Details of the Target

General Information of Target

Target ID LDTP13260
Target Name LIM domain and actin-binding protein 1 (LIMA1)
Gene Name LIMA1
Gene ID 51474
Synonyms
EPLIN; SREBP3; LIM domain and actin-binding protein 1; Epithelial protein lost in neoplasm
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCAT
TGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLG
GSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLF
LQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGI
SFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVS
HYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDF
PHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSS
WLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGN
FLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLD
RQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments. Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake.
Uniprot ID
Q9UHB6
Ensemble ID
ENST00000341247.9
HGNC ID
HGNC:24636

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.I530T DBIA    Probe Info 
CHL1 SNV: p.P522L DBIA    Probe Info 
HCT15 SNV: p.P313H DBIA    Probe Info 
MDAMB453 SNV: p.Q215Ter DBIA    Probe Info 
YSCCC SNV: p.D182Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AZ-9
 Probe Info  		2.88  LDD0393  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
ONAyne
 Probe Info  		K268(10.00)  LDD0274  [4]
STPyne
 Probe Info  		K160(10.00); K189(10.00); K198(7.19); K203(5.21)  LDD0277  [4]
Probe 1
 Probe Info  		Y229(9.62); Y274(138.82)  LDD3495  [5]
DBIA
 Probe Info  		C316(0.72)  LDD3311  [6]
BTD
 Probe Info  		C316(1.46)  LDD1700  [7]
Jackson_14
 Probe Info  		2.22  LDD0123  [8]
AHL-Pu-1
 Probe Info  		C316(2.95); C164(2.07)  LDD0168  [9]
HHS-482
 Probe Info  		Y190(0.75); Y429(0.73)  LDD0285  [10]
HHS-475
 Probe Info  		Y287(0.66); Y190(1.05); Y274(1.14); Y429(1.21)  LDD0264  [11]
5E-2FA
 Probe Info  		H111(0.00); H103(0.00); H125(0.00); H489(0.00)  LDD2235  [12]
ATP probe
 Probe Info  		N.A.  LDD0199  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [14]
NAIA_4
 Probe Info  		N.A.  LDD2226  [15]
ENE
 Probe Info  		N.A.  LDD0006  [16]
IPM
 Probe Info  		C316(0.00); C164(0.00)  LDD0005  [16]
SF
 Probe Info  		Y429(0.00); Y398(0.00)  LDD0028  [17]
TFBX
 Probe Info  		C438(0.00); C417(0.00); C414(0.00); C316(0.00)  LDD0148  [18]
VSF
 Probe Info  		C316(0.00); C164(0.00)  LDD0007  [16]
Phosphinate-6
 Probe Info  		C414(0.00); C316(0.00)  LDD0018  [19]
Ox-W18
 Probe Info  		N.A.  LDD2175  [20]
Acrolein
 Probe Info  		C316(0.00); C164(0.00); C390(0.00); H489(0.00)  LDD0217  [21]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [21]
Methacrolein
 Probe Info  		C316(0.00); C164(0.00)  LDD0218  [21]
W1
 Probe Info  		N.A.  LDD0236  [22]
AOyne
 Probe Info  		14.30  LDD0443  [23]
NAIA_5
 Probe Info  		C438(0.00); C164(0.00); C414(0.00)  LDD2223  [15]
HHS-465
