Details of the Target

General Information of Target

Target ID LDTP00223
Target Name 26S proteasome non-ATPase regulatory subunit 11 (PSMD11)
Gene Name PSMD11
Gene ID 5717
Synonyms
26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit S9; 26S proteasome regulatory subunit p44.5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKT
GQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSE
KRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHAL
SNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYD
SIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLA
DFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKAD
VERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKK
LT
Target Bioclass
Other
Family
Proteasome subunit S9 family
Subcellular location
Nucleus
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
Uniprot ID
O00231
Ensemble ID
ENST00000261712.8
HGNC ID
HGNC:9556
ChEMBL ID
CHEMBL3831212

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.K373E DBIA    Probe Info 
HCT15 SNV: p.F232L; p.P245H DBIA    Probe Info 
MDST8 SNV: p.E112V DBIA    Probe Info 
TE4 SNV: p.L356F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.30  LDD0402  [1]
A-EBA
 Probe Info  		4.59  LDD0215  [2]
AZ-5
 Probe Info  		10.00  LDD0394  [3]
CHEMBL5175495
 Probe Info  		5.15  LDD0196  [4]
CY4
 Probe Info  		100.00  LDD0244  [5]
N1
 Probe Info  		100.00  LDD0242  [5]
TH211
 Probe Info  		Y415(7.28)  LDD0260  [6]
TH216
 Probe Info  		Y415(9.25)  LDD0259  [6]
ONAyne
 Probe Info  		K32(1.07)  LDD0274  [7]
Probe 1
 Probe Info  		Y72(24.78); Y177(40.82)  LDD3495  [8]
DBIA
 Probe Info  		C289(4.09); C202(1.79)  LDD3311  [9]
AHL-Pu-1
 Probe Info  		C289(3.40)  LDD0168  [10]
HHS-482
 Probe Info  		Y415(0.90)  LDD0285  [11]
HHS-475
 Probe Info  		Y253(0.61); Y233(0.65); Y231(0.72); Y229(0.79)  LDD0264  [12]
HHS-465
 Probe Info  		Y72(5.78)  LDD2237  [13]
5E-2FA
 Probe Info  		H28(0.00); H148(0.00)  LDD2235  [14]
AMP probe
 Probe Info  		N.A.  LDD0200  [15]
ATP probe
 Probe Info  		K32(0.00); K185(0.00); K304(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C202(0.00); C289(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [17]
Lodoacetamide azide
 Probe Info  		C202(0.00); C289(0.00)  LDD0037  [16]
BTD
 Probe Info  		N.A.  LDD0004  [18]
WYneN
 Probe Info  		N.A.  LDD0021  [18]
IPM
 Probe Info  		N.A.  LDD0147  [19]
NHS
 Probe Info  		K32(0.00); K141(0.00)  LDD0010  [18]
NPM
 Probe Info  		N.A.  LDD0016  [18]
PF-06672131
 Probe Info  		N.A.  LDD0017  [20]
SF
 Probe Info  		N.A.  LDD0028  [21]
STPyne
 Probe Info  		K32(0.00); K417(0.00)  LDD0009  [18]
TFBX
 Probe Info  		C202(0.00); C257(0.00); C289(0.00)  LDD0148  [19]
1c-yne
 Probe Info  		K325(0.00); K71(0.00); K409(0.00); K46(0.00)  LDD0228  [22]
Acrolein
 Probe Info  		H28(0.00); C202(0.00); C257(0.00)  LDD0217  [23]
Crotonaldehyde
 Probe Info  		C257(0.00); C202(0.00)  LDD0219  [23]
Methacrolein
 Probe Info  		C202(0.00); C257(0.00)  LDD0218  [23]
W1
 Probe Info  		N.A.  LDD0236  [24]
AOyne
 Probe Info  		5.00  LDD0443  [25]
NAIA_5
 Probe Info  		C257(0.00); C289(0.00); C202(0.00)  LDD2223  [26]
PAL-AfBPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C063
