Details of the Target

General Information of Target

Target ID LDTP03330
Target Name Proteasome subunit alpha type-1 (PSMA1)
Gene Name PSMA1
Gene ID 5682
Synonyms
HC2; NU; PROS30; PSC2; Proteasome subunit alpha type-1; 30 kDa prosomal protein; PROS-30; Macropain subunit C2; Multicatalytic endopeptidase complex subunit C2; Proteasome component C2; Proteasome nu chain
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ
KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPT
QRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFM
ECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERP
QRKAQPAQPADEPAEKADEPMEH
Target Bioclass
Enzyme
Family
Peptidase T1A family
Subcellular location
Cytoplasm
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Uniprot ID
P25786
Ensemble ID
ENST00000396394.7
HGNC ID
HGNC:9530
ChEMBL ID
CHEMBL4879432

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.M261V DBIA    Probe Info 
HUH7 Deletion: .
SNV: p.F145S		 DBIA    Probe Info 
KYM1 SNV: p.M176L DBIA    Probe Info 
SUPT1 SNV: p.A75V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.32  LDD0402  [1]
A-EBA
 Probe Info  		3.54  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y24(9.44); Y6(8.46)  LDD0257  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
BTD
 Probe Info  		C92(3.70)  LDD1699  [6]
OPA-S-S-alkyne
 Probe Info  		K115(4.28)  LDD3494  [7]
Probe 1
 Probe Info  		Y224(49.91)  LDD3495  [8]
DA-P3
 Probe Info  		5.99  LDD0183  [9]
HPAP
 Probe Info  		3.22  LDD0063  [10]
DBIA
 Probe Info  		C85(33.39); C85(84.06)  LDD0209  [11]
HHS-482
 Probe Info  		Y24(0.89); Y6(0.91)  LDD0285  [12]
HHS-475
 Probe Info  		Y128(0.09)  LDD0264  [13]
HHS-465
 Probe Info  		Y128(10.00); Y24(8.91)  LDD2237  [14]
5E-2FA
 Probe Info  		N.A.  LDD2235  [15]
AMP probe
 Probe Info  		N.A.  LDD0200  [16]
ATP probe
 Probe Info  		K115(0.00); K30(0.00); K39(0.00); K243(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C182(0.00); C85(0.00); C92(0.00); C148(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [18]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [19]
IPIAA_L
 Probe Info  		C92(0.00); C182(0.00); C148(0.00)  LDD0031  [19]
Lodoacetamide azide
 Probe Info  		C182(0.00); C85(0.00); C92(0.00); C148(0.00)  LDD0037  [17]
ATP probe
 Probe Info  		K189(0.00); K41(0.00); K39(0.00)  LDD0035  [20]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [21]
IPM
 Probe Info  		N.A.  LDD0147  [21]
NHS
 Probe Info  		K115(0.00); K243(0.00)  LDD0010  [22]
OSF
 Probe Info  		N.A.  LDD0029  [23]
SF
 Probe Info  		N.A.  LDD0028  [23]
STPyne
 Probe Info  		K115(0.00); K243(0.00)  LDD0009  [22]
TFBX
 Probe Info  		N.A.  LDD0148  [21]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [24]
Ox-W18
 Probe Info  		N.A.  LDD2175  [25]
1c-yne
 Probe Info  		K256(0.00); K208(0.00); K30(0.00)  LDD0228  [26]
1d-yne
 Probe Info  		N.A.  LDD0357  [26]
Acrolein
 Probe Info  		C182(0.00); H263(0.00); H175(0.00); H20(0.00)  LDD0217  [27]
Crotonaldehyde
 Probe Info  		H59(0.00); C85(0.00)  LDD0219  [27]
Methacrolein
 Probe Info  		H59(0.00); C85(0.00); C92(0.00)  LDD0218  [27]
MPP-AC
 Probe Info  		N.A.  LDD0428  [28]
NAIA_5
 Probe Info  		C182(0.00); C85(0.00)  LDD2223  [29]
TER-AC
 Probe Info  		N.A.  LDD0426  [28]
TPP-AC
 Probe Info  		N.A.  LDD0427  [28]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		6.23  LDD0475  [30]
FFF probe14
 Probe Info  		13.43  LDD0477  [30]
FFF probe3
 Probe Info  		10.90  LDD0464  [30]
FFF probe6
 Probe Info  		7.72  LDD0467  [30]
VE-P
 Probe Info  		N.A.  LDD0396  [31]
DA-2
 Probe Info  		N.A.  LDD0070  [32]
STS-1
 Probe Info  		N.A.  LDD0068  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C85(0.38); C92(0.32)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C85(0.67); C92(0.65)  LDD2112  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C85(1.05); C92(1.05)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C85(1.18); C92(1.45); C182(1.70)  LDD2152  [6]
 LDCM0214  AC1 HEK-293T C92(1.01); C85(0.94); C148(0.95)  LDD1507  [34]
 LDCM0215  AC10 HEK-293T C92(1.02); C85(1.01); C148(1.04); C156(1.50)  LDD1508  [34]
 LDCM0226  AC11 HEK-293T C92(1.14); C85(1.03); C148(0.86)  LDD1509  [34]