 Probe Info  		Y452(0.00); Y287(0.00); Y429(0.00); Y398(0.00)  LDD2240  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C316(0.65)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C316(0.89)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C316(0.52)  LDD2095  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C316(1.03)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C316(1.14)  LDD2152  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C316(0.69)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C316(0.85)  LDD2131  [7]
 LDCM0025  4SU-RNA HEK-293T C316(2.95); C164(2.07)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C164(2.05)  LDD0169  [9]
 LDCM0214  AC1 HEK-293T C164(1.04); C316(1.01); C414(1.04); C390(0.99)  LDD1507  [25]
 LDCM0215  AC10 HEK-293T C164(1.02); C316(1.05); C390(1.00); C417(1.00)  LDD1508  [25]
 LDCM0226  AC11 HEK-293T C164(1.01); C316(1.01); C390(0.96); C417(0.99)  LDD1509  [25]
 LDCM0237  AC12 HEK-293T C164(1.04); C316(1.02); C414(0.75); C390(1.05)  LDD1510  [25]
 LDCM0259  AC14 HEK-293T C164(0.96); C316(0.93); C390(0.98); C417(1.10)  LDD1512  [25]
 LDCM0270  AC15 HEK-293T C164(0.99); C316(0.98); C414(0.80); C417(0.98)  LDD1513  [25]
 LDCM0276  AC17 HEK-293T C164(1.03); C316(0.93); C414(1.06); C390(0.96)  LDD1515  [25]
 LDCM0277  AC18 HEK-293T C164(1.03); C316(1.00); C390(0.97); C417(0.96)  LDD1516  [25]
 LDCM0278  AC19 HEK-293T C164(0.98); C316(0.98); C390(0.87); C417(0.71)  LDD1517  [25]
 LDCM0279  AC2 HEK-293T C164(0.96); C316(1.03); C390(1.02); C417(1.03)  LDD1518  [25]
 LDCM0280  AC20 HEK-293T C164(1.01); C316(1.02); C414(0.48); C390(0.95)  LDD1519  [25]
 LDCM0281  AC21 HEK-293T C164(1.05); C316(0.97); C414(0.90); C390(0.92)  LDD1520  [25]
 LDCM0282  AC22 HEK-293T C164(0.97); C316(0.94); C390(0.87); C417(1.00)  LDD1521  [25]
 LDCM0283  AC23 HEK-293T C164(1.00); C316(0.95); C414(0.93); C417(0.96)  LDD1522  [25]
 LDCM0284  AC24 HEK-293T C164(1.01); C316(0.97); C414(0.97)  LDD1523  [25]
 LDCM0285  AC25 HEK-293T C164(1.05); C316(0.96); C414(0.94); C390(1.06)  LDD1524  [25]
 LDCM0286  AC26 HEK-293T C164(0.97); C316(1.01); C390(1.01); C417(0.99)  LDD1525  [25]
 LDCM0287  AC27 HEK-293T C164(0.94); C316(0.97); C390(1.22); C417(0.98)  LDD1526  [25]
 LDCM0288  AC28 HEK-293T C164(1.00); C316(1.00); C414(0.62); C390(0.90)  LDD1527  [25]
 LDCM0289  AC29 HEK-293T C164(1.02); C316(0.94); C414(0.97); C390(0.99)  LDD1528  [25]
 LDCM0290  AC3 HEK-293T C164(0.91); C316(1.08); C390(0.93); C417(0.90)  LDD1529  [25]
 LDCM0291  AC30 HEK-293T C164(1.00); C316(0.97); C390(0.97); C417(0.89)  LDD1530  [25]
 LDCM0292  AC31 HEK-293T C164(0.98); C316(0.94); C414(0.98); C417(1.00)  LDD1531  [25]
 LDCM0293  AC32 HEK-293T C164(1.00); C316(0.96); C414(1.18)  LDD1532  [25]
 LDCM0294  AC33 HEK-293T C164(1.02); C316(1.02); C414(1.00); C390(0.85)  LDD1533  [25]
 LDCM0295  AC34 HEK-293T C164(1.02); C316(1.06); C390(1.03); C417(1.16)  LDD1534  [25]
 LDCM0296  AC35 HEK-293T C164(0.90); C316(1.02); C390(0.83); C417(1.01)  LDD1535  [25]
 LDCM0297  AC36 HEK-293T C164(1.03); C316(1.07); C414(0.67); C390(1.37)  LDD1536  [25]
 LDCM0298  AC37 HEK-293T C164(1.06); C316(0.96); C414(0.99); C390(0.91)  LDD1537  [25]
 LDCM0299  AC38 HEK-293T C164(0.92); C316(0.97); C390(0.94); C417(1.14)  LDD1538  [25]
 LDCM0300  AC39 HEK-293T C164(0.98); C316(1.08); C414(0.97); C417(0.97)  LDD1539  [25]
 LDCM0301  AC4 HEK-293T C164(1.03); C316(1.02); C414(0.69); C390(1.17)  LDD1540  [25]
