Details of the Target

General Information of Target

Target ID LDTP00150
Target Name Acyl-coenzyme A diphosphatase NUDT19 (NUDT19)
Gene Name NUDT19
Gene ID 390916
Synonyms
Acyl-coenzyme A diphosphatase NUDT19; EC 3.6.1.-; Nucleoside diphosphate-linked moiety X motif 19; Nudix motif 19
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSSLRPGPSRWRRAASIVLAAGWSRPETATPPSRPPPAEGFRLLLLQRSPHQGFMPGAH
VFSGGVLDAADRSADWLGLFAPHHGPPRFGLGPAPFSRTAFPSLPDTDDHKTDNTGTLPE
DVAFRICAVREAFEEAGVLLLRPRTSPPGPAPGPGLALEPPPGLASWRDRVRQDPRHFLR
LCAHLDCTPDIWALHNWSAWLTPFLRGTTRRFDTAFFLCCLREPPPVYPDLAEVVGYQWS
SPSEATESFLSKEIWLPPPQFYEVRRLANFASLSDLHKFCLGRALEGLERWLPIILLTAD
GMVHLLPGDELYLEDSDFLENLMSTEKKTEEIMKEGKQFHRIVTYHRHLYDIHVTVQPKY
KHVYPKNSVVRKSHL
Target Bioclass
Enzyme
Family
Nudix hydrolase family
Subcellular location
Peroxisome
Function
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates. Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters. Exhibits decapping activity towards dpCoA-capped RNAs in vitro.
Uniprot ID
A8MXV4
Ensemble ID
ENST00000397061.4
HGNC ID
HGNC:32036

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.08  LDD0403  [1]
HHS-475
 Probe Info  		Y237(1.02)  LDD0264  [2]
Acrolein
 Probe Info  		N.A.  LDD0226  [3]
DBIA
 Probe Info  		C219(0.92); C220(0.92)  LDD0532  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
IA-alkyne
 Probe Info  		C219(0.00); C182(0.00)  LDD0162  [6]
HHS-465
 Probe Info  		Y237(0.00); K252(0.00)  LDD2240  [7]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C007
 Probe Info  		7.52  LDD1716  [8]
C169
 Probe Info  		20.53  LDD1849  [8]
C391
 Probe Info  		15.14  LDD2050  [8]
FFF probe3
 Probe Info  		20.00  LDD0464  [9]
FFF probe4
 Probe Info  		20.00  LDD0466  [9]
FFF probe6
 Probe Info  		20.00  LDD0467  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C187(1.05)  LDD1507  [10]
 LDCM0215  AC10 HCT 116 C219(0.92); C220(0.92)  LDD0532  [4]
 LDCM0216  AC100 HEK-293T C220(0.66)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C220(0.91)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C220(1.20)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C220(0.95)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C220(0.71)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C220(0.88)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C220(0.84)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C220(0.85)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C220(0.88)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C220(1.07)  LDD0823  [4]
 LDCM0226  AC11 HCT 116 C219(0.81); C220(0.81)  LDD0543  [4]
 LDCM0227  AC110 HEK-293T C220(0.98)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C220(0.97)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C220(0.88)  LDD0827  [4]
 LDCM0230  AC113 HCT 116 C219(0.96); C220(0.96)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C219(0.96); C220(1.05)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C219(0.78); C220(0.99)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C219(0.78); C220(1.11)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C219(0.82); C220(1.01)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C219(0.98); C220(1.04)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C219(0.79); C220(0.92)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C219(0.92); C220(0.92)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C219(0.75); C220(1.05)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C219(0.77); C220(0.95)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C219(0.83); C220(0.97)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C219(0.86); C220(0.92)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C219(0.92); C220(0.90)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C219(0.95); C220(1.01)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C219(1.05); C220(1.00)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C219(0.89); C220(0.89)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C219(0.96); C220(0.96)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C219(1.02); C220(1.02)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C219(0.79); C220(0.79)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C219(1.20); C220(1.20)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C219(1.42); C220(1.42)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C219(0.79); C220(0.79)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C219(0.91); C220(0.91)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C219(1.06); C220(1.06)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C219(0.93); C220(0.93)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C219(0.77); C220(0.77)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C219(0.76); C220(0.76)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C219(0.77); C220(0.77)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C219(0.88); C220(0.88)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C219(0.92); C220(0.92)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C219(0.92); C220(0.92)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C219(0.78); C220(0.78)  LDD0579  [4]
