Details of the Target

General Information of Target

Target ID LDTP04903
Target Name Actin-related protein 2 (ACTR2)
Gene Name ACTR2
Gene ID 10097
Synonyms
ARP2; Actin-related protein 2; Actin-like protein 2
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDE
ASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNR
EKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTR
RLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVL
VESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKH
IVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAV
LADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR
Target Bioclass
Other
Family
Actin family, ARP2 subfamily
Subcellular location
Cytoplasm, cytoskeleton
Function
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Uniprot ID
P61160
Ensemble ID
ENST00000260641.10
HGNC ID
HGNC:169
ChEMBL ID
CHEMBL6090

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FTC133 SNV: p.E377D DBIA    Probe Info 
HEC1B SNV: p.Q379R .
JURKAT SNV: p.P33L Compound 10    Probe Info 
MOLT4 SNV: p.S304Y IA-alkyne    Probe Info 
NCIH1944 SNV: p.R343L DBIA    Probe Info 
NCIH196 SNV: p.R214L DBIA    Probe Info 
SKMEL2 SNV: p.A142T DBIA    Probe Info 
SUPT1 SNV: p.A23V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 40 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		10.00  LDD0393  [1]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y91(17.46); Y72(9.45); Y378(5.88)  LDD0260  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [5]
STPyne
 Probe Info  		K118(5.94); K253(5.06); K299(6.87); K322(9.49)  LDD0277  [6]
ONAyne
 Probe Info  		N.A.  LDD0273  [6]
OPA-S-S-alkyne
 Probe Info  		K118(0.09); K381(2.70); K253(3.35); K368(3.41)  LDD3494  [7]
Probe 1
 Probe Info  		Y72(8.65); Y202(18.42); Y378(38.45)  LDD3495  [8]
DBIA
 Probe Info  		C20(1.70); C11(1.79); C226(2.38)  LDD3311  [9]
BTD
 Probe Info  		C11(1.11)  LDD1700  [10]
DA-P3
 Probe Info  		12.50  LDD0185  [11]
HPAP
 Probe Info  		3.03  LDD0062  [12]
EA-probe
 Probe Info  		N.A.  LDD0440  [13]
HHS-475
 Probe Info  		Y72(0.64)  LDD0264  [14]
HHS-465
 Probe Info  		Y310(7.90); Y91(2.75)  LDD2237  [15]
5E-2FA
 Probe Info  		N.A.  LDD2235  [16]
ATP probe
 Probe Info  		K19(0.00); K351(0.00); K299(0.00); K219(0.00)  LDD0199  [17]
m-APA
 Probe Info  		N.A.  LDD2231  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C20(0.00); C221(0.00); C11(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [19]
IPIAA_H
 Probe Info  		C221(0.00); C20(0.00)  LDD0030  [20]
IPIAA_L
 Probe Info  		C20(0.00); C221(0.00)  LDD0031  [20]
Lodoacetamide azide
 Probe Info  		C20(0.00); C221(0.00); C11(0.00)  LDD0037  [18]
ATP probe
 Probe Info  		K19(0.00); K351(0.00)  LDD0035  [21]
IPM
 Probe Info  		N.A.  LDD0025  [22]
NAIA_4
 Probe Info  		C11(0.00); C221(0.00)  LDD2226  [23]
TFBX
 Probe Info  		C221(0.00); C11(0.00)  LDD0027  [22]
WYneN
 Probe Info  		N.A.  LDD0021  [24]
Compound 10
 Probe Info  		C11(0.00); C20(0.00)  LDD2216  [25]
Compound 11
 Probe Info  		N.A.  LDD2213  [25]
SF
 Probe Info  		N.A.  LDD0028  [26]
1c-yne
 Probe Info  		N.A.  LDD0228  [27]
1d-yne
