Details of the Target

General Information of Target

Target ID LDTP04875
Target Name Myosin light polypeptide 6 (MYL6)
Gene Name MYL6
Gene ID 4637
Synonyms
Myosin light polypeptide 6; 17 kDa myosin light chain; LC17; Myosin light chain 3; MLC-3; Myosin light chain alkali 3; Myosin light chain A3; Smooth muscle and nonmuscle myosin light chain alkali 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCDFTEDQTAEFKEAFQLFDRTGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDEM
NVKVLDFEHFLPMLQTVAKNKDQGTYEDYVEGLRVFDKEGNGTVMGAEIRHVLVTLGEKM
TEEEVEMLVAGHEDSNGCINYEAFVRHILSG
Target Bioclass
Other
Function Regulatory light chain of myosin. Does not bind calcium.
Uniprot ID
P60660
Ensemble ID
ENST00000547649.5
HGNC ID
HGNC:7587

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 48 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P2
 Probe Info  		3.23  LDD0449  [2]
P3
 Probe Info  		2.82  LDD0450  [2]
P8
 Probe Info  		3.86  LDD0451  [2]
AZ-9
 Probe Info  		4.63  LDD0393  [3]
CY-1
 Probe Info  		6.40  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
W1
 Probe Info  		14.44  LDD0235  [5]
TH211
 Probe Info  		Y29(7.51)  LDD0260  [6]
TH216
 Probe Info  		Y29(11.00)  LDD0259  [6]
YN-4
 Probe Info  		100.00  LDD0445  [7]
ONAyne
 Probe Info  		K50(0.00); K98(0.00)  LDD0273  [8]
OPA-S-S-alkyne
 Probe Info  		K26(1.69); K81(3.44); K98(3.79)  LDD3494  [9]
Probe 1
 Probe Info  		Y86(86.46); Y89(153.87)  LDD3495  [10]
DBIA
 Probe Info  		C138(1.33)  LDD3332  [11]
BTD
 Probe Info  		C32(2.66)  LDD1700  [12]
DA-P3
 Probe Info  		4.05  LDD0182  [13]
AHL-Pu-1
 Probe Info  		C32(3.10)  LDD0171  [14]
HHS-482
 Probe Info  		Y86(1.54); Y89(1.96)  LDD0286  [15]
HHS-475
 Probe Info  		Y29(0.86); Y86(0.98)  LDD0264  [16]
5E-2FA
 Probe Info  		H111(0.00); H69(0.00)  LDD2235  [17]
ATP probe
 Probe Info  		N.A.  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [19]
IA-alkyne
 Probe Info  		C2(0.00); C32(0.00)  LDD0162  [20]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [19]
ATP probe
 Probe Info  		K79(0.00); K63(0.00)  LDD0035  [21]
IPM
 Probe Info  		C32(0.00); C2(0.00)  LDD0025  [22]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [22]
NAIA_4
 Probe Info  		C138(0.00); C32(0.00)  LDD2226  [23]
TFBX
 Probe Info  		C2(0.00); C32(0.00)  LDD0027  [22]
WYneN
 Probe Info  		N.A.  LDD0021  [24]
WYneO
 Probe Info  		C32(0.00); C2(0.00)  LDD0022  [24]
1d-yne
 Probe Info  		K79(0.00); K81(0.00)  LDD0356  [25]
ENE
 Probe Info  		N.A.  LDD0006  [24]
NHS
 Probe Info  		K50(0.00); K81(0.00)  LDD0010  [24]
PF-06672131
 Probe Info  		N.A.  LDD0017  [26]
SF
 Probe Info  		Y86(0.00); Y89(0.00)  LDD0028  [27]
STPyne
 Probe Info  		N.A.  LDD0009  [24]
VSF
 Probe Info  		N.A.  LDD0007  [24]
Phosphinate-6
 Probe Info  		C32(0.00); C2(0.00)  LDD0018  [28]
1c-yne
 Probe Info  		K26(0.00); K81(0.00); K79(0.00); K63(0.00)  LDD0228  [25]
Acrolein
