Details of the Target

General Information of Target

Target ID LDTP05652
Target Name Aspartyl/asparaginyl beta-hydroxylase (ASPH)
Gene Name ASPH
Gene ID 444
Synonyms
BAH; Aspartyl/asparaginyl beta-hydroxylase; EC 1.14.11.16; Aspartate beta-hydroxylase; ASP beta-hydroxylase; Peptide-aspartate beta-dioxygenase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGGHKNGRKGGLSGTSFFTWFMV
IALLGVWTSVAVVWFDLVDYEEVLGKLGIYDADGDGDFDVDDAKVLLGLKERSTSEPAVP
PEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHVEGEDLQQEDGPTGEPQ
QEDDEFLMATDVDDRFETLEPEVSHEETEHSYHVEETVSQDCNQDMEEMMSEQENPDSSE
PVVEDERLHHDTDDVTYQVYEEQAVYEPLENEGIEITEVTAPPEDNPVEDSQVIVEEVSI
FPVEEQQEVPPETNRKTDDPEQKAKVKKKKPKLLNKFDKTIKAELDAAEKLRKRGKIEEA
VNAFKELVRKYPQSPRARYGKAQCEDDLAEKRRSNEVLRGAIETYQEVASLPDVPADLLK
LSLKRRSDRQQFLGHMRGSLLTLQRLVQLFPNDTSLKNDLGVGYLLIGDNDNAKKVYEEV
LSVTPNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRFYFHLGDAMQRVGN
KEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPKETGYTELVKSLERNWKLIRDE
GLAVMDKAKGLFLPEDENLREKGDWSQFTLWQQGRRNENACKGAPKTCTLLEKFPETTGC
RRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANETKTWEEGKVLIFD
DSFEHEVWQDASSFRLIFIVDVWHPELTPQQRRSLPAI
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Aspartyl/asparaginyl beta-hydroxylase family
Subcellular location
Sarcoplasmic reticulum membrane; Endoplasmic reticulum membrane
Function
[Isoform 1]: Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.; [Isoform 8]: Membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells.
TTD ID
T52133
Uniprot ID
Q12797
DrugMap ID
TT2KHP7
Ensemble ID
ENST00000356457.9
HGNC ID
HGNC:757
ChEMBL ID
CHEMBL4680030

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.V159A DBIA    Probe Info 
CAL148 SNV: p.R378T DBIA    Probe Info 
DU145 SNV: p.S20T DBIA    Probe Info 
IGROV1 SNV: p.V259I .
KYSE510 Insertion: . DBIA    Probe Info 
LN18 SNV: p.T629R DBIA    Probe Info 
MDAMB436 SNV: p.K499N DBIA    Probe Info 
RL952 SNV: p.E580G DBIA    Probe Info 
SUDHL4 SNV: p.K336Ter .