 Probe Info  		N.A.  LDD0357  [27]
Acrolein
 Probe Info  		C11(0.00); H87(0.00)  LDD0217  [28]
Methacrolein
 Probe Info  		N.A.  LDD0218  [28]
AOyne
 Probe Info  		11.20  LDD0443  [29]
NAIA_5
 Probe Info  		C20(0.00); C11(0.00); C221(0.00)  LDD2223  [23]
HHS-482
 Probe Info  		Y72(0.90)  LDD2239  [15]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		5.83  LDD0475  [30]
FFF probe9
 Probe Info  		11.93  LDD0470  [30]
STS-2
 Probe Info  		N.A.  LDD0138  [31]
VE-P
 Probe Info  		N.A.  LDD0396  [32]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [33]
STS-1
 Probe Info  		N.A.  LDD0068  [34]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C221(0.58)  LDD2142  [10]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C221(0.62)  LDD2112  [10]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C221(0.95)  LDD2130  [10]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C11(1.02)  LDD2117  [10]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C11(1.24)  LDD2152  [10]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C11(0.69)  LDD2132  [10]
 LDCM0214  AC1 HEK-293T C221(0.95); C20(1.03); C11(1.01)  LDD1507  [35]
 LDCM0215  AC10 HEK-293T C221(0.93); C20(1.19)  LDD1508  [35]
 LDCM0226  AC11 HEK-293T C221(0.95); C20(1.16)  LDD1509  [35]
 LDCM0237  AC12 HEK-293T C221(1.01); C20(1.17); C11(0.87)  LDD1510  [35]
 LDCM0259  AC14 HEK-293T C221(0.93); C20(1.08); C11(1.01)  LDD1512  [35]
 LDCM0270  AC15 HEK-293T C221(0.91); C20(1.01); C11(0.91)  LDD1513  [35]
 LDCM0276  AC17 HEK-293T C221(0.96); C20(1.14); C11(0.92)  LDD1515  [35]
 LDCM0277  AC18 HEK-293T C221(0.93); C20(1.03)  LDD1516  [35]
 LDCM0278  AC19 HEK-293T C221(0.91); C20(1.23)  LDD1517  [35]
 LDCM0279  AC2 HEK-293T C221(0.93); C20(1.12)  LDD1518  [35]
 LDCM0280  AC20 HEK-293T C221(0.94); C20(0.99); C11(0.94)  LDD1519  [35]
 LDCM0281  AC21 HEK-293T C221(0.97); C20(1.09)  LDD1520  [35]
 LDCM0282  AC22 HEK-293T C221(0.94); C20(1.07); C11(0.98)  LDD1521  [35]
 LDCM0283  AC23 HEK-293T C221(0.93); C20(1.04); C11(0.98)  LDD1522  [35]
 LDCM0284  AC24 HEK-293T C221(0.93); C20(1.04)  LDD1523  [35]
 LDCM0285  AC25 HEK-293T C221(0.94); C20(0.99); C11(1.00)  LDD1524  [35]
 LDCM0286  AC26 HEK-293T C221(0.95); C20(1.17)  LDD1525  [35]
 LDCM0287  AC27 HEK-293T C221(1.00); C20(1.19)  LDD1526  [35]
 LDCM0288  AC28 HEK-293T C221(1.05); C20(1.13); C11(0.91)  LDD1527  [35]
 LDCM0289  AC29 HEK-293T C221(0.97); C20(1.04)  LDD1528  [35]
 LDCM0290  AC3 HEK-293T C221(1.00); C20(1.00)  LDD1529  [35]
 LDCM0291  AC30 HEK-293T C221(0.93); C20(1.01); C11(1.15)  LDD1530  [35]
 LDCM0292  AC31 HEK-293T C221(0.97); C20(1.03); C11(1.03)  LDD1531  [35]
 LDCM0293  AC32 HEK-293T C221(0.95); C20(1.00)  LDD1532  [35]
 LDCM0294  AC33 HEK-293T C221(0.88); C20(1.02); C11(0.96)  LDD1533  [35]
 LDCM0295  AC34 HEK-293T C221(0.91); C20(1.15)  LDD1534  [35]
 LDCM0296  AC35 HEK-293T C221(0.94); C20(1.07)  LDD1535  [35]
 LDCM0297  AC36 HEK-293T C221(0.86); C20(1.06); C11(0.71)  LDD1536  [35]
 LDCM0298  AC37 HEK-293T C221(0.99); C20(1.13)  LDD1537  [35]
 LDCM0299  AC38 HEK-293T C221(0.87); C20(1.08); C11(1.13)  LDD1538  [35]