 Probe Info  		C32(0.00); H111(0.00); H69(0.00)  LDD0217  [29]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [29]
Crotonaldehyde
 Probe Info  		C32(0.00); H111(0.00)  LDD0219  [29]
Methacrolein
 Probe Info  		N.A.  LDD0218  [29]
AOyne
 Probe Info  		15.00  LDD0443  [30]
NAIA_5
 Probe Info  		N.A.  LDD2223  [23]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C284
 Probe Info  		29.04  LDD1954  [31]
C388
 Probe Info  		56.10  LDD2047  [31]
FFF probe12
 Probe Info  		6.18  LDD0473  [32]
FFF probe13
 Probe Info  		8.22  LDD0475  [32]
FFF probe2
 Probe Info  		5.38  LDD0463  [32]
STS-2
 Probe Info  		N.A.  LDD0138  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C32(0.40)  LDD2142  [12]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C32(0.82)  LDD2112  [12]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C32(1.10)  LDD2117  [12]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C32(1.34)  LDD2152  [12]
 LDCM0026  4SU-RNA+native RNA DM93 C32(3.10)  LDD0171  [14]
 LDCM0214  AC1 HEK-293T C138(1.14)  LDD1507  [34]
 LDCM0215  AC10 HEK-293T C138(1.07)  LDD1508  [34]
 LDCM0237  AC12 HEK-293T C138(1.11)  LDD1510  [34]
 LDCM0259  AC14 HEK-293T C138(1.05)  LDD1512  [34]
 LDCM0270  AC15 HEK-293T C138(1.16)  LDD1513  [34]
 LDCM0276  AC17 HEK-293T C138(1.14)  LDD1515  [34]
 LDCM0277  AC18 HEK-293T C138(1.09)  LDD1516  [34]
 LDCM0279  AC2 HEK-293T C138(1.17)  LDD1518  [34]
 LDCM0280  AC20 HEK-293T C138(1.07)  LDD1519  [34]
 LDCM0281  AC21 HEK-293T C138(1.21)  LDD1520  [34]
 LDCM0282  AC22 HEK-293T C138(1.16)  LDD1521  [34]
 LDCM0283  AC23 HEK-293T C138(1.04)  LDD1522  [34]
 LDCM0284  AC24 HEK-293T C138(1.27)  LDD1523  [34]
 LDCM0285  AC25 HEK-293T C138(0.99)  LDD1524  [34]
 LDCM0286  AC26 HEK-293T C138(1.08)  LDD1525  [34]
 LDCM0288  AC28 HEK-293T C138(1.15)  LDD1527  [34]
 LDCM0289  AC29 HEK-293T C138(1.08)  LDD1528  [34]
 LDCM0291  AC30 HEK-293T C138(1.11)  LDD1530  [34]
 LDCM0292  AC31 HEK-293T C138(1.01)  LDD1531  [34]
 LDCM0293  AC32 HEK-293T C138(1.26)  LDD1532  [34]
 LDCM0294  AC33 HEK-293T C138(1.09)  LDD1533  [34]
 LDCM0295  AC34 HEK-293T C138(1.17)  LDD1534  [34]
 LDCM0297  AC36 HEK-293T C138(1.13)  LDD1536  [34]
 LDCM0298  AC37 HEK-293T C138(1.32)  LDD1537  [34]
 LDCM0299  AC38 HEK-293T C138(1.15)  LDD1538  [34]
 LDCM0300  AC39 HEK-293T C138(1.28)  LDD1539  [34]
 LDCM0301  AC4 HEK-293T C138(0.96)  LDD1540  [34]
 LDCM0302  AC40 HEK-293T C138(1.07)  LDD1541  [34]
 LDCM0303  AC41 HEK-293T C138(1.01)  LDD1542  [34]
 LDCM0304  AC42 HEK-293T C138(1.14)  LDD1543  [34]
 LDCM0306  AC44 HEK-293T C138(1.03)  LDD1545  [34]
 LDCM0307  AC45 HEK-293T C138(1.17)  LDD1546  [34]
 LDCM0308  AC46 HEK-293T C138(1.25)  LDD1547  [34]
 LDCM0309  AC47 HEK-293T C138(1.04)  LDD1548  [34]
 LDCM0310  AC48 HEK-293T C138(1.44)  LDD1549  [34]
 LDCM0311  AC49 HEK-293T C138(1.25)  LDD1550  [34]
 LDCM0312  AC5 HEK-293T C138(1.05)  LDD1551  [34]
 LDCM0313  AC50 HEK-293T C138(1.12)  LDD1552  [34]
 LDCM0315  AC52 HEK-293T C138(1.13)  LDD1554  [34]