 LDCM0237  AC12 HEK-293T C92(1.03); C85(0.96); C148(0.92)  LDD1510  [34]
 LDCM0259  AC14 HEK-293T C92(1.13); C85(1.02); C182(0.85); C148(0.99)  LDD1512  [34]
 LDCM0270  AC15 HEK-293T C92(1.07); C85(0.99); C148(0.95)  LDD1513  [34]
 LDCM0276  AC17 HEK-293T C92(1.06); C85(0.88); C148(0.95)  LDD1515  [34]
 LDCM0277  AC18 HEK-293T C92(1.15); C85(0.97); C148(0.91); C156(0.94)  LDD1516  [34]
 LDCM0278  AC19 HEK-293T C92(1.02); C85(0.90); C148(0.73)  LDD1517  [34]
 LDCM0279  AC2 HEK-293T C92(0.99); C85(0.99); C148(1.00); C156(0.92)  LDD1518  [34]
 LDCM0280  AC20 HEK-293T C92(1.08); C85(0.94); C148(0.83)  LDD1519  [34]
 LDCM0281  AC21 HEK-293T C92(1.08); C85(0.98); C182(1.11); C148(0.91)  LDD1520  [34]
 LDCM0282  AC22 HEK-293T C92(1.05); C85(0.92); C182(1.10); C148(0.98)  LDD1521  [34]
 LDCM0283  AC23 HEK-293T C92(0.92); C85(1.01); C148(0.93)  LDD1522  [34]
 LDCM0284  AC24 HEK-293T C92(1.02); C85(1.02); C182(0.86); C148(0.94)  LDD1523  [34]
 LDCM0285  AC25 HEK-293T C92(0.99); C85(0.95); C148(1.00)  LDD1524  [34]
 LDCM0286  AC26 HEK-293T C92(1.04); C85(0.91); C148(0.98); C156(1.02)  LDD1525  [34]
 LDCM0287  AC27 HEK-293T C92(1.12); C85(1.04); C148(0.90)  LDD1526  [34]
 LDCM0288  AC28 HEK-293T C92(0.96); C85(0.93); C148(0.87)  LDD1527  [34]
 LDCM0289  AC29 HEK-293T C92(1.00); C85(0.99); C182(1.34); C148(0.95)  LDD1528  [34]
 LDCM0290  AC3 HEK-293T C92(1.02); C85(1.16); C148(1.05)  LDD1529  [34]
 LDCM0291  AC30 HEK-293T C92(1.08); C85(1.00); C182(0.91); C148(0.97)  LDD1530  [34]
 LDCM0292  AC31 HEK-293T C92(1.09); C85(1.00); C148(0.97)  LDD1531  [34]
 LDCM0293  AC32 HEK-293T C92(1.13); C85(1.02); C182(1.17); C148(0.87)  LDD1532  [34]
 LDCM0294  AC33 HEK-293T C92(0.94); C85(1.00); C148(0.95)  LDD1533  [34]
 LDCM0295  AC34 HEK-293T C92(1.06); C85(0.99); C148(0.96); C156(1.01)  LDD1534  [34]
 LDCM0296  AC35 HEK-293T C92(1.01); C85(1.12); C148(0.88)  LDD1535  [34]
 LDCM0297  AC36 HEK-293T C92(1.04); C85(1.08); C148(0.86)  LDD1536  [34]
 LDCM0298  AC37 HEK-293T C92(1.02); C85(0.93); C182(1.27); C148(0.94)  LDD1537  [34]
 LDCM0299  AC38 HEK-293T C92(1.06); C85(1.17); C182(0.70); C148(0.96)  LDD1538  [34]
 LDCM0300  AC39 HEK-293T C92(1.00); C85(1.15); C148(0.92)  LDD1539  [34]
 LDCM0301  AC4 HEK-293T C92(0.95); C85(1.01); C148(0.92)  LDD1540  [34]
 LDCM0302  AC40 HEK-293T C92(0.91); C85(1.08); C182(1.19); C148(0.84)  LDD1541  [34]
 LDCM0303  AC41 HEK-293T C92(1.00); C85(0.92); C148(0.98)  LDD1542  [34]
 LDCM0304  AC42 HEK-293T C92(0.97); C85(0.91); C148(1.00); C156(1.11)  LDD1543  [34]
 LDCM0305  AC43 HEK-293T C92(1.10); C85(1.15); C148(0.87)  LDD1544  [34]
 LDCM0306  AC44 HEK-293T C92(1.02); C85(1.05); C148(0.89)  LDD1545  [34]
 LDCM0307  AC45 HEK-293T C92(1.12); C85(0.94); C182(1.29); C148(0.91)  LDD1546  [34]
 LDCM0308  AC46 HEK-293T C92(0.98); C85(0.98); C182(0.93); C148(0.93)  LDD1547  [34]
 LDCM0309  AC47 HEK-293T C92(0.99); C85(1.06); C148(0.94)  LDD1548  [34]
 LDCM0310  AC48 HEK-293T C92(1.05); C85(1.02); C182(1.11); C148(0.83)  LDD1549  [34]
 LDCM0311  AC49 HEK-293T C92(0.92); C85(0.97); C148(0.98)  LDD1550  [34]
 LDCM0312  AC5 HEK-293T C92(1.01); C85(0.96); C182(0.92); C148(0.96)  LDD1551  [34]
 LDCM0313  AC50 HEK-293T C92(1.10); C85(0.98); C148(0.99); C156(1.12)  LDD1552  [34]
 LDCM0314  AC51 HEK-293T C92(1.02); C85(1.12); C148(0.85)  LDD1553  [34]
 LDCM0315  AC52 HEK-293T C92(1.03); C85(1.05); C148(0.86)  LDD1554  [34]
 LDCM0316  AC53 HEK-293T C92(1.01); C85(0.94); C182(1.02); C148(0.89)  LDD1555  [34]
 LDCM0317  AC54 HEK-293T C92(1.09); C85(1.09); C182(0.87); C148(1.04)  LDD1556  [34]
 LDCM0318  AC55 HEK-293T C92(0.96); C85(1.02); C148(0.95)  LDD1557  [34]
 LDCM0319  AC56 HEK-293T C92(1.02); C85(1.06); C182(0.94); C148(0.90)  LDD1558  [34]
 LDCM0320  AC57 HEK-293T C92(1.09); C85(0.95); C148(1.02)  LDD1559  [34]
 LDCM0321  AC58 HEK-293T C92(1.07); C85(0.98); C148(0.98); C156(1.39)  LDD1560  [34]
 LDCM0322  AC59 HEK-293T C92(1.02); C85(1.07); C148(0.91)  LDD1561  [34]
 LDCM0323  AC6 HEK-293T C92(1.08); C85(1.01); C182(0.87); C148(0.94)  LDD1562  [34]
 LDCM0324  AC60 HEK-293T C92(0.97); C85(0.94); C148(0.86)  LDD1563  [34]
 LDCM0325  AC61 HEK-293T C92(0.99); C85(0.94); C182(0.97); C148(0.96)  LDD1564  [34]