 LDCM0300  AC39 HEK-293T C221(0.95); C20(1.08); C11(0.91)  LDD1539  [35]
 LDCM0301  AC4 HEK-293T C221(0.94); C20(1.10); C11(0.84)  LDD1540  [35]
 LDCM0302  AC40 HEK-293T C221(0.99); C20(0.93)  LDD1541  [35]
 LDCM0303  AC41 HEK-293T C221(0.86); C20(1.05); C11(0.99)  LDD1542  [35]
 LDCM0304  AC42 HEK-293T C221(0.95); C20(1.35)  LDD1543  [35]
 LDCM0305  AC43 HEK-293T C221(0.93); C20(1.20)  LDD1544  [35]
 LDCM0306  AC44 HEK-293T C221(0.93); C20(1.19); C11(0.83)  LDD1545  [35]
 LDCM0307  AC45 HEK-293T C221(0.87); C20(1.16)  LDD1546  [35]
 LDCM0308  AC46 HEK-293T C221(0.93); C20(1.05); C11(0.98)  LDD1547  [35]
 LDCM0309  AC47 HEK-293T C221(0.96); C20(1.09); C11(0.95)  LDD1548  [35]
 LDCM0310  AC48 HEK-293T C221(0.97); C20(1.11)  LDD1549  [35]
 LDCM0311  AC49 HEK-293T C221(0.88); C20(1.08); C11(1.02)  LDD1550  [35]
 LDCM0312  AC5 HEK-293T C221(0.95); C20(1.07)  LDD1551  [35]
 LDCM0313  AC50 HEK-293T C221(0.93); C20(1.17)  LDD1552  [35]
 LDCM0314  AC51 HEK-293T C221(0.98); C20(1.16)  LDD1553  [35]
 LDCM0315  AC52 HEK-293T C221(0.95); C20(1.08); C11(0.86)  LDD1554  [35]
 LDCM0316  AC53 HEK-293T C221(0.91); C20(1.08)  LDD1555  [35]
 LDCM0317  AC54 HEK-293T C221(0.88); C20(1.03); C11(0.87)  LDD1556  [35]
 LDCM0318  AC55 HEK-293T C221(0.98); C20(1.08); C11(0.94)  LDD1557  [35]
 LDCM0319  AC56 HEK-293T C221(0.92); C20(1.06)  LDD1558  [35]
 LDCM0320  AC57 HEK-293T C221(0.92); C20(1.03); C11(0.98)  LDD1559  [35]
 LDCM0321  AC58 HEK-293T C221(0.95); C20(1.08)  LDD1560  [35]
 LDCM0322  AC59 HEK-293T C221(0.99); C20(1.14)  LDD1561  [35]
 LDCM0323  AC6 HEK-293T C221(0.94); C20(1.03); C11(1.05)  LDD1562  [35]
 LDCM0324  AC60 HEK-293T C221(0.98); C20(1.03); C11(0.92)  LDD1563  [35]
 LDCM0325  AC61 HEK-293T C221(0.99); C20(1.07)  LDD1564  [35]
 LDCM0326  AC62 HEK-293T C221(0.94); C20(1.02); C11(0.97)  LDD1565  [35]
 LDCM0327  AC63 HEK-293T C221(1.03); C20(0.97); C11(0.98)  LDD1566  [35]
 LDCM0328  AC64 HEK-293T C221(0.97); C20(1.04)  LDD1567  [35]
 LDCM0334  AC7 HEK-293T C221(0.99); C20(1.03); C11(0.86)  LDD1568  [35]
 LDCM0345  AC8 HEK-293T C221(0.98); C20(1.02)  LDD1569  [35]
 LDCM0520  AKOS000195272 MDA-MB-231 C11(0.77)  LDD2113  [10]
 LDCM0248  AKOS034007472 HEK-293T C221(0.96); C20(1.11)  LDD1511  [35]
 LDCM0356  AKOS034007680 HEK-293T C221(0.94); C20(1.04); C11(0.94)  LDD1570  [35]
 LDCM0275  AKOS034007705 HEK-293T C221(0.94); C20(1.11)  LDD1514  [35]
 LDCM0498  BS-3668 MDA-MB-231 C11(0.92)  LDD2091  [10]
 LDCM0087  Capsaicin HEK-293T 12.50  LDD0185  [11]
 LDCM0108  Chloroacetamide HeLa C11(0.00); H300(0.00); H87(0.00); H206(0.00)  LDD0222  [28]
 LDCM0632  CL-Sc Hep-G2 C20(0.85)  LDD2227  [23]
 LDCM0367  CL1 HEK-293T C221(0.94); C20(0.95)  LDD1571  [35]
 LDCM0368  CL10 HEK-293T C221(1.02); C20(0.91); C11(0.85)  LDD1572  [35]
 LDCM0369  CL100 HEK-293T C221(0.88); C20(1.03); C11(0.89)  LDD1573  [35]
 LDCM0370  CL101 HEK-293T C221(0.88); C20(1.01)  LDD1574  [35]
 LDCM0371  CL102 HEK-293T C221(0.97); C20(1.10)  LDD1575  [35]
 LDCM0372  CL103 HEK-293T C221(0.92); C20(1.06); C11(0.95)  LDD1576  [35]
 LDCM0373  CL104 HEK-293T C221(1.01); C20(1.07); C11(0.91)  LDD1577  [35]