 LDCM0316  AC53 HEK-293T C138(1.24)  LDD1555  [34]
 LDCM0317  AC54 HEK-293T C138(1.31)  LDD1556  [34]
 LDCM0318  AC55 HEK-293T C138(1.18)  LDD1557  [34]
 LDCM0319  AC56 HEK-293T C138(1.16)  LDD1558  [34]
 LDCM0320  AC57 HEK-293T C138(1.03)  LDD1559  [34]
 LDCM0321  AC58 HEK-293T C138(1.14)  LDD1560  [34]
 LDCM0323  AC6 HEK-293T C138(0.99)  LDD1562  [34]
 LDCM0324  AC60 HEK-293T C138(1.11)  LDD1563  [34]
 LDCM0325  AC61 HEK-293T C138(1.10)  LDD1564  [34]
 LDCM0326  AC62 HEK-293T C138(1.15)  LDD1565  [34]
 LDCM0327  AC63 HEK-293T C138(1.19)  LDD1566  [34]
 LDCM0328  AC64 HEK-293T C138(1.09)  LDD1567  [34]
 LDCM0334  AC7 HEK-293T C138(1.02)  LDD1568  [34]
 LDCM0345  AC8 HEK-293T C138(0.95)  LDD1569  [34]
 LDCM0545  Acetamide MDA-MB-231 C32(0.38)  LDD2138  [12]
 LDCM0520  AKOS000195272 MDA-MB-231 C32(0.78)  LDD2113  [12]
 LDCM0248  AKOS034007472 HEK-293T C138(1.25)  LDD1511  [34]
 LDCM0356  AKOS034007680 HEK-293T C138(1.01)  LDD1570  [34]
 LDCM0275  AKOS034007705 HEK-293T C138(1.03)  LDD1514  [34]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C32(0.80)  LDD2091  [12]
 LDCM0630  CCW28-3 231MFP C32(1.36); C2(0.69)  LDD2214  [35]
 LDCM0108  Chloroacetamide HeLa C32(0.00); H111(0.00)  LDD0222  [29]
 LDCM0632  CL-Sc Hep-G2 C2(1.47)  LDD2227  [23]
 LDCM0367  CL1 HEK-293T C138(1.03)  LDD1571  [34]
 LDCM0368  CL10 HEK-293T C138(0.98)  LDD1572  [34]
 LDCM0369  CL100 HEK-293T C138(1.08)  LDD1573  [34]
 LDCM0370  CL101 HEK-293T C138(1.15)  LDD1574  [34]
 LDCM0371  CL102 HEK-293T C138(0.95)  LDD1575  [34]
 LDCM0372  CL103 HEK-293T C138(0.99)  LDD1576  [34]
 LDCM0373  CL104 HEK-293T C138(0.94)  LDD1577  [34]
 LDCM0374  CL105 HEK-293T C138(0.86)  LDD1578  [34]
 LDCM0375  CL106 HEK-293T C138(0.89)  LDD1579  [34]
 LDCM0376  CL107 HEK-293T C138(1.03)  LDD1580  [34]
 LDCM0377  CL108 HEK-293T C138(1.05)  LDD1581  [34]
 LDCM0378  CL109 HEK-293T C138(0.80)  LDD1582  [34]
 LDCM0379  CL11 HEK-293T C138(0.94)  LDD1583  [34]
 LDCM0380  CL110 HEK-293T C138(1.08)  LDD1584  [34]
 LDCM0381  CL111 HEK-293T C138(0.97)  LDD1585  [34]
 LDCM0382  CL112 HEK-293T C138(0.88)  LDD1586  [34]
 LDCM0383  CL113 HEK-293T C138(1.22)  LDD1587  [34]
 LDCM0384  CL114 HEK-293T C138(0.91)  LDD1588  [34]
 LDCM0385  CL115 HEK-293T C138(1.16)  LDD1589  [34]
 LDCM0386  CL116 HEK-293T C138(1.18)  LDD1590  [34]
 LDCM0387  CL117 HEK-293T C138(1.25)  LDD1591  [34]
 LDCM0388  CL118 HEK-293T C138(0.90)  LDD1592  [34]
 LDCM0389  CL119 HEK-293T C138(1.21)  LDD1593  [34]
 LDCM0390  CL12 HEK-293T C138(0.89)  LDD1594  [34]
 LDCM0391  CL120 HEK-293T C138(1.13)  LDD1595  [34]
 LDCM0392  CL121 HEK-293T C138(1.19)  LDD1596  [34]
 LDCM0393  CL122 HEK-293T C138(0.91)  LDD1597  [34]
 LDCM0394  CL123 HEK-293T C138(1.05)  LDD1598  [34]
 LDCM0395  CL124 HEK-293T C138(0.93)  LDD1599  [34]
 LDCM0396  CL125 HEK-293T C138(1.09)  LDD1600  [34]
 LDCM0397  CL126 HEK-293T C138(1.01)  LDD1601  [34]
 LDCM0398  CL127 HEK-293T C138(1.06)  LDD1602  [34]
