Details of the Target

General Information of Target

Target ID LDTP04224
Target Name MARCKS-related protein (MARCKSL1)
Gene Name MARCKSL1
Gene ID 65108
Synonyms
MLP; MRP; MARCKS-related protein; MARCKS-like protein 1; Macrophage myristoylated alanine-rich C kinase substrate; Mac-MARCKS; MacMARCKS
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGSQSSKAPRGDVTAEEAAGASPAKANGQENGHVKSNGDLSPKGEGESPPVNGTDEAAGA
TGDAIEPAPPSQGAEAKGEVPPKETPKKKKKFSFKKPFKLSGLSFKRNRKEGGGDSSASS
PTEEEQEQGEIGACSDEGTAQEGKAAATPESQEPQAKGAEASAASEEEAGPQATEPSTPS
GPESGPTPASAEQNE
Target Bioclass
Other
Family
MARCKS family
Subcellular location
Cytoplasm, cytoskeleton
Function
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems.
Uniprot ID
P49006
Ensemble ID
ENST00000329421.8
HGNC ID
HGNC:7142

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		10.00  LDD0393  [1]
TG42
 Probe Info  		5.11  LDD0043  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K106(5.76); K95(10.00); K99(9.82)  LDD0277  [4]
DBIA
 Probe Info  		C134(0.86)  LDD0078  [5]
ATP probe
 Probe Info  		K99(0.00); K95(0.00); K96(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [8]
ATP probe
 Probe Info  		N.A.  LDD0035  [9]
IPM
 Probe Info  		N.A.  LDD0025  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
NAIA_5
 Probe Info  		N.A.  LDD2224  [11]
1d-yne
 Probe Info  		N.A.  LDD0356  [12]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C134(0.65)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C134(0.91)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C134(0.98)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C134(1.36)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C134(1.17)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C134(1.35)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C134(1.32)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C134(1.46)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C134(1.07)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C134(1.38)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C134(1.12)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C134(0.97)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C134(0.90)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C134(0.86)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C134(0.79)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C134(1.31)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C134(1.41)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C134(1.12)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C134(1.30)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C134(1.73)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C134(1.35)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C134(1.40)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C134(1.26)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C134(0.81)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C134(1.39)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C134(1.40)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C134(1.21)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C134(1.10)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C134(1.17)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C134(1.27)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C134(1.50)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C134(1.53)  LDD0562  [5]
 LDCM0259  AC14 HCT 116 C134(1.10)  LDD0576  [5]
 LDCM0263  AC143 HCT 116 C134(0.89)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C134(1.59)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C134(1.13)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C134(1.29)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C134(1.45)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C134(2.00)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C134(1.57)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C134(0.99)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C134(0.99)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C134(1.15)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C134(1.26)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C134(2.43)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C134(1.63)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C134(1.59)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C134(1.15)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C134(0.96)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C134(1.29)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C134(1.10)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C134(1.45)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C134(0.76)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C134(1.65)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C134(1.52)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C134(1.23)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C134(1.14)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C134(1.18)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C134(1.68)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C134(1.19)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C134(2.04)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C134(1.57)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C134(2.27)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C134(0.78)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C134(1.53)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C134(1.30)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C134(2.07)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C134(2.45)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C134(1.68)  LDD0612  [5]
 LDCM0296  AC35 HEK-293T C134(1.07)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C134(0.93)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C134(0.89)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C134(1.11)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C134(0.91)  LDD1539  [17]
 LDCM0301  AC4 HCT 116 C134(0.43)  LDD0618  [5]
 LDCM0303  AC41 HEK-293T C134(0.97)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C134(1.08)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C134(1.06)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C134(0.99)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C134(0.80)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C134(0.89)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C134(1.02)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C134(0.91)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C134(1.08)  LDD0909  [5]
 LDCM0312  AC5 HCT 116 C134(0.51)  LDD0629  [5]
 LDCM0313  AC50 HEK-293T C134(0.98)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C134(1.31)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C134(1.00)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C134(1.27)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C134(1.13)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C134(0.95)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C134(0.99)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C134(0.63)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C134(0.71)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C134(0.64)  LDD0920  [5]
 LDCM0323  AC6 HCT 116 C134(0.95)  LDD0640  [5]
 LDCM0324  AC60 HEK-293T C134(0.91)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C134(0.94)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C134(0.90)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C134(0.90)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C134(0.80)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C134(0.86)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C134(0.68)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C134(0.58)  LDD0929  [5]