 Probe Info  		14.42  LDD1760  [27]
C106
 Probe Info  		16.00  LDD1793  [27]
C143
 Probe Info  		12.55  LDD1825  [27]
C178
 Probe Info  		15.24  LDD1857  [27]
C201
 Probe Info  		33.13  LDD1877  [27]
C243
 Probe Info  		11.88  LDD1916  [27]
C244
 Probe Info  		16.11  LDD1917  [27]
C245
 Probe Info  		16.00  LDD1918  [27]
C246
 Probe Info  		12.21  LDD1919  [27]
C249
 Probe Info  		12.21  LDD1922  [27]
C277
 Probe Info  		7.52  LDD1947  [27]
C284
 Probe Info  		23.75  LDD1954  [27]
C288
 Probe Info  		13.45  LDD1958  [27]
C313
 Probe Info  		13.36  LDD1980  [27]
C314
 Probe Info  		12.13  LDD1981  [27]
C350
 Probe Info  		22.63  LDD2011  [27]
C356
 Probe Info  		8.88  LDD2017  [27]
C388
 Probe Info  		51.63  LDD2047  [27]
C413
 Probe Info  		12.21  LDD2069  [27]
FFF probe11
 Probe Info  		5.17  LDD0471  [28]
FFF probe12
 Probe Info  		7.01  LDD0473  [28]
FFF probe13
 Probe Info  		16.62  LDD0475  [28]
FFF probe14
 Probe Info  		13.34  LDD0477  [28]
FFF probe15
 Probe Info  		5.79  LDD0490  [28]
FFF probe2
 Probe Info  		20.00  LDD0463  [28]
FFF probe3
 Probe Info  		8.90  LDD0464  [28]
FFF probe4
 Probe Info  		12.87  LDD0466  [28]
JN0003
 Probe Info  		13.43  LDD0469  [28]
STS-2
 Probe Info  		N.A.  LDD0138  [29]
VE-P
 Probe Info  		N.A.  LDD0396  [30]
Diazir
 Probe Info  		N.A.  LDD0011  [18]
LD-F
 Probe Info  		F236(0.00); A235(0.00)  LDD0015  [31]
DA-2
 Probe Info  		N.A.  LDD0070  [32]
OEA-DA
 Probe Info  		4.01  LDD0046  [33]
STS-1
 Probe Info  		N.A.  LDD0068  [34]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C289(0.58)  LDD2142  [35]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C289(0.74)  LDD2112  [35]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C289(0.99)  LDD2095  [35]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C289(0.90)  LDD2130  [35]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C289(0.79); C202(0.99)  LDD2117  [35]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C289(1.20); C202(1.20)  LDD2152  [35]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C289(0.87)  LDD2103  [35]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C289(0.51)  LDD2132  [35]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C289(0.73); C202(1.01)  LDD2131  [35]
 LDCM0025  4SU-RNA HEK-293T C289(3.40)  LDD0168  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C289(3.71)  LDD0169  [10]
 LDCM0214  AC1 HEK-293T C202(0.99); C289(0.78)  LDD1507  [36]
 LDCM0215  AC10 HEK-293T C289(1.07)  LDD1508  [36]
 LDCM0226  AC11 HEK-293T C202(1.13); C289(1.02)  LDD1509  [36]
 LDCM0237  AC12 HEK-293T C202(1.23); C289(1.08)  LDD1510  [36]
 LDCM0259  AC14 HEK-293T C202(1.05); C289(1.10)  LDD1512  [36]
 LDCM0270  AC15 HEK-293T C202(1.07); C289(0.97)  LDD1513  [36]
 LDCM0276  AC17 HEK-293T C202(1.00); C289(0.90)  LDD1515  [36]
 LDCM0277  AC18 HEK-293T C289(1.03)  LDD1516  [36]
 LDCM0278  AC19 HEK-293T C202(1.06); C289(1.03)  LDD1517  [36]
 LDCM0279  AC2 HEK-293T C289(1.01)  LDD1518  [36]
 LDCM0280  AC20 HEK-293T C202(1.09); C289(1.09)  LDD1519  [36]
 LDCM0281  AC21 HEK-293T C202(0.95); C289(1.00)  LDD1520  [36]
 LDCM0282  AC22 HEK-293T C202(1.19); C289(0.96)  LDD1521  [36]
 LDCM0283  AC23 HEK-293T C202(1.11); C289(1.05)  LDD1522  [36]