TYKNU SNV: p.D194N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.44  LDD0402  [1]
AZ-9
 Probe Info  		4.02  LDD0393  [2]
W1
 Probe Info  		13.82  LDD0235  [3]
STPyne
 Probe Info  		K110(3.12); K339(10.00); K350(0.80); K356(9.21)  LDD0277  [4]
OPA-S-S-alkyne
 Probe Info  		K588(1.10); K609(1.47); K552(4.20); K110(4.50)  LDD3494  [5]
P12
 Probe Info  		18.43  LDD0202  [6]
BTD
 Probe Info  		C648(0.97)  LDD2093  [7]
DBIA
 Probe Info  		C641(0.85)  LDD0078  [8]
ATP probe
 Probe Info  		K350(0.00); K365(0.00)  LDD0199  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
ATP probe
 Probe Info  		K350(0.00); K503(0.00); K356(0.00); K8(0.00)  LDD0035  [11]
IPM
 Probe Info  		N.A.  LDD0025  [12]
Acrolein
 Probe Info  		C384(0.00); H127(0.00); H493(0.00); C660(0.00)  LDD0217  [13]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [13]
Crotonaldehyde
 Probe Info  		C384(0.00); C660(0.00); H675(0.00); C648(0.00)  LDD0219  [13]
Methacrolein
 Probe Info  		C384(0.00); C685(0.00); C641(0.00); C660(0.00)  LDD0218  [13]
AOyne
 Probe Info  		11.80  LDD0443  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C196
 Probe Info  		14.32  LDD1872  [16]
C322
 Probe Info  		5.70  LDD1988  [16]
FFF probe11
 Probe Info  		20.00  LDD0471  [17]
FFF probe13
 Probe Info  		20.00  LDD0475  [17]
FFF probe14
 Probe Info  		20.00  LDD0477  [17]
FFF probe9
 Probe Info  		20.00  LDD0470  [17]
STS-1
 Probe Info  		N.A.  LDD0136  [18]
STS-2
 Probe Info  		N.A.  LDD0138  [18]
OEA-DA
 Probe Info  		10.17  LDD0046  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C648(0.87); C641(0.57)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C648(0.99); C641(1.29)  LDD2152  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C641(0.50)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C648(0.62)  LDD2131  [7]
 LDCM0214  AC1 HCT 116 C641(0.94); C648(1.27); C660(1.29)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C641(0.91); C660(1.14)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C648(0.77); C660(0.88)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C648(0.68); C660(0.64)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C648(0.62); C660(0.78)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C648(0.57); C660(0.59)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C648(0.59); C660(0.95)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C648(0.55); C660(0.68)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C648(0.68); C660(0.68)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C648(0.55); C660(0.76)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C648(0.74); C660(0.63)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C648(0.65); C660(0.70)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C641(0.87); C660(1.25)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C648(0.59); C660(0.66)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C648(0.61); C660(0.60)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C648(0.65); C660(0.63)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C641(1.06); C648(1.25); C660(1.03)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C641(1.10); C648(0.97); C660(0.97)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C641(0.97); C648(0.80); C660(0.90)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C641(0.98); C648(0.90); C660(0.93)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C641(0.79); C648(1.03); C660(1.04)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C641(0.85); C648(0.95); C660(1.02)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C641(1.04); C648(0.78); C660(0.97)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C641(0.73); C660(1.35)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C641(0.93); C648(0.98); C660(0.94)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C641(0.82); C648(0.93); C660(1.10)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C641(1.17); C648(0.93); C660(0.93)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C641(0.90); C648(0.76); C660(1.13)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C641(0.93); C648(0.96); C660(1.04)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C641(1.06); C648(0.99); C660(0.94)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C641(1.46); C648(1.04); C660(0.92)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C641(0.85); C648(0.91); C660(0.97)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C660(0.72)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C660(0.99)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C660(0.80)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C660(1.04)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C660(1.11)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C660(0.99)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C660(0.83)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C660(0.88)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C660(0.97)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C660(0.96)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C660(0.87)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C660(0.97)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C641(0.79); C660(1.19)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C660(0.75)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C660(0.82)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C660(1.14)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C641(1.16); C660(1.06)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C660(0.93); C641(0.97)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C641(0.73); C660(1.02)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C641(0.75); C660(1.16)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C641(0.37); C660(0.85)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C641(0.31); C660(2.04)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C641(0.29); C660(1.83)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C641(0.88); C660(1.18)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C641(0.26); C660(1.15)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C641(0.93); C660(1.06)