 LDCM0374  CL105 HEK-293T C221(0.90); C20(1.03)  LDD1578  [35]
 LDCM0375  CL106 HEK-293T C221(0.93); C20(1.02)  LDD1579  [35]
 LDCM0376  CL107 HEK-293T C221(0.93); C20(1.07); C11(0.93)  LDD1580  [35]
 LDCM0377  CL108 HEK-293T C221(1.00); C20(0.98); C11(0.91)  LDD1581  [35]
 LDCM0378  CL109 HEK-293T C221(0.94); C20(1.05)  LDD1582  [35]
 LDCM0379  CL11 HEK-293T C221(1.30); C20(0.88); C11(0.93)  LDD1583  [35]
 LDCM0380  CL110 HEK-293T C221(0.93); C20(1.02)  LDD1584  [35]
 LDCM0381  CL111 HEK-293T C221(0.99); C20(1.00); C11(0.91)  LDD1585  [35]
 LDCM0382  CL112 HEK-293T C221(1.04); C20(1.02); C11(0.96)  LDD1586  [35]
 LDCM0383  CL113 HEK-293T C221(0.89); C20(1.06)  LDD1587  [35]
 LDCM0384  CL114 HEK-293T C221(0.94); C20(1.13)  LDD1588  [35]
 LDCM0385  CL115 HEK-293T C221(0.96); C20(1.19); C11(0.90)  LDD1589  [35]
 LDCM0386  CL116 HEK-293T C221(1.01); C20(1.06); C11(0.93)  LDD1590  [35]
 LDCM0387  CL117 HEK-293T C221(0.86); C20(1.04)  LDD1591  [35]
 LDCM0388  CL118 HEK-293T C221(0.95); C20(1.18)  LDD1592  [35]
 LDCM0389  CL119 HEK-293T C221(0.94); C20(1.06); C11(0.90)  LDD1593  [35]
 LDCM0390  CL12 HEK-293T C221(1.21); C20(0.86)  LDD1594  [35]
 LDCM0391  CL120 HEK-293T C221(0.94); C20(1.06); C11(0.95)  LDD1595  [35]
 LDCM0392  CL121 HEK-293T C221(0.95); C20(1.03)  LDD1596  [35]
 LDCM0393  CL122 HEK-293T C221(0.88); C20(1.08)  LDD1597  [35]
 LDCM0394  CL123 HEK-293T C221(0.90); C20(0.98); C11(0.93)  LDD1598  [35]
 LDCM0395  CL124 HEK-293T C221(0.95); C20(1.06); C11(0.85)  LDD1599  [35]
 LDCM0396  CL125 HEK-293T C221(1.01); C20(1.00)  LDD1600  [35]
 LDCM0397  CL126 HEK-293T C221(0.98); C20(1.03)  LDD1601  [35]
 LDCM0398  CL127 HEK-293T C221(0.94); C20(1.01); C11(0.87)  LDD1602  [35]
 LDCM0399  CL128 HEK-293T C221(1.02); C20(1.03); C11(0.92)  LDD1603  [35]
 LDCM0400  CL13 HEK-293T C221(0.89); C20(0.96)  LDD1604  [35]
 LDCM0401  CL14 HEK-293T C221(0.89); C20(1.15)  LDD1605  [35]
 LDCM0402  CL15 HEK-293T C221(1.02); C20(1.02); C11(0.80)  LDD1606  [35]
 LDCM0403  CL16 HEK-293T C221(0.99); C20(1.06); C11(0.86)  LDD1607  [35]
 LDCM0404  CL17 HEK-293T C221(0.91); C20(1.02); C11(0.81)  LDD1608  [35]
 LDCM0405  CL18 HEK-293T C221(0.95); C20(1.24)  LDD1609  [35]
 LDCM0406  CL19 HEK-293T C221(0.98); C20(1.20)  LDD1610  [35]
 LDCM0407  CL2 HEK-293T C221(0.99); C20(1.09)  LDD1611  [35]
 LDCM0408  CL20 HEK-293T C221(1.03); C20(1.23); C11(0.70)  LDD1612  [35]
 LDCM0409  CL21 HEK-293T C221(1.03); C20(1.16)  LDD1613  [35]
 LDCM0410  CL22 HEK-293T C221(1.07); C20(0.97); C11(0.85)  LDD1614  [35]
 LDCM0411  CL23 HEK-293T C221(1.25); C20(0.92); C11(0.96)  LDD1615  [35]
 LDCM0412  CL24 HEK-293T C221(1.06); C20(0.89)  LDD1616  [35]
 LDCM0413  CL25 HEK-293T C221(0.95); C20(0.91)  LDD1617  [35]
 LDCM0414  CL26 HEK-293T C221(1.01); C20(1.14)  LDD1618  [35]
 LDCM0415  CL27 HEK-293T C221(0.97); C20(1.02); C11(0.88)  LDD1619  [35]
 LDCM0416  CL28 HEK-293T C221(0.96); C20(1.01); C11(0.86)  LDD1620  [35]
 LDCM0417  CL29 HEK-293T C221(0.87); C20(1.04); C11(0.93)  LDD1621  [35]
 LDCM0418  CL3 HEK-293T C221(0.95); C20(1.31); C11(0.94)  LDD1622  [35]