 LDCM0263  AC143 PaTu 8988t C219(0.59); C220(0.59)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C219(0.66); C220(0.66)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C219(0.59); C220(0.59)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C219(1.52); C220(1.52)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C219(1.02); C220(1.02)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C219(0.45); C220(0.45)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C219(0.76); C220(0.76)  LDD1148  [4]
 LDCM0270  AC15 HCT 116 C219(0.93); C220(0.93)  LDD0587  [4]
 LDCM0271  AC150 PaTu 8988t C219(1.02); C220(1.02)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C219(0.89); C220(0.89)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C219(0.88); C220(0.88)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C219(0.84); C220(0.84)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C219(0.87); C220(0.87)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C219(0.67); C220(0.67)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C219(0.94); C220(0.94)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C219(1.00); C220(1.00)  LDD2169  [4]
 LDCM0276  AC17 HEK-293T C220(0.71)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C220(0.90)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C220(0.86)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C220(1.00)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C220(0.86)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C220(1.03)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C220(1.03)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C220(0.82)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C220(1.06)  LDD0882  [4]
 LDCM0285  AC25 HCT 116 C219(0.88); C220(0.88)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C219(0.91); C220(0.91)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C219(1.15); C220(1.15)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C219(0.98); C220(0.98)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C219(1.29); C220(1.29)  LDD0606  [4]
 LDCM0291  AC30 HCT 116 C219(1.21); C220(1.21)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C219(0.98); C220(0.98)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C219(0.95); C220(0.95)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C219(1.15); C220(1.15)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C219(1.24); C220(1.24)  LDD0612  [4]
 LDCM0296  AC35 PaTu 8988t C219(1.34); C220(1.34)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C219(1.15); C220(1.15)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C219(1.19); C220(1.19)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C219(1.25); C220(1.25)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C219(1.44); C220(1.44)  LDD1179  [4]
 LDCM0301  AC4 HEK-293T C187(1.03)  LDD1540  [10]
 LDCM0302  AC40 PaTu 8988t C219(1.30); C220(1.30)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C219(1.03); C220(1.03)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C219(1.10); C220(1.10)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C219(1.28); C220(1.28)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C219(0.68); C220(0.68)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C219(0.59); C220(0.59)  LDD1186  [4]
 LDCM0308  AC46 HCT 116 C219(0.96); C220(0.96)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C219(0.96); C220(0.96)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C219(0.53); C220(0.53)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C219(0.90); C220(0.90)  LDD0628  [4]
 LDCM0312  AC5 HEK-293T C182(1.34); C187(0.97); C220(0.91)  LDD1551  [10]