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C641(0.78); C660(1.07)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C641(0.46); C660(1.70)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C641(1.08); C660(0.90)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C641(1.61); C660(1.07)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C641(1.48); C660(0.90)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C641(1.21); C660(1.24)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C641(0.80); C660(1.05); C648(1.14)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C641(0.83); C648(0.83); C660(0.96)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C641(0.81); C660(0.95); C648(0.97)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C641(0.93); C648(1.00); C660(1.15)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C641(0.65); C648(0.97); C660(0.97)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C648(0.92); C660(1.04); C641(1.05)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C641(0.91); C660(1.06); C648(1.12)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C641(0.82); C660(0.99); C648(1.05)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C641(0.82); C648(0.95); C660(0.98)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C648(0.85); C660(0.87); C641(0.94)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C648(0.66); C641(0.81); C660(0.86)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C648(0.62); C641(0.75); C660(0.79)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C648(0.58); C641(0.71); C660(0.87)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C648(0.38); C641(0.68); C660(0.80)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C641(1.05); C648(1.14); C660(1.24)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C648(0.35); C660(0.66); C641(0.69)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C648(0.56); C641(0.82); C660(0.87)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C648(0.38); C641(0.60); C660(0.75)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C641(0.72); C648(0.72); C660(0.85)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C648(0.61); C641(0.71); C660(0.79)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C660(1.35); C641(1.35); C648(1.42)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C641(1.04); C648(1.13); C660(1.18)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C641(1.05); C660(1.39); C648(1.39)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C648(1.02); C660(1.12); C641(1.18)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C648(0.99); C660(1.19); C641(1.20)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C641(0.92); C660(1.27); C648(1.39)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C641(0.78); C660(1.03); C648(1.07)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C648(0.75); C660(1.25); C641(1.33)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C648(0.76); C641(0.86); C660(1.15)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C648(0.67); C660(1.08); C641(1.12)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C648(0.93); C641(0.95); C660(1.33)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C641(0.83); C648(1.00); C660(1.38)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C641(0.84); C660(0.88)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C641(0.89); C660(1.06)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C641(0.81); C660(1.00)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C641(0.58); C660(0.94)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C641(0.87); C648(1.01); C660(1.25)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C641(0.46); C660(0.89)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C660(0.87); C641(1.30)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C660(1.00); C641(1.00)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C641(0.75); C660(1.10)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C641(0.68); C660(0.92)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C641(0.48); C660(1.26)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C641(0.47); C660(1.00)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C660(1.13)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C660(0.88)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C660(0.89)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C641(0.77); C660(0.93)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C660(0.96)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C660(1.02)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C660(1.00)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C660(1.30)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C660(1.07)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C660(0.83)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C660(0.97)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C660(0.74)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C648(0.88); C660(1.04); C641(1.29)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C660(0.89); C641(0.94); C648(0.94)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C641(0.87); C660(1.01)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C641(0.63); C648(0.70); C660(0.77)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C660(1.16); C648(1.22); C641(1.29)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C648(0.69); C660(1.07); C641(1.15)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C641(0.56); C648(0.75); C660(0.84)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C641(0.65); C660(0.84); C648(1.18)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C648(0.61); C641(0.65); C660(0.85)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C641(0.79); C648(1.01); C660(1.05)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C648(0.71); C641(0.72); C660(0.93)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C648(0.73); C660(1.20); C641(1.25)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C648(0.61); C641(1.09); C660(1.19)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C641(0.82); C660(1.02)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