 LDCM0302  AC40 HEK-293T C164(1.01); C316(1.06); C414(1.10)  LDD1541  [25]
 LDCM0303  AC41 HEK-293T C164(1.05); C316(0.94); C414(1.03); C390(1.08)  LDD1542  [25]
 LDCM0304  AC42 HEK-293T C164(1.03); C316(1.02); C390(1.03); C417(1.00)  LDD1543  [25]
 LDCM0305  AC43 HEK-293T C164(1.01); C316(1.02); C390(0.94); C417(0.99)  LDD1544  [25]
 LDCM0306  AC44 HEK-293T C164(1.03); C316(1.04); C414(0.76); C390(1.06)  LDD1545  [25]
 LDCM0307  AC45 HEK-293T C164(1.02); C316(1.07); C414(0.78); C390(0.89)  LDD1546  [25]
 LDCM0308  AC46 HEK-293T C164(0.96); C316(1.01); C390(0.98); C417(1.15)  LDD1547  [25]
 LDCM0309  AC47 HEK-293T C164(0.95); C316(1.12); C414(1.20); C417(0.98)  LDD1548  [25]
 LDCM0310  AC48 HEK-293T C164(0.97); C316(1.06); C414(1.05)  LDD1549  [25]
 LDCM0311  AC49 HEK-293T C164(1.01); C316(0.94); C414(0.97); C390(0.97)  LDD1550  [25]
 LDCM0312  AC5 HEK-293T C164(1.00); C316(1.03); C414(1.08); C390(0.92)  LDD1551  [25]
 LDCM0313  AC50 HEK-293T C164(1.01); C316(1.06); C390(0.99); C417(1.13)  LDD1552  [25]
 LDCM0314  AC51 HEK-293T C164(1.00); C316(1.09); C390(0.87); C417(1.07)  LDD1553  [25]
 LDCM0315  AC52 HEK-293T C164(1.07); C316(1.03); C414(0.94); C390(1.24)  LDD1554  [25]
 LDCM0316  AC53 HEK-293T C164(1.05); C316(0.96); C414(1.19); C390(0.90)  LDD1555  [25]
 LDCM0317  AC54 HEK-293T C164(0.96); C316(0.97); C390(0.96); C417(1.09)  LDD1556  [25]
 LDCM0318  AC55 HEK-293T C164(0.97); C316(0.94); C414(1.27); C417(0.98)  LDD1557  [25]
 LDCM0319  AC56 HEK-293T C164(1.01); C316(0.95); C414(1.04)  LDD1558  [25]
 LDCM0320  AC57 HEK-293T C164(1.06); C316(0.99); C414(1.06); C390(0.98)  LDD1559  [25]
 LDCM0321  AC58 HEK-293T C164(0.98); C316(0.98); C390(0.99); C417(1.03)  LDD1560  [25]
 LDCM0322  AC59 HEK-293T C164(0.97); C316(0.96); C390(0.93); C417(0.97)  LDD1561  [25]
 LDCM0323  AC6 HEK-293T C164(0.97); C316(1.04); C390(1.13); C417(1.02)  LDD1562  [25]
 LDCM0324  AC60 HEK-293T C164(1.04); C316(1.01); C414(0.70); C390(1.09)  LDD1563  [25]
 LDCM0325  AC61 HEK-293T C164(1.04); C316(0.98); C414(0.95); C390(0.90)  LDD1564  [25]
 LDCM0326  AC62 HEK-293T C164(0.98); C316(0.99); C390(1.00); C417(1.04)  LDD1565  [25]
 LDCM0327  AC63 HEK-293T C164(0.98); C316(0.87); C414(1.04); C417(0.95)  LDD1566  [25]
 LDCM0328  AC64 HEK-293T C164(0.91); C316(0.98); C414(1.09)  LDD1567  [25]
 LDCM0334  AC7 HEK-293T C164(0.97); C316(1.12); C414(0.82); C417(0.99)  LDD1568  [25]
 LDCM0345  AC8 HEK-293T C164(0.92); C316(0.99); C414(1.08)  LDD1569  [25]
 LDCM0545  Acetamide MDA-MB-231 C316(0.48)  LDD2138  [7]
 LDCM0248  AKOS034007472 HEK-293T C164(1.03); C316(0.96); C414(1.03); C390(0.91)  LDD1511  [25]
 LDCM0356  AKOS034007680 HEK-293T C164(1.04); C316(0.96); C414(1.06); C390(0.93)  LDD1570  [25]
 LDCM0275  AKOS034007705 HEK-293T C164(1.01); C316(1.02); C414(1.06)  LDD1514  [25]
 LDCM0156  Aniline NCI-H1299 13.15  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C316(0.66)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C316(0.00); C164(0.00); C390(0.00)  LDD0222  [21]
 LDCM0367  CL1 HEK-293T C164(0.92); C316(1.05); C414(0.94); C390(0.72)  LDD1571  [25]