 LDCM0284  AC24 HEK-293T C289(1.12)  LDD1523  [36]
 LDCM0285  AC25 HEK-293T C202(1.06); C289(0.88)  LDD1524  [36]
 LDCM0286  AC26 HEK-293T C289(1.03)  LDD1525  [36]
 LDCM0287  AC27 HEK-293T C202(1.15); C289(0.96)  LDD1526  [36]
 LDCM0288  AC28 HEK-293T C202(1.16); C289(1.16)  LDD1527  [36]
 LDCM0289  AC29 HEK-293T C202(1.02); C289(1.07)  LDD1528  [36]
 LDCM0290  AC3 HEK-293T C202(1.10); C289(0.92)  LDD1529  [36]
 LDCM0291  AC30 HEK-293T C202(1.15); C289(1.55)  LDD1530  [36]
 LDCM0292  AC31 HEK-293T C202(1.19); C289(1.02)  LDD1531  [36]
 LDCM0293  AC32 HEK-293T C289(1.06)  LDD1532  [36]
 LDCM0294  AC33 HEK-293T C202(1.06); C289(0.85)  LDD1533  [36]
 LDCM0295  AC34 HEK-293T C289(0.96)  LDD1534  [36]
 LDCM0296  AC35 HEK-293T C202(1.14); C289(0.87)  LDD1535  [36]
 LDCM0297  AC36 HEK-293T C202(1.10); C289(0.97)  LDD1536  [36]
 LDCM0298  AC37 HEK-293T C202(1.07); C289(0.95)  LDD1537  [36]
 LDCM0299  AC38 HEK-293T C202(1.07); C289(1.63)  LDD1538  [36]
 LDCM0300  AC39 HEK-293T C202(1.07); C289(0.99)  LDD1539  [36]
 LDCM0301  AC4 HEK-293T C202(1.13); C289(1.00)  LDD1540  [36]
 LDCM0302  AC40 HEK-293T C289(0.94)  LDD1541  [36]
 LDCM0303  AC41 HEK-293T C202(0.98); C289(0.91)  LDD1542  [36]
 LDCM0304  AC42 HEK-293T C289(1.01)  LDD1543  [36]
 LDCM0305  AC43 HEK-293T C202(1.12); C289(0.98)  LDD1544  [36]
 LDCM0306  AC44 HEK-293T C202(1.27); C289(0.98)  LDD1545  [36]
 LDCM0307  AC45 HEK-293T C202(0.90); C289(0.93)  LDD1546  [36]
 LDCM0308  AC46 HEK-293T C202(1.07); C289(1.14)  LDD1547  [36]
 LDCM0309  AC47 HEK-293T C202(1.14); C289(1.01)  LDD1548  [36]
 LDCM0310  AC48 HEK-293T C289(1.03)  LDD1549  [36]
 LDCM0311  AC49 HEK-293T C202(1.02); C289(0.88)  LDD1550  [36]
 LDCM0312  AC5 HEK-293T C202(1.05); C289(0.95)  LDD1551  [36]
 LDCM0313  AC50 HEK-293T C289(1.11)  LDD1552  [36]
 LDCM0314  AC51 HEK-293T C202(1.11); C289(1.16)  LDD1553  [36]
 LDCM0315  AC52 HEK-293T C202(1.13); C289(0.95)  LDD1554  [36]
 LDCM0316  AC53 HEK-293T C202(1.02); C289(0.93)  LDD1555  [36]
 LDCM0317  AC54 HEK-293T C202(1.02); C289(1.03)  LDD1556  [36]
 LDCM0318  AC55 HEK-293T C202(1.09); C289(1.01)  LDD1557  [36]
 LDCM0319  AC56 HEK-293T C289(1.03)  LDD1558  [36]
 LDCM0320  AC57 HEK-293T C202(1.06); C289(0.79)  LDD1559  [36]
 LDCM0321  AC58 HEK-293T C289(1.17)  LDD1560  [36]
 LDCM0322  AC59 HEK-293T C202(1.25); C289(0.95)  LDD1561  [36]
 LDCM0323  AC6 HEK-293T C202(1.15); C289(1.12)  LDD1562  [36]
 LDCM0324  AC60 HEK-293T C202(1.18); C289(1.00)  LDD1563  [36]
 LDCM0325  AC61 HEK-293T C202(1.02); C289(0.96)  LDD1564  [36]
 LDCM0326  AC62 HEK-293T C202(1.07); C289(1.25)  LDD1565  [36]
 LDCM0327  AC63 HEK-293T C202(1.22); C289(1.01)  LDD1566  [36]
 LDCM0328  AC64 HEK-293T C289(1.14)  LDD1567  [36]
 LDCM0334  AC7 HEK-293T C202(1.10); C289(1.01)  LDD1568  [36]
 LDCM0345  AC8 HEK-293T C289(1.00)  LDD1569  [36]
 LDCM0545  Acetamide MDA-MB-231 C289(0.31); C202(0.63)  LDD2138  [35]
 LDCM0520  AKOS000195272 MDA-MB-231 C289(0.71)  LDD2113  [35]
 LDCM0248  AKOS034007472 HEK-293T C202(0.96); C289(1.02)  LDD1511  [36]
 LDCM0356  AKOS034007680 HEK-293T C202(1.04); C289(0.90)  LDD1570  [36]
 LDCM0275  AKOS034007705 HEK-293T C289(1.01)  LDD1514  [36]
