843
Transferrin receptor protein 1 (TFRC) Peptidase M28 family P02786
Potassium voltage-gated channel subfamily A member 1 (KCNA1) Potassium channel family Q09470
Potassium voltage-gated channel subfamily A member 10 (KCNA10) Potassium channel family Q16322
Potassium voltage-gated channel subfamily E regulatory beta subunit 5 (KCNE5) Potassium channel KCNE family Q9UJ90
Syndecan-4 (SDC4) Syndecan proteoglycan family P31431
Uroplakin-3a (UPK3A) Uroplakin-3 family O75631
Neurensin-2 (NRSN2) VMP family Q9GZP1
Adiponectin (ADIPOQ) . Q15848
Transmembrane protein 174 (TMEM174) . Q8WUU8
Transmembrane protein 31 (TMEM31) . Q5JXX7
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3) BZIP family Q68CJ9
Interferon regulatory factor 3 (IRF3) IRF family Q14653
Interferon regulatory factor 5 (IRF5) IRF family Q13568
Fer3-like protein (FERD3L) . Q96RJ6
Zinc finger and BTB domain-containing protein 8B (ZBTB8B) . Q8NAP8
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Frizzled-7 (FZD7) G-protein coupled receptor Fz/Smo family O75084
Immunoglobulin
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctional adhesion molecule A (F11R) Immunoglobulin superfamily Q9Y624
B-cell antigen receptor complex-associated protein beta chain (CD79B) . P40259
Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2) . Q6ISS4
Cytokine and receptor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Osteopontin (SPP1) Osteopontin family P10451
Tumor necrosis factor ligand superfamily member 12 (TNFSF12) Tumor necrosis factor family O43508
Interleukin-6 receptor subunit beta (IL6ST) Type I cytokine receptor family P40189
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) . O14798
Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) . O14836
Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) . O75509
Tumor necrosis factor receptor superfamily member 27 (EDA2R) . Q9HAV5
Other
Click To Hide/Show 82 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-defensin 131A (DEFB131A) Beta-defensin family P59861
Beta-microseminoprotein (MSMB) Beta-microseminoprotein family P08118
Neutrophil gelatinase-associated lipocalin (LCN2) Lipocalin family P80188
CD99 antigen-like protein 2 (CD99L2) CD99 family Q8TCZ2
Reticulocalbin-1 (RCN1) CREC family Q15293
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Cystatin-SN (CST1) Cystatin family P01037
Dermokine (DMKN) Dermokine family Q6E0U4
Dickkopf-related protein 3 (DKK3) Dickkopf family Q9UBP4
Protein eva-1 homolog B (EVA1B) EVA1 family Q9NVM1
Pro-FMRFamide-related neuropeptide VF (NPVF) FARP (FMRFamide related peptide) family Q9HCQ7
Collagen alpha-2(I) chain (COL1A2) Fibrillar collagen family P08123
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) Fibulin family Q12805
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
P antigen family member 3 (PAGE3) GAGE family Q5JUK9
Galanin peptides (GAL) Galanin family P22466
Galanin-like peptide (GALP) Galanin family Q9UBC7
Gastric inhibitory polypeptide (GIP) Glucagon family P09681
VIP peptides (VIP) Glucagon family P01282
Progranulin (GRN) Granulin family P28799
Guanylin (GUCA2A) Guanylin family Q02747
Heat shock 70 kDa protein 13 (HSPA13) Heat shock protein 70 family P48723
Fibroblast growth factor 21 (FGF21) Heparin-binding growth factors family Q9NSA1
Radiation-inducible immediate-early gene IEX-1 (IER3) IER3 family P46695
Keratin, type II cytoskeletal 6A (KRT6A) Intermediate filament family P02538
Pancreatic adenocarcinoma up-regulated factor (ZG16B) Jacalin lectin family Q96DA0
Zymogen granule membrane protein 16 (ZG16) Jacalin lectin family O60844
Kinectin (KTN1) Kinectin family Q86UP2