 LDCM0419  CL30 HEK-293T C221(0.99); C20(1.19)  LDD1623  [35]
 LDCM0420  CL31 HEK-293T C221(1.04); C20(1.08)  LDD1624  [35]
 LDCM0421  CL32 HEK-293T C221(1.06); C20(1.13); C11(0.81)  LDD1625  [35]
 LDCM0422  CL33 HEK-293T C221(1.13); C20(1.27)  LDD1626  [35]
 LDCM0423  CL34 HEK-293T C221(1.00); C20(0.97); C11(1.15)  LDD1627  [35]
 LDCM0424  CL35 HEK-293T C221(1.12); C20(0.85); C11(0.87)  LDD1628  [35]
 LDCM0425  CL36 HEK-293T C221(1.09); C20(0.89)  LDD1629  [35]
 LDCM0426  CL37 HEK-293T C221(0.96); C20(0.92)  LDD1630  [35]
 LDCM0428  CL39 HEK-293T C221(1.00); C20(1.13); C11(0.90)  LDD1632  [35]
 LDCM0429  CL4 HEK-293T C221(1.01); C20(1.02); C11(0.79)  LDD1633  [35]
 LDCM0430  CL40 HEK-293T C221(0.92); C20(1.03); C11(0.86)  LDD1634  [35]
 LDCM0431  CL41 HEK-293T C221(0.91); C20(1.07); C11(0.97)  LDD1635  [35]
 LDCM0432  CL42 HEK-293T C221(0.97); C20(1.17)  LDD1636  [35]
 LDCM0433  CL43 HEK-293T C221(1.01); C20(1.27)  LDD1637  [35]
 LDCM0434  CL44 HEK-293T C221(1.01); C20(1.06); C11(0.69)  LDD1638  [35]
 LDCM0435  CL45 HEK-293T C221(1.09); C20(1.37)  LDD1639  [35]
 LDCM0436  CL46 HEK-293T C221(1.07); C20(0.94); C11(0.97)  LDD1640  [35]
 LDCM0437  CL47 HEK-293T C221(1.17); C20(0.89); C11(0.95)  LDD1641  [35]
 LDCM0438  CL48 HEK-293T C221(1.22); C20(0.94)  LDD1642  [35]
 LDCM0439  CL49 HEK-293T C221(0.89); C20(1.04)  LDD1643  [35]
 LDCM0440  CL5 HEK-293T C221(1.02); C20(1.00); C11(0.92)  LDD1644  [35]
 LDCM0441  CL50 HEK-293T C221(0.88); C20(1.17)  LDD1645  [35]
 LDCM0443  CL52 HEK-293T C221(0.97); C20(1.02); C11(0.86)  LDD1646  [35]
 LDCM0444  CL53 HEK-293T C221(0.91); C20(1.05); C11(0.89)  LDD1647  [35]
 LDCM0445  CL54 HEK-293T C221(0.97); C20(1.08)  LDD1648  [35]
 LDCM0446  CL55 HEK-293T C221(0.98); C20(1.17)  LDD1649  [35]
 LDCM0447  CL56 HEK-293T C221(1.00); C20(1.04); C11(0.73)  LDD1650  [35]
 LDCM0448  CL57 HEK-293T C221(0.96); C20(1.23)  LDD1651  [35]
 LDCM0449  CL58 HEK-293T C221(1.03); C20(1.01); C11(0.91)  LDD1652  [35]
 LDCM0450  CL59 HEK-293T C221(1.12); C20(0.88); C11(0.86)  LDD1653  [35]
 LDCM0451  CL6 HEK-293T C221(0.99); C20(1.20)  LDD1654  [35]
 LDCM0452  CL60 HEK-293T C221(1.11); C20(0.99)  LDD1655  [35]
 LDCM0453  CL61 HEK-293T C221(0.88); C20(0.95)  LDD1656  [35]
 LDCM0454  CL62 HEK-293T C221(0.93); C20(1.15)  LDD1657  [35]
 LDCM0455  CL63 HEK-293T C221(0.98); C20(0.97); C11(0.88)  LDD1658  [35]
 LDCM0456  CL64 HEK-293T C221(0.85); C20(1.00); C11(0.84)  LDD1659  [35]
 LDCM0457  CL65 HEK-293T C221(0.88); C20(1.03); C11(0.94)  LDD1660  [35]
 LDCM0458  CL66 HEK-293T C221(1.01); C20(1.06)  LDD1661  [35]
 LDCM0459  CL67 HEK-293T C221(0.93); C20(1.14)  LDD1662  [35]
 LDCM0460  CL68 HEK-293T C221(0.96); C20(1.24); C11(0.77)  LDD1663  [35]
 LDCM0461  CL69 HEK-293T C221(1.05); C20(1.25)  LDD1664  [35]
 LDCM0462  CL7 HEK-293T C221(1.02); C20(1.08)  LDD1665  [35]
 LDCM0463  CL70 HEK-293T C221(1.05); C20(1.00); C11(1.00)  LDD1666  [35]
 LDCM0464  CL71 HEK-293T C221(1.19); C20(0.96); C11(0.87)  LDD1667  [35]
 LDCM0465  CL72 HEK-293T C221(1.01); C20(1.03)  LDD1668  [35]
 LDCM0466  CL73 HEK-293T C221(0.90); C20(0.94)  LDD1669  [35]