 LDCM0498  BS-3668 MDA-MB-231 C289(0.35); C202(0.98)  LDD2091  [35]
 LDCM0108  Chloroacetamide HeLa C202(0.00); H28(0.00); H148(0.00); H218(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C202(0.47)  LDD2227  [26]
 LDCM0367  CL1 HEK-293T C202(1.08); C289(0.94)  LDD1571  [36]
 LDCM0368  CL10 HEK-293T C202(1.05); C289(0.99)  LDD1572  [36]
 LDCM0369  CL100 HEK-293T C202(1.00); C289(0.88)  LDD1573  [36]
 LDCM0370  CL101 HEK-293T C202(1.03); C289(0.91)  LDD1574  [36]
 LDCM0371  CL102 HEK-293T C202(1.06); C289(0.92)  LDD1575  [36]
 LDCM0372  CL103 HEK-293T C202(1.10); C289(0.96)  LDD1576  [36]
 LDCM0373  CL104 HEK-293T C202(1.05); C289(1.08)  LDD1577  [36]
 LDCM0374  CL105 HEK-293T C202(1.08); C289(0.90)  LDD1578  [36]
 LDCM0375  CL106 HEK-293T C202(0.98); C289(1.02)  LDD1579  [36]
 LDCM0376  CL107 HEK-293T C202(1.04); C289(1.04)  LDD1580  [36]
 LDCM0377  CL108 HEK-293T C202(0.99); C289(1.04)  LDD1581  [36]
 LDCM0378  CL109 HEK-293T C202(1.09); C289(0.94)  LDD1582  [36]
 LDCM0379  CL11 HEK-293T C202(0.93); C289(0.87)  LDD1583  [36]
 LDCM0380  CL110 HEK-293T C202(1.00); C289(0.92)  LDD1584  [36]
 LDCM0381  CL111 HEK-293T C202(1.03); C289(1.02)  LDD1585  [36]
 LDCM0382  CL112 HEK-293T C202(1.06); C289(1.01)  LDD1586  [36]
 LDCM0383  CL113 HEK-293T C202(1.03); C289(0.92)  LDD1587  [36]
 LDCM0384  CL114 HEK-293T C202(0.98); C289(0.89)  LDD1588  [36]
 LDCM0385  CL115 HEK-293T C202(1.20); C289(1.04)  LDD1589  [36]
 LDCM0386  CL116 HEK-293T C202(1.09); C289(0.95)  LDD1590  [36]
 LDCM0387  CL117 HEK-293T C202(1.06); C289(0.92)  LDD1591  [36]
 LDCM0388  CL118 HEK-293T C202(1.01); C289(0.97)  LDD1592  [36]
 LDCM0389  CL119 HEK-293T C202(1.10); C289(0.97)  LDD1593  [36]
 LDCM0390  CL12 HEK-293T C289(0.97)  LDD1594  [36]
 LDCM0391  CL120 HEK-293T C202(0.99); C289(0.94)  LDD1595  [36]
 LDCM0392  CL121 HEK-293T C202(1.09); C289(0.97)  LDD1596  [36]
 LDCM0393  CL122 HEK-293T C202(1.06); C289(0.99)  LDD1597  [36]
 LDCM0394  CL123 HEK-293T C202(0.99); C289(0.95)  LDD1598  [36]
 LDCM0395  CL124 HEK-293T C202(1.04); C289(0.91)  LDD1599  [36]
 LDCM0396  CL125 HEK-293T C202(1.18); C289(0.93)  LDD1600  [36]
 LDCM0397  CL126 HEK-293T C202(1.06); C289(0.96)  LDD1601  [36]
 LDCM0398  CL127 HEK-293T C202(1.07); C289(0.98)  LDD1602  [36]
 LDCM0399  CL128 HEK-293T C202(1.15); C289(1.09)  LDD1603  [36]
 LDCM0400  CL13 HEK-293T C202(0.96); C289(0.80)  LDD1604  [36]
 LDCM0401  CL14 HEK-293T C202(1.06); C289(1.02)  LDD1605  [36]
 LDCM0402  CL15 HEK-293T C202(1.01); C289(0.85)  LDD1606  [36]
 LDCM0403  CL16 HEK-293T C202(1.16); C289(0.97)  LDD1607  [36]
 LDCM0404  CL17 HEK-293T C202(0.97); C289(0.73)  LDD1608  [36]
 LDCM0405  CL18 HEK-293T C289(1.06)  LDD1609  [36]
 LDCM0406  CL19 HEK-293T C202(1.00); C289(0.90)  LDD1610  [36]
 LDCM0407  CL2 HEK-293T C202(0.99); C289(0.92)  LDD1611  [36]
 LDCM0408  CL20 HEK-293T C202(1.10); C289(0.88)  LDD1612  [36]
 LDCM0409  CL21 HEK-293T C202(1.05); C289(0.93)  LDD1613  [36]
 LDCM0410  CL22 HEK-293T C202(1.03); C289(0.87)  LDD1614  [36]
 LDCM0411  CL23 HEK-293T C202(0.91); C289(0.91)  LDD1615  [36]
 LDCM0412  CL24 HEK-293T C289(0.92)  LDD1616  [36]
 LDCM0413  CL25 HEK-293T C202(0.88); C289(0.90)  LDD1617  [36]
