Details of the Target

General Information of Target

Target ID LDTP11597
Target Name 182 kDa tankyrase-1-binding protein (TNKS1BP1)
Gene Name TNKS1BP1
Gene ID 85456
Synonyms
KIAA1741; TAB182; 182 kDa tankyrase-1-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAESGKRFKPSKYVPVSAAAIFLVGATTLFFAFTCPGLSLYVSPAVPIYNAIMFLFVLA
NFSMATFMDPGIFPRAEEDEDKEDDFRAPLYKTVEIKGIQVRMKWCATCRFYRPPRCSHC
SVCDNCVEEFDHHCPWVNNCIGRRNYRYFFLFLLSLTAHIMGVFGFGLLYVLYHIEELSG
VRTAVTMAVMCVAGLFFIPVAGLTGFHVVLVARGRTTNEQVTGKFRGGVNPFTNGCCNNV
SRVLCSSPAPRYLGRPKKEKTIVIRPPFLRPEVSDGQITVKIMDNGIQGELRRTKSKGSL
EITESQSADAEPPPPPKPDLSRYTGLRTHLGLATNEDSSLLAKDSPPTPTMYKYRPGYSS
SSTSAAMPHSSSAKLSRGDSLKEPTSIAESSRHPSYRSEPSLEPESFRSPTFGKSFHFDP
LSSGSRSSSLKSAQGTGFELGQLQSIRSEGTTSTSYKSLANQTRNGSLSYDSLLTPSDSP
DFESVQAGPEPDPPLGYTSPFLSARLAQQREAERHPRLVPTGPTHREPSPVRYDNLSRHI
VASLQEREKLLRQSPPLPGREEEPGLGDSGIQSTPGSGHAPRTSSSSDDSKRSPLGKTPL
GRPAVPRFGKPDGLRGRGVGSPEPGPTAPYLGRSMSYSSQKAQPGVSETEEVALQPLLTP
KDEVQLKTTYSKSNGQPKSLGSASPGPGQPPLSSPTRGGVKKVSGVGGTTYEISV
Target Bioclass
Other
Subcellular location
Nucleus
Uniprot ID
Q9C0C2
Ensemble ID
ENST00000358252.8
HGNC ID
HGNC:19081
ChEMBL ID
CHEMBL4295939

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.K1270R DBIA    Probe Info 
AU565 SNV: p.S1503F DBIA    Probe Info 
CHL1 Substitution: p.A944G DBIA    Probe Info 
COLO678 Substitution: p.A944G DBIA    Probe Info 
COLO829 SNV: p.P291S DBIA    Probe Info 
DU145 SNV: p.S519N; p.P1151H DBIA    Probe Info 
HCC15 Insertion: p.R483SfsTer191 DBIA    Probe Info 
HCT116 SNV: p.A1467V DBIA    Probe Info 
HCT15 SNV: p.E241K DBIA    Probe Info 
HT115 SNV: p.S712P DBIA    Probe Info 
JURKAT SNV: p.R1531K .
MEWO SNV: p.A78S DBIA    Probe Info 
MFE319 SNV: p.V489A DBIA    Probe Info 
NCIH196 SNV: p.Q666P DBIA    Probe Info 
NCIH2170 Insertion: p.G1400AfsTer5 DBIA    Probe Info 
REH SNV: p.K144N .