 LDCM0399  CL128 HEK-293T C138(1.01)  LDD1603  [34]
 LDCM0400  CL13 HEK-293T C138(0.96)  LDD1604  [34]
 LDCM0401  CL14 HEK-293T C138(0.83)  LDD1605  [34]
 LDCM0402  CL15 HEK-293T C138(1.00)  LDD1606  [34]
 LDCM0403  CL16 HEK-293T C138(1.09)  LDD1607  [34]
 LDCM0404  CL17 HEK-293T C138(0.97)  LDD1608  [34]
 LDCM0405  CL18 HEK-293T C138(1.20)  LDD1609  [34]
 LDCM0407  CL2 HEK-293T C138(1.00)  LDD1611  [34]
 LDCM0408  CL20 HEK-293T C138(1.01)  LDD1612  [34]
 LDCM0409  CL21 HEK-293T C138(1.33)  LDD1613  [34]
 LDCM0410  CL22 HEK-293T C138(1.01)  LDD1614  [34]
 LDCM0411  CL23 HEK-293T C138(1.16)  LDD1615  [34]
 LDCM0412  CL24 HEK-293T C138(1.12)  LDD1616  [34]
 LDCM0413  CL25 HEK-293T C138(0.98)  LDD1617  [34]
 LDCM0414  CL26 HEK-293T C138(0.91)  LDD1618  [34]
 LDCM0415  CL27 HEK-293T C138(0.99)  LDD1619  [34]
 LDCM0416  CL28 HEK-293T C138(1.19)  LDD1620  [34]
 LDCM0417  CL29 HEK-293T C138(1.19)  LDD1621  [34]
 LDCM0418  CL3 HEK-293T C138(0.98)  LDD1622  [34]
 LDCM0419  CL30 HEK-293T C138(1.15)  LDD1623  [34]
 LDCM0421  CL32 HEK-293T C138(1.04)  LDD1625  [34]
 LDCM0422  CL33 HEK-293T C138(1.03)  LDD1626  [34]
 LDCM0423  CL34 HEK-293T C138(1.04)  LDD1627  [34]
 LDCM0424  CL35 HEK-293T C138(1.16)  LDD1628  [34]
 LDCM0425  CL36 HEK-293T C138(1.12)  LDD1629  [34]
 LDCM0426  CL37 HEK-293T C138(1.12)  LDD1630  [34]
 LDCM0428  CL39 HEK-293T C138(1.16)  LDD1632  [34]
 LDCM0429  CL4 HEK-293T C138(0.93)  LDD1633  [34]
 LDCM0430  CL40 HEK-293T C138(1.16)  LDD1634  [34]
 LDCM0431  CL41 HEK-293T C138(1.03)  LDD1635  [34]
 LDCM0432  CL42 HEK-293T C138(1.19)  LDD1636  [34]
 LDCM0434  CL44 HEK-293T C138(1.06)  LDD1638  [34]
 LDCM0435  CL45 HEK-293T C138(1.09)  LDD1639  [34]
 LDCM0436  CL46 HEK-293T C138(1.07)  LDD1640  [34]
 LDCM0437  CL47 HEK-293T C138(1.05)  LDD1641  [34]
 LDCM0438  CL48 HEK-293T C138(0.94)  LDD1642  [34]
 LDCM0439  CL49 HEK-293T C138(1.04)  LDD1643  [34]
 LDCM0440  CL5 HEK-293T C138(1.14)  LDD1644  [34]
 LDCM0441  CL50 HEK-293T C138(1.07)  LDD1645  [34]
 LDCM0443  CL52 HEK-293T C138(1.05)  LDD1646  [34]
 LDCM0444  CL53 HEK-293T C138(0.86)  LDD1647  [34]
 LDCM0445  CL54 HEK-293T C138(1.16)  LDD1648  [34]
 LDCM0447  CL56 HEK-293T C138(1.03)  LDD1650  [34]
 LDCM0448  CL57 HEK-293T C138(1.17)  LDD1651  [34]
 LDCM0449  CL58 HEK-293T C138(1.15)  LDD1652  [34]
 LDCM0450  CL59 HEK-293T C138(1.06)  LDD1653  [34]
 LDCM0451  CL6 HEK-293T C138(1.07)  LDD1654  [34]
 LDCM0452  CL60 HEK-293T C138(1.20)  LDD1655  [34]
 LDCM0453  CL61 HEK-293T C138(0.94)  LDD1656  [34]
 LDCM0454  CL62 HEK-293T C138(1.01)  LDD1657  [34]
 LDCM0455  CL63 HEK-293T C138(1.01)  LDD1658  [34]
 LDCM0456  CL64 HEK-293T C138(0.98)  LDD1659  [34]
 LDCM0457  CL65 HEK-293T C138(1.13)  LDD1660  [34]
 LDCM0458  CL66 HEK-293T C138(1.22)  LDD1661  [34]
 LDCM0460  CL68 HEK-293T C138(0.96)  LDD1663  [34]
 LDCM0461  CL69 HEK-293T C138(1.11)  LDD1664  [34]
 LDCM0463  CL70 HEK-293T C138(1.21)  LDD1666  [34]
 LDCM0464  CL71 HEK-293T C138(1.00)  LDD1667  [34]