 LDCM0326  AC62 HEK-293T C92(1.08); C85(0.95); C182(0.98); C148(1.05)  LDD1565  [34]
 LDCM0327  AC63 HEK-293T C92(0.99); C85(0.98); C148(0.90)  LDD1566  [34]
 LDCM0328  AC64 HEK-293T C92(0.93); C85(1.09); C182(1.22); C148(0.94)  LDD1567  [34]
 LDCM0334  AC7 HEK-293T C92(0.93); C85(0.96); C148(1.02)  LDD1568  [34]
 LDCM0345  AC8 HEK-293T C92(1.06); C85(1.02); C182(1.24); C148(0.88)  LDD1569  [34]
 LDCM0545  Acetamide MDA-MB-231 C85(0.57)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C85(0.34); C92(0.54); C182(0.53)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C92(1.05); C85(0.90); C182(0.92); C148(0.94)  LDD1511  [34]
 LDCM0356  AKOS034007680 HEK-293T C92(0.99); C85(0.94); C148(0.95)  LDD1570  [34]
 LDCM0275  AKOS034007705 HEK-293T C92(1.04); C85(0.98); C182(1.13); C148(0.89)  LDD1514  [34]
 LDCM0156  Aniline NCI-H1299 11.97  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C148(1.50)  LDD2214  [35]
 LDCM0108  Chloroacetamide HeLa C182(0.00); H59(0.00); C85(0.00); C92(0.00)  LDD0222  [27]
 LDCM0367  CL1 HEK-293T C92(0.93); C85(0.94); C182(1.03); C148(0.98)  LDD1571  [34]
 LDCM0368  CL10 HEK-293T C92(0.83); C85(0.76); C182(0.80); C148(1.01)  LDD1572  [34]
 LDCM0369  CL100 HEK-293T C92(1.07); C85(0.96); C148(0.90)  LDD1573  [34]
 LDCM0370  CL101 HEK-293T C92(1.03); C85(0.97); C182(0.98); C148(0.99)  LDD1574  [34]
 LDCM0371  CL102 HEK-293T C92(0.91); C85(0.92); C148(0.91)  LDD1575  [34]
 LDCM0372  CL103 HEK-293T C92(1.03); C85(0.88); C182(1.21); C148(0.91)  LDD1576  [34]
 LDCM0373  CL104 HEK-293T C92(1.08); C85(0.97); C148(0.89)  LDD1577  [34]
 LDCM0374  CL105 HEK-293T C92(0.96); C85(0.97); C182(1.07); C148(0.96)  LDD1578  [34]
 LDCM0375  CL106 HEK-293T C92(0.92); C85(1.01); C148(0.98)  LDD1579  [34]
 LDCM0376  CL107 HEK-293T C92(1.22); C85(0.99); C182(1.26); C148(0.90)  LDD1580  [34]
 LDCM0377  CL108 HEK-293T C92(1.15); C85(1.08); C148(0.99)  LDD1581  [34]
 LDCM0378  CL109 HEK-293T C92(0.97); C85(0.98); C182(0.96); C148(0.95)  LDD1582  [34]
 LDCM0379  CL11 HEK-293T C92(0.90); C85(0.81); C148(0.99)  LDD1583  [34]
 LDCM0380  CL110 HEK-293T C92(0.88); C85(0.84); C148(0.88)  LDD1584  [34]
 LDCM0381  CL111 HEK-293T C92(1.01); C85(1.00); C182(1.63); C148(0.92)  LDD1585  [34]
 LDCM0382  CL112 HEK-293T C92(1.01); C85(1.00); C148(0.85)  LDD1586  [34]
 LDCM0383  CL113 HEK-293T C92(1.13); C85(1.02); C182(1.00); C148(1.00)  LDD1587  [34]
 LDCM0384  CL114 HEK-293T C92(0.88); C85(0.98); C148(0.97)  LDD1588  [34]
 LDCM0385  CL115 HEK-293T C92(1.06); C85(1.02); C182(1.21); C148(1.05)  LDD1589  [34]
 LDCM0386  CL116 HEK-293T C92(1.03); C85(0.99); C148(0.95)  LDD1590  [34]
 LDCM0387  CL117 HEK-293T C92(1.04); C85(1.00); C182(1.12); C148(0.99)  LDD1591  [34]
 LDCM0388  CL118 HEK-293T C92(1.04); C85(1.02); C148(0.98)  LDD1592  [34]
 LDCM0389  CL119 HEK-293T C92(1.11); C85(0.88); C182(0.98); C148(0.92)  LDD1593  [34]
 LDCM0390  CL12 HEK-293T C92(0.91); C85(0.89); C182(0.75); C148(1.07)  LDD1594  [34]
 LDCM0391  CL120 HEK-293T C92(0.95); C85(1.02); C148(0.91)  LDD1595  [34]
 LDCM0392  CL121 HEK-293T C92(0.89); C85(1.06); C182(1.08); C148(0.97)  LDD1596  [34]
 LDCM0393  CL122 HEK-293T C92(1.00); C85(1.04); C148(0.97)  LDD1597  [34]
 LDCM0394  CL123 HEK-293T C92(0.96); C85(0.88); C182(1.33); C148(0.85)  LDD1598  [34]
 LDCM0395  CL124 HEK-293T C92(1.00); C85(0.98); C148(0.92)  LDD1599  [34]
 LDCM0396  CL125 HEK-293T C92(0.96); C85(0.97); C182(0.80); C148(0.94)  LDD1600  [34]
 LDCM0397  CL126 HEK-293T C92(0.97); C85(1.01); C148(1.00)  LDD1601  [34]
 LDCM0398  CL127 HEK-293T C92(0.95); C85(0.98); C182(1.00); C148(0.95)  LDD1602  [34]
 LDCM0399  CL128 HEK-293T C92(0.98); C85(0.99); C148(1.00)  LDD1603  [34]
 LDCM0400  CL13 HEK-293T C92(0.97); C85(0.94); C182(1.00); C148(0.94)  LDD1604  [34]
 LDCM0401  CL14 HEK-293T C92(1.01); C85(0.98); C148(1.01)  LDD1605  [34]
 LDCM0402  CL15 HEK-293T C92(0.86); C85(0.75); C182(1.29); C148(0.82)  LDD1606  [34]
 LDCM0403  CL16 HEK-293T C92(1.08); C85(0.97); C148(0.96)  LDD1607  [34]
 LDCM0404  CL17 HEK-293T C92(0.93); C85(0.84); C148(0.85)  LDD1608  [34]
 LDCM0405  CL18 HEK-293T C92(1.03); C85(0.89); C148(1.04); C156(1.04)  LDD1609  [34]