SW1573 Deletion: p.G1523DfsTer38; p.G1526AfsTer100 DBIA    Probe Info 
SW756 SNV: p.M81I DBIA    Probe Info 
TOV21G SNV: p.M1081I DBIA    Probe Info 
UMUC3 SNV: p.T1611R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AZ-9
 Probe Info  		7.75  LDD0393  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
STPyne
 Probe Info  		K1657(10.00); K1723(1.20); K827(8.71)  LDD0277  [4]
OPA-S-S-alkyne
 Probe Info  		K1680(2.22); K1676(2.22)  LDD3494  [5]
Probe 1
 Probe Info  		Y90(8.36); Y778(17.50); Y897(12.70); Y918(22.57)  LDD3495  [6]
BTD
 Probe Info  		C669(0.98)  LDD1700  [7]
Sulforaphane-probe2
 Probe Info  		1.81  LDD0160  [8]
DA-P3
 Probe Info  		9.42  LDD0179  [9]
AHL-Pu-1
 Probe Info  		C232(5.07); C1373(2.31)  LDD0168  [10]
EA-probe
 Probe Info  		N.A.  LDD0440  [11]
HHS-475
 Probe Info  		Y897(0.71); Y1122(1.06); Y778(1.42)  LDD0264  [12]
DBIA
 Probe Info  		C1114(1.25); C749(1.13); C1175(1.11); C794(1.05)  LDD0078  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [14]
Lodoacetamide azide
 Probe Info  		C1373(0.00); C1296(0.00)  LDD0037  [14]
NAIA_4
 Probe Info  		C232(0.00); C631(0.00); C716(0.00); C749(0.00)  LDD2226  [15]
NAIA_5
 Probe Info  		C794(0.00); C1443(0.00); C1324(0.00); C1373(0.00)  LDD2224  [15]
WYneN
 Probe Info  		C136(0.00); C1373(0.00); C1175(0.00)  LDD0021  [16]
WYneO
 Probe Info  		C232(0.00); C1373(0.00); C669(0.00)  LDD0022  [16]
aHNE
 Probe Info  		N.A.  LDD0001  [16]
ENE
 Probe Info  		N.A.  LDD0006  [16]
IPM
 Probe Info  		C1443(0.00); C1373(0.00); C136(0.00)  LDD0005  [16]
TFBX
 Probe Info  		C1373(0.00); C669(0.00); C1114(0.00); C1296(0.00)  LDD0148  [17]
VSF
 Probe Info  		C1175(0.00); C1443(0.00)  LDD0007  [16]
YN-1
 Probe Info  		N.A.  LDD0447  [18]
Phosphinate-6
 Probe Info  		C1690(0.00); C1373(0.00); C1175(0.00); C794(0.00)  LDD0018  [19]
Acrolein
 Probe Info  		C1373(0.00); C1296(0.00); C1114(0.00); C1175(0.00)  LDD0217  [20]
Methacrolein
 Probe Info  		C1175(0.00); C1373(0.00); C669(0.00); C232(0.00)  LDD0218  [20]
W1
 Probe Info  		C1324(0.00); C1296(0.00)  LDD0236  [21]
AOyne
 Probe Info  		8.00  LDD0443  [22]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		7.00  LDD0472  [23]
FFF probe13
 Probe Info  		12.04  LDD0476  [23]
FFF probe3
 Probe Info  		20.00  LDD0465  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C669(0.86); C232(1.24)  LDD2117  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1373(0.66)  LDD2132  [7]
 LDCM0025  4SU-RNA HEK-293T C232(5.07); C1373(2.31)  LDD0168  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C232(9.01)  LDD0169  [10]
 LDCM0214  AC1 HCT 116 C669(1.47); C1114(1.28); C1175(0.92); C136(0.83)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C1114(0.94); C1175(0.82); C136(1.03); C794(0.69)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C669(1.80); C1114(1.26); C1175(1.79); C136(1.14)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C669(1.47); C1114(0.93); C1175(1.45); C136(1.28)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C669(1.16); C1114(0.95); C1175(1.17); C136(1.05)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C669(1.57); C1114(1.19); C1175(1.70); C136(1.23)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C669(1.16); C1114(1.14); C1175(1.44); C136(0.92)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C669(1.48); C1114(1.05); C1175(1.70); C136(1.38)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C669(1.66); C1114(1.33); C1175(1.98); C136(1.57)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C669(1.25); C1114(1.15); C1175(1.68); C136(1.15)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C669(1.45); C1114(0.98); C1175(1.46); C136(1.20)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C669(1.00); C1114(0.81); C1175(1.45); C136(0.87)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C1114(1.03); C1175(0.97); C136(1.40); C794(0.79)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C669(1.44); C1114(1.07); C1175(1.96); C136(1.10)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C669(1.32); C1114(1.03); C1175(1.67); C136(1.34)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C669(1.24); C1114(1.07); C1175(1.64); C136(1.28)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C669(0.70); C1114(1.01); C1175(1.00); C136(0.90)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C669(0.68); C1114(1.08); C1175(1.13); C136(1.20)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C669(0.79); C1114(1.14); C1175(1.09); C136(1.00)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C669(0.82); C1114(1.05); C1175(1.19); C136(1.14)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C669(0.70); C1114(1.21); C1175(1.08); C136(1.17)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C669(0.90); C1114(1.12); C1175(1.06); C136(1.00)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C669(0.80); C1114(1.08); C1175(1.11); C136(1.03)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C1114(0.93); C1175(1.10); C136(0.99); C794(0.88)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C669(0.78); C1114(1.35); C1175(1.15); C136(0.82)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C669(0.85); C1114(1.12); C1175(0.89); C136(0.95)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C669(0.75); C1114(1.05); C1175(1.16); C136(1.19)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C669(0.67); C1114(0.97); C1175(0.83); C136(0.88)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C669(0.88); C1114(1.02); C1175(0.96); C136(0.94)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C669(0.69); C1114(