 LDCM0368  CL10 HEK-293T C164(0.82); C316(0.85); C390(0.99); C417(0.96)  LDD1572  [25]
 LDCM0369  CL100 HEK-293T C164(0.94); C316(0.94); C390(0.87); C417(0.87)  LDD1573  [25]
 LDCM0370  CL101 HEK-293T C164(1.06); C316(1.15); C414(1.02); C390(0.80)  LDD1574  [25]
 LDCM0371  CL102 HEK-293T C164(0.92); C316(0.87); C414(0.83); C390(0.88)  LDD1575  [25]
 LDCM0372  CL103 HEK-293T C164(0.89); C316(1.01); C414(1.04); C390(1.04)  LDD1576  [25]
 LDCM0373  CL104 HEK-293T C164(0.95); C316(0.91); C390(1.11); C417(1.08)  LDD1577  [25]
 LDCM0374  CL105 HEK-293T C164(1.03); C316(1.10); C414(0.93); C390(1.12)  LDD1578  [25]
 LDCM0375  CL106 HEK-293T C164(0.99); C316(0.94); C414(0.88); C390(0.83)  LDD1579  [25]
 LDCM0376  CL107 HEK-293T C164(0.92); C316(0.94); C414(0.92); C390(0.93)  LDD1580  [25]
 LDCM0377  CL108 HEK-293T C164(0.97); C316(0.91); C390(0.89); C417(1.02)  LDD1581  [25]
 LDCM0378  CL109 HEK-293T C164(1.00); C316(0.95); C414(1.03); C390(0.90)  LDD1582  [25]
 LDCM0379  CL11 HEK-293T C164(0.90); C316(1.00); C414(1.11); C417(0.98)  LDD1583  [25]
 LDCM0380  CL110 HEK-293T C164(0.94); C316(0.85); C414(0.88); C390(0.74)  LDD1584  [25]
 LDCM0381  CL111 HEK-293T C164(0.89); C316(0.97); C414(0.95); C390(0.95)  LDD1585  [25]
 LDCM0382  CL112 HEK-293T C164(1.01); C316(0.92); C390(1.08); C417(1.09)  LDD1586  [25]
 LDCM0383  CL113 HEK-293T C164(1.01); C316(1.01); C414(1.00); C390(0.58)  LDD1587  [25]
 LDCM0384  CL114 HEK-293T C164(0.92); C316(0.89); C414(0.72); C390(0.84)  LDD1588  [25]
 LDCM0385  CL115 HEK-293T C164(0.91); C316(1.07); C414(1.03); C390(1.06)  LDD1589  [25]
 LDCM0386  CL116 HEK-293T C164(0.98); C316(0.96); C390(0.98); C417(1.25)  LDD1590  [25]
 LDCM0387  CL117 HEK-293T C164(1.07); C316(1.02); C414(1.00); C390(0.86)  LDD1591  [25]
 LDCM0388  CL118 HEK-293T C164(1.01); C316(0.98); C414(0.93); C390(0.90)  LDD1592  [25]
 LDCM0389  CL119 HEK-293T C164(0.84); C316(1.00); C414(0.97); C390(1.11)  LDD1593  [25]
 LDCM0390  CL12 HEK-293T C164(1.08); C316(1.02); C414(1.03)  LDD1594  [25]
 LDCM0391  CL120 HEK-293T C164(0.90); C316(1.06); C390(1.20); C417(0.88)  LDD1595  [25]
 LDCM0392  CL121 HEK-293T C164(0.99); C316(1.10); C414(1.02); C390(0.59)  LDD1596  [25]
 LDCM0393  CL122 HEK-293T C164(0.96); C316(0.91); C414(0.84); C390(0.81)  LDD1597  [25]
 LDCM0394  CL123 HEK-293T C164(0.82); C316(0.91); C414(0.84); C390(1.00)  LDD1598  [25]
 LDCM0395  CL124 HEK-293T C164(0.87); C316(1.06); C390(1.09); C417(0.98)  LDD1599  [25]
 LDCM0396  CL125 HEK-293T C164(1.12); C316(0.99); C414(1.00); C390(0.89)  LDD1600  [25]
 LDCM0397  CL126 HEK-293T C164(0.98); C316(0.93); C414(1.05); C390(0.92)  LDD1601  [25]
 LDCM0398  CL127 HEK-293T C164(0.99); C316(1.02); C414(1.15); C390(1.00)  LDD1602  [25]
 LDCM0399  CL128 HEK-293T C164(0.95); C316(0.96); C390(1.11); C417(1.14)  LDD1603  [25]
 LDCM0400  CL13 HEK-293T C164(1.06); C316(1.04); C414(0.87); C390(0.58)  LDD1604  [25]
 LDCM0401  CL14 HEK-293T C164(0.88); C316(0.93); C414(1.08); C390(1.43)  LDD1605  [25]
 LDCM0402  CL15 HEK-293T C164(0.74); C316(0.93); C414(0.82); C390(0.83)  LDD1606  [25]
 LDCM0403  CL16 HEK-293T C164(0.88); C316(1.02); C390(0.92); C417(1.06)  LDD1607  [25]
