Details of the Target

General Information of Target

Target ID LDTP11535
Target Name Ras-related protein Rab-34 (RAB34)
Gene Name RAB34
Gene ID 83871
Synonyms
RAB39; RAH; Ras-related protein Rab-34; Ras-related protein Rab-39; Ras-related protein Rah
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKSLKSRLRRQDVPGPASSGAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVN
PGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKL
LQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRP
TICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYA
RIGDNLDILTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLE
IENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHE
ESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSR
SMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALE
CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE
ELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEM
EREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKS
LSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIE
KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKL
EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEK
IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKI
KDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI
VTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSE
EEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYT
EVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQR
CYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE
VSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEE
VLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNK
ITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV
IAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGLVC
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Cytoplasm
Function
Transport protein involved in the redistribution of lysosomes to the peri-Golgi region. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Involved in ciliogenesis. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function.
Uniprot ID
Q9BZG1
Ensemble ID
ENST00000301043.10
HGNC ID
HGNC:16519

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.G124E .
HCT15 SNV: p.E153Ter .
SW1990 Substitution: p.K254P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AZ-9
 Probe Info  		4.04  LDD0393  [2]
Jackson_1
 Probe Info  		10.60  LDD0122  [3]
STPyne
 Probe Info  		K252(10.00); K51(8.44)  LDD0277  [4]
BTD
 Probe Info  		C67(2.34)  LDD1699  [5]
AHL-Pu-1
 Probe Info  		C116(2.16)  LDD0171  [6]
DBIA
 Probe Info  		C38(1.80)  LDD0080  [7]
IA-alkyne
 Probe Info  		C19(0.00); C116(0.00)  LDD0162  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
TFBX
 Probe Info  		C116(0.00); C38(0.00); C40(0.00); C19(0.00)  LDD0027  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
WYneO
 Probe Info  		C19(0.00); C67(0.00)  LDD0022  [10]
IPM
 Probe Info  		C19(0.00); C38(0.00)  LDD0005  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
Acrolein
 Probe Info  		C38(0.00); C40(0.00)  LDD0217  [12]
Methacrolein
 Probe Info  		C19(0.00); C38(0.00)  LDD0218  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		20.11  LDD1753  [14]
C228
 Probe Info  		15.45  LDD1901  [14]
C235
 Probe Info  		17.63  LDD1908  [14]
C313
 Probe Info  		12.21  LDD1980  [14]
C314
 Probe Info  		13.45  LDD1981  [14]
C388
 Probe Info  		44.32  LDD2047  [14]
C390
 Probe Info  		21.11  LDD2049  [14]
C391
 Probe Info  		14.72  LDD2050  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C38(0.78)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C38(1.01); C40(0.87)  LDD2112  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C19(0.78); C38(0.97); C67(0.83); C40(0.93)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C38(1.02); C67(1.18)  LDD2152  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C19(0.98)  LDD2103  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C38(0.73)  LDD2132  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C38(0.86)  LDD2131  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C116(2.16)  LDD0171  [6]
 LDCM0214  AC1 HEK-293T C116(0.97); C19(0.92); C38(1.07)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C116(1.01); C19(1.09); C38(0.94); C40(0.99)  LDD1508  [15]
 LDCM0226  AC11 HEK-293T C116(0.94); C19(0.94); C40(0.89)  LDD1509  [15]
 LDCM0237  AC12 HEK-293T C116(1.04); C19(1.01); C38(0.98); C40(0.86)  LDD1510  [15]
 LDCM0259  AC14 HEK-293T C116(0.99); C19(0.98); C38(0.94)  LDD1512  [15]
 LDCM0270  AC15 HEK-293T C116(1.06); C19(0.96); C38(1.13)  LDD1513  [15]
 LDCM0276  AC17 HEK-293T C116(1.01); C19(0.88); C38(0.98)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C116(1.00); C19(1.08); C38(0.90); C40(0.92)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C116(1.29); C19(0.96); C40(0.62)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C116(0.94); C19(1.05); C38(0.96); C40(1.23)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C116(0.98); C19(0.96); C38(1.03); C40(0.82)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C116(0.97); C19(1.00); C38(0.91)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C116(0.84); C19(1.03); C38(0.99)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C116(1.03); C19(0.98); C38(1.09)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C116(0.99); C19(1.01); C38(0.92); C40(0.72)  LDD1523  [15]