 LDCM0467  CL74 HEK-293T C221(0.89); C20(1.10)  LDD1670  [35]
 LDCM0469  CL76 HEK-293T C221(0.82); C20(1.04); C11(0.91)  LDD1672  [35]
 LDCM0470  CL77 HEK-293T C221(0.89); C20(1.09); C11(0.89)  LDD1673  [35]
 LDCM0471  CL78 HEK-293T C221(0.93); C20(1.21)  LDD1674  [35]
 LDCM0472  CL79 HEK-293T C221(1.02); C20(1.22)  LDD1675  [35]
 LDCM0473  CL8 HEK-293T C221(1.05); C20(1.07); C11(0.57)  LDD1676  [35]
 LDCM0474  CL80 HEK-293T C221(0.97); C20(1.26); C11(0.75)  LDD1677  [35]
 LDCM0475  CL81 HEK-293T C221(1.03); C20(1.22)  LDD1678  [35]
 LDCM0476  CL82 HEK-293T C221(0.95); C20(1.04); C11(0.97)  LDD1679  [35]
 LDCM0477  CL83 HEK-293T C221(1.11); C20(0.98); C11(0.86)  LDD1680  [35]
 LDCM0478  CL84 HEK-293T C221(1.03); C20(0.95)  LDD1681  [35]
 LDCM0479  CL85 HEK-293T C221(0.98); C20(0.88)  LDD1682  [35]
 LDCM0480  CL86 HEK-293T C221(0.97); C20(0.97)  LDD1683  [35]
 LDCM0481  CL87 HEK-293T C221(0.96); C20(0.91); C11(1.03)  LDD1684  [35]
 LDCM0482  CL88 HEK-293T C221(1.00); C20(1.10); C11(0.86)  LDD1685  [35]
 LDCM0483  CL89 HEK-293T C221(0.97); C20(0.98); C11(0.97)  LDD1686  [35]
 LDCM0484  CL9 HEK-293T C221(1.06); C20(1.15)  LDD1687  [35]
 LDCM0485  CL90 HEK-293T C221(1.00); C20(1.23)  LDD1688  [35]
 LDCM0486  CL91 HEK-293T C221(1.01); C20(1.14)  LDD1689  [35]
 LDCM0487  CL92 HEK-293T C221(0.91); C20(0.99); C11(0.62)  LDD1690  [35]
 LDCM0488  CL93 HEK-293T C221(0.99); C20(1.24)  LDD1691  [35]
 LDCM0489  CL94 HEK-293T C221(0.97); C20(1.08); C11(0.93)  LDD1692  [35]
 LDCM0490  CL95 HEK-293T C221(1.16); C20(0.87); C11(0.90)  LDD1693  [35]
 LDCM0491  CL96 HEK-293T C221(1.10); C20(1.00)  LDD1694  [35]
 LDCM0492  CL97 HEK-293T C221(0.95); C20(0.93)  LDD1695  [35]
 LDCM0493  CL98 HEK-293T C221(1.01); C20(1.01)  LDD1696  [35]
 LDCM0494  CL99 HEK-293T C221(0.87); C20(0.94); C11(0.84)  LDD1697  [35]
 LDCM0634  CY-0357 Hep-G2 C221(2.37)  LDD2228  [23]
 LDCM0495  E2913 HEK-293T C221(0.86); C20(0.97); C11(0.89)  LDD1698  [35]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C11(1.57)  LDD1702  [10]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [13]
 LDCM0625  F8 Ramos C11(1.00); C221(0.88); C20(2.45)  LDD2187  [36]
 LDCM0572  Fragment10 Ramos C11(0.71); C221(1.02)  LDD2189  [36]
 LDCM0573  Fragment11 Ramos C11(0.48); C20(4.58)  LDD2190  [36]
 LDCM0574  Fragment12 Ramos C11(0.70); C221(0.76)  LDD2191  [36]
 LDCM0575  Fragment13 Ramos C11(1.08); C221(1.05)  LDD2192  [36]
 LDCM0576  Fragment14 Ramos C11(0.90); C221(0.67); C20(0.70)  LDD2193  [36]
 LDCM0579  Fragment20 Ramos C11(0.61); C221(0.67)  LDD2194  [36]
 LDCM0580  Fragment21 Ramos C11(0.96); C221(0.95)  LDD2195  [36]
 LDCM0582  Fragment23 Ramos C11(1.10); C221(1.14)  LDD2196  [36]
 LDCM0578  Fragment27 Ramos C11(1.05); C221(0.82)  LDD2197  [36]
 LDCM0586  Fragment28 Ramos C11(0.71); C221(0.63); C20(0.66)  LDD2198  [36]
 LDCM0588  Fragment30 Ramos C11(1.17); C221(0.91)  LDD2199  [36]
 LDCM0589  Fragment31 Ramos C11(1.23); C221(1.18)  LDD2200  [36]
 LDCM0590  Fragment32 Ramos C11(0.60); C221(0.60)  LDD2201  [36]
 LDCM0468  Fragment33 HEK-293T C221(0.93); C20(1.01); C11(0.81)  LDD1671  [35]