 LDCM0313  AC50 HCT 116 C219(0.82); C220(0.82)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C219(0.88); C220(0.88)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C219(1.24); C220(1.24)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C219(1.10); C220(1.10)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C219(0.90); C220(0.90)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C219(0.89); C220(0.89)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C219(0.72); C220(0.72)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C219(0.84); C220(0.84)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C219(0.93); C220(0.93)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C219(1.07); C220(1.07)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C219(1.25); C220(1.25)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C219(0.71); C220(0.71)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C219(0.43); C220(0.43)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C219(0.88); C220(0.88)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C219(0.75); C220(0.75)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C219(0.76); C220(0.76)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C219(0.82); C220(0.82)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C219(0.84); C220(0.84)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C219(0.38); C220(0.38)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C219(0.84); C220(0.84)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C219(0.66); C220(0.66)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C219(1.02); C220(1.02)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C219(0.56); C220(0.56)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C219(0.71); C220(0.71)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C219(1.03); C220(1.03)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C219(0.65); C220(0.65)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C219(0.43); C220(0.43)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C219(0.41); C220(0.41)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C219(0.99); C220(0.99)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C219(0.76); C220(0.76)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C219(0.55); C220(0.55)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C219(0.74); C220(0.74)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C219(0.85); C220(0.85)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C219(0.77); C220(0.77)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C219(0.43); C220(0.43)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C219(0.15); C220(0.15)  LDD0665  [4]
 LDCM0349  AC83 PaTu 8988t C219(1.05); C220(1.05)  LDD1228  [4]
 LDCM0350  AC84 PaTu 8988t C219(0.91); C220(0.91)  LDD1229  [4]
 LDCM0351  AC85 PaTu 8988t C219(1.14); C220(1.14)  LDD1230  [4]
 LDCM0352  AC86 PaTu 8988t C219(1.03); C220(1.03)  LDD1231  [4]
 LDCM0353  AC87 PaTu 8988t C219(1.13); C220(1.13)  LDD1232  [4]
 LDCM0354  AC88 PaTu 8988t C219(1.05); C220(1.05)  LDD1233  [4]
 LDCM0355  AC89 PaTu 8988t C219(1.06); C220(1.06)  LDD1234  [4]
 LDCM0357  AC90 PaTu 8988t C219(1.21); C220(1.21)  LDD1236  [4]
 LDCM0358  AC91 PaTu 8988t C219(1.11); C220(1.11)  LDD1237  [4]
 LDCM0359  AC92 PaTu 8988t C219(1.27); C220(1.27)  LDD1238  [4]
 LDCM0360  AC93 PaTu 8988t C219(1.13); C220(1.13)  LDD1239  [4]
 LDCM0361  AC94 PaTu 8988t C219(1.44); C220(1.44)  LDD1240  [4]
 LDCM0362  AC95 PaTu 8988t C219(1.24); C220(1.24)  LDD1241  [4]
 LDCM0363  AC96 PaTu 8988t C219(1.29); C220(1.29)  LDD1242  [4]
 LDCM0364  AC97 PaTu 8988t C219(1.05); C220(1.05)  LDD1243  [4]
 LDCM0365  AC98 HEK-293T C220(0.78)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C220(0.68)  LDD0964  [4]
 LDCM0248  AKOS034007472 HCT 116 C219(1.05); C220(1.05)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C219(1.01); C220(1.01)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C219(0.82); C220(0.82)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 9.08  LDD0403  [1]
 LDCM0367  CL1 PaTu 8988t C219(1.17); C220(0.91)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C219(1.17); C220(0.97)  LDD1247  [4]
 LDCM0370  CL101 HCT 116 C219(1.24); C220(1.24)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C219(0.71); C220(0.71)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C219(1.10); C220(1.10)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C219(1.02); C220(1.02)  LDD0690  [4]
 LDCM0374  CL105 HEK-293T C220(0.91)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C220(0.83)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C220(0.99)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C220(0.76)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C220(0.82)  LDD0976  [4]