 LDCM0332  AC68 HCT 116 C134(1.17)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C134(1.19)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C134(0.92)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C134(0.92)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C134(0.80)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C134(1.27)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C134(1.74)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C134(1.40)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C134(2.37)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C134(1.40)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C134(1.22)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C134(1.30)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C134(1.23)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C134(1.03)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C134(1.02)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C134(1.06)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C134(2.11)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C134(2.15)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C134(1.27)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C134(1.06)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C134(1.43)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C134(1.04)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C134(1.25)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C134(1.33)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C134(0.71)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C134(2.94)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C134(2.11)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C134(1.27)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C134(1.16)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C134(1.26)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C134(1.72)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C134(1.35)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C134(2.86)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C134(0.89)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C134(0.90)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C134(0.86)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C134(1.18)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C134(0.86)  LDD0078  [5]
 LDCM0368  CL10 HEK-293T C134(0.88)  LDD1572  [17]
 LDCM0369  CL100 HCT 116 C134(0.42)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C134(1.08)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C134(1.19)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C134(0.92)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C134(1.03)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C134(1.09)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C134(1.04)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C134(1.17)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C134(1.25)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C134(1.15)  LDD0695  [5]
 LDCM0379  CL11 HEK-293T C134(1.08)  LDD1583  [17]
 LDCM0380  CL110 HCT 116 C134(1.28)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C134(1.50)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C134(1.25)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C134(2.03)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C134(0.90)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C134(1.74)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C134(1.53)  LDD0703  [5]
 LDCM0389  CL119 HEK-293T C134(0.94)  LDD1593  [17]
 LDCM0391  CL120 HEK-293T C134(1.02)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C134(1.05)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C134(1.03)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C134(1.11)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C134(1.10)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C134(0.75)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C134(0.84)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C134(0.75)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C134(0.94)  LDD0997  [5]
 LDCM0402  CL15 HEK-293T C134(0.88)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C134(1.21)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C134(1.00)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C134(1.10)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C134(0.94)  LDD1004  [5]
 LDCM0408  CL20 HEK-293T C134(1.01)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C134(1.01)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C134(1.13)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C134(0.80)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C134(0.85)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C134(0.97)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C134(0.75)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C134(0.76)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C134(0.90)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C134(0.88)  LDD1015  [5]
 LDCM0418  CL3 HEK-293T C134(1.04)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C134(0.91)  LDD1017  [5]
 LDCM0420  CL31 HCT 116 C134(1.77)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C134(1.28)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C134(1.49)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C134(2.22)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C134(2.07)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C134(1.59)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C134(3.26)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C134(2.28)  LDD0745  [5]
 LDCM0429  CL4 HEK-293T C134(1.08)  LDD1633  [17]
 LDCM0430  CL40 HCT 116 C134(1.84)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C134(2.01)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C134(3.98)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C134(2.48)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C134(1.69)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C134(3.71)  LDD0752  [5]
 LDCM0436  CL46 HEK-293T C134(1.03)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C134(1.24)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C134(0.91)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C134(1.27)  LDD1037  [5]
 LDCM0440  CL5 HEK-293T C134(1.05)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C134(0.89)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C134(1.58)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C134(1.22)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C134(1.58)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C134(1.24)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C134(0.87)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C134(1.01)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C134(1.79)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C134(1.60)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C134(1.37)  LDD1048  [5]
 LDCM0451  CL6 HEK-293T C134(0.98)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C134(1.61)  LDD1050  [5]
 LDCM0453  CL61 HEK-293T C134(0.89)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C134(1.34)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C134(0.90)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C134(1.62)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C134(1.05)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C134(1.25)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C134(1.10)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C134(0.91)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C134(0.97)  LDD1059  [5]
 LDCM0462  CL7 HEK-293T C134(1.07)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C134(0.81)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C134(0.79)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C134(0.99)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C134(1.09)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C134(0.82)  LDD1065  [5]
 LDCM0469  CL76 HEK-293T C134(0.94)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C134(0.93)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C134(1.31)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C134(1.01)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C134(0.55)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C134(0.93)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C134(0.97)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C134(1.11)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C134(1.02)  LDD1680  [17]
 LDCM0481  CL87 HEK-293T C134(0.95)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C134(0.99)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C134(1.04)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C134(0.70)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C134(0.72)  LDD1688  [17]
 LDCM0486  CL91 HCT 116 C134(0.54)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C134(0.50)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C134(0.49)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C134(0.59)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C134(0.37)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C134(0.43)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C134(0.44)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C134(0.57)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C134(0.60)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C134(1.13); C134(0.94)  LDD2228  [11]
 LDCM0495  E2913 HEK-293T C134(1.03)  LDD1698  [17]
 LDCM0468  Fragment33 HEK-293T C134(1.17)  LDD1066  [5]
 LDCM0427  Fragment51 HCT 116 C134(2.89)  LDD0744  [5]
 LDCM0022  KB02 HCT 116 C134(1.32)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C134(1.25)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C134(1.29)  LDD0082  [5]
 LDCM0131  RA190 MM1.R C134(1.50)  LDD0304  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysyl oxidase homolog 2 (LOXL2) Lysyl oxidase family Q9Y4K0

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.