Details of the Target

General Information of Target

Target ID LDTP00759
Target Name Tumor protein D54 (TPD52L2)
Gene Name TPD52L2
Gene ID 7165
Synonyms
Tumor protein D54; hD54; Tumor protein D52-like 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSAGQDINLNSPNKGLLSDSMTDVPVDTGVAARTPAVEGLTEAEEEELRAELTKVEEEI
VTLRQVLAAKERHCGELKRRLGLSTLGELKQNLSRSWHDVQVSSAYVKTSEKLGEWNEKV
TQSDLYKKTQETLSQAGQKTSAALSTVGSAISRKLGDMRNSATFKSFEDRVGTIKSKVVG
DRENGSDNLPSSAGSGDKPLSDPAPF
Target Bioclass
Other
Family
TPD52 family
Uniprot ID
O43399
Ensemble ID
ENST00000217121.9
HGNC ID
HGNC:12007

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1954 SNV: p.S104R .
LS123 SNV: p.D197E .
WM793 SNV: p.S104G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.84  LDD0402  [1]
AZ-9
 Probe Info  		3.25  LDD0393  [2]
FBPP2
 Probe Info  		3.08  LDD0318  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
SAA-alkyne
 Probe Info  		1.18  LDD0252  [5]
TH211
 Probe Info  		Y126(20.00)  LDD0260  [6]
C-Sul
 Probe Info  		6.75  LDD0066  [7]
FBP2
 Probe Info  		4.22  LDD0317  [3]
TH214
 Probe Info  		Y106(20.00); Y126(11.46)  LDD0258  [6]
TH216
 Probe Info  		Y126(12.89); Y106(10.83)  LDD0259  [6]
YN-1
 Probe Info  		100.00  LDD0444  [8]
IPM
 Probe Info  		C74(3.07)  LDD2229  [9]
ONAyne
 Probe Info  		N.A.  LDD0273  [10]
Probe 1
 Probe Info  		Y126(94.52)  LDD3495  [11]
DBIA
 Probe Info  		C74(1.44)  LDD3339  [12]
BTD
 Probe Info  		C74(1.01)  LDD1700  [13]
HHS-475
 Probe Info  		Y106(0.48)  LDD0264  [14]
HHS-465
 Probe Info  		Y106(10.00)  LDD2237  [15]
5E-2FA
 Probe Info  		N.A.  LDD2235  [16]
ATP probe
 Probe Info  		K90(0.00); K108(0.00); K112(0.00); K128(0.00)  LDD0199  [17]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [18]
ATP probe
 Probe Info  		K108(0.00); K177(0.00); K119(0.00)  LDD0035  [19]
WYneO
 Probe Info  		N.A.  LDD0022  [20]
NHS
 Probe Info  		K128(0.00); K90(0.00); K139(0.00)  LDD0010  [20]
STPyne
 Probe Info  		K128(0.00); K90(0.00)  LDD0009  [20]
TFBX
 Probe Info  		N.A.  LDD0148  [21]
1c-yne
 Probe Info  		N.A.  LDD0228  [22]
Acrolein
 Probe Info  		N.A.  LDD0217  [23]
Methacrolein
 Probe Info  		N.A.  LDD0218  [23]
AOyne
 Probe Info  		8.30  LDD0443  [24]
MPP-AC
 Probe Info  		N.A.  LDD0428  [25]
NAIA_5
 Probe Info  		N.A.  LDD2223  [26]
TER-AC
 Probe Info  		N.A.  LDD0426  [25]
PAL-AfBPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		16.68  LDD1753  [27]
C092
 Probe Info  		16.80  LDD1783  [27]
C187
 Probe Info  		44.02  LDD1865  [27]
C191
 Probe Info  		28.84  LDD1868  [27]
C193
 Probe Info  		13.83  LDD1869  [27]
C362
 Probe Info  		39.67  LDD2023  [27]
C388
 Probe Info  		38.05  LDD2047  [27]
FFF probe11
 Probe Info  		13.79  LDD0471  [28]
FFF probe13
 Probe Info  		20.00  LDD0475  [28]
FFF probe14
 Probe Info  		20.00  LDD0477  [28]
FFF probe3
 Probe Info  		12.18  LDD0464  [28]
VE-P
 Probe Info  		N.A.  LDD0396  [29]
DFG-out-4
 Probe Info  		7.90; 6.30  LDD0075  [30]
A-DA
 Probe Info  		2.79  LDD0143  [31]
Alk-rapa
 Probe Info  		6.42  LDD0213  [32]
DA-2
 Probe Info  		N.A.  LDD0070  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C74(0.42)  LDD2142  [13]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C74(0.66)  LDD2112  [13]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C74(0.89)  LDD2117  [13]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C74(1.46)  LDD2152  [13]
 LDCM0520  AKOS000195272 MDA-MB-231 C74(0.88)  LDD2113  [13]
 LDCM0156  Aniline NCI-H1299 14.37  LDD0403  [1]
 LDCM0083  Avasimibe A-549 2.79  LDD0143  [31]
 LDCM0498  BS-3668 MDA-MB-231 C74(0.29)  LDD2091  [13]
 LDCM0108  Chloroacetamide HeLa C74(0.00); H98(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C74(20.00)  LDD2227  [26]
 LDCM0017  DFG-out-2 A431 7.90; 6.30  LDD0075  [30]
 LDCM0116  HHS-0101 DM93 Y106(0.48)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y106(0.74)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y106(0.59)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y106(0.71)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y106(0.53)  LDD0268  [14]
 LDCM0107  IAA HeLa N.A.  LDD0221  [23]
 LDCM0022  KB02 769-P C74(1.41)  LDD2246  [12]
 LDCM0023  KB03 769-P C74(1.30)  LDD2663  [12]
 LDCM0024  KB05 NALM-6 C74(1.44)  LDD3339  [12]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C74(1.03)  LDD2102  [13]