 LDCM0285  AC25 HEK-293T C116(0.97); C19(0.93); C38(1.01)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C116(0.96); C19(1.06); C38(0.93); C40(0.90)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C116(0.90); C19(0.96); C40(1.05)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C116(1.02); C19(0.94); C38(0.89); C40(0.91)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C116(0.98); C19(1.01); C38(0.86)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C116(1.03); C19(0.96); C40(1.02)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C116(0.93); C19(1.03); C38(0.77)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C116(0.99); C19(0.98); C38(1.05)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C116(0.99); C19(0.95); C38(0.83); C40(0.84)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C116(0.95); C19(0.96); C38(0.98)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C116(1.00); C19(1.09); C38(1.03); C40(0.99)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C116(1.03); C19(0.93); C40(0.98)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C116(1.05); C19(1.01); C38(1.04); C40(1.38)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C116(1.00); C19(1.06); C38(0.89)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C116(1.02); C19(1.00); C38(0.92)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C116(1.06); C19(0.94); C38(0.92)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C116(0.99); C19(0.96); C38(0.96); C40(1.02)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C116(1.02); C19(1.01); C38(0.87); C40(0.77)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C116(0.96); C19(0.95); C38(1.03)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C116(0.99); C19(1.00); C38(1.01); C40(0.92)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C116(0.95); C19(0.99); C40(0.85)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C116(1.04); C19(0.98); C38(0.97); C40(0.93)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C116(0.96); C19(1.01); C38(0.96)  LDD1546  [15]
 LDCM0308  AC46 HEK-293T C116(1.02); C19(0.95); C38(1.02)  LDD1547  [15]
 LDCM0309  AC47 HEK-293T C116(1.04); C19(0.92); C38(1.04)  LDD1548  [15]
 LDCM0310  AC48 HEK-293T C116(1.02); C19(0.97); C38(1.00); C40(0.93)  LDD1549  [15]
 LDCM0311  AC49 HEK-293T C116(0.99); C19(1.05); C38(0.95)  LDD1550  [15]
 LDCM0312  AC5 HEK-293T C116(1.02); C19(0.95); C38(0.88)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C116(1.01); C19(1.09); C38(0.93); C40(0.81)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C116(0.96); C19(1.06); C40(0.98)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C116(1.05); C19(0.97); C38(0.92); C40(0.93)  LDD1554  [15]
 LDCM0316  AC53 HEK-293T C116(0.94); C19(0.99); C38(0.92)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C116(0.99); C19(0.98); C38(0.91)  LDD1556  [15]
 LDCM0318  AC55 HEK-293T C116(1.02); C19(0.95); C38(1.01)  LDD1557  [15]
 LDCM0319  AC56 HEK-293T C116(1.02); C19(1.00); C38(0.89); C40(0.86)  LDD1558  [15]
 LDCM0320  AC57 HEK-293T C116(0.97); C19(0.96); C38(1.04)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C116(1.04); C19(1.10); C38(0.97); C40(0.85)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C116(0.95); C19(1.01); C40(0.99)  LDD1561  [15]
 LDCM0323  AC6 HEK-293T C116(1.05); C19(0.92); C38(0.83)  LDD1562  [15]
 LDCM0324  AC60 HEK-293T C116(1.01); C19(1.01); C38(0.98); C40(1.11)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C116(0.94); C19(1.00); C38(0.89)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C116(0.97); C19(1.03); C38(0.94)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C116(1.02); C19(0.92); C38(1.09)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C116(1.03); C19(1.06); C38(0.86); C40(1.49)  LDD1567  [15]
 LDCM0334  AC7 HEK-293T C116(1.01); C19(0.96); C38(0.98)  LDD1568  [15]
 LDCM0345  AC8 HEK-293T C116(1.02); C19(0.96); C38(0.98); C40(0.72)  LDD1569  [15]
 LDCM0545  Acetamide MDA-MB-231 C38(0.46)  LDD2138  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C38(1.52); C67(1.03); C40(1.16)  LDD2113  [5]
 LDCM0248  AKOS034007472 HEK-293T C116(0.97); C19(0.95); C38(0.90)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C116(0.95); C19(0.96); C38(1.06)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C116(1.01); C19(0.98); C38(0.91); C40(0.94)  LDD1514  [15]
 LDCM0156  Aniline NCI-H1299 10.17  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C19(0.50); C38(0.64)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0367  CL1 HEK-293T C116(0.95); C19(1.12); C38(0.78)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C116(1.20); C19(0.93); C38(1.03)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C116(0.98); C19(0.95); C38(1.04)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C116(1.02); C19(0.95); C38(0.94)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C116(0.96); C19(0.96); C38(1.04); C40(0.93)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C116(1.00); C19(0.90); C38(0.91); C40(0.88)  LDD1576  [15]
 LDCM0373  CL104 HEK-293T C116(0.90); C19(0.96); C38(0.98)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C116(0.98); C19(0.98); C38(0.96)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C116(1.07); C19(0.93); C38(1.02); C40(0.84)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C116(1.03); C19(1.00); C38(0.92); C40(0.94)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C116(0.90); C19(0.99); C38(0.98)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C116(1.01); C19(1.03); C38(0.89)  LDD1582  [15]
