Details of the Target

General Information of Target

Target ID LDTP03779
Target Name Copper-transporting ATPase 2 (ATP7B)
Gene Name ATP7B
Gene ID 540
Synonyms
PWD; WC1; WND; Copper-transporting ATPase 2; EC 7.2.2.8; Copper pump 2; Wilson disease-associated protein) [Cleaved into: WND/140 kDa]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGLDGLGPSSQVATS
TVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMG
FEASIAEGKAASWPSRSLPAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSN
QEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSAN
QNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVK
YDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCST
TLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDM
GFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQ
STRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPL
EIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALA
TSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVF
GIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYK
SLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWL
EHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFP
VDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIV
KLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKH
ISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHK
IKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCK
EELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAV
PQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQ
EAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGK
KVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRR
IRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPD
LERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSR
HSAAADDDGDKWSLLLNGRDEEQYI
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Cation transport ATPase (P-type) (TC 3.A.3) family, Type IB subfamily
Subcellular location
Cytoplasm; Mitochondrion; Golgi apparatus, trans-Golgi network membrane; Golgi apparatus membrane
Function
Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload.
TTD ID
T63202
Uniprot ID
P35670
DrugMap ID
TTOPO51
Ensemble ID
ENST00000242839.10
HGNC ID
HGNC:870

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BICR22 SNV: p.V392L .
CHL1 SNV: p.V903E .
HCT15 SNV: p.S393Y; p.G515D .
HDQP1 SNV: p.L282V .
HEL SNV: p.G869E .
HEL9217 SNV: p.G869E .
HT115 SNV: p.R234I .
ICC137 SNV: p.Y403C .
MCAS SNV: p.C656Ter .
MCC13 Substitution: p.S986F .
MEWO SNV: p.P346L .
MFE319 SNV: p.P320L .
MOLT4 SNV: p.A38T .
NB1 SNV: p.S428C .
NCIH1703 SNV: p.Q951H .
OSRC2 SNV: p.V1262I .
OVCAR5 SNV: p.L1008I .
SKMEL5 SNV: p.D730N .
TOV21G SNV: p.G151C; p.E1081D .
U118MG SNV: p.I582V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C154(4.03); C157(4.03)  LDD0080  [2]
W1
 Probe Info  		N.A.  LDD0236  [1]
PAL-AfBPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C070
 Probe Info  		10.41  LDD1766  [3]
C072
 Probe Info  		8.28  LDD1768  [3]
C112
 Probe Info  		22.47  LDD1799  [3]
C134
 Probe Info  		28.44  LDD1816  [3]
C135
 Probe Info  		10.93  LDD1817  [3]
C139
 Probe Info  		10.63  LDD1821  [3]
C161
 Probe Info  		12.91  LDD1841  [3]
C187
 Probe Info  		19.16  LDD1865  [3]
C201
 Probe Info  		81.01  LDD1877  [3]
C206
 Probe Info  		33.59  LDD1881  [3]
C207
 Probe Info  		19.70  LDD1882  [3]
C219
 Probe Info  		5.43  LDD1893  [3]
C220
 Probe Info  		12.73  LDD1894  [3]
C225
 Probe Info  		6.15  LDD1898  [3]
C228
 Probe Info  		19.43  LDD1901  [3]
C246
 Probe Info  		16.45  LDD1919  [3]
C282
 Probe Info  		16.56  LDD1952  [3]
C326
 Probe Info  		8.75  LDD1990  [3]
C350
 Probe Info  		23.75  LDD2011  [3]
C355
 Probe Info  		22.78  LDD2016  [3]
C362
 Probe Info  		31.34  LDD2023  [3]
C388
 Probe Info  		44.02  LDD2047  [3]
C390
 Probe Info  		22.94  LDD2049  [3]
C413
 Probe Info  		13.18  LDD2069  [3]
C429
 Probe Info  		13.64  LDD2084  [3]
C431
 Probe Info  		15.56  LDD2086  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C499(0.99); C1100(0.74); C157(0.90); C502(1.03)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C154(1.31); C1104(1.25); C157(1.31); C502(1.09)  LDD0813  [2]
 LDCM0216  AC100 HEK-293T C499(1.08); C154(0.90); C1100(0.77); C1104(1.35)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C499(0.99); C154(1.21); C1100(0.92); C1104(1.10)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C499(0.79); C154(1.13); C1100(0.72); C1104(0.75)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C499(1.22); C154(1.06); C1100(0.87); C1104(1.64)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C499(0.91); C154(0.98); C1100(0.77); C1104(0.85)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C499(1.14); C154(1.19); C1100(0.92); C1104(1.28)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C499(0.82); C154(1.17); C1100(1.06); C1104(1.69)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C499(0.83); C154(1.17); C1100(0.91); C1104(1.02)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C499(0.87); C154(1.04); C1100(0.99); C1104(1.11)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C499(0.79); C154(0.93); C1100(1.00); C1104(1.44)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C154(1.33); C1104(1.27); C157(1.33); C502(1.03)  LDD0824  [2]
 LDCM0227  AC110 HEK-293T C499(0.92); C154(1.13); C1100(0.78); C1104(1.22)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C499(0.87); C154(0.79); C1100(0.71); C1104(1.98)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C499(0.79); C154(0.84); C1100(0.69); C1104(1.31)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C499(0.90); C502(0.90)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C499(1.08); C502(1.00)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C499(1.04); C502(0.89)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C499(0.95); C502(1.11)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C499(1.02); C502(1.15)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C499(0.98); C502(0.94)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C499(1.17); C502(0.94)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C154(1.43); C1104(0.92); C157(1.43); C502(1.09)  LDD0835  [2]