C660(0.97); C641(1.08); C648(1.30)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C648(0.81); C660(1.18); C641(1.35)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C641(0.72); C648(0.90); C660(0.96)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C641(0.69); C660(0.85)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C641(0.78); C660(0.90)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C641(0.82); C660(1.10)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C641(0.81); C660(0.98)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C641(0.96); C660(1.10)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C641(0.69); C660(0.92)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C641(0.71); C660(0.91)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C641(1.05); C660(1.06)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C641(0.70); C660(0.86)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C641(0.66); C660(0.94)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C641(0.88); C660(1.16)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C641(0.97); C660(1.04)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C641(0.94); C660(1.27)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C641(0.78); C660(1.07)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C641(0.63); C660(0.89)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C648(0.33); C660(0.47)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C648(0.55); C660(0.80)  LDD0683  [8]
 LDCM0545  Acetamide MDA-MB-231 C641(0.53)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C641(0.89)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C641(0.96); C660(1.33)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C641(0.95); C660(1.34)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C641(0.48); C660(0.86)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 12.55  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C641(0.85)  LDD0078  [8]
 LDCM0088  C45 HEK-293T 18.43  LDD0202  [6]
 LDCM0108  Chloroacetamide HeLa C685(0.00); H725(0.00); C384(0.00); H690(0.00)  LDD0222  [13]
 LDCM0367  CL1 HCT 116 C641(1.04); C660(1.21)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C641(0.88); C660(1.08)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C641(1.02); C660(1.11); C648(1.12)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C641(0.91); C660(0.93)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C641(0.93); C660(1.08)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C641(0.85); C660(1.25)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C641(0.93); C660(1.27)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C648(0.80); C660(0.86); C641(1.01)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C660(0.83); C648(0.88); C641(1.06)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C641(0.85); C648(0.92); C660(0.92)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C641(0.61); C660(0.86); C648(1.07)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C641(0.79); C648(0.86); C660(0.90)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C641(0.78); C660(0.94)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C641(0.63); C660(0.87); C648(0.94)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C641(0.64); C648(0.70); C660(0.97)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C648(0.74); C660(0.76); C641(0.78)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C648(0.37); C641(0.66); C660(0.74)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C648(0.37); C641(0.74); C660(0.78)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C648(0.47); C641(0.70); C660(0.80)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C641(0.70); C648(0.71); C660(0.84)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C641(0.58); C660(0.81); C648(0.85)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C648(0.98); C660(1.14); C641(1.20)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C648(0.78); C660(1.09); C641(1.09)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C641(0.83); C660(0.90)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C648(0.68); C660(1.06); C641(1.13)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C641(0.76); C660(1.23)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C641(0.82); C660(0.99)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C641(0.53); C660(0.94)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C641(0.57); C660(1.04)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C660(1.06)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C660(0.97)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C660(1.28)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C660(1.03)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C660(1.01); C641(1.05)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C641(1.04); C660(1.12)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C641(0.98); C660(1.11)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C641(0.65); C648(0.85); C660(0.90)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C641(0.65); C660(0.89); C648(0.98)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C641(0.96); C648(1.02); C660(1.10)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C641(0.62); C648(0.82); C660(0.86)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C641(1.29); C660(1.64)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C641(0.53); C648(0.75); C660(0.78)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C641(0.42); C648(0.69); C660(0.69)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C641(0.36); C648(0.62); C660(0.65)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C641(0.81); C660(0.87); C648(0.88)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C641(0.47); C660(0.74); C648(0.79)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C641(0.56); C648(0.72); C660(0.70)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C641(0.74); C648(0.91); C660(0.88)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C641(0.60); C648(0.87); C660(0.93)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C641(0.54); C648(0.80); C660(0.76)