Details of the Target

General Information of Target

Target ID LDTP09176
Target Name Casein kinase II subunit alpha 3 (CSNK2A3)
Gene Name CSNK2A3
Gene ID 283106
Synonyms
CSNK2A1P; Casein kinase II subunit alpha 3; CK II alpha 3; EC 2.7.11.1; Casein kinase II alpha 1 polypeptide pseudogene
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWRLGCMLASMIFRKEPFFHGRDNYD
QLVRIAKFLGTEDLYGYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANVMSGISSVPT
PSPLGPLAGSPVIAAANPLGMPVPAATGAQQ
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Ser/Thr protein kinase family, CK2 subfamily
Function
Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.
Uniprot ID
Q8NEV1
Ensemble ID
ENST00000528848.3
HGNC ID
HGNC:2458
ChEMBL ID
CHEMBL3832943

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		10.00  LDD0393  [1]
TH211
 Probe Info  		Y307(20.00); Y182(5.05)  LDD0260  [2]
TH216
 Probe Info  		Y307(11.68)  LDD0259  [2]
STPyne
 Probe Info  		K102(8.74); K329(5.88)  LDD0277  [3]
BTD
 Probe Info  		C147(1.98)  LDD2093  [4]
HHS-475
 Probe Info  		Y325(0.88); Y323(1.17)  LDD0264  [5]
HHS-465
 Probe Info  		Y325(10.00)  LDD2237  [6]
DBIA
 Probe Info  		C147(0.44)  LDD0533  [7]
Ox-W18
 Probe Info  		W24(0.00); W33(0.00); W176(0.00)  LDD2175  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
W1
 Probe Info  		K102(0.00); R107(0.00); S106(0.00)  LDD0236  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C147(1.25)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C147(1.41)  LDD2152  [4]
 LDCM0216  AC100 HCT 116 C147(0.44)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C147(0.53)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C147(0.62)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C147(0.47)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C147(1.06)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C147(0.47)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C147(0.45)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C147(0.54)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C147(0.44)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C147(0.70)  LDD0542  [7]
 LDCM0227  AC110 HCT 116 C147(0.47)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C147(0.42)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C147(0.46)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C147(1.30)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C147(1.14)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C147(1.01)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C147(1.08)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C147(1.31)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C147(1.30)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C147(1.20)  LDD0553  [7]
 LDCM0238  AC120 HCT 116 C147(1.13)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C147(1.23)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C147(1.05)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C147(1.72)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C147(1.22)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C147(1.14)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C147(1.08)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C147(1.16)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C147(1.13)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C147(1.14)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C147(1.20)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C147(1.20)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C147(1.05)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C147(1.29)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C147(1.06)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C147(1.23)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C147(0.99)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C147(1.00)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C147(0.81)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C147(0.85)  LDD0575  [7]
 LDCM0260  AC140 HCT 116 C147(0.82)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C147(0.81)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C147(1.13)  LDD0579  [7]
 LDCM0285  AC25 HCT 116 C147(1.01)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C147(0.69)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C147(0.77)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C147(0.64)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C147(0.54)  LDD0606  [7]
 LDCM0291  AC30 HCT 116 C147(0.51)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C147(0.80)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C147(0.47)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C147(0.89)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C147(0.99)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C147(1.27)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C147(1.53)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C147(0.92)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C147(0.93)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C147(1.08)  LDD0617  [7]
 LDCM0302  AC40 HCT 116 C147(0.83)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C147(1.02)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C147(0.98)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C147(1.08)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C147(1.11)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C147(0.87)  LDD0624  [7]
 LDCM0365  AC98 HCT 116 C147(0.44)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C147(0.51)  LDD0683  [7]
 LDCM0108  Chloroacetamide HeLa C147(0.00); H286(0.00); H115(0.00); H183(0.00)  LDD0222  [9]
 LDCM0382  CL112 HCT 116 C147(0.66)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C147(0.46)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C147(0.49)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C147(0.68)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C147(0.87)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C147(0.56)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C147(1.03)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C147(1.02)  LDD0706  [7]
 LDCM0391  CL120 HCT 116 C147(0.99)  LDD0708  [7]
 LDCM0403  CL16 HCT 116 C147(0.93)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C147(1.04)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C147(1.39)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C147(0.97)  LDD0723  [7]
 LDCM0408  CL20 HCT 116 C147(0.81)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C147(0.74)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C147(0.39)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C147(0.74)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C147(0.69)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C147(0.69)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C147(0.89)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C147(0.83)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C147(0.75)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C147(0.83)  LDD0734  [7]
 LDCM0419  CL30 HCT 116 C147(0.86)  LDD0736  [7]
 LDCM0436  CL46 HCT 116 C147(0.85)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C147(0.89)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C147(0.82)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C147(0.76)  LDD0756  [7]
 LDCM0441  CL50 HCT 116 C147(0.80)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C147(0.78)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C147(0.84)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C147(0.84)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C147(0.72)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C147(0.77)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C147(0.86)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C147(0.83)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C147(0.88)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C147(0.84)  LDD0767  [7]
 LDCM0452  CL60 HCT 116 C147(0.85)  LDD0769  [7]
 LDCM0116  HHS-0101 DM93 Y325(0.88); Y323(1.17)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y323(0.81); Y325(0.93)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y323(0.84); Y325(0.92)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y325(0.67); Y323(0.75)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y323(0.74); Y325(1.01)  LDD0268  [5]
 LDCM0107  IAA HeLa H115(0.00); H286(0.00); C147(0.00)  LDD0221  [9]
 LDCM0022  KB02 22RV1 C147(2.27)  LDD2243  [11]
 LDCM0023  KB03 22RV1 C147(3.30)  LDD2660  [11]
 LDCM0024  KB05 HMCB C147(2.35)  LDD3312  [11]
 LDCM0109  NEM HeLa N.A.  LDD0223  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C147(1.98)  LDD2093  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C147(0.93)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C147(0.64)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C147(1.25)  LDD2111  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C147(1.61)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C147(1.38)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C147(1.17)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C147(1.42)  LDD2127  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C147(1.69)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C147(1.28)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C147(1.45)  LDD2140  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C147(0.99)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C147(1.29)  LDD2146  [4]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840