1.08); C1175(1.16); C136(1.31)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C669(0.80); C1114(1.25); C1175(1.08); C136(1.38)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C669(0.64); C1114(1.34); C1175(0.96); C136(1.36)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C669(0.97); C1114(0.59); C1175(0.77); C136(0.39)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C669(0.89); C1114(0.68); C1175(0.63); C136(0.40)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C669(0.99); C1114(0.64); C1175(1.07); C136(0.40)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C669(0.61); C1114(0.69); C1175(0.75); C136(0.42)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C669(0.75); C1114(0.76); C1175(0.88); C136(0.49)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C669(0.79); C1114(0.68); C1175(0.78); C136(0.44)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C669(0.87); C1114(0.74); C1175(0.98); C136(0.63)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C669(0.95); C1114(0.62); C1175(0.85); C136(0.52)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C669(0.79); C1114(0.72); C1175(0.86); C136(0.65)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C669(0.60); C1114(0.82); C1175(1.09); C136(0.50)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C669(0.73); C1114(0.77); C1175(0.96); C136(0.69)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C669(0.94); C1114(1.02); C1175(0.99); C136(0.57)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C1114(0.71); C1175(0.90); C136(0.97); C794(1.01)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C669(0.88); C1114(1.00); C1175(1.08); C136(0.53)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C669(0.83); C1114(0.93); C1175(1.06); C136(0.77)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C669(0.60); C1114(0.64); C1175(0.83); C136(0.49)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C669(1.44); C136(1.07); C1114(1.13); C794(1.27)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C1175(0.94); C136(1.16); C669(1.19); C794(1.27)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C1175(1.06); C794(1.14); C136(1.15); C669(1.17)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C1175(0.99); C794(1.10); C136(1.10); C669(1.29)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C1175(1.01); C136(1.01); C669(1.02); C794(1.48)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C1175(0.94); C136(1.04); C669(1.60); C794(1.68)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C136(1.06); C1175(1.11); C794(1.25); C669(1.39)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C1114(0.69); C1175(0.90); C136(0.93); C794(1.21)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C1175(0.98); C136(1.10); C794(1.13); C669(1.23)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C1175(0.96); C669(1.07); C136(1.08); C794(1.17)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C136(1.05); C1175(1.07); C669(1.14); C794(1.16)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C136(1.06); C1175(1.14); C669(1.44); C794(2.61)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C669(1.21); C1114(2.02); C1175(1.13); C136(1.30)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C669(1.17); C1114(2.72); C1175(1.27); C136(1.22)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C669(1.15); C1114(1.95); C1175(1.22); C136(1.11)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C669(1.40); C1114(1.56); C1175(1.03); C136(1.19)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C794(0.51); C136(0.74); C1114(0.82); C1175(1.10)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C136(0.60); C794(0.73); C1175(1.05); C1114(1.09)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C794(0.57); C136(0.64); C1114(0.78); C1175(1.30)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C136(0.94); C1175(1.09); C794(1.18); C669(1.27)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C794(0.44); C1114(0.81); C136(0.86); C1175(1.19)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C794(0.47); C136(0.65); C1175(1.44); C1114(1.53)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C794(0.52); C136(0.69); C1114(0.99); C1175(1.18)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C794(0.46); C136(0.76); C1114(1.01); C1175(1.07)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C794(0.47); C1114(0.80); C136(0.88); C1175(1.13)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C1175(0.98); C1114(1.19); C136(1.40)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C136(1.34); C1175(1.38); C1114(1.38)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C1114(1.32); C136(1.39); C1175(1.54)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C1114(1.14); C1175(1.39); C136(1.60)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C1114(1.32); C1175(1.62); C136(1.64)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C136(0.96); C1175(0.98); C669(1.00); C794(1.09)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C136(0.83); C1114(1.12); C1175(1.12)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C136(1.12); C1175(1.26); C1114(1.51)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C1114(1.53); C136(1.65); C1175(1.71)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C1114(1.32); C1175(1.75); C136(2.44)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C1114(1.27); C1175(1.62); C136(1.85)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C1175(0.80); C1114(0.87)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C1114(0.85); C1175(1.02)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