 LDCM0414  CL26 HEK-293T C202(0.98); C289(0.99)  LDD1618  [36]
 LDCM0415  CL27 HEK-293T C202(1.03); C289(1.13)  LDD1619  [36]
 LDCM0416  CL28 HEK-293T C202(1.04); C289(0.94)  LDD1620  [36]
 LDCM0417  CL29 HEK-293T C202(1.04); C289(0.92)  LDD1621  [36]
 LDCM0418  CL3 HEK-293T C202(0.92); C289(0.86)  LDD1622  [36]
 LDCM0419  CL30 HEK-293T C289(1.17)  LDD1623  [36]
 LDCM0420  CL31 HEK-293T C202(1.02); C289(0.99)  LDD1624  [36]
 LDCM0421  CL32 HEK-293T C202(1.12); C289(1.00)  LDD1625  [36]
 LDCM0422  CL33 HEK-293T C202(0.91); C289(0.81)  LDD1626  [36]
 LDCM0423  CL34 HEK-293T C202(1.01); C289(0.93)  LDD1627  [36]
 LDCM0424  CL35 HEK-293T C202(1.15); C289(0.97)  LDD1628  [36]
 LDCM0425  CL36 HEK-293T C289(0.99)  LDD1629  [36]
 LDCM0426  CL37 HEK-293T C202(1.02); C289(0.96)  LDD1630  [36]
 LDCM0428  CL39 HEK-293T C202(1.03); C289(0.96)  LDD1632  [36]
 LDCM0429  CL4 HEK-293T C202(1.10); C289(0.87)  LDD1633  [36]
 LDCM0430  CL40 HEK-293T C202(1.14); C289(0.99)  LDD1634  [36]
 LDCM0431  CL41 HEK-293T C202(0.97); C289(0.80)  LDD1635  [36]
 LDCM0432  CL42 HEK-293T C289(1.07)  LDD1636  [36]
 LDCM0433  CL43 HEK-293T C202(1.17); C289(1.04)  LDD1637  [36]
 LDCM0434  CL44 HEK-293T C202(1.31); C289(1.01)  LDD1638  [36]
 LDCM0435  CL45 HEK-293T C202(0.93); C289(0.97)  LDD1639  [36]
 LDCM0436  CL46 HEK-293T C202(1.11); C289(0.83)  LDD1640  [36]
 LDCM0437  CL47 HEK-293T C202(1.21); C289(1.01)  LDD1641  [36]
 LDCM0438  CL48 HEK-293T C289(1.07)  LDD1642  [36]
 LDCM0439  CL49 HEK-293T C202(1.06); C289(0.91)  LDD1643  [36]
 LDCM0440  CL5 HEK-293T C202(1.03); C289(0.68)  LDD1644  [36]
 LDCM0441  CL50 HEK-293T C202(0.90); C289(0.88)  LDD1645  [36]
 LDCM0443  CL52 HEK-293T C202(1.02); C289(0.87)  LDD1646  [36]
 LDCM0444  CL53 HEK-293T C202(0.92); C289(0.70)  LDD1647  [36]
 LDCM0445  CL54 HEK-293T C289(0.89)  LDD1648  [36]
 LDCM0446  CL55 HEK-293T C202(1.09); C289(0.96)  LDD1649  [36]
 LDCM0447  CL56 HEK-293T C202(1.23); C289(0.99)  LDD1650  [36]
 LDCM0448  CL57 HEK-293T C202(0.88); C289(0.84)  LDD1651  [36]
 LDCM0449  CL58 HEK-293T C202(1.06); C289(0.93)  LDD1652  [36]
 LDCM0450  CL59 HEK-293T C202(1.07); C289(0.92)  LDD1653  [36]
 LDCM0451  CL6 HEK-293T C289(0.92)  LDD1654  [36]
 LDCM0452  CL60 HEK-293T C289(0.97)  LDD1655  [36]
 LDCM0453  CL61 HEK-293T C202(1.00); C289(0.91)  LDD1656  [36]
 LDCM0454  CL62 HEK-293T C202(0.97); C289(0.94)  LDD1657  [36]
 LDCM0455  CL63 HEK-293T C202(0.97); C289(1.00)  LDD1658  [36]
 LDCM0456  CL64 HEK-293T C202(1.02); C289(0.84)  LDD1659  [36]
 LDCM0457  CL65 HEK-293T C202(0.99); C289(0.84)  LDD1660  [36]
 LDCM0458  CL66 HEK-293T C289(1.00)  LDD1661  [36]
 LDCM0459  CL67 HEK-293T C202(1.08); C289(0.95)  LDD1662  [36]
 LDCM0460  CL68 HEK-293T C202(1.18); C289(0.98)  LDD1663  [36]
 LDCM0461  CL69 HEK-293T C202(1.01); C289(0.93)  LDD1664  [36]
 LDCM0462  CL7 HEK-293T C202(0.94); C289(0.91)  LDD1665  [36]
 LDCM0463  CL70 HEK-293T C202(1.14); C289(1.12)  LDD1666  [36]
 LDCM0464  CL71 HEK-293T C202(1.08); C289(0.99)  LDD1667  [36]
 LDCM0465  CL72 HEK-293T C289(0.94)  LDD1668  [36]
 LDCM0466  CL73 HEK-293T C202(1.08); C289(0.87)  LDD1669  [36]
 LDCM0467  CL74 HEK-293T C202(0.99); C289(0.96)  LDD1670  [36]
 LDCM0469  CL76 HEK-293T C202(1.07); C289(0.92)  LDD1672  [36]
