Details of the Target

General Information of Target

Target ID LDTP05012
Target Name Small ribosomal subunit protein eS24 (RPS24)
Gene Name RPS24
Gene ID 6229
Synonyms
Small ribosomal subunit protein eS24; 40S ribosomal protein S24
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGF
RTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGT
AKANVGAGKKPKE
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eS24 family
Subcellular location
Cytoplasm
Function
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Uniprot ID
P62847
Ensemble ID
ENST00000372360.9
HGNC ID
HGNC:10411

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P8
 Probe Info  		10.00  LDD0451  [1]
AZ-9
 Probe Info  		4.06  LDD0393  [2]
C-Sul
 Probe Info  		6.55  LDD0066  [3]
TH211
 Probe Info  		Y76(14.34); Y81(8.61)  LDD0257  [4]
TH214
 Probe Info  		Y81(20.00); Y76(12.38)  LDD0258  [4]
TH216
 Probe Info  		Y76(15.41); Y81(15.30); Y97(7.51)  LDD0259  [4]
STPyne
 Probe Info  		K11(1.56); K21(10.00); K37(10.00); K68(1.32)  LDD0277  [5]
ONAyne
 Probe Info  		K11(0.00); K37(0.00); K99(0.00)  LDD0273  [5]
HHS-482
 Probe Info  		Y76(0.69); Y81(1.00); Y97(0.81)  LDD0285  [6]
HHS-475
 Probe Info  		Y97(0.84); Y81(1.19)  LDD0264  [7]
HHS-465
 Probe Info  		Y97(6.93)  LDD2237  [8]
ATP probe
 Probe Info  		K37(0.00); K68(0.00); K32(0.00); K122(0.00)  LDD0199  [9]
CY-1
 Probe Info  		K21(0.00); M23(0.00); Q22(0.00)  LDD0246  [10]
ATP probe
 Probe Info  		K68(0.00); K21(0.00); K37(0.00)  LDD0035  [11]
NHS
 Probe Info  		N.A.  LDD0010  [12]
OSF
 Probe Info  		N.A.  LDD0029  [13]
SF
 Probe Info  		Y76(0.00); K129(0.00); Y81(0.00); K83(0.00)  LDD0028  [13]
1c-yne
 Probe Info  		K21(0.00); K68(0.00); K49(0.00)  LDD0228  [14]
Acrolein
 Probe Info  		H63(0.00); H29(0.00); H94(0.00)  LDD0217  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C139
 Probe Info  		18.00  LDD1821  [16]
C313
 Probe Info  		27.47  LDD1980  [16]
C339
 Probe Info  		6.36  LDD2002  [16]
C348
 Probe Info  		13.93  LDD2009  [16]
FFF probe15
 Probe Info  		9.09  LDD0478  [17]
FFF probe3
 Probe Info  		5.53  LDD0464  [17]
STS-1
 Probe Info  		N.A.  LDD0137  [18]
STS-2
 Probe Info  		N.A.  LDD0138  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H29(0.00); H63(0.00); H94(0.00)  LDD0222  [15]
 LDCM0116  HHS-0101 DM93 Y97(0.84); Y81(1.19)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y97(0.90); Y81(10.47)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y97(0.92); Y81(1.18)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y81(0.81); Y97(0.98)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y81(0.74); Y97(0.79)  LDD0268  [7]
 LDCM0107  IAA HeLa H29(0.00); H63(0.00)  LDD0221  [15]
 LDCM0123  JWB131 DM93 Y76(0.69); Y81(1.00); Y97(0.81)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y76(0.86); Y81(1.12); Y97(0.67)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y76(0.84); Y81(1.96); Y97(0.95)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y76(1.94); Y81(3.20); Y97(2.22)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y76(1.30); Y81(2.71); Y97(1.61)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y76(0.86); Y81(1.47); Y97(0.84)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y76(0.59); Y81(0.50); Y97(0.39)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y76(0.70); Y81(1.24); Y97(0.96)  LDD0292  [6]
 LDCM0109  NEM HeLa H63(0.00); H29(0.00); H94(0.00)  LDD0223  [15]

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
11 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.