C1114(0.92); C1175(1.11)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C1114(0.78); C1175(0.96)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C1175(1.00); C1114(1.15)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C794(0.80); C136(0.90); C1175(0.92); C669(1.31)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C1114(0.88); C1175(0.92)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C1114(0.85); C1175(1.18)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C1114(0.81); C1175(1.04)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C1114(0.81); C1175(1.34)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C1114(0.86); C1175(1.29)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C1114(0.92); C1175(1.33)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C1114(1.20); C136(1.26); C1175(1.44)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C1114(1.12); C1175(1.17); C136(1.43)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C136(0.93); C1114(1.19); C1175(1.28)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C136(1.11); C1114(1.26); C1175(1.33)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C136(0.78); C794(0.89); C1175(0.90); C669(1.19)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C136(0.90); C1114(1.36); C1175(1.44)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C136(0.76); C1114(1.11); C1175(1.25)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C136(0.89); C1175(1.29); C1114(1.33)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C136(0.98); C1175(1.25); C1114(1.28)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C136(1.01); C1114(1.24); C1175(1.25)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C136(1.10); C1175(1.21); C1114(1.52)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C1114(1.33); C136(1.38); C1175(1.41)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C669(0.85); C136(1.20); C1175(1.31)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C136(1.02); C669(1.20); C1175(1.39)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C669(1.12); C1175(1.16); C136(1.17)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C1114(0.83); C136(0.85); C794(0.87); C1175(0.90)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C669(0.70); C1175(1.22); C136(1.25)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C669(0.84); C1175(1.10); C136(1.14)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C669(0.85); C1175(1.34); C136(1.45)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C669(0.65); C1175(1.23); C136(1.42)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C669(0.63); C136(1.17); C1175(1.25)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C1175(0.92); C669(1.23); C136(1.24)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C1175(0.88); C669(1.03); C136(1.18)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C669(0.96); C1175(1.03); C136(1.61)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C794(0.97); C1114(1.01); C1175(1.27); C669(6.26)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C794(1.17); C1114(1.23); C1175(1.32); C669(4.31)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C794(0.73); C1175(0.89); C1114(0.92); C136(0.99)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C794(1.03); C1175(1.22); C1114(1.45); C669(5.54)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C794(0.84); C1175(1.00); C1114(1.11); C669(2.60)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C1114(1.24); C794(1.30); C1175(1.61); C669(4.28)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C669(3.47); C1175(1.65); C1114(1.67); C794(2.15)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C1175(1.29); C1114(1.50); C794(1.69); C669(2.85)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C1175(1.60); C1114(1.85); C794(2.92); C669(3.35)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C1175(1.20); C794(1.33); C1114(1.37); C669(2.19)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C1175(1.32); C1114(1.34); C794(1.74); C669(4.66)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C1114(1.06); C794(1.16); C1175(1.23); C669(3.60)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C794(1.00); C1114(1.13); C1175(1.32); C669(11.56)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C1175(0.83); C136(1.12); C1114(1.32); C794(1.44)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C1175(1.18); C794(1.22); C1114(1.34); C669(2.14)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C794(0.83); C1175(1.08); C1114(1.13); C669(2.49)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C1175(1.51); C1114(1.88); C669(2.91); C794(3.02)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C1175(1.15); C1114(1.51); C669(1.73); C794(1.75)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C1175(1.26); C1114(1.27); C669(1.35); C136(1.47)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C136(1.00); C794(1.32); C1175(1.45); C1114(1.45)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C136(1.20); C1114(1.29); C1175(1.38); C794(1.49)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C136(1.04); C1114(1.18); C794(1.19); C1175(1.25)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C1114(1.21); C136(1.29); C1175(1.32); C794(1.47)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C136(1.30); C1175(1.45); C669(1.57); C1114(1.59)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C136(1.27); C1175(1.42); C1114(1.43); C794(1.45)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C1175(1.30); C669(1.35); C136(1.78); C1114(1.80)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C1175(1.26); C1114(1.37); C669(1.46); C136(1.61)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C136(1.14); C1114(1.21); C669(1.22); C1175(1.24)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C136(0.88); C1114(0.90); C669(0.91); C794(1.07)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C1114(1.12); C136(1.36); C1175(1.48); C669(1.68)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C669(0.75); C1114(0.99); C1175(1.24); C136(1.24)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C136(1.47); C1175(1.51); C669(1.83); C1114(1.91)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C136(1.18); C1114(1.60); C1175(1.68); C669(1.79)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C794(0.79); C1114(0.94); C136(1.14); C1175(1.41)  LDD0683  [13]