 LDCM0379  CL11 HEK-293T C116(1.36); C19(0.93); C38(1.08)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C116(0.99); C19(0.91); C38(1.05); C40(0.89)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C116(1.01); C19(0.91); C38(0.94); C40(0.85)  LDD1585  [15]
 LDCM0382  CL112 HEK-293T C116(0.93); C19(1.03); C38(1.07)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C116(1.01); C19(0.97); C38(0.85)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C116(0.96); C19(0.97); C38(1.03); C40(0.93)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C116(1.04); C19(0.97); C38(0.97); C40(0.91)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C116(0.81); C19(1.02); C38(0.93)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C116(0.98); C19(0.96); C38(0.97)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C116(1.01); C19(1.03); C38(1.06); C40(0.94)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C116(1.03); C19(1.01); C38(0.94); C40(0.84)  LDD1593  [15]
 LDCM0390  CL12 HEK-293T C116(1.38); C19(1.07); C38(0.96); C40(0.98)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C116(0.87); C19(1.01); C38(0.96)  LDD1595  [15]
 LDCM0392  CL121 HEK-293T C116(0.99); C19(0.98); C38(0.92)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C116(0.97); C19(1.07); C38(0.99); C40(0.89)  LDD1597  [15]
 LDCM0394  CL123 HEK-293T C116(1.05); C19(0.88); C38(0.84); C40(0.76)  LDD1598  [15]
 LDCM0395  CL124 HEK-293T C116(0.97); C19(0.94); C38(0.90)  LDD1599  [15]
 LDCM0396  CL125 HEK-293T C116(1.04); C19(0.98); C38(0.86)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C116(1.01); C19(1.07); C38(0.97); C40(0.98)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C116(0.96); C19(1.04); C38(0.94); C40(0.97)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C116(0.87); C19(1.12); C38(0.95)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C116(1.02); C19(1.00); C38(0.91)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C116(1.00); C19(1.10); C38(0.89); C40(0.89)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C116(1.03); C19(0.98); C38(0.88); C40(0.67)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C116(1.00); C19(1.13); C38(0.94)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C116(1.00); C19(1.01); C38(0.99)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C116(1.12); C19(1.10); C38(0.98); C40(1.09)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C116(1.13); C19(0.97); C40(1.02)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C116(1.03); C19(1.03); C38(0.99); C40(0.84)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C116(1.26); C19(1.06); C38(1.06); C40(0.97)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C116(1.19); C19(0.98); C38(0.86)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C116(1.19); C19(1.10); C38(0.78)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C116(1.35); C19(1.00); C38(1.14)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C116(1.31); C19(1.11); C38(0.99); C40(1.37)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C116(0.97); C19(0.93); C38(0.76)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C116(0.98); C19(1.02); C38(0.94); C40(1.00)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C116(1.04); C19(1.06); C38(0.93); C40(0.90)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C116(0.99); C19(0.95); C38(0.94)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C116(1.00); C19(0.82); C38(1.08)  LDD1621  [15]
 LDCM0418  CL3 HEK-293T C116(1.03); C19(1.04); C38(0.93); C40(0.84)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C116(1.00); C19(1.06); C38(0.96); C40(0.95)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C116(1.05); C19(1.01); C40(1.14)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C116(1.15); C19(0.98); C38(1.07); C40(1.04)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C116(1.15); C19(0.86); C38(0.97)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C116(1.18); C19(1.04); C38(0.87)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C116(1.31); C19(0.99); C38(1.11)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C116(1.25); C19(0.96); C38(0.96); C40(1.53)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C116(0.95); C19(1.06); C38(0.80)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C116(0.98); C19(0.97); C38(0.92); C40(1.10)  LDD1632  [15]
 LDCM0429  CL4 HEK-293T C116(0.80); C19(1.04); C38(0.94)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C116(0.98); C19(0.98); C38(1.02)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C116(0.99); C19(0.95); C38(1.07)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C116(1.01); C19(1.19); C38(0.99); C40(0.99)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C116(1.05); C19(0.95); C40(1.03)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C116(1.25); C19(0.98); C38(1.10); C40(1.26)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C116(1.18); C19(0.93); C38(1.14)  LDD1639  [15]