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C641(0.57); C648(0.79); C660(0.88)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C641(1.06); C660(1.18)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C641(0.85); C648(0.83); C660(0.95)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C648(1.00); C660(0.76)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C660(0.87)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C660(0.85)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C660(0.72)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C660(0.78)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C660(0.68)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C660(0.67)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C660(0.78)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C641(1.13); C660(1.13)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C660(0.75)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C660(0.88)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C660(0.67)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C660(0.67)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C660(0.82)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C660(0.79)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C648(0.89); C660(1.27)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C648(0.91); C660(1.12)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C648(0.95); C660(1.27)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C648(0.96); C660(1.19)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C641(1.19); C660(1.13)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C648(0.94); C660(1.15)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C648(0.96); C660(1.23)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C648(0.75); C660(1.11)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C648(0.88); C660(1.01)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C648(0.98); C660(1.19)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C648(1.08); C660(1.19)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C648(0.94); C660(1.08)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C648(1.10); C660(1.17)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C648(0.87); C660(1.17)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C648(0.98); C660(1.14)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C641(1.19); C660(1.04)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C648(0.90); C660(1.34)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C641(1.14); C660(0.90)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C641(0.93); C660(0.87)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C641(0.77); C660(0.91)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C641(0.92); C660(0.97)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C641(0.75); C660(0.93)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C641(0.83); C660(0.81)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C641(0.88); C660(0.94)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C641(1.10); C660(0.95)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C641(0.63); C660(1.26)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C641(0.99); C660(1.10)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C641(0.72); C660(0.95)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C641(0.76); C660(0.96)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C641(0.81); C660(1.06)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C641(0.74); C660(0.96)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C641(0.71); C660(0.92)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C641(0.71); C660(1.13)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C641(0.78); C660(0.92)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C641(0.66); C660(0.94)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C641(0.57); C660(0.93)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C641(0.74); C660(0.85)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C641(0.73); C660(1.09)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C641(0.61); C660(0.97)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C641(0.42); C660(0.72)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C641(0.44); C660(0.91)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C641(0.31); C660(0.71)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C641(0.56); C660(0.99)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C641(0.82); C660(1.06)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C641(0.66); C660(1.06)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C641(0.40); C660(0.84)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C641(0.37); C660(0.74)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C641(1.27); C660(1.32)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C641(0.87); C660(1.13)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C641(0.95); C648(1.16); C660(1.11)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C641(0.90); C648(1.14); C660(0.99)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C641(0.98); C648(1.11); C660(1.07)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C641(1.12); C648(1.05); C660(1.11)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C641(0.93); C648(1.12); C660(0.96)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C641(0.85); C648(1.18); C660(1.09)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C641(0.87); C648(0.97); C660(1.08)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C641(0.88); C648(1.19); C660(1.16)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C641(0.91); C648(1.33); C660(1.14)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C660(1.16); C384(1.08); C641(1.05)  LDD1698  [20]
 LDCM0468  Fragment33 HCT 116 C641(0.91); C660(0.96)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C660(0.56)  LDD0744  [8]
 LDCM0107  IAA HeLa H127(0.00); C384(0.00); H690(0.00); H493(0.00)  LDD0221  [13]
 LDCM0022  KB02 HEK-293T C641(0.99); C384(1.01); C660(0.95)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C641(0.86); C384(1.02); C660(0.94)  LDD1497  [20]