 LDCM0404  CL17 HEK-293T C164(0.92); C316(0.89); C414(0.96); C390(0.83)  LDD1608  [25]
 LDCM0405  CL18 HEK-293T C164(0.99); C316(0.96); C390(1.05); C417(1.04)  LDD1609  [25]
 LDCM0406  CL19 HEK-293T C164(0.96); C316(1.03); C390(0.79); C417(1.11)  LDD1610  [25]
 LDCM0407  CL2 HEK-293T C164(0.95); C316(1.03); C414(0.81); C390(0.77)  LDD1611  [25]
 LDCM0408  CL20 HEK-293T C164(1.04); C316(1.12); C414(1.27); C390(1.18)  LDD1612  [25]
 LDCM0409  CL21 HEK-293T C164(1.00); C316(0.89); C414(0.65); C390(0.85)  LDD1613  [25]
 LDCM0410  CL22 HEK-293T C164(0.91); C316(1.01); C390(1.16); C417(1.41)  LDD1614  [25]
 LDCM0411  CL23 HEK-293T C164(0.88); C316(1.17); C414(1.05); C417(1.05)  LDD1615  [25]
 LDCM0412  CL24 HEK-293T C164(1.15); C316(1.08); C414(1.09)  LDD1616  [25]
 LDCM0413  CL25 HEK-293T C164(1.03); C316(0.97); C414(0.91); C390(0.72)  LDD1617  [25]
 LDCM0414  CL26 HEK-293T C164(0.97); C316(0.89); C414(0.92); C390(0.84)  LDD1618  [25]
 LDCM0415  CL27 HEK-293T C164(0.93); C316(1.01); C414(0.92); C390(1.05)  LDD1619  [25]
 LDCM0416  CL28 HEK-293T C164(0.95); C316(1.02); C390(0.94); C417(1.09)  LDD1620  [25]
 LDCM0417  CL29 HEK-293T C164(1.00); C316(0.96); C414(1.09); C390(0.77)  LDD1621  [25]
 LDCM0418  CL3 HEK-293T C164(0.86); C316(0.99); C414(0.91); C390(1.02)  LDD1622  [25]
 LDCM0419  CL30 HEK-293T C164(0.97); C316(1.04); C390(0.80); C417(1.20)  LDD1623  [25]
 LDCM0420  CL31 HEK-293T C164(1.03); C316(1.03); C390(0.87); C417(0.98)  LDD1624  [25]
 LDCM0421  CL32 HEK-293T C164(1.05); C316(0.99); C414(0.85); C390(0.94)  LDD1625  [25]
 LDCM0422  CL33 HEK-293T C164(0.92); C316(0.77); C414(0.79); C390(0.61)  LDD1626  [25]
 LDCM0423  CL34 HEK-293T C164(0.94); C316(0.99); C390(0.95); C417(1.31)  LDD1627  [25]
 LDCM0424  CL35 HEK-293T C164(0.94); C316(1.15); C414(0.83); C417(0.99)  LDD1628  [25]
 LDCM0425  CL36 HEK-293T C164(1.20); C316(1.05); C414(1.00)  LDD1629  [25]
 LDCM0426  CL37 HEK-293T C164(1.08); C316(1.01); C414(0.99); C390(0.76)  LDD1630  [25]
 LDCM0428  CL39 HEK-293T C164(0.94); C316(1.05); C414(0.92); C390(0.86)  LDD1632  [25]
 LDCM0429  CL4 HEK-293T C164(0.90); C316(1.00); C390(1.06); C417(0.97)  LDD1633  [25]
 LDCM0430  CL40 HEK-293T C164(0.96); C316(1.06); C390(0.96); C417(1.09)  LDD1634  [25]
 LDCM0431  CL41 HEK-293T C164(1.00); C316(0.89); C414(1.08); C390(0.95)  LDD1635  [25]
 LDCM0432  CL42 HEK-293T C164(0.99); C316(1.00); C390(0.97); C417(1.13)  LDD1636  [25]
 LDCM0433  CL43 HEK-293T C164(1.08); C316(1.01); C390(1.01); C417(1.13)  LDD1637  [25]
 LDCM0434  CL44 HEK-293T C164(1.02); C316(1.04); C414(0.59); C390(0.69)  LDD1638  [25]
 LDCM0435  CL45 HEK-293T C164(1.04); C316(0.92); C414(0.96); C390(0.85)  LDD1639  [25]
 LDCM0436  CL46 HEK-293T C164(0.96); C316(0.88); C390(0.98); C417(1.07)  LDD1640  [25]
 LDCM0437  CL47 HEK-293T C164(0.88); C316(1.02); C414(0.88); C417(1.02)  LDD1641  [25]
 LDCM0438  CL48 HEK-293T C164(1.08); C316(0.95); C414(0.91)  LDD1642  [25]
 LDCM0439  CL49 HEK-293T C164(1.08); C316(1.01); C414(0.96); C390(0.89)  LDD1643  [25]
 LDCM0440  CL5 HEK-293T C164(1.06); C316(0.98); C414(1.00); C390(1.02)  LDD1644  [25]