 LDCM0406  CL19 HEK-293T C92(1.00); C85(1.01); C148(0.96)  LDD1610  [34]
 LDCM0407  CL2 HEK-293T C92(0.98); C85(0.95); C148(0.98)  LDD1611  [34]
 LDCM0408  CL20 HEK-293T C92(0.92); C85(0.88); C148(1.07)  LDD1612  [34]
 LDCM0409  CL21 HEK-293T C92(0.85); C85(0.80); C182(1.20); C148(0.84)  LDD1613  [34]
 LDCM0410  CL22 HEK-293T C92(0.96); C85(0.94); C182(1.00); C148(1.06)  LDD1614  [34]
 LDCM0411  CL23 HEK-293T C92(0.97); C85(1.02); C148(1.07)  LDD1615  [34]
 LDCM0412  CL24 HEK-293T C92(1.02); C85(0.84); C182(0.97); C148(1.07)  LDD1616  [34]
 LDCM0413  CL25 HEK-293T C92(1.02); C85(1.13); C182(0.95); C148(0.90)  LDD1617  [34]
 LDCM0414  CL26 HEK-293T C92(1.04); C85(1.07); C148(0.97)  LDD1618  [34]
 LDCM0415  CL27 HEK-293T C92(1.22); C85(1.05); C182(1.31); C148(1.02)  LDD1619  [34]
 LDCM0416  CL28 HEK-293T C92(1.04); C85(0.95); C148(0.88)  LDD1620  [34]
 LDCM0417  CL29 HEK-293T C92(1.03); C85(0.91); C148(0.93)  LDD1621  [34]
 LDCM0418  CL3 HEK-293T C92(0.95); C85(0.85); C182(1.15); C148(0.89)  LDD1622  [34]
 LDCM0419  CL30 HEK-293T C92(1.13); C85(1.01); C148(1.00); C156(1.07)  LDD1623  [34]
 LDCM0420  CL31 HEK-293T C92(1.09); C85(1.04); C148(0.97)  LDD1624  [34]
 LDCM0421  CL32 HEK-293T C92(1.02); C85(0.91); C148(1.00)  LDD1625  [34]
 LDCM0422  CL33 HEK-293T C92(0.86); C85(0.79); C182(0.67); C148(0.80)  LDD1626  [34]
 LDCM0423  CL34 HEK-293T C92(1.07); C85(0.95); C182(0.89); C148(0.97)  LDD1627  [34]
 LDCM0424  CL35 HEK-293T C92(1.09); C85(0.99); C148(0.99)  LDD1628  [34]
 LDCM0425  CL36 HEK-293T C92(0.99); C85(0.97); C182(0.95); C148(1.09)  LDD1629  [34]
 LDCM0426  CL37 HEK-293T C92(0.96); C85(1.10); C182(0.92); C148(0.94)  LDD1630  [34]
 LDCM0428  CL39 HEK-293T C92(1.03); C85(1.19); C182(1.37); C148(0.94)  LDD1632  [34]
 LDCM0429  CL4 HEK-293T C92(1.02); C85(0.93); C148(1.00)  LDD1633  [34]
 LDCM0430  CL40 HEK-293T C92(1.10); C85(0.98); C148(0.89)  LDD1634  [34]
 LDCM0431  CL41 HEK-293T C92(1.11); C85(0.94); C148(0.91)  LDD1635  [34]
 LDCM0432  CL42 HEK-293T C92(1.08); C85(0.93); C148(0.99); C156(0.90)  LDD1636  [34]
 LDCM0433  CL43 HEK-293T C92(1.20); C85(1.08); C148(0.92)  LDD1637  [34]
 LDCM0434  CL44 HEK-293T C92(1.14); C85(0.93); C148(0.91)  LDD1638  [34]
 LDCM0435  CL45 HEK-293T C92(0.91); C85(0.81); C182(1.09); C148(0.97)  LDD1639  [34]
 LDCM0436  CL46 HEK-293T C92(1.09); C85(0.96); C182(0.96); C148(0.94)  LDD1640  [34]
 LDCM0437  CL47 HEK-293T C92(0.97); C85(0.87); C148(1.02)  LDD1641  [34]
 LDCM0438  CL48 HEK-293T C92(1.03); C85(0.91); C182(0.82); C148(1.00)  LDD1642  [34]
 LDCM0439  CL49 HEK-293T C92(0.98); C85(1.16); C182(1.16); C148(0.90)  LDD1643  [34]
 LDCM0440  CL5 HEK-293T C92(1.05); C85(0.96); C148(1.02)  LDD1644  [34]
 LDCM0441  CL50 HEK-293T C92(1.00); C85(0.99); C148(0.87)  LDD1645  [34]
 LDCM0443  CL52 HEK-293T C92(1.08); C85(0.99); C148(0.95)  LDD1646  [34]
 LDCM0444  CL53 HEK-293T C92(0.99); C85(0.88); C148(0.88)  LDD1647  [34]
 LDCM0445  CL54 HEK-293T C92(0.96); C85(0.87); C148(0.98); C156(1.12)  LDD1648  [34]
 LDCM0446  CL55 HEK-293T C92(1.12); C85(1.09); C148(0.97)  LDD1649  [34]
 LDCM0447  CL56 HEK-293T C92(1.11); C85(1.03); C148(1.01)  LDD1650  [34]
 LDCM0448  CL57 HEK-293T C92(0.94); C85(0.80); C182(1.09); C148(1.10)  LDD1651  [34]
 LDCM0449  CL58 HEK-293T C92(1.05); C85(0.94); C182(1.34); C148(1.02)  LDD1652  [34]
 LDCM0450  CL59 HEK-293T C92(0.96); C85(0.93); C148(1.08)  LDD1653  [34]
 LDCM0451  CL6 HEK-293T C92(0.91); C85(0.79); C148(0.96); C156(1.09)  LDD1654  [34]
 LDCM0452  CL60 HEK-293T C92(1.02); C85(0.99); C182(1.03); C148(1.01)  LDD1655  [34]
 LDCM0453  CL61 HEK-293T C92(1.07); C85(1.04); C182(1.09); C148(0.97)  LDD1656  [34]
 LDCM0454  CL62 HEK-293T C92(1.06); C85(1.11); C148(1.04)  LDD1657  [34]
 LDCM0455  CL63 HEK-293T C92(1.19); C85(0.88); C182(1.24); C148(0.90)  LDD1658  [34]
 LDCM0456  CL64 HEK-293T C92(0.90); C85(0.92); C148(0.86)  LDD1659  [34]
 LDCM0457  CL65 HEK-293T C92(1.02); C85(0.91); C148(0.89)  LDD1660  [34]
 LDCM0458  CL66 HEK-293T C92(1.06); C85(0.86); C148(0.98); C156(0.90)  LDD1661  [34]
 LDCM0459  CL67 HEK-293T C92(1.10); C85(1.12); C148(0.97)  LDD1662  [34]
 LDCM0460  CL68 HEK-293T C92(0.95); C85(0.96); C148(0.96)  LDD1663  [34]