 LDCM0545  Acetamide MDA-MB-231 C1373(0.46)  LDD2138  [7]
 LDCM0248  AKOS034007472 HCT 116 C1114(0.86); C1175(0.94); C136(1.03); C794(1.05)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C794(0.75); C1175(1.02); C136(1.03); C1114(1.24)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C1114(0.79); C1175(0.91); C136(1.01); C794(1.09)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C1114(1.25); C749(1.13); C1175(1.11); C794(1.05)  LDD0078  [13]
 LDCM0498  BS-3668 MDA-MB-231 C1373(0.67)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C1324(0.00); C1114(0.00); C232(0.00); C669(0.00)  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C232(1.14); C716(0.53); C1175(0.26)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C1175(0.81); C669(0.99)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C669(0.72); C1175(1.14)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C794(0.85); C136(0.91); C1175(0.93); C669(1.68)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C136(0.80); C1114(0.83); C794(0.90); C1175(0.98)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C794(0.64); C1114(0.86); C136(0.99); C1175(1.19)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C1114(0.76); C794(0.79); C136(0.87); C1175(0.95)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C794(0.75); C136(0.85); C1114(0.90); C1175(1.01)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C794(0.57); C136(0.79); C1114(1.05); C1175(1.16)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C794(0.51); C136(0.68); C1114(0.97); C1175(1.35)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C136(0.73); C794(0.77); C1114(0.92); C1175(1.22)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C794(0.47); C136(0.77); C1114(1.27); C1175(1.36)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C136(0.90); C794(0.91); C1114(1.01); C1175(1.48)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C669(0.82); C1175(1.25)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C794(0.57); C1114(0.81); C136(0.85); C1175(1.34)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C794(0.55); C136(0.89); C1114(0.97); C1175(1.13)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C136(0.72); C1175(0.94); C1114(1.15)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C1175(1.40); C1114(1.42); C136(1.51)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C1175(1.08); C136(1.28); C1114(1.43)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C136(1.26); C1114(1.33); C1175(1.55)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C136(1.03); C1175(1.41); C1114(1.57)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C1175(0.93); C1114(1.22)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C1114(0.74); C1175(1.00)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C1114(0.99); C1175(1.14)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C669(0.89); C1175(1.41)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C1114(0.76); C1175(1.21)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C1175(1.27); C1114(1.43); C136(1.66)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C1175(1.20); C1114(1.28); C136(1.50)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C136(0.80); C1175(0.99); C1114(1.54)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C136(0.85); C1175(1.26); C1114(1.59)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C669(0.94); C1175(1.00); C136(1.45)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C1175(0.94); C669(1.03); C136(1.33)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C1175(0.94); C136(1.17); C669(1.27)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C669(0.95); C136(1.37); C1175(1.55)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C669(0.69); C1175(1.02)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C669(0.66); C1175(1.11)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C669(0.80); C1175(1.05)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C794(0.81); C1175(0.92); C1114(1.08); C669(1.14)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C1175(0.96); C1114(0.98); C136(1.34)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C1114(1.11); C1175(1.24); C136(1.53)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C1114(1.03); C136(1.12); C1175(1.35)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C669(0.75); C1175(0.86)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C136(1.19); C1114(1.22); C1175(1.54)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C1114(0.97); C136(1.34); C1175(2.13)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C136(1.03); C1114(1.05); C1175(2.67)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C1114(1.12); C1175(1.25); C136(1.37)