 LDCM0024  KB05 G361 C704(2.47); C660(4.05); C648(6.55)  LDD3311  [21]
 LDCM0109  NEM HeLa H530(0.00); H127(0.00); H690(0.00); C384(0.00)  LDD0223  [13]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C648(0.97)  LDD2093  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C641(0.94)  LDD2097  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C648(1.03); C641(0.96)  LDD2099  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C641(0.98)  LDD2101  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C648(1.03); C641(1.02)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C641(0.90)  LDD2109  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C648(0.88); C641(0.94)  LDD2111  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C641(0.52)  LDD2115  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C648(0.96); C641(1.64)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C641(0.89)  LDD2120  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C641(0.89)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C648(0.92); C641(0.73)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C648(0.73); C641(0.84)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C641(0.79)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C648(1.13); C641(0.84)  LDD2129  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C641(1.05)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C648(1.09); C641(1.11)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C641(0.87)  LDD2137  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C648(0.93); C641(0.66)  LDD2140  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C641(1.26)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C641(2.37)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C648(0.81); C641(0.69)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C641(2.50)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C641(0.76)  LDD2148  [7]
 LDCM0021  THZ1 HCT 116 C641(1.01)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
ATPase GET3 (GET3) ArsA ATPase family O43681
Extracellular superoxide dismutase [Cu-Zn] (SOD3) Cu-Zn superoxide dismutase family P08294
Glutathione peroxidase 7 (GPX7) Glutathione peroxidase family Q96SL4
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Phospholipase A and acyltransferase 2 (PLAAT2) H-rev107 family Q9NWW9
Glycerophosphocholine cholinephosphodiesterase ENPP6 (ENPP6) Nucleotide pyrophosphatase/phosphodiesterase family Q6UWR7
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Proprotein convertase subtilisin/kexin type 4 (PCSK4) Peptidase S8 family Q6UW60
Ribonuclease H1 (RNASEH1) RNase H family O60930
Dehydrogenase/reductase SDR family member on chromosome X (DHRSX) Short-chain dehydrogenases/reductases (SDR) family Q8N5I4
UDP-glucuronosyltransferase 2B11 (UGT2B11) UDP-glycosyltransferase family O75310
Dermcidin (DCD) . P81605
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-defensin 1 (DEFB1) Beta-defensin family P60022
Huntingtin (HTT) Huntingtin family P42858
Organic solute transporter subunit beta (SLC51B) OST-beta family Q86UW2
Calsenilin (KCNIP3) Recoverin family Q9Y2W7
Kv channel-interacting protein 4 (KCNIP4) Recoverin family Q6PIL6
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein goosecoid-2 (GSC2) Paired homeobox family O15499
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glucose-dependent insulinotropic receptor (GPR119) G-protein coupled receptor 1 family Q8TDV5
Cytokine and receptor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-21 (IL21) IL-15/IL-21 family Q9HBE4
Secretoglobin family 1C member 2 (SCGB1C2) Secretoglobin family P0DMR2
Lymphotoxin-alpha (LTA) Tumor necrosis factor family P01374
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) . O14763
Other
Click To Hide/Show 33 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-2-macroglobulin receptor-associated protein (LRPAP1) Alpha-2-MRAP family P30533
Neutrophil gelatinase-associated lipocalin (LCN2) Lipocalin family P80188
Reticulocalbin-1 (RCN1) CREC family Q15293
Cystatin-SN (CST1) Cystatin family P01037
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) Dynein heavy chain family Q14204
Fibroblast growth factor-binding protein 1 (FGFBP1) Fibroblast growth factor-binding protein family Q14512
Galanin peptides (GAL) Galanin family P22466
Gastrin (GAST) Gastrin/cholecystokinin family P01350
Golgi membrane protein 1 (GOLM1) GOLM family Q8NBJ4
Guanylin (GUCA2A) Guanylin family Q02747
Insulin-like peptide INSL5 (INSL5) Insulin family Q9Y5Q6
Zymogen granule membrane protein 16 (ZG16) Jacalin lectin family O60844
Protein kish-B (TMEM167B) KISH family Q9NRX6
OCIA domain-containing protein 1 (OCIAD1) OCIAD1 family Q9NX40
Osteocalcin (BGLAP) Osteocalcin/matrix Gla protein family P02818
Parathyroid hormone (PTH) Parathyroid hormone family P01270
Pleiotrophin (PTN) Pleiotrophin family P21246
RELT-like protein 2 (RELL2) RELT family Q8NC24
Splicing factor 3A subunit 2 (SF3A2) SF3A2 family Q15428
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0
Protein shisa-like-1 (SHISAL1) Shisa family Q3SXP7
Small integral membrane protein 19 (SMIM19) SMIM19 family Q96E16
Syndecan-2 (SDC2) Syndecan proteoglycan family P34741
Basic salivary proline-rich protein 2 (PRB2) . P02812
Follicular dendritic cell secreted peptide (FDCSP) . Q8NFU4
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Proline-rich acidic protein 1 (PRAP1) . Q96NZ9
Serine protease inhibitor Kazal-type 1 (SPINK1) . P00995
Small integral membrane protein 11 (SMIM11) . P58511
Thioredoxin domain-containing protein 15 (TXNDC15) . Q96J42
Uncharacterized protein CXorf66 (CXorf66) . Q5JRM2
WAP four-disulfide core domain protein 12 (WFDC12) . Q8WWY7
WAP four-disulfide core domain protein 5 (WFDC5) . Q8TCV5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aspartic Acid Small molecular drug DB00128
Succinic Acid Small molecular drug DB00139

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
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Mass spectrometry data entry: PXD039908 , PXD029761
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD007570
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840