 LDCM0238  AC120 HCT 116 C499(0.93); C502(0.91)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C499(0.87); C502(1.02)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C499(1.12); C502(0.95)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C499(1.73); C502(0.83)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C499(0.82); C502(1.12)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C499(1.07); C502(0.94)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C499(0.99); C502(0.88)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C499(0.96); C502(1.00)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C154(1.10); C1104(1.18); C157(1.03); C502(1.01)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C154(1.10); C1104(1.10); C157(1.19); C502(1.12)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C154(1.06); C1104(0.98); C157(1.03); C502(1.00)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C154(1.04); C1104(1.07); C157(0.96); C502(1.21)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C154(1.34); C1104(1.16); C157(1.70); C502(1.19)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C154(1.01); C1104(1.26); C157(1.10); C502(1.10)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C154(1.21); C1104(1.28); C157(1.38); C502(1.42)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C154(1.05); C1104(1.04); C157(0.99); C502(1.09)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C154(1.19); C1104(0.95); C157(1.47); C502(1.10)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C154(1.24); C1104(1.27); C157(1.52); C502(1.22)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C154(0.91); C1104(1.16); C157(0.85); C502(1.14)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C154(0.99); C1104(1.08); C157(0.92); C502(1.46)  LDD0856  [2]
 LDCM0259  AC14 HEK-293T C154(2.04); C1104(1.27); C157(2.04); C502(1.24)  LDD0857  [2]
 LDCM0260  AC140 HEK-293T C154(0.95); C1104(1.21); C157(0.94); C502(1.10)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C154(1.10); C1104(1.30); C157(1.10); C502(1.38)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C154(1.11); C1104(1.18); C157(1.10); C502(1.22)  LDD0860  [2]
 LDCM0263  AC143 HCT 116 C499(1.31); C502(1.31)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C499(1.10); C502(1.10)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C499(1.03); C502(1.03)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C499(1.01); C502(1.01)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C499(0.89); C502(0.89)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C499(0.90); C502(0.90)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C499(0.87); C502(0.87)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C154(1.57); C1104(1.19); C157(1.57); C502(1.27)  LDD0868  [2]
 LDCM0271  AC150 HCT 116 C499(1.13); C502(1.13)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C499(1.25); C502(1.25)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C499(0.90); C502(0.90)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C499(0.92); C502(0.92)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C499(0.96); C502(0.96)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C499(0.96); C502(0.96)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C499(0.88); C502(0.88)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C499(0.92); C502(0.92)  LDD2161  [2]
 LDCM0276  AC17 HEK-293T C499(1.21); C154(0.88); C1104(0.68); C157(1.26)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C499(1.74); C154(0.96); C1104(0.65); C157(1.08)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C499(1.26); C154(0.86); C1104(0.71); C157(1.00)  LDD0876  [2]
 LDCM0279  AC2 HEK-293T C499(1.21); C1100(0.81); C157(0.99); C502(1.16)  LDD0877  [2]
 LDCM0280  AC20 HEK-293T C499(1.28); C154(1.11); C1104(0.60); C157(1.09)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C499(1.21); C154(0.92); C1104(0.71); C157(1.12)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C499(1.20); C154(1.06); C1104(0.64); C157(1.18)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C499(1.48); C154(1.00); C1104(0.62); C157(1.35)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C499(1.30); C154(1.06); C1104(0.69); C157(1.23)  LDD0882  [2]
 LDCM0285  AC25 HEK-293T C499(0.67); C1100(0.76); C157(1.26); C502(0.67)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C499(0.88); C1100(0.87); C157(1.41); C502(0.88)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C499(0.86); C1100(1.05); C157(1.27); C502(0.86)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C499(0.79); C1100(1.37); C157(1.29); C502(0.79)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C499(0.77); C1100(0.76); C157(1.19); C502(0.77)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C499(1.05); C1100(1.04); C157(0.87); C502(1.00)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C499(0.79); C1100(0.94); C157(1.33); C502(0.79)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C499(0.93); C1100(1.13); C157(1.11); C502(0.93)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C499(0.81); C1100(1.05); C157(1.12); C502(0.81)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C499(0.94); C1100(0.86); C157(1.32); C502(0.94)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C499(0.77); C1100(1.14); C157(1.20); C502(0.77)  LDD0893  [2]
 LDCM0296  AC35 HCT 116 C499(0.97); C502(0.97)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C499(0.92); C502(0.92)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C499(0.64); C502(0.64)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C499(0.96); C502(0.96)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C499(1.05); C502(1.05)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C499(1.10); C1100(1.03); C157(0.60); C502(1.07)  LDD0899  [2]