 LDCM0461  CL69 HEK-293T C92(1.03); C85(0.86); C182(1.14); C148(0.94)  LDD1664  [34]
 LDCM0462  CL7 HEK-293T C92(0.97); C85(1.03); C148(0.93)  LDD1665  [34]
 LDCM0463  CL70 HEK-293T C92(1.11); C85(0.97); C182(0.86); C148(1.02)  LDD1666  [34]
 LDCM0464  CL71 HEK-293T C92(1.02); C85(0.94); C148(1.07)  LDD1667  [34]
 LDCM0465  CL72 HEK-293T C92(1.07); C85(0.89); C182(1.05); C148(1.13)  LDD1668  [34]
 LDCM0466  CL73 HEK-293T C92(0.85); C85(0.99); C182(1.00); C148(0.94)  LDD1669  [34]
 LDCM0467  CL74 HEK-293T C92(1.01); C85(1.02); C148(1.01)  LDD1670  [34]
 LDCM0469  CL76 HEK-293T C92(1.10); C85(1.04); C148(1.01)  LDD1672  [34]
 LDCM0470  CL77 HEK-293T C92(0.86); C85(0.83); C148(0.88)  LDD1673  [34]
 LDCM0471  CL78 HEK-293T C92(1.14); C85(0.97); C148(0.94); C156(1.13)  LDD1674  [34]
 LDCM0472  CL79 HEK-293T C92(1.08); C85(1.08); C148(0.92)  LDD1675  [34]
 LDCM0473  CL8 HEK-293T C92(0.66); C85(0.77); C148(0.83)  LDD1676  [34]
 LDCM0474  CL80 HEK-293T C92(1.07); C85(0.96); C148(0.91)  LDD1677  [34]
 LDCM0475  CL81 HEK-293T C92(0.91); C85(0.89); C182(0.94); C148(1.00)  LDD1678  [34]
 LDCM0476  CL82 HEK-293T C92(1.08); C85(1.01); C182(0.94); C148(1.01)  LDD1679  [34]
 LDCM0477  CL83 HEK-293T C92(1.03); C85(0.95); C148(0.95)  LDD1680  [34]
 LDCM0478  CL84 HEK-293T C92(0.96); C85(0.86); C182(0.98); C148(1.03)  LDD1681  [34]
 LDCM0479  CL85 HEK-293T C92(1.05); C85(0.99); C182(0.79); C148(0.97)  LDD1682  [34]
 LDCM0480  CL86 HEK-293T C92(1.17); C85(1.18); C148(1.01)  LDD1683  [34]
 LDCM0481  CL87 HEK-293T C92(1.03); C85(0.98); C182(1.09); C148(0.91)  LDD1684  [34]
 LDCM0482  CL88 HEK-293T C92(1.14); C85(0.98); C148(0.99)  LDD1685  [34]
 LDCM0483  CL89 HEK-293T C92(1.03); C85(0.96); C148(0.95)  LDD1686  [34]
 LDCM0484  CL9 HEK-293T C92(0.97); C85(0.78); C182(0.86); C148(0.92)  LDD1687  [34]
 LDCM0485  CL90 HEK-293T C92(0.88); C85(0.78); C148(0.88); C156(0.83)  LDD1688  [34]
 LDCM0486  CL91 HEK-293T C92(1.20); C85(1.08); C148(0.89)  LDD1689  [34]
 LDCM0487  CL92 HEK-293T C92(0.94); C85(0.93); C148(0.91)  LDD1690  [34]
 LDCM0488  CL93 HEK-293T C92(0.90); C85(0.85); C182(0.96); C148(0.99)  LDD1691  [34]
 LDCM0489  CL94 HEK-293T C92(1.03); C85(0.94); C182(0.92); C148(1.09)  LDD1692  [34]
 LDCM0490  CL95 HEK-293T C92(0.79); C85(0.74); C148(0.75)  LDD1693  [34]
 LDCM0491  CL96 HEK-293T C92(0.95); C85(0.92); C182(0.80); C148(1.00)  LDD1694  [34]
 LDCM0492  CL97 HEK-293T C92(0.90); C85(0.90); C182(1.08); C148(0.93)  LDD1695  [34]
 LDCM0493  CL98 HEK-293T C92(1.07); C85(1.02); C148(1.00)  LDD1696  [34]
 LDCM0494  CL99 HEK-293T C92(1.13); C85(0.94); C182(1.19); C148(1.06)  LDD1697  [34]
 LDCM0495  E2913 HEK-293T C92(1.28); C85(1.11); C182(1.33); C148(1.05)  LDD1698  [34]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C85(2.06)  LDD1702  [6]
 LDCM0031  Epigallocatechin gallate HEK-293T 5.99  LDD0183  [9]
 LDCM0201  EV-3 T cell C148, C156(8.84)  LDD0528  [36]
 LDCM0625  F8 Ramos C85(0.78); C182(1.55)  LDD2187  [37]
 LDCM0572  Fragment10 Ramos C85(0.61)  LDD2189  [37]
 LDCM0573  Fragment11 Ramos C85(0.34); C182(2.66)  LDD2190  [37]
 LDCM0574  Fragment12 Ramos C85(0.64); C182(0.36)  LDD2191  [37]
 LDCM0575  Fragment13 Ramos C85(1.07)  LDD2192  [37]
 LDCM0576  Fragment14 Ramos C85(0.86); C182(0.71)  LDD2193  [37]
 LDCM0579  Fragment20 Ramos C85(0.51); C182(0.59)  LDD2194  [37]
 LDCM0580  Fragment21 Ramos C85(0.85); C182(1.06)  LDD2195  [37]
 LDCM0582  Fragment23 Ramos C85(1.15); C182(0.95)  LDD2196  [37]
 LDCM0578  Fragment27 Ramos C85(0.80); C182(0.79)  LDD2197  [37]
 LDCM0586  Fragment28 Ramos C85(0.49); C182(1.36)  LDD2198  [37]
 LDCM0588  Fragment30 Ramos C85(1.04); C182(0.12)  LDD2199  [37]
 LDCM0589  Fragment31 Ramos C85(1.57); C182(0.94)  LDD2200  [37]
 LDCM0590  Fragment32 Ramos C85(0.59); C182(0.52)  LDD2201  [37]
 LDCM0468  Fragment33 HEK-293T C92(1.03); C85(0.95); C182(1.21); C148(0.90)  LDD1671  [34]
 LDCM0596  Fragment38 Ramos C85(0.89); C182(0.68)  LDD2203  [37]
 LDCM0566  Fragment4 Ramos C85(0.81); C182(0.65)  LDD2184  [37]
 LDCM0427  Fragment51 HEK-293T C92(1.11); C85(1.07); C148(0.86)  LDD1631  [34]
 LDCM0610  Fragment52 Ramos C85(1.05)  LDD2204  [37]
 LDCM0614  Fragment56 Ramos C85(1.62)  LDD2205  [37]