 LDCM0441  CL50 HEK-293T C164(0.95); C316(0.95); C414(0.87); C390(0.85)  LDD1645  [25]
 LDCM0443  CL52 HEK-293T C164(0.91); C316(1.01); C390(1.13); C417(0.94)  LDD1646  [25]
 LDCM0444  CL53 HEK-293T C164(1.00); C316(1.02); C414(1.03); C390(0.56)  LDD1647  [25]
 LDCM0445  CL54 HEK-293T C164(0.89); C316(0.92); C390(0.64); C417(1.18)  LDD1648  [25]
 LDCM0446  CL55 HEK-293T C164(1.07); C316(1.10); C390(0.93); C417(1.07)  LDD1649  [25]
 LDCM0447  CL56 HEK-293T C164(1.04); C316(1.06); C414(0.60); C390(0.87)  LDD1650  [25]
 LDCM0448  CL57 HEK-293T C164(0.99); C316(0.92); C414(0.85); C390(0.55)  LDD1651  [25]
 LDCM0449  CL58 HEK-293T C164(0.89); C316(0.91); C390(0.84); C417(1.39)  LDD1652  [25]
 LDCM0450  CL59 HEK-293T C164(0.91); C316(0.98); C414(0.90); C417(1.06)  LDD1653  [25]
 LDCM0451  CL6 HEK-293T C164(0.92); C316(0.98); C390(1.03); C417(1.11)  LDD1654  [25]
 LDCM0452  CL60 HEK-293T C164(1.11); C316(1.04); C414(1.04)  LDD1655  [25]
 LDCM0453  CL61 HEK-293T C164(1.14); C316(1.05); C414(0.95); C390(0.67)  LDD1656  [25]
 LDCM0454  CL62 HEK-293T C164(1.04); C316(0.96); C414(1.08); C390(0.79)  LDD1657  [25]
 LDCM0455  CL63 HEK-293T C164(0.90); C316(1.05); C414(1.09); C390(1.13)  LDD1658  [25]
 LDCM0456  CL64 HEK-293T C164(0.84); C316(0.91); C390(0.96); C417(1.13)  LDD1659  [25]
 LDCM0457  CL65 HEK-293T C164(1.05); C316(0.98); C414(1.09); C390(0.85)  LDD1660  [25]
 LDCM0458  CL66 HEK-293T C164(1.05); C316(1.05); C390(0.96); C417(1.03)  LDD1661  [25]
 LDCM0459  CL67 HEK-293T C164(0.96); C316(0.97); C390(0.92); C417(1.08)  LDD1662  [25]
 LDCM0460  CL68 HEK-293T C164(1.00); C316(0.99); C414(0.72); C390(1.01)  LDD1663  [25]
 LDCM0461  CL69 HEK-293T C164(1.01); C316(0.91); C414(0.90); C390(0.85)  LDD1664  [25]
 LDCM0462  CL7 HEK-293T C164(0.99); C316(1.01); C390(0.96); C417(1.03)  LDD1665  [25]
 LDCM0463  CL70 HEK-293T C164(0.92); C316(0.98); C390(0.97); C417(1.15)  LDD1666  [25]
 LDCM0464  CL71 HEK-293T C164(0.93); C316(1.00); C414(0.83); C417(1.18)  LDD1667  [25]
 LDCM0465  CL72 HEK-293T C164(1.17); C316(1.11); C414(1.11)  LDD1668  [25]
 LDCM0466  CL73 HEK-293T C164(1.05); C316(0.91); C414(1.04); C390(0.88)  LDD1669  [25]
 LDCM0467  CL74 HEK-293T C164(0.95); C316(0.93); C414(0.92); C390(0.82)  LDD1670  [25]
 LDCM0469  CL76 HEK-293T C164(0.93); C316(1.01); C390(1.08); C417(1.03)  LDD1672  [25]
 LDCM0470  CL77 HEK-293T C164(0.95); C316(0.87); C414(0.87); C390(0.96)  LDD1673  [25]
 LDCM0471  CL78 HEK-293T C164(1.06); C316(1.01); C390(1.19); C417(1.23)  LDD1674  [25]
 LDCM0472  CL79 HEK-293T C164(1.01); C316(1.01); C390(0.87); C417(1.06)  LDD1675  [25]
 LDCM0473  CL8 HEK-293T C164(0.81); C316(0.81); C414(0.47); C390(1.21)  LDD1676  [25]
 LDCM0474  CL80 HEK-293T C164(0.96); C316(1.08); C414(0.76); C390(1.40)  LDD1677  [25]
 LDCM0475  CL81 HEK-293T C164(1.10); C316(0.92); C414(0.81); C390(1.02)  LDD1678  [25]
 LDCM0476  CL82 HEK-293T C164(0.94); C316(0.95); C390(1.12); C417(1.08)  LDD1679  [25]
 LDCM0477  CL83 HEK-293T C164(0.88); C316(1.02); C414(1.13); C417(1.02)  LDD1680  [25]
 LDCM0478  CL84 HEK-293T C164(1.08); C316(0.98); C414(1.00)  LDD1681  [25]
 LDCM0479  CL85 HEK-293T C164(1.16); C316(1.07); C414(0.89); C390(1.05)  LDD1682  [25]