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C1114(1.25); C1175(1.72); C136(1.84)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C1114(1.26); C1175(1.67); C136(1.53)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C1114(1.42); C1175(1.18); C136(1.40)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C1114(1.17); C1175(1.18); C136(1.59)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C1114(1.22); C1175(1.45); C136(2.41)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C1114(1.09); C1175(2.06); C136(1.63)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C669(0.73); C1175(1.01)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C1114(1.21); C1175(1.11); C136(1.46)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C669(0.81); C1175(1.03)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C669(1.19); C1114(1.03); C1175(0.99); C794(1.28)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C669(1.01); C1114(0.93); C1175(1.12); C794(0.90)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C669(0.95); C1114(0.99); C1175(1.14); C794(0.75)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C669(1.06); C1114(0.86); C1175(1.28); C794(0.91)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C669(0.94); C1114(0.78); C1175(1.33); C794(0.65)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C669(1.20); C1114(1.26); C1175(1.19); C794(0.83)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C669(1.20); C1114(0.92); C1175(1.18); C794(1.39)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C669(0.82); C1175(1.15)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C669(1.06); C1114(0.63); C1175(1.20); C794(0.91)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C669(1.01); C1114(0.79); C1175(1.21); C794(0.66)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C669(0.85); C1114(0.88); C1175(1.14); C794(0.67)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C669(1.12); C1114(0.89); C1175(1.17); C794(1.03)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C669(1.04); C1114(1.47); C1175(1.10); C794(0.89)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C669(1.13); C1114(0.81); C1175(1.03); C794(0.86)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C669(0.89); C1114(1.05); C1175(0.99); C136(1.09)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C669(0.79); C1114(1.00); C1175(0.94); C136(0.98)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C669(0.89); C1114(1.27); C1175(1.06); C136(1.32)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C669(0.74); C1114(0.96); C1175(1.10); C136(0.73)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C669(0.83); C1175(0.92)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C669(0.85); C1114(1.15); C1175(1.17); C136(0.88)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C669(0.97); C1114(0.96); C1175(1.15); C136(0.96)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C669(0.85); C1114(1.05); C1175(1.17); C136(1.68)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C669(0.96); C1114(1.07); C1175(1.05); C136(1.17)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C669(0.79); C1114(1.06); C1175(0.90); C136(0.92)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C669(0.57); C1114(0.91); C1175(1.16); C136(1.00)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C669(0.82); C1114(0.86); C1175(1.15); C136(1.06)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C669(0.71); C1114(0.90); C1175(1.00); C136(1.10)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C669(0.87); C1114(1.01); C1175(1.08); C136(1.78)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C669(0.91); C1114(0.92); C1175(1.12); C136(1.00)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C669(0.80); C1175(1.04)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C669(0.93); C1114(1.06); C1175(1.08); C136(1.15)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C669(0.86); C1114(1.29); C1175(1.13); C136(1.15)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C669(1.22); C1114(2.18); C1175(1.71); C136(1.17)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C669(1.03); C1114(1.24); C1175(1.50); C136(0.99)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C669(0.86); C1114(0.84); C1175(1.79); C136(0.98)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C669(0.84); C1114(1.22); C1175(0.93); C136(1.08)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C669(1.09); C1114(0.99); C1175(1.75); C136(1.12)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C669(0.91); C1114(1.13); C1175(1.42); C136(1.30)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C669(0.78); C1114(1.44); C1175(1.25); C136(1.04)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C669(1.26); C1114(1.32); C1175(1.15); C136(0.93)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C669(1.01); C1175(1.20)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C669(0.78); C1114(1.54); C1175(1.32); C136(1.30)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C669(0.87); C1114(1.32); C1175(1.55); C136(1.23)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C669(0.76); C1114(1.07); C1175(1.22); C136(1.15)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C669(0.89); C1114(0.85); C1175(1.29); C136(0.94)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C669(0.93); C1114(1.33); C1175(1.24); C136(1.09)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C669(0.76); C1114(0.91); C1175(0.73); C136(0.72)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C669(0.94); C1114(0.95); C1175(0.68); C136(0.70)