 LDCM0569  Fragment7 Ramos C85(0.51); C182(0.54)  LDD2186  [37]
 LDCM0571  Fragment9 Ramos C85(0.61); C182(0.33)  LDD2188  [37]
 LDCM0116  HHS-0101 DM93 Y128(0.09)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y128(1.60)  LDD0265  [13]
 LDCM0119  HHS-0401 DM93 Y128(0.62)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y128(0.94)  LDD0268  [13]
 LDCM0107  IAA HeLa H175(0.00); C85(0.00); H263(0.00); C92(0.00)  LDD0221  [27]
 LDCM0123  JWB131 DM93 Y24(0.89); Y6(0.91)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y24(0.65); Y6(1.68)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y24(0.95); Y6(0.90)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y24(2.13); Y6(4.11)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y24(1.87); Y6(3.63)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y24(1.24)  LDD0290  [12]
 LDCM0129  JWB202 DM93 Y24(0.54); Y6(0.84)  LDD0291  [12]
 LDCM0130  JWB211 DM93 Y24(0.81); Y6(0.63)  LDD0292  [12]
 LDCM0022  KB02 HEK-293T C92(0.87); C85(0.95); C182(1.03); C148(1.00)  LDD1492  [34]
 LDCM0023  KB03 Jurkat C85(33.39); C85(84.06)  LDD0209  [11]
 LDCM0024  KB05 COLO792 C91(2.10); C98(1.43)  LDD3310  [38]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C85(1.22)  LDD2102  [6]
 LDCM0109  NEM HeLa H175(0.00); H20(0.00); H263(0.00); C92(0.00)  LDD0223  [27]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C85(0.99)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C85(1.37); C182(2.04)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C85(1.46)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C182(2.57)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C182(0.20)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C85(0.46); C182(0.81)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C85(0.77); C182(0.60)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C85(1.21); C92(1.23)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C85(0.40)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C85(0.45); C92(0.49); C182(0.81)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C85(0.55); C92(0.35); C182(0.51)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C85(1.58); C92(0.99); C182(1.38)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C85(0.26)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C85(0.96); C92(0.88)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C85(0.40); C92(0.39); C182(0.69)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C85(0.66); C92(0.59)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C92(1.46); C182(1.32)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C85(0.74); C92(0.52); C182(0.48)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C85(0.50); C182(0.48)  LDD2115  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C92(2.31); C182(1.87)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C85(0.70); C92(0.83); C182(0.89)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C182(0.32)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C85(1.01); C182(1.12)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C92(0.84); C182(0.28)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C85(0.99); C92(0.81)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C182(0.28)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C85(1.05); C92(0.95)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C85(0.75); C182(0.99)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C85(1.20); C92(1.09)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C85(0.50); C92(0.26)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C85(0.49); C182(0.58)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C85(1.35); C92(1.03)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C85(1.16); C92(1.16)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C85(1.05); C92(0.98)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C92(3.45)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C85(0.91); C92(0.99); C182(1.09)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C85(0.48); C92(0.69)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C85(0.54); C182(0.79)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C85(2.17)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C85(0.23); C92(0.17); C182(0.23)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C85(0.97); C92(1.04); C182(1.07)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C85(0.95)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C85(0.33); C182(0.37)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C85(0.51)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C182(0.24)  LDD2151  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C148(1.26); C148(1.04)  LDD2206  [39]