 LDCM0436  CL46 HEK-293T C116(1.26); C19(0.95); C38(1.11)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C116(1.28); C19(0.98); C38(1.21)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C116(1.25); C19(0.98); C38(0.95); C40(1.11)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C116(0.97); C19(0.95); C38(0.84)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C116(1.04); C19(1.10); C38(1.12)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C116(1.01); C19(0.98); C38(0.99); C40(0.88)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C116(0.99); C19(0.98); C38(1.02)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C116(1.02); C19(1.01); C38(1.07)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C116(1.06); C19(0.98); C38(1.02); C40(0.77)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C116(1.13); C19(0.99); C40(0.99)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C116(1.20); C19(1.00); C38(1.09); C40(1.01)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C116(1.24); C19(0.52); C38(0.90)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C116(1.31); C19(1.01); C38(1.01)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C116(1.24); C19(0.96); C38(1.16)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C116(1.08); C19(1.18); C38(0.99); C40(0.81)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C116(1.27); C19(1.11); C38(1.02); C40(1.07)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C116(1.07); C19(1.03); C38(0.89)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C116(0.98); C19(1.03); C38(0.95); C40(0.81)  LDD1657  [15]
 LDCM0455  CL63 HEK-293T C116(0.99); C19(0.94); C38(0.92); C40(1.06)  LDD1658  [15]
 LDCM0456  CL64 HEK-293T C116(0.94); C19(0.92); C38(0.97)  LDD1659  [15]
 LDCM0457  CL65 HEK-293T C116(0.96); C19(1.03); C38(1.05)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C116(0.96); C19(1.07); C38(1.01); C40(0.98)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C116(1.00); C19(0.96); C40(1.07)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C116(1.18); C19(0.98); C38(0.98); C40(1.03)  LDD1663  [15]
 LDCM0461  CL69 HEK-293T C116(1.13); C19(0.93); C38(0.89)  LDD1664  [15]
 LDCM0462  CL7 HEK-293T C116(1.07); C19(0.98); C40(1.08)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C116(1.20); C19(0.95); C38(0.90)  LDD1666  [15]
 LDCM0464  CL71 HEK-293T C116(1.19); C19(0.90); C38(1.12)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C116(1.26); C19(1.05); C38(0.93); C40(0.96)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C116(0.96); C19(0.96); C38(0.96)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C116(0.94); C19(1.06); C38(1.02); C40(0.92)  LDD1670  [15]
 LDCM0469  CL76 HEK-293T C116(1.01); C19(0.95); C38(1.01)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C116(0.93); C19(0.92); C38(0.99)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C116(1.00); C19(1.06); C38(0.92); C40(1.06)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C116(1.11); C19(0.90); C40(0.81)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C116(1.16); C19(0.85); C38(1.05); C40(0.69)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C116(1.15); C19(1.00); C38(1.05); C40(1.28)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C116(1.13); C19(1.06); C38(0.89)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C116(1.16); C19(0.96); C38(0.94)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C116(1.21); C19(0.92); C38(1.04)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C116(1.20); C19(0.92); C38(0.94); C40(0.83)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C116(1.03); C19(1.02); C38(0.89)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C116(0.97); C19(1.02); C38(1.01); C40(0.85)  LDD1683  [15]
 LDCM0481  CL87 HEK-293T C116(1.00); C19(0.90); C38(0.96); C40(0.85)  LDD1684  [15]
 LDCM0482  CL88 HEK-293T C116(0.85); C19(0.94); C38(0.94)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C116(0.98); C19(0.89); C38(0.95)  LDD1686  [15]
 LDCM0484  CL9 HEK-293T C116(1.20); C19(1.05); C38(0.87)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C116(0.96); C19(0.90); C38(0.93); C40(0.84)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C116(0.99); C19(0.97); C40(1.05)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C116(1.10); C19(0.88); C38(0.96); C40(1.06)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C116(1.11); C19(0.93); C38(0.88)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C116(1.16); C19(0.94); C38(1.00)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C116(1.12); C19(0.79); C38(1.01)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C116(1.03); C19(0.94); C38(0.98); C40(1.43)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C116(1.00); C19(1.04); C38(0.83)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C116(0.94); C19(0.98); C38(0.96); C40(0.90)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C116(1.00); C19(0.94); C38(0.92); C40(0.95)  LDD1697  [15]
 LDCM0495  E2913 HEK-293T C116(1.03); C19(0.88); C38(0.89); C40(0.83)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C116(4.72); C40(3.51); C38(3.00); C19(2.42)  LDD1702  [5]