 LDCM0465  CL72 HEK-293T C138(1.17)  LDD1668  [34]
 LDCM0466  CL73 HEK-293T C138(0.97)  LDD1669  [34]
 LDCM0467  CL74 HEK-293T C138(1.02)  LDD1670  [34]
 LDCM0469  CL76 HEK-293T C138(1.15)  LDD1672  [34]
 LDCM0470  CL77 HEK-293T C138(0.99)  LDD1673  [34]
 LDCM0471  CL78 HEK-293T C138(1.03)  LDD1674  [34]
 LDCM0473  CL8 HEK-293T C138(0.63)  LDD1676  [34]
 LDCM0474  CL80 HEK-293T C138(0.91)  LDD1677  [34]
 LDCM0475  CL81 HEK-293T C138(1.10)  LDD1678  [34]
 LDCM0476  CL82 HEK-293T C138(0.95)  LDD1679  [34]
 LDCM0477  CL83 HEK-293T C138(0.73)  LDD1680  [34]
 LDCM0478  CL84 HEK-293T C138(0.89)  LDD1681  [34]
 LDCM0479  CL85 HEK-293T C138(0.96)  LDD1682  [34]
 LDCM0480  CL86 HEK-293T C138(0.97)  LDD1683  [34]
 LDCM0481  CL87 HEK-293T C138(1.17)  LDD1684  [34]
 LDCM0482  CL88 HEK-293T C138(0.95)  LDD1685  [34]
 LDCM0483  CL89 HEK-293T C138(1.16)  LDD1686  [34]
 LDCM0484  CL9 HEK-293T C138(0.95)  LDD1687  [34]
 LDCM0485  CL90 HEK-293T C138(1.04)  LDD1688  [34]
 LDCM0487  CL92 HEK-293T C138(1.06)  LDD1690  [34]
 LDCM0488  CL93 HEK-293T C138(1.17)  LDD1691  [34]
 LDCM0489  CL94 HEK-293T C138(1.19)  LDD1692  [34]
 LDCM0490  CL95 HEK-293T C138(0.94)  LDD1693  [34]
 LDCM0491  CL96 HEK-293T C138(1.16)  LDD1694  [34]
 LDCM0492  CL97 HEK-293T C138(0.88)  LDD1695  [34]
 LDCM0493  CL98 HEK-293T C138(0.92)  LDD1696  [34]
 LDCM0494  CL99 HEK-293T C138(0.97)  LDD1697  [34]
 LDCM0495  E2913 HEK-293T C138(1.13)  LDD1698  [34]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C32(1.17)  LDD1702  [12]
 LDCM0625  F8 Ramos C32(0.59)  LDD2187  [36]
 LDCM0572  Fragment10 Ramos C32(0.87)  LDD2189  [36]
 LDCM0573  Fragment11 Ramos C32(0.02)  LDD2190  [36]
 LDCM0574  Fragment12 Ramos C32(0.92)  LDD2191  [36]
 LDCM0575  Fragment13 Ramos C32(1.31)  LDD2192  [36]
 LDCM0576  Fragment14 Ramos C32(0.64)  LDD2193  [36]
 LDCM0579  Fragment20 Ramos C32(0.75)  LDD2194  [36]
 LDCM0580  Fragment21 Ramos C32(1.17)  LDD2195  [36]
 LDCM0582  Fragment23 Ramos C32(1.64)  LDD2196  [36]
 LDCM0578  Fragment27 Ramos C32(1.17)  LDD2197  [36]
 LDCM0586  Fragment28 Ramos C32(1.54)  LDD2198  [36]
 LDCM0588  Fragment30 Ramos C32(1.55)  LDD2199  [36]
 LDCM0589  Fragment31 Ramos C32(1.74)  LDD2200  [36]
 LDCM0590  Fragment32 Ramos C32(0.67)  LDD2201  [36]
 LDCM0468  Fragment33 HEK-293T C138(0.96)  LDD1671  [34]
 LDCM0596  Fragment38 Ramos C32(1.83)  LDD2203  [36]
 LDCM0566  Fragment4 Ramos C32(0.86)  LDD2184  [36]
 LDCM0427  Fragment51 HEK-293T C138(0.95)  LDD1631  [34]
 LDCM0610  Fragment52 Ramos C32(1.79)  LDD2204  [36]
 LDCM0614  Fragment56 Ramos C32(1.68)  LDD2205  [36]
 LDCM0569  Fragment7 Ramos C32(0.63)  LDD2186  [36]
 LDCM0571  Fragment9 Ramos C32(0.82)  LDD2188  [36]
 LDCM0116  HHS-0101 DM93 Y29(0.86); Y86(0.98)  LDD0264  [16]
 LDCM0117  HHS-0201 DM93 Y86(0.73); Y29(0.85)  LDD0265  [16]
 LDCM0118  HHS-0301 DM93 Y86(0.66); Y29(0.85)  LDD0266  [16]
 LDCM0119  HHS-0401 DM93 Y29(0.69); Y86(0.78)  LDD0267  [16]