Melanocortin-2 receptor accessory protein 2 (MRAP2) MRAP family Q96G30
Myeloid-derived growth factor (MYDGF) MYDGF family Q969H8
Alpha-sarcoglycan (SGCA) Sarcoglycan alpha/epsilon family Q16586
Serglycin (SRGN) Serglycin family P10124
Plasminogen activator inhibitor 1 (SERPINE1) Serpin family P05121
Serpin I2 (SERPINI2) Serpin family O75830
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0
Protein shisa-4 (SHISA4) Shisa family Q96DD7
Small cell adhesion glycoprotein (SMAGP) SMAGP family Q0VAQ4
Short transmembrane mitochondrial protein 1 (STMP1) STMP1 family E0CX11
Synaptotagmin-11 (SYT11) Synaptotagmin family Q9BT88
Synaptotagmin-4 (SYT4) Synaptotagmin family Q9H2B2
Transmembrane protein 98 (TMEM98) TMEM98 family Q9Y2Y6
Twisted gastrulation protein homolog 1 (TWSG1) Twisted gastrulation protein family Q9GZX9
Antileukoproteinase (SLPI) . P03973
BAG family molecular chaperone regulator 2 (BAG2) . O95816
Cadherin-15 (CDH15) . P55291
Complement C1q tumor necrosis factor-related protein 1 (C1QTNF1) . Q9BXJ1
Complement C1q tumor necrosis factor-related protein 5 (C1QTNF5) . Q9BXJ0
Complement C1q tumor necrosis factor-related protein 6 (C1QTNF6) . Q9BXI9
Complement C1q-like protein 4 (C1QL4) . Q86Z23
Endoplasmic reticulum resident protein 29 (ERP29) . P30040
Follistatin-related protein 1 (FSTL1) . Q12841
Insulin-like growth factor-binding protein 6 (IGFBP6) . P24592
Large proline-rich protein BAG6 (BAG6) . P46379
Leucine-rich single-pass membrane protein 2 (LSMEM2) . Q8N112
Leukosialin (SPN) . P16150
Linker for activation of T-cells family member 1 (LAT) . O43561
Macrophage colony-stimulating factor 1 (CSF1) . P09603
Myocilin (MYOC) . Q99972
Pre-B-cell leukemia transcription factor-interacting protein 1 (PBXIP1) . Q96AQ6
Probetacellulin (BTC) . P35070
Proline-rich acidic protein 1 (PRAP1) . Q96NZ9
Protein KASH5 (KASH5) . Q8N6L0
Protocadherin alpha-4 (PCDHA4) . Q9UN74
Protocadherin gamma-A4 (PCDHGA4) . Q9Y5G9
Protransforming growth factor alpha (TGFA) . P01135
Psoriasis susceptibility 1 candidate gene 2 protein (PSORS1C2) . Q9UIG4
Serine protease inhibitor Kazal-type 9 (SPINK9) . Q5DT21
Small integral membrane protein 14 (SMIM14) . Q96QK8
Small integral membrane protein 5 (SMIM5) . Q71RC9
Stromal cell-derived factor 2-like protein 1 (SDF2L1) . Q9HCN8
TPA-induced transmembrane protein (TTMP) . Q5BVD1
Transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2) . Q71RG4
Transmembrane protein 154 (TMEM154) . Q6P9G4
Trefoil factor 3 (TFF3) . Q07654
Ubiquilin-2 (UBQLN2) . Q9UHD9
Ubiquitin-like protein 4A (UBL4A) . P11441
Uncharacterized protein C5orf46 (C5orf46) . Q6UWT4
WAP four-disulfide core domain protein 12 (WFDC12) . Q8WWY7
WAP four-disulfide core domain protein 13 (WFDC13) . Q8IUB5
WAP four-disulfide core domain protein 5 (WFDC5) . Q8TCV5
WW domain binding protein 1-like (WBP1L) . Q9NX94

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
23 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
26 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
27 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
28 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
29 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
30 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
31 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
32 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
33 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
34 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
35 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
36 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
37 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.