 LDCM0379  CL11 PaTu 8988t C219(1.16); C220(1.00)  LDD1258  [4]
 LDCM0380  CL110 HEK-293T C220(0.84)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C220(1.00)  LDD0979  [4]
 LDCM0382  CL112 HCT 116 C219(0.82); C220(0.82)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C219(1.17); C220(1.17)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C219(0.95); C220(0.95)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C219(0.95); C220(0.95)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C219(0.85); C220(0.85)  LDD0703  [4]
 LDCM0387  CL117 PaTu 8988t C219(1.24); C220(1.24)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C219(0.68); C220(0.68)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C219(1.15); C220(1.15)  LDD1268  [4]
 LDCM0390  CL12 PaTu 8988t C219(0.96); C220(0.89)  LDD1269  [4]
 LDCM0391  CL120 PaTu 8988t C219(1.31); C220(1.31)  LDD1270  [4]
 LDCM0392  CL121 HCT 116 C219(1.57); C220(1.57)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C219(0.67); C220(0.67)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C219(1.65); C220(1.65)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C219(0.96); C220(0.96)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C219(0.88); C220(0.88)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C219(1.20); C220(1.20)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C219(0.84); C220(0.84)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C219(1.20); C220(1.20)  LDD0716  [4]
 LDCM0400  CL13 PaTu 8988t C219(0.76); C220(0.69)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C219(0.74); C220(0.92)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C219(1.09); C220(0.97)  LDD1281  [4]
 LDCM0403  CL16 HCT 116 C219(0.71); C220(0.71)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C219(0.66); C220(0.66)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C219(0.46); C220(0.46)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C219(0.59); C220(0.59)  LDD0723  [4]
 LDCM0407  CL2 PaTu 8988t C219(1.06); C220(1.15)  LDD1286  [4]
 LDCM0408  CL20 HCT 116 C219(0.69); C220(0.69)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C219(0.72); C220(0.72)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C219(0.97); C220(0.97)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C219(1.10); C220(1.10)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C219(0.87); C220(0.87)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C219(0.81); C220(0.81)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C219(0.84); C220(0.84)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C219(0.88); C220(0.88)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C219(0.76); C220(0.76)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C219(0.67); C220(0.67)  LDD0734  [4]
 LDCM0418  CL3 PaTu 8988t C219(0.49); C220(0.45)  LDD1297  [4]
 LDCM0419  CL30 HCT 116 C219(0.78); C220(0.78)  LDD0736  [4]
 LDCM0420  CL31 PaTu 8988t C219(0.99); C220(0.99)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C219(0.91); C220(0.91)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C219(0.93); C220(0.93)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C219(0.68); C220(0.68)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C219(0.79); C220(0.79)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C219(0.37); C220(0.37)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C219(0.59); C220(0.59)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C219(0.72); C220(0.72)  LDD1307  [4]
 LDCM0429  CL4 PaTu 8988t C219(0.44); C220(0.47)  LDD1308  [4]
 LDCM0430  CL40 PaTu 8988t C219(0.90); C220(0.90)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C219(0.88); C220(0.88)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C219(0.85); C220(0.85)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C219(0.57); C220(0.57)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C219(0.84); C220(0.84)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C219(0.89); C220(0.89)  LDD1314  [4]
 LDCM0436  CL46 PaTu 8988t C182(1.38); C187(1.38); C219(1.00); C220(1.00)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C182(0.83); C187(0.83); C219(1.19); C220(1.19)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C182(1.53); C187(1.53); C219(1.27); C220(1.27)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C182(1.13); C187(1.13); C219(1.00); C220(1.00)  LDD1318  [4]
 LDCM0440  CL5 PaTu 8988t C219(0.96); C220(0.81)  LDD1319  [4]