 LDCM0480  CL86 HEK-293T C164(1.03); C316(0.95); C414(0.74); C390(0.97)  LDD1683  [25]
 LDCM0481  CL87 HEK-293T C164(0.98); C316(1.01); C414(0.91); C390(1.10)  LDD1684  [25]
 LDCM0482  CL88 HEK-293T C164(0.96); C316(1.03); C390(0.95); C417(0.97)  LDD1685  [25]
 LDCM0483  CL89 HEK-293T C164(1.09); C316(1.00); C414(1.00); C390(1.09)  LDD1686  [25]
 LDCM0484  CL9 HEK-293T C164(1.02); C316(0.99); C414(0.94); C390(0.89)  LDD1687  [25]
 LDCM0485  CL90 HEK-293T C164(0.86); C316(0.83); C390(1.01); C417(0.95)  LDD1688  [25]
 LDCM0486  CL91 HEK-293T C164(0.90); C316(1.09); C390(1.00); C417(1.07)  LDD1689  [25]
 LDCM0487  CL92 HEK-293T C164(0.92); C316(1.01); C414(0.60); C390(1.17)  LDD1690  [25]
 LDCM0488  CL93 HEK-293T C164(1.05); C316(0.90); C414(0.72); C390(0.89)  LDD1691  [25]
 LDCM0489  CL94 HEK-293T C164(0.97); C316(1.03); C390(1.04); C417(1.04)  LDD1692  [25]
 LDCM0490  CL95 HEK-293T C164(0.87); C316(0.91); C414(0.92); C417(0.92)  LDD1693  [25]
 LDCM0491  CL96 HEK-293T C164(0.86); C316(0.84); C414(0.96)  LDD1694  [25]
 LDCM0492  CL97 HEK-293T C164(1.03); C316(0.92); C414(0.95); C390(1.00)  LDD1695  [25]
 LDCM0493  CL98 HEK-293T C164(0.93); C316(0.98); C414(0.84); C390(0.90)  LDD1696  [25]
 LDCM0494  CL99 HEK-293T C164(0.99); C316(1.03); C414(1.11); C390(1.28)  LDD1697  [25]
 LDCM0634  CY-0357 Hep-G2 C164(0.50)  LDD2228  [15]
 LDCM0495  E2913 HEK-293T C164(0.89); C316(0.98); C414(0.93); C390(0.86)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C417(1.14); C316(0.95)  LDD1702  [7]
 LDCM0468  Fragment33 HEK-293T C164(0.90); C316(1.00); C414(0.97); C390(1.00)  LDD1671  [25]
 LDCM0427  Fragment51 HEK-293T C164(0.98); C316(0.98); C414(0.94); C390(0.80)  LDD1631  [25]
 LDCM0116  HHS-0101 DM93 Y287(0.66); Y190(1.05); Y274(1.14); Y429(1.21)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y287(0.62); Y229(1.05); Y190(1.06); Y274(1.23)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y190(0.89); Y229(1.04); Y287(1.08); Y274(1.11)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y287(0.55); Y274(0.91); Y190(1.09); Y429(1.18)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y190(0.78); Y287(0.88); Y274(0.88); Y429(1.27)  LDD0268  [11]
 LDCM0107  IAA HeLa N.A.  LDD0221  [21]
 LDCM0123  JWB131 DM93 Y190(0.75); Y429(0.73)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y429(1.44)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y190(2.05); Y429(1.08)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y429(3.50)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y429(2.45)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y429(1.17)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y190(1.38); Y429(0.86)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y190(1.26); Y429(0.73)  LDD0292  [10]
 LDCM0022  KB02 HEK-293T C164(1.02); C316(1.01); C414(0.98); C420(0.86)  LDD1492  [25]
 LDCM0023  KB03 HEK-293T C164(1.07); C316(0.88); C414(1.05); C420(1.09)  LDD1497  [25]
 LDCM0024  KB05 G361 C316(0.72)  LDD3311  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C316(0.64)  LDD2121  [7]