 LDCM0625  F8 Ramos C19(1.04); C116(3.68); 0.56  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C19(1.25); C116(1.16); 1.27  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C19(0.05); C116(2.01); 12.74  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C19(1.34); C116(1.07); 1.31  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C19(1.10); C116(0.95); 1.10  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C19(1.30); 0.46  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C19(2.11); C116(1.76); 1.93  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C19(1.00); C116(0.98); 0.93  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C19(0.84); C116(1.07); 1.36  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C19(0.87); C116(0.89); 0.89  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C19(0.70); C116(0.73); 0.97  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C19(1.06); C116(1.04); 1.02  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C19(0.94); C116(0.93); 1.48  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C19(1.45); 1.71  LDD2201  [16]
 LDCM0468  Fragment33 HEK-293T C116(1.01); C19(0.90); C38(0.95); C40(0.96)  LDD1671  [15]
 LDCM0596  Fragment38 Ramos C19(0.83); 1.29  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C19(1.38); 1.04  LDD2184  [16]
 LDCM0427  Fragment51 HEK-293T C116(1.02); C19(1.07); C38(0.95); C40(0.83)  LDD1631  [15]
 LDCM0610  Fragment52 Ramos C19(1.35); 0.92  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C19(1.27); C116(1.14); 1.33  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C19(1.56); C116(1.81); 0.72  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C19(1.99); 0.92  LDD2188  [16]
 LDCM0015  HNE MDA-MB-231 C19(0.81)  LDD0346  [16]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C38(1.80)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C38(1.45)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C38(1.61)  LDD0082  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C19(1.04); C67(0.83)  LDD2102  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C38(1.00)  LDD2121  [5]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C19(0.59); C38(0.88); C67(0.56)  LDD2089  [5]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C19(0.94)  LDD2090  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C19(0.87); C38(0.89); C67(0.72); C40(0.99)  LDD2092  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C38(1.05)  LDD2093  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C38(1.21)  LDD2094  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C38(0.24)  LDD2096  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C38(1.83); C67(1.35)  LDD2097  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C19(0.73); C38(0.97); C40(0.88)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C19(0.90); C67(1.15); C40(1.67)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C19(0.44); C38(1.08)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C19(0.83); C67(0.90)  LDD2101  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C38(1.03)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C19(1.19); C67(1.12)  LDD2105  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C19(0.94); C38(1.33); C40(1.29)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C38(0.78)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C19(0.93); C38(1.04); C40(1.03)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C19(1.00)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C38(0.73); C67(0.92)  LDD2114  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C19(0.46); C38(0.54); C67(0.85); C40(1.05)  LDD2115  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C19(0.88); C38(1.25); C40(1.08)  LDD2119  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C40(1.26)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C19(0.92); C38(0.76); C40(0.81)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C19(0.85); C38(1.01); C67(1.00); C40(0.84)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C19(0.99); C38(0.91); C40(0.82)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C38(1.20)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C19(1.02); C38(0.80)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C19(0.98); C38(1.10); C67(0.87)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C19(0.51); C38(1.06); C67(0.82); C40(0.86)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C19(1.01); C67(0.97)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C19(1.19); C38(1.55); C40(1.69)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C19(1.02); C38(0.99); C67(0.66); C40(0.81)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C40(2.11); C38(1.31)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C19(0.74); C38(1.17); C67(0.96); C40(1.30)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C19(0.73); C38(0.75); C67(0.64)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C19(1.09); C67(0.55)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C19(2.71); C38(1.55); C67(2.50); C40(1.76)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C19(0.80); C38(0.99); C40(0.99)  LDD2146  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C19(0.53); C38(0.68); C67(0.44); C40(0.65)  LDD2148  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C19(0.53)  LDD2150  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C19(1.27)  LDD2153  [5]
 LDCM0628  OTUB2-COV-1 HEK-293T C38(0.35)  LDD2207  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carbonic anhydrase-related protein (CA8) Alpha-carbonic anhydrase family P35219

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.