 LDCM0470  CL77 HEK-293T C202(1.02); C289(0.80)  LDD1673  [36]
 LDCM0471  CL78 HEK-293T C289(1.01)  LDD1674  [36]
 LDCM0472  CL79 HEK-293T C202(1.09); C289(0.95)  LDD1675  [36]
 LDCM0473  CL8 HEK-293T C202(1.21); C289(0.73)  LDD1676  [36]
 LDCM0474  CL80 HEK-293T C202(1.19); C289(1.04)  LDD1677  [36]
 LDCM0475  CL81 HEK-293T C202(1.03); C289(0.98)  LDD1678  [36]
 LDCM0476  CL82 HEK-293T C202(1.22); C289(1.12)  LDD1679  [36]
 LDCM0477  CL83 HEK-293T C202(1.24); C289(0.95)  LDD1680  [36]
 LDCM0478  CL84 HEK-293T C289(0.95)  LDD1681  [36]
 LDCM0479  CL85 HEK-293T C202(1.06); C289(0.92)  LDD1682  [36]
 LDCM0480  CL86 HEK-293T C202(0.95); C289(0.96)  LDD1683  [36]
 LDCM0481  CL87 HEK-293T C202(1.03); C289(0.97)  LDD1684  [36]
 LDCM0482  CL88 HEK-293T C202(1.06); C289(0.97)  LDD1685  [36]
 LDCM0483  CL89 HEK-293T C202(1.10); C289(0.88)  LDD1686  [36]
 LDCM0484  CL9 HEK-293T C202(1.06); C289(0.87)  LDD1687  [36]
 LDCM0485  CL90 HEK-293T C289(0.78)  LDD1688  [36]
 LDCM0486  CL91 HEK-293T C202(1.15); C289(0.93)  LDD1689  [36]
 LDCM0487  CL92 HEK-293T C202(1.14); C289(0.98)  LDD1690  [36]
 LDCM0488  CL93 HEK-293T C202(0.94); C289(0.91)  LDD1691  [36]
 LDCM0489  CL94 HEK-293T C202(1.07); C289(1.21)  LDD1692  [36]
 LDCM0490  CL95 HEK-293T C202(0.99); C289(0.76)  LDD1693  [36]
 LDCM0491  CL96 HEK-293T C289(0.87)  LDD1694  [36]
 LDCM0492  CL97 HEK-293T C202(1.07); C289(0.83)  LDD1695  [36]
 LDCM0493  CL98 HEK-293T C202(1.07); C289(0.88)  LDD1696  [36]
 LDCM0494  CL99 HEK-293T C202(1.03); C289(0.94)  LDD1697  [36]
 LDCM0185  Compound 17 HEK-293T 3.21  LDD0512  [28]
 LDCM0191  Compound 21 HEK-293T 4.66  LDD0508  [28]
 LDCM0190  Compound 34 HEK-293T 4.49  LDD0510  [28]
 LDCM0192  Compound 35 HEK-293T 3.38  LDD0509  [28]
 LDCM0193  Compound 36 HEK-293T 4.26  LDD0511  [28]
 LDCM0495  E2913 HEK-293T C202(1.13); C289(0.96)  LDD1698  [36]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C289(1.11); C202(0.95)  LDD1702  [35]
 LDCM0625  F8 Ramos C289(1.09); C202(0.89)  LDD2187  [37]
 LDCM0572  Fragment10 Ramos C289(0.86); C202(0.67)  LDD2189  [37]
 LDCM0573  Fragment11 Ramos C289(10.37); C202(2.31)  LDD2190  [37]
 LDCM0574  Fragment12 Ramos C289(0.98); C202(0.75)  LDD2191  [37]
 LDCM0575  Fragment13 Ramos C289(1.13); C202(1.39)  LDD2192  [37]
 LDCM0576  Fragment14 Ramos C289(0.73); C202(1.06)  LDD2193  [37]
 LDCM0579  Fragment20 Ramos C289(1.08); C202(0.60)  LDD2194  [37]
 LDCM0580  Fragment21 Ramos C289(0.98); C202(1.21)  LDD2195  [37]
 LDCM0582  Fragment23 Ramos C289(0.39); C202(0.58)  LDD2196  [37]
 LDCM0578  Fragment27 Ramos C289(1.17); C202(1.22)  LDD2197  [37]
 LDCM0586  Fragment28 Ramos C289(0.78); C202(0.67)  LDD2198  [37]
 LDCM0588  Fragment30 Ramos C289(1.44); C202(1.46)  LDD2199  [37]
 LDCM0589  Fragment31 Ramos C289(1.16); C202(1.60)  LDD2200  [37]
 LDCM0590  Fragment32 Ramos C289(0.84); C202(0.69)  LDD2201  [37]
 LDCM0468  Fragment33 HEK-293T C202(1.07); C289(0.99)  LDD1671  [36]
 LDCM0596  Fragment38 Ramos C289(1.31); C202(1.27)  LDD2203  [37]
 LDCM0566  Fragment4 Ramos C289(0.81); C202(0.79)  LDD2184  [37]
 LDCM0427  Fragment51 HEK-293T C202(1.00); C289(1.04)  LDD1631  [36]