 LDCM0120  HHS-0701 DM93 Y29(0.74); Y86(1.26)  LDD0268  [16]
 LDCM0107  IAA HeLa C32(0.00); H111(0.00)  LDD0221  [29]
 LDCM0124  JWB142 DM93 Y86(1.54); Y89(1.96)  LDD0286  [15]
 LDCM0125  JWB146 DM93 Y86(0.71)  LDD0287  [15]
 LDCM0127  JWB152 DM93 Y86(1.27)  LDD0289  [15]
 LDCM0129  JWB202 DM93 Y86(0.43)  LDD0291  [15]
 LDCM0130  JWB211 DM93 Y86(0.44)  LDD0292  [15]
 LDCM0022  KB02 Ramos C32(0.50)  LDD2182  [36]
 LDCM0023  KB03 MDA-MB-231 C32(1.01)  LDD1701  [12]
 LDCM0024  KB05 MKN45 C138(1.33)  LDD3332  [11]
 LDCM0030  Luteolin HEK-293T 4.05  LDD0182  [13]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C32(0.70)  LDD2102  [12]
 LDCM0109  NEM HeLa H111(0.00); H69(0.00); C32(0.00)  LDD0223  [29]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C32(0.76)  LDD2089  [12]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C32(1.45)  LDD2090  [12]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C32(1.23)  LDD2093  [12]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C32(0.76)  LDD2097  [12]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C32(1.26)  LDD2099  [12]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C32(0.54)  LDD2100  [12]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C32(1.00)  LDD2101  [12]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C32(0.36)  LDD2104  [12]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C32(1.46)  LDD2105  [12]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C32(1.26)  LDD2107  [12]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C32(0.71)  LDD2108  [12]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C32(0.74)  LDD2109  [12]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C32(0.37)  LDD2110  [12]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C32(1.24)  LDD2111  [12]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C32(0.38)  LDD2114  [12]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C32(0.49)  LDD2115  [12]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C32(3.12)  LDD2116  [12]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C32(1.70)  LDD2118  [12]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C32(2.34)  LDD2119  [12]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C32(0.44)  LDD2122  [12]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C32(1.01)  LDD2123  [12]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C32(9.02)  LDD2124  [12]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C32(0.95)  LDD2125  [12]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C32(7.69)  LDD2126  [12]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C32(1.17)  LDD2127  [12]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C32(1.56)  LDD2129  [12]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C32(0.61)  LDD2133  [12]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C32(0.44)  LDD2134  [12]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C32(1.81)  LDD2135  [12]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C32(1.63)  LDD2136  [12]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C32(1.34)  LDD2137  [12]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C32(2.66)  LDD1700  [12]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C32(0.97)  LDD2140  [12]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C32(0.80)  LDD2141  [12]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C32(2.49)  LDD2144  [12]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C32(0.92)  LDD2145  [12]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C32(1.04)  LDD2146  [12]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C32(8.92)  LDD2149  [12]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C32(0.68)  LDD2150  [12]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C32(0.45)  LDD2151  [12]
 LDCM0627  NUDT7-COV-1 HEK-293T C2(1.10); C32(1.03); C2(0.80)  LDD2206  [37]
 LDCM0628  OTUB2-COV-1 HEK-293T C32(1.00); C2(0.79); C2(0.62)  LDD2207  [37]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Cleavage and polyadenylation specificity factor subunit 5 (NUDT21) Nudix hydrolase family O43809
A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12) . P58397
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Estrogen receptor (ESR1) Nuclear hormone receptor family P03372
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
GAS2-like protein 3 (GAS2L3) GAS2 family Q86XJ1

References

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2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
14 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
15 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
16 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
17 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
18 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
19 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
20 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
21 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
22 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
23 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
24 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
25 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
26 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
27 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
28 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
29 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
30 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
31 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
32 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
33 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
34 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
35 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
36 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
37 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.