 LDCM0596  Fragment38 Ramos C11(0.97); C221(0.93)  LDD2203  [36]
 LDCM0566  Fragment4 Ramos C11(0.89); C221(0.78); C20(0.84)  LDD2184  [36]
 LDCM0427  Fragment51 HEK-293T C221(0.88); C20(1.13)  LDD1631  [35]
 LDCM0610  Fragment52 Ramos C11(1.25); C221(0.80)  LDD2204  [36]
 LDCM0614  Fragment56 Ramos C11(1.30); C221(0.84)  LDD2205  [36]
 LDCM0569  Fragment7 Ramos C11(1.01); C221(0.67); C20(0.76)  LDD2186  [36]
 LDCM0571  Fragment9 Ramos C11(0.65); C221(0.77)  LDD2188  [36]
 LDCM0116  HHS-0101 DM93 Y72(0.64)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y72(0.62)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y72(0.61)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y72(0.58)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y72(0.56)  LDD0268  [14]
 LDCM0107  IAA HeLa H206(0.00); H87(0.00); H300(0.00); C11(0.00)  LDD0221  [28]
 LDCM0022  KB02 HEK-293T C11(0.97); C221(0.97); C20(1.02)  LDD1492  [35]
 LDCM0023  KB03 Jurkat C11(6.09)  LDD0315  [19]
 LDCM0024  KB05 G361 C20(1.70); C11(1.79); C226(2.38)  LDD3311  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C11(0.67)  LDD2121  [10]
 LDCM0109  NEM HeLa H206(0.00); H87(0.00); H300(0.00)  LDD0223  [28]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C221(1.28)  LDD2089  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C11(1.08)  LDD2093  [10]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C221(0.25); C11(0.30)  LDD2096  [10]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C11(0.95)  LDD2097  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C11(1.00)  LDD2099  [10]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C221(0.47)  LDD2100  [10]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C11(1.01)  LDD2101  [10]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C221(0.75)  LDD2104  [10]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C221(0.37)  LDD2106  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C221(1.30); C11(1.02)  LDD2107  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C11(0.56)  LDD2109  [10]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C221(0.98)  LDD2110  [10]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C11(0.51)  LDD2115  [10]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C221(0.26)  LDD2116  [10]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C221(0.39)  LDD2118  [10]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C221(1.25); C11(1.95)  LDD2119  [10]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C221(1.00); C11(0.53)  LDD2120  [10]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C11(0.29)  LDD2122  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C221(0.96); C11(0.90)  LDD2123  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C221(1.18)  LDD2125  [10]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C221(1.73)  LDD2127  [10]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C221(0.77)  LDD2128  [10]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C11(0.63)  LDD2133  [10]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C221(1.66); C11(1.39)  