 LDCM0628  OTUB2-COV-1 HEK-293T C148(1.67); C148(0.60)  LDD2207  [39]
 LDCM0014  Panhematin K562 3.22  LDD0063  [10]
 LDCM0131  RA190 MM1.R C182(1.57)  LDD0304  [40]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 34 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
Diamine acetyltransferase 1 (SAT1) Acetyltransferase family P21673
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Methylthioribulose-1-phosphate dehydratase (APIP) Aldolase class II family Q96GX9
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
PR domain zinc finger protein 14 (PRDM14) Class V-like SAM-binding methyltransferase superfamily Q9GZV8
Cystathionine beta-synthase (CBS) Cysteine synthase/cystathionine beta-synthase family P35520
Cytidine deaminase (CDA) Cytidine and deoxycytidylate deaminase family P32320
Deoxycytidylate deaminase (DCTD) Cytidine and deoxycytidylate deaminase family P32321
Ethanolamine-phosphate cytidylyltransferase (PCYT2) Cytidylyltransferase family Q99447
Eukaryotic initiation factor 4A-III (EIF4A3) DEAD box helicase family P38919
DNA-directed primase/polymerase protein (PRIMPOL) Eukaryotic-type primase small subunit family Q96LW4
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
Xaa-Arg dipeptidase (PM20D2) Peptidase M20A family Q8IYS1
Proteasome subunit alpha type-2 (PSMA2) Peptidase T1A family P25787
Proteasome subunit alpha type-3 (PSMA3) Peptidase T1A family P25788
Proteasome subunit alpha type-4 (PSMA4) Peptidase T1A family P25789
Proteasome subunit alpha type-7 (PSMA7) Peptidase T1A family O14818
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Proteasome subunit beta type-2 (PSMB2) Peptidase T1B family P49721
Mitogen-activated protein kinase 1 (MAPK1) CMGC Ser/Thr protein kinase family P28482
Pterin-4-alpha-carbinolamine dehydratase (PCBD1) Pterin-4-alpha-carbinolamine dehydratase family P61457
RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) RBR family Q9BYM8
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) Short-chain dehydrogenases/reductases (SDR) family Q9BPX1
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) Stealth family Q3T906
Tripartite motif-containing protein 10 (TRIM10) TRIM/RBCC family Q9UDY6
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Protein yippee-like 5 (YPEL5) Yippee family P62699
dCTP pyrophosphatase 1 (DCTPP1) . Q9H773
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-2 (ACTN2) Alpha-actinin family P35609
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Gasdermin-D (GSDMD) Gasdermin family P57764
Huntingtin (HTT) Huntingtin family P42858
Importin-13 (IPO13) Importin beta family O94829
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Transcription factor
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C11 (HOXC11) Abd-B homeobox family O43248
SAM pointed domain-containing Ets transcription factor (SPDEF) ETS family O95238
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Leucine zipper transcription factor-like protein 1 (LZTFL1) LZTFL1 family Q9NQ48
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Golgin-45 (BLZF1) . Q9H2G9
Myb/SANT-like DNA-binding domain-containing protein 4 (MSANTD4) . Q8NCY6
Proto-oncogene c-Rel (REL) . Q04864
Transcription factor 12 (TCF12) . Q99081
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 74 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ABI gene family member 3 (ABI3) ABI family Q9P2A4
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Ataxin-1 (ATXN1) ATXN1 family P54253
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (KCTD13) BACURD family Q8WZ19
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1) BACURD family Q13829