 LDCM0109  NEM HeLa H170(0.00); H63(0.00)  LDD0223  [21]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C316(0.95)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C316(1.02)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C316(1.00)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C316(1.27)  LDD2093  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C316(0.77)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C316(0.82)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C316(0.58)  LDD2100  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C316(1.10)  LDD2104  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C316(0.53)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C316(1.08)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C316(0.72)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C316(0.86)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C316(1.00)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C316(1.02)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C316(0.71)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C390(0.90)  LDD2115  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C316(1.17)  LDD2118  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C316(0.98)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C316(1.40)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C316(1.03)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C316(1.21)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C316(0.86)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C316(1.05)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C316(1.09)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C316(0.93)  LDD2128  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C316(0.51); C393(0.60)  LDD2134  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C316(1.86); C393(1.21); C390(0.86)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C316(0.95)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C316(1.46)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C316(0.87)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C316(0.95)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C316(0.90)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C316(3.06)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C316(3.38)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C316(1.02)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C316(2.55)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C316(0.56); C393(0.37)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C316(1.28)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C316(0.47)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C316(1.55)  LDD2151  [7]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.22  LDD0123  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Death-associated protein kinase 1 (DAPK1) CAMK Ser/Thr protein kinase family P53355
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cadherin-1 (CDH1) . P12830
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin alpha-1 (CTNNA1) Vinculin/alpha-catenin family P35221

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402