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C669(1.24); C1114(0.87); C1175(0.95); C136(0.74)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C669(1.07); C1114(0.99); C1175(0.93); C136(0.59)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C669(1.02); C1175(1.40)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C669(0.97); C1114(0.83); C1175(0.91); C136(0.67)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C669(0.94); C1114(0.89); C1175(0.74); C136(0.68)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C669(0.80); C1114(0.93); C1175(0.68); C136(0.54)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C669(1.12); C1114(1.06); C1175(0.87); C136(0.52)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C669(0.82); C1114(1.06); C1175(0.98); C136(0.81)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C669(0.82); C1114(0.86); C1175(0.92); C136(0.92)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C669(0.89); C1114(0.96); C1175(0.77); C136(0.64)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C669(0.91); C1114(1.48); C1175(0.69); C136(0.55)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C669(0.89); C1114(0.90); C1175(0.91); C136(0.53)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C669(0.90); C1114(0.85); C1175(0.92); C136(0.63)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C669(0.81); C1175(1.01)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C669(0.86); C1114(0.74); C1175(0.67); C136(0.67)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C669(1.41); C1114(1.51); C1175(1.01); C136(0.80)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C669(1.70); C1114(1.46); C1175(1.11); C136(1.01)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C669(1.01); C1114(1.15); C1175(0.95); C136(0.87)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C669(2.07); C1114(1.36); C1175(0.90); C136(1.16)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C669(2.27); C1114(1.19); C1175(0.99); C136(0.93)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C669(1.30); C1114(1.20); C1175(1.09); C136(0.84)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C669(0.82); C1114(1.53); C1175(1.10); C136(0.92)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C669(1.18); C1114(1.54); C1175(1.14); C136(1.06)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C669(1.07); C1114(2.20); C1175(0.89); C136(1.05)  LDD0811  [13]
 LDCM0634  CY-0357 Hep-G2 C669(1.63); C1373(1.09); C794(1.08); C1175(1.07)  LDD2228  [15]
 LDCM0027  Dopamine HEK-293T 9.42  LDD0179  [9]
 LDCM0495  E2913 HEK-293T C136(1.15); C1373(0.74); C1175(0.92); C1296(0.95)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1443(1.06); C1373(1.00); C1175(0.83)  LDD1702  [7]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [11]
 LDCM0468  Fragment33 HCT 116 C669(1.03); C1114(1.21); C1175(1.37); C136(0.93)  LDD0785  [13]
 LDCM0427  Fragment51 HCT 116 C669(0.94); C1114(0.94); C1175(1.33); C794(0.73)  LDD0744  [13]
 LDCM0116  HHS-0101 DM93 Y897(0.71); Y1122(1.06); Y778(1.42)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y778(0.44); Y1122(0.88); Y897(6.28)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y90(0.05); Y778(0.73); Y1122(1.08); Y897(8.35)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y778(0.77); Y1122(1.02); Y897(9.24)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y778(0.97); Y1122(1.43); Y897(8.67)  LDD0268  [12]
 LDCM0107  IAA HeLa N.A.  LDD0221  [20]
 LDCM0022  KB02 HCT 116 C749(2.45); C1337(2.26); C1114(1.61); C794(1.57)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C749(1.34); C1337(1.92); C1114(1.36); C794(1.25)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C749(2.32); C1337(1.66); C1114(1.65); C794(1.65)  LDD0082  [13]
 LDCM0109  NEM HeLa H191(0.00); H1605(0.00); H1034(0.00)  LDD0223  [20]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1373(0.89); C232(0.62)  LDD2092  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1373(0.67)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C232(1.15)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1373(0.69)  LDD2100  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C232(0.95)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C669(1.64)  LDD2105  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1373(0.98)  LDD2107  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1373(1.08)  LDD2118  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1373(0.73)  LDD2122  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C232(0.98)  LDD2125  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C232(1.15)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C669(0.98)  LDD1700  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C232(0.96)  LDD2141  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C669(0.79)  LDD2146  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1373(0.32)  LDD2150  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C669(1.44)  LDD2153  [7]
 LDCM0003  Sulforaphane MDA-MB-231 1.81  LDD0160  [8]
 LDCM0021  THZ1 HCT 116 C669(1.32); C1175(1.19); C716(1.10); C794(0.95)  LDD2173  [13]
 LDCM0112  W16 Hep-G2 C1373(0.55)  LDD0239  [21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Poly [ADP-ribose] polymerase tankyrase-1 (TNKS) ARTD/PARP family O95271
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2) ARTD/PARP family Q9H2K2
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Four and a half LIM domains protein 2 (FHL2) . Q14192

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
9 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402