 LDCM0610  Fragment52 Ramos C289(2.15); C202(1.69)  LDD2204  [37]
 LDCM0614  Fragment56 Ramos C289(2.21); C202(1.68)  LDD2205  [37]
 LDCM0569  Fragment7 Ramos C289(0.72); C202(0.68)  LDD2186  [37]
 LDCM0571  Fragment9 Ramos C289(0.65); C202(0.56)  LDD2188  [37]
 LDCM0116  HHS-0101 DM93 Y253(0.61); Y233(0.65); Y231(0.72); Y229(0.79)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y201(0.05); Y253(0.66); Y233(0.79); Y229(0.79)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y233(0.46); Y229(0.56); Y253(0.78); Y415(0.83)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y233(0.76); Y229(0.77); Y231(0.84); Y253(0.87)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y253(0.67); Y233(0.89); Y231(1.08); Y415(1.21)  LDD0268  [12]
 LDCM0107  IAA HeLa H218(0.00); H28(0.00); H148(0.00); H322(0.00)  LDD0221  [23]
 LDCM0123  JWB131 DM93 Y415(0.90)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y415(1.02)  LDD0286  [11]
 LDCM0125  JWB146 DM93 Y415(0.73)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y415(3.61)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y415(2.21)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y415(0.14)  LDD0290  [11]
 LDCM0129  JWB202 DM93 Y415(0.53)  LDD0291  [11]
 LDCM0130  JWB211 DM93 Y415(0.68)  LDD0292  [11]
 LDCM0022  KB02 HEK-293T C289(0.90); C202(0.85)  LDD1492  [36]
 LDCM0023  KB03 HEK-293T C289(0.99); C202(0.92)  LDD1497  [36]
 LDCM0024  KB05 G361 C289(4.09); C202(1.79)  LDD3311  [9]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C289(0.65)  LDD2102  [35]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C289(0.45); C202(0.70)  LDD2121  [35]
 LDCM0109  NEM HeLa H28(0.00); H349(0.00); H322(0.00)  LDD0223  [23]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C289(0.42); C202(0.82)  LDD2089  [35]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C289(0.99); C202(1.08)  LDD2090  [35]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C289(0.76)  LDD2092  [35]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C289(0.92); C202(1.14)  LDD2093  [35]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C202(0.69)  LDD2094  [35]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C289(0.59); C202(0.36)  LDD2096  [35]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C289(0.84); C202(1.94)  LDD2097  [35]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C289(0.72); C202(0.84)  LDD2098  [35]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C289(0.71); C202(1.02); C257(1.72)  LDD2099  [35]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C202(0.63)  LDD2100  [35]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C289(0.80); C202(5.92)  LDD2101  [35]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C289(0.61)  LDD2104  [35]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C289(1.37)  LDD2105  [35]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C289(0.57)  LDD2106  [35]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C289(0.88); C202(0.90)  LDD2107  [35]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C289(0.43); C202(0.53)  LDD2109  [35]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C289(0.99)  LDD2110  [35]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C289(0.78); C202(1.07)  