LDD2135  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C221(1.56); C11(1.43)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C11(0.93)  LDD2137  [10]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C11(1.11)  LDD1700  [10]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C221(1.03); C11(1.10)  LDD2140  [10]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C221(0.79); C11(0.70)  LDD2143  [10]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C221(1.79); C11(2.40)  LDD2144  [10]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C221(0.14)  LDD2145  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C11(0.99)  LDD2146  [10]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C221(2.12); C11(0.90)  LDD2147  [10]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C11(0.50)  LDD2148  [10]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C221(0.87)  LDD2150  [10]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C221(0.28); C11(0.42)  LDD2151  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C20(1.06); C221(0.54); C11(0.50)  LDD2206  [37]
 LDCM0628  OTUB2-COV-1 HEK-293T C11(0.97); C221(0.76); C20(0.60); C11(0.52)  LDD2207  [37]
 LDCM0014  Panhematin HEK-293T 3.03  LDD0062  [12]
 LDCM0131  RA190 MM1.R C221(1.32)  LDD0304  [38]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [33]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(2s)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-13-thiazolidin-4-one . DB08236
N-[2-(2-methyl-1h-indol-3-yl)Ethyl]Thiophene-2-carboxamide . DB08235

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
12 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
13 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
14 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
15 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
16 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
17 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
18 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
19 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
21 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
22 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
23 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
24 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
25 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
26 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
27 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
28 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
29 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
30 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
31 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
32 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
33 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
34 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
35 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
36 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
37 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
38 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.