 LDCM0441  CL50 PaTu 8988t C182(0.60); C187(0.60); C219(1.21); C220(1.21)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C182(1.48); C187(1.48); C219(1.19); C220(1.19)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C182(1.29); C187(1.29); C219(1.03); C220(1.03)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C182(0.74); C187(0.74); C219(1.02); C220(1.02)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C182(1.35); C187(1.35); C219(0.88); C220(0.88)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C182(1.09); C187(1.09); C219(0.90); C220(0.90)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C182(1.01); C187(1.01); C219(0.64); C220(0.64)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C182(1.22); C187(1.22); C219(0.87); C220(0.87)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C182(1.34); C187(1.34); C219(1.07); C220(1.07)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C182(1.17); C187(1.17); C219(0.75); C220(0.75)  LDD1329  [4]
 LDCM0451  CL6 PaTu 8988t C219(1.16); C220(1.12)  LDD1330  [4]
 LDCM0452  CL60 PaTu 8988t C182(1.13); C187(1.13); C219(0.96); C220(0.96)  LDD1331  [4]
 LDCM0453  CL61 HEK-293T C182(1.14); C220(1.04)  LDD1656  [10]
 LDCM0455  CL63 HEK-293T C187(1.09); C220(1.08)  LDD1658  [10]
 LDCM0457  CL65 HEK-293T C187(0.96)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C220(1.02)  LDD1661  [10]
 LDCM0460  CL68 HEK-293T C187(0.99)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C182(1.07); C187(0.89); C220(1.03)  LDD1664  [10]
 LDCM0462  CL7 PaTu 8988t C219(0.93); C220(0.78)  LDD1341  [4]
 LDCM0464  CL71 HEK-293T C187(0.82); C219(1.27)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C187(0.85); C220(1.05)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C182(1.00); C220(0.80)  LDD1669  [10]
 LDCM0469  CL76 HCT 116 C219(0.83); C220(0.83)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C219(2.67); C220(2.67)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C219(1.05); C220(1.05)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C219(1.06); C220(1.06)  LDD0789  [4]
 LDCM0473  CL8 PaTu 8988t C219(0.53); C220(0.41)  LDD1352  [4]
 LDCM0474  CL80 HCT 116 C219(0.76); C220(0.76)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C219(1.07); C220(1.07)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C219(0.82); C220(0.82)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C219(1.04); C220(1.04)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C219(0.96); C220(0.96)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C219(1.02); C220(1.02)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C219(1.03); C220(1.03)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C219(0.99); C220(0.99)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C219(1.18); C220(1.18)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C219(0.48); C220(0.48)  LDD0800  [4]
 LDCM0484  CL9 PaTu 8988t C219(0.79); C220(0.84)  LDD1363  [4]
 LDCM0485  CL90 HCT 116 C219(0.64); C220(0.64)  LDD0802  [4]
 LDCM0487  CL92 HEK-293T C187(0.98)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C182(1.10); C187(0.81); C220(0.91)  LDD1691  [10]
 LDCM0490  CL95 HEK-293T C187(1.16); C219(1.06)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C187(0.92); C220(0.95)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C182(0.90); C220(0.96)  LDD1695  [10]
 LDCM0494  CL99 HEK-293T C187(1.06); C220(0.96)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C187(1.03); C220(0.91)  LDD1698  [10]
 LDCM0625  F8 Ramos C280(1.11)  LDD2187  [11]
 LDCM0573  Fragment11 Ramos C280(0.68)  LDD2190  [11]
 LDCM0576  Fragment14 Ramos C280(0.75)  LDD2193  [11]
 LDCM0586  Fragment28 Ramos C280(1.78)  LDD2198  [11]
 LDCM0468  Fragment33 HEK-293T C187(1.02); C220(1.04)  LDD1671  [10]
 LDCM0566  Fragment4 Ramos C280(0.76)  LDD2184  [11]
 LDCM0427  Fragment51 PaTu 8988t C219(0.42); C220(0.42)  LDD1306  [4]
 LDCM0569  Fragment7 Ramos C280(0.82)  LDD2186  [11]
 LDCM0116  HHS-0101 DM93 Y237(1.02)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y237(0.63)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y237(1.30)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y237(0.76)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y237(0.96)  LDD0268  [2]
 LDCM0022  KB02 HEK-293T C187(1.07); C182(1.55); C187(1.55)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C187(1.05); C182(1.22); C187(1.22)  LDD1497  [10]
 LDCM0024  KB05 HEK-293T C187(1.08); C182(1.35); C187(1.35)  LDD1502  [10]
 LDCM0109  NEM HeLa N.A.  LDD0226  [3]

References

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2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578