 LDCM0109  NEM HeLa N.A.  LDD0224  [23]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C74(0.98)  LDD2090  [13]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C74(1.12)  LDD2092  [13]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C74(1.83)  LDD2093  [13]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C74(1.85)  LDD2094  [13]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C74(0.57)  LDD2096  [13]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C74(0.92)  LDD2097  [13]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C74(0.56)  LDD2098  [13]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C74(0.81)  LDD2099  [13]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C74(0.42)  LDD2100  [13]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C74(1.34)  LDD2101  [13]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C74(0.57)  LDD2104  [13]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C74(0.36)  LDD2106  [13]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C74(0.88)  LDD2107  [13]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C74(0.99)  LDD2109  [13]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C74(0.65)  LDD2110  [13]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C74(0.98)  LDD2111  [13]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C74(0.64)  LDD2114  [13]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C74(0.90)  LDD2115  [13]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C74(0.71)  LDD2116  [13]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C74(0.73)  LDD2118  [13]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C74(4.54)  LDD2119  [13]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C74(0.89)  LDD2120  [13]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C74(0.77)  LDD2122  [13]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C74(0.70)  LDD2123  [13]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C74(0.76)  LDD2124  [13]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C74(1.03)  LDD2125  [13]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C74(0.70)  LDD2126  [13]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C74(1.04)  LDD2127  [13]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C74(0.80)  LDD2128  [13]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C74(0.94)  LDD2129  [13]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C74(0.86)  LDD2133  [13]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C74(0.91)  LDD2134  [13]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C74(0.94)  LDD2135  [13]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C74(1.17)  LDD2136  [13]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C74(0.88)  LDD2137  [13]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C74(1.01)  LDD1700  [13]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C74(0.72)  LDD2140  [13]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C74(1.02)  LDD2143  [13]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C74(5.24)  LDD2144  [13]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C74(0.84)  LDD2146  [13]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C74(4.18)  LDD2147  [13]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C74(0.61)  LDD2149  [13]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C74(0.33)  LDD2150  [13]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C74(0.63)  LDD2151  [13]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C74(2.03)  LDD2153  [13]
 LDCM0090  Rapamycin JHH-7 6.42  LDD0213  [32]
 LDCM0084  Ro 48-8071 A-549 8.38  LDD0145  [31]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5) Peptidase S33 family Q8WTS1
Atypical kinase COQ8A, mitochondrial (COQ8A) ADCK protein kinase family Q8NI60
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phenethyl Isothiocyanate Small molecular drug DB12695

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1. J Proteome Res. 2023 Jul 7;22(7):2450-2459. doi: 10.1021/acs.jproteome.3c00188. Epub 2023 Jun 22.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
8 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
9 A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes. Nat Protoc. 2020 Sep;15(9):2891-2919. doi: 10.1038/s41596-020-0352-2. Epub 2020 Jul 20.
Mass spectrometry data entry: PXD016048
10 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
11 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
14 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
15 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
16 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
17 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
25 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
26 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
30 Affinity-based probes based on type II kinase inhibitors. J Am Chem Soc. 2012 Nov 21;134(46):19017-25. doi: 10.1021/ja306035v. Epub 2012 Nov 6.
31 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
32 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
33 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.