Details of the Target

General Information of Target

Target ID LDTP02234
Target Name Tropomyosin beta chain (TPM2)
Gene Name TPM2
Gene ID 7169
Synonyms
TMSB; Tropomyosin beta chain; Beta-tropomyosin; Tropomyosin-2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKY
SESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA
DESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSE
ERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAE
FAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL
Target Bioclass
Other
Family
Tropomyosin family
Subcellular location
Cytoplasm, cytoskeleton
Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.
Uniprot ID
P07951
Ensemble ID
ENST00000378292.9
HGNC ID
HGNC:12011

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AZ-9
 Probe Info  		10.25  LDD0393  [2]
HHS-475
 Probe Info  		Y162(0.89); Y60(1.47)  LDD0264  [3]
HHS-465
 Probe Info  		Y162(10.00)  LDD2237  [4]
DBIA
 Probe Info  		C190(1.32)  LDD0532  [5]
N1
 Probe Info  		C190(0.00); D192(0.00)  LDD0245  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
IPM
 Probe Info  		C36(0.00); C190(0.00)  LDD0147  [7]
Acrolein
 Probe Info  		H153(0.00); C190(0.00); K189(0.00)  LDD0217  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
Methacrolein
 Probe Info  		K37(0.00); H153(0.00)  LDD0218  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0072  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C190(1.32)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C190(0.64)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C190(0.83)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C190(0.61)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C190(0.75)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C190(0.66)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C190(0.93)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C190(0.84)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C190(0.80)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C190(0.64)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C190(0.62)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C190(1.05)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C190(0.69)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C190(0.62)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C190(0.72)  LDD0546  [5]
 LDCM0237  AC12 HCT 116 C190(1.02)  LDD0554  [5]
 LDCM0246  AC128 HCT 116 C190(1.54)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C190(1.42)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C190(1.56)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C190(1.18)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C190(1.67)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C190(1.79)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C190(1.86)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C190(2.24)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C190(1.20)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C190(1.23)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C190(1.87)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C190(1.81)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C190(1.42)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C190(2.14)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C190(1.85)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C190(1.55)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C190(1.21)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C190(1.45)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C190(1.07)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C190(1.41)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C190(1.54)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C190(2.13)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C190(2.63)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C190(1.20)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C190(1.55)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C190(1.21)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C190(0.96)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C190(1.48)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C190(1.62)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C190(1.09)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C190(0.94)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C190(1.43)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C190(0.90)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C190(0.63)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C190(0.91)  LDD0595  [5]
 LDCM0280  AC20 HCT 116 C190(0.90)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C190(0.72)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C190(0.84)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C190(0.90)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C190(0.97)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C190(1.04)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C190(1.23)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C190(1.13)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C190(0.97)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C190(1.10)  LDD0606  [5]
 LDCM0291  AC30 HCT 116 C190(1.19)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C190(1.11)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C190(1.10)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C190(1.12)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C190(0.98)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C190(0.81)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C190(1.02)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C190(1.22)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C190(1.13)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C190(1.05)  LDD0617  [5]
 LDCM0302  AC40 HCT 116 C190(1.15)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C190(0.99)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C190(1.26)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C190(1.28)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C190(1.25)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C190(1.18)  LDD0624  [5]
 LDCM0320  AC57 HCT 116 C190(1.85)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C190(1.72)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C190(1.40)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C190(1.34)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C190(1.97)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C190(1.72)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C190(1.66)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C190(1.46)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C190(1.66)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C190(2.68)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C190(2.41)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C190(2.20)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C190(1.42)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C190(1.02)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C190(1.20)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C190(0.87)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C190(1.47)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C190(0.93)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C190(0.82)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C190(1.08)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C190(0.77)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C190(1.17)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C190(1.25)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C190(1.24)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C190(1.01)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C190(0.92)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C190(1.05)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C190(0.85)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C190(0.68)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C190(1.22)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C190(0.89)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C190(0.82)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C190(0.92)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C190(0.88)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C190(0.94)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C190(0.87)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C190(1.01)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C190(1.00)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C190(0.81)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C190(0.67)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C190(0.58)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C190(1.09)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C190(1.01)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C190(0.72)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C190(0.61)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C190(0.61)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C190(1.35)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C190(1.28)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C190(1.50)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.82  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C190(0.00); K189(0.00); H153(0.00)  LDD0222  [8]
 LDCM0367  CL1 HCT 116 C190(1.19)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C190(1.43)  LDD0685  [5]
 LDCM0370  CL101 HCT 116 C190(1.41)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C190(1.35)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C190(1.05)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C190(1.12)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C190(1.06)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C190(0.88)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C190(1.03)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C190(0.88)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C190(0.86)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C190(1.38)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C190(0.88)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C190(0.74)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C190(0.82)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C190(0.93)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C190(1.07)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C190(0.95)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C190(1.20)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C190(1.05)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C190(1.09)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C190(0.92)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C190(1.90)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C190(1.18)  LDD0708  [5]
 LDCM0396  CL125 HCT 116 C190(1.63)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C190(1.58)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C190(1.31)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C190(1.42)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C190(1.60)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C190(1.53)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C190(1.27)  LDD0719  [5]
 LDCM0407  CL2 HCT 116 C190(1.07)  LDD0724  [5]
 LDCM0418  CL3 HCT 116 C190(1.13)  LDD0735  [5]
 LDCM0429  CL4 HCT 116 C190(1.50)  LDD0746  [5]
 LDCM0440  CL5 HCT 116 C190(1.59)  LDD0757  [5]
 LDCM0451  CL6 HCT 116 C190(1.43)  LDD0768  [5]
 LDCM0453  CL61 HCT 116 C190(0.70)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C190(0.85)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C190(1.60)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C190(0.99)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C190(1.15)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C190(1.29)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C190(1.56)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C190(1.81)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C190(1.22)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C190(1.60)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C190(1.51)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C190(1.25)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C190(1.64)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C190(1.11)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C190(1.68)  LDD0784  [5]
 LDCM0473  CL8 HCT 116 C190(0.97)  LDD0790  [5]
 LDCM0484  CL9 HCT 116 C190(1.15)  LDD0801  [5]
 LDCM0468  Fragment33 HCT 116 C190(1.62)  LDD0785  [5]
 LDCM0116  HHS-0101 DM93 Y162(0.89); Y60(1.47)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y162(0.77); Y60(1.47)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y162(0.89); Y60(1.32)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y162(0.86); Y60(1.06)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y162(0.74); Y60(1.10)  LDD0268  [3]
 LDCM0107  IAA HeLa H153(0.00); K189(0.00); C190(0.00)  LDD0221  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
Superoxide dismutase [Cu-Zn] (SOD1) Cu-Zn superoxide dismutase family P00441
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SNARE-associated protein Snapin (SNAPIN) SNAPIN family O95295
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 229 (ZNF229) Krueppel C2H2-type zinc-finger protein family Q9UJW7
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Zinc finger protein 785 (ZNF785) Krueppel C2H2-type zinc-finger protein family A8K8V0
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
LRP chaperone MESD (MESD) MESD family Q14696
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
TCF3 fusion partner (TFPT) . P0C1Z6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.