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) CDKN2 cyclin-dependent kinase inhibitor family P55273
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Centrosomal protein of 72 kDa (CEP72) CEP72 family Q9P209
Cilia- and flagella-associated protein 206 (CFAP206) CFAP206 family Q8IYR0
Cyclin-dependent kinase 2-interacting protein (CINP) CINP family Q9BW66
Conserved oligomeric Golgi complex subunit 4 (COG4) COG4 family Q9H9E3
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
Cyclin-H (CCNH) Cyclin family P51946
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
DPY30 domain-containing protein 1 (DYDC1) Dpy-30 family Q8WWB3
Dynein light chain Tctex-type 1 (DYNLT1) Dynein light chain Tctex-type family P63172
SMC5-SMC6 complex localization factor protein 2 (SLF2) FAM178 family Q8IX21
Pre-mRNA-splicing regulator WTAP (WTAP) Fl(2)d family Q15007
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6A (GOLGA6A) GOLGA6 family Q9NYA3
Protein HEXIM2 (HEXIM2) HEXIM family Q96MH2
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cuticular Ha7 (KRT37) Intermediate filament family O76014
Keratin, type I cuticular Ha8 (KRT38) Intermediate filament family O76015
Keratin, type I cytoskeletal 13 (KRT13) Intermediate filament family P13646
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Peripherin (PRPH) Intermediate filament family P41219
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) KHDRBS family O75525
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 4-1 (KRTAP4-1) KRTAP type 4 family Q9BYQ7
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Protein LDOC1 (LDOC1) LDOC1 family O95751
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) MAD1 family Q9Y6D9
Microtubule-associated protein RP/EB family member 1 (MAPRE1) MAPRE family Q15691
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8
MORF4 family-associated protein 1-like 1 (MRFAP1L1) MORF4 family-associated protein family Q96HT8
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Paraneoplastic antigen Ma2 (PNMA2) PNMA family Q9UL42
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
Ropporin-1A (ROPN1) Ropporin family Q9HAT0
Mitochondrial dynamics protein MIEF1 (MIEF1) SMCR7 family Q9NQG6
Charged multivesicular body protein 1a (CHMP1A) SNF7 family Q9HD42
Tektin-4 (TEKT4) Tektin family Q8WW24
TNF receptor-associated factor 5 (TRAF5) TNF receptor-associated factor family O00463
Synaptic plasticity regulator PANTS (C22orf39) UPF0545 family Q6P5X5
BTB/POZ domain-containing protein KCTD1 (KCTD1) . Q719H9
BTB/POZ domain-containing protein KCTD6 (KCTD6) . Q8NC69
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Calcium-binding protein 5 (CABP5) . Q9NP86
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Differentially expressed in FDCP 6 homolog (DEF6) . Q9H4E7
Fibronectin type III domain-containing protein 11 (FNDC11) . Q9BVV2
Heat shock factor 2-binding protein (HSF2BP) . O75031
INO80 complex subunit E (INO80E) . Q8NBZ0
Intraflagellar transport protein 20 homolog (IFT20) . Q8IY31
PRKCA-binding protein (PICK1) . Q9NRD5
Regulator of G-protein signaling 19 (RGS19) . P49795
TNF receptor-associated factor 1 (TRAF1) . Q13077
UBX domain-containing protein 11 (UBXN11) . Q5T124
Vimentin-type intermediate filament-associated coiled-coil protein (VMAC) . Q2NL98
Zinc finger MYND domain-containing protein 19 (ZMYND19) . Q96E35

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(3ar6r6as)-6-((S)-((S)-cyclohex-2-enyl)(Hydroxy)Methyl)-6a-methyl-4-oxo-hexahydro-2h-furo[32-c]Pyrrole-6-carbaldehyde . DB08515

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
10 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
11 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
12 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
20 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
23 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
26 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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Mass spectrometry data entry: PXD041264
30 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD047840
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