LDD2111  [35]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C289(0.61)  LDD2114  [35]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C289(0.72)  LDD2116  [35]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C289(0.69)  LDD2118  [35]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C289(2.51); C202(2.28)  LDD2119  [35]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C289(0.87); C202(0.77); C257(1.13)  LDD2120  [35]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C202(0.54)  LDD2122  [35]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C289(0.65); C202(0.67)  LDD2123  [35]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C289(0.68); C202(0.99)  LDD2124  [35]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C289(0.53); C202(0.71)  LDD2125  [35]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C289(0.67)  LDD2126  [35]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C289(0.90); C202(1.07)  LDD2127  [35]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C289(1.06); C202(0.78)  LDD2128  [35]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C289(0.89)  LDD2129  [35]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C202(1.83)  LDD2133  [35]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C289(0.58)  LDD2134  [35]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C289(0.87)  LDD2135  [35]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C289(1.09); C202(1.13)  LDD2136  [35]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C289(0.92); C202(0.74)  LDD2137  [35]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C202(1.89); C289(1.04)  LDD1700  [35]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C289(0.47); C202(0.75)  LDD2140  [35]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C289(0.57)  LDD2141  [35]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C289(1.20); C202(0.81); C257(1.08)  LDD2143  [35]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C289(3.32); C202(2.93)  LDD2144  [35]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C289(7.02)  LDD2145  [35]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C289(0.72); C202(0.97)  LDD2146  [35]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C289(1.92); C202(1.61)  LDD2147  [35]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C289(0.50); C202(1.87)  LDD2148  [35]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C289(0.76); C202(0.53)  LDD2149  [35]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C289(0.29); C202(0.96)  LDD2150  [35]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C289(0.64); C202(0.44)  LDD2151  [35]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C289(0.93); C202(2.13)  LDD2153  [35]
 LDCM0131  RA190 MM1.R C202(1.91)  LDD0304  [38]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Protein arginine N-methyltransferase 6 (PRMT6) Protein arginine N-methyltransferase family Q96LA8
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 2 (COPS2) CSN2 family P61201

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD025652
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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