 LDCM0302  AC40 HCT 116 C499(0.85); C502(0.85)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C499(0.96); C502(0.96)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C499(0.92); C502(0.92)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C499(1.24); C502(1.24)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C499(0.79); C502(0.79)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C499(0.82); C502(0.82)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C499(0.86); C154(0.87); C1100(0.90); C157(1.13)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C499(0.88); C154(0.78); C1100(0.91); C157(0.97)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C499(0.96); C154(0.91); C1100(0.81); C157(1.09)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C499(0.92); C154(1.07); C1100(0.75); C157(1.42)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C499(1.03); C1100(0.85); C157(0.85); C502(1.18)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C499(0.94); C154(0.95); C1100(0.91); C157(1.22)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C499(1.01); C154(1.13); C1100(0.69); C157(1.34)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C499(0.88); C154(0.92); C1100(0.72); C157(1.17)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C499(0.85); C154(0.91); C1100(0.79); C157(1.08)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C499(1.00); C154(0.89); C1100(0.71); C157(1.19)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C499(1.04); C154(0.96); C1100(0.70); C157(1.11)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C499(0.85); C154(1.25); C1100(0.78); C157(1.25)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C154(0.92); C157(0.85); C72(1.23)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C154(0.95); C157(0.91); C72(1.20)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C154(1.02); C157(1.06); C72(1.15)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C154(1.06); C1104(0.89); C157(1.06); C502(1.26)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C154(0.83); C157(0.83); C72(0.94)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C154(0.79); C157(0.72); C72(0.51)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C154(0.86); C157(0.81); C72(0.88)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C154(0.90); C157(0.96); C72(0.88)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C154(0.99); C157(1.03); C72(1.01)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C154(0.90); C157(0.92); C72(0.69)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C154(0.83); C157(0.80); C72(1.16)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C154(0.90); C157(0.89); C72(0.85)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C499(0.78); C502(0.78)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C499(0.55); C502(0.55)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C154(0.92); C1104(1.08); C157(0.92); C502(1.39)  LDD0932  [2]
 LDCM0335  AC70 HCT 116 C499(0.86); C502(0.86)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C499(0.65); C502(0.65)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C499(0.68); C502(0.68)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C499(0.71); C502(0.71)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C499(0.83); C502(0.83)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C499(0.38); C502(0.38)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C499(0.59); C502(0.59)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C499(0.78); C502(0.78)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C499(0.85); C502(0.85)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C499(0.84); C502(0.84)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C154(1.13); C1104(1.00); C157(1.13); C502(1.72)  LDD0943  [2]
 LDCM0346  AC80 HCT 116 C499(0.71); C502(0.71)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C499(0.66); C502(0.66)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C499(0.75); C502(0.75)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C499(1.49); C502(1.49)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C499(1.66); C502(1.66)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C499(1.82); C502(1.82)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C499(1.56); C502(1.56)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C499(1.43); C502(1.43)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C499(2.15); C502(2.15)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C499(2.64); C502(2.64)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C499(1.58); C502(1.58)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C499(1.36); C502(1.36)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C499(1.55); C502(1.55)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C499(1.58); C502(1.58)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C499(1.57); C502(1.57)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C499(2.18); C502(2.18)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C499(1.02); C502(1.02)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C499(1.67); C502(1.67)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C499(0.74); C154(0.95); C1100(1.01); C1104(1.39)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C499(0.92); C154(1.10); C1100(0.86); C1104(1.06)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C154(1.55); C1104(1.20); C157(1.55); C502(1.32)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C154(1.47); C1104(1.22); C157(1.47); C502(1.36)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C154(2.02); C1104(1.17); C157(2.02); C502(1.41)  LDD0873  [2]
 LDCM0367  CL1 HEK-293T C499(2.37); C154(1.00); C502(1.80); C69(1.18)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C499(2.36); C154(0.77); C502(2.02); C69(1.43)  LDD0966  [2]
 LDCM0369  CL100 HEK-293T C499(0.94); C1100(0.76); C157(0.93); C502(0.99)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C154(1.25); C1104(1.04); C157(1.25); C502(1.68)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C154(2.21); C1104(1.12); C157(2.21); C502(1.48)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C154(1.27); C1104(1.03); C157(1.27); C502(1.42)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C154(0.99); C1104(1.46); C157(0.99); C502(1.48)  LDD0971  [2]
 LDCM0374  CL105 HEK-293T C499(1.57); C154(1.16); C1104(0.72); C157(1.24)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C499(1.98); C154(1.09); C1104(0.67); C157(1.10)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C499(1.48); C154(1.16); C1104(0.72); C157(1.17)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C499(1.50); C154(0.95); C1104(0.73); C157(1.29)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C499(2.56); C154(1.53); C1104(0.69); C157(1.63)  LDD0976  [2]
 LDCM0379  CL11 HEK-293T C499(2.00); C154(0.85); C502(1.76); C69(0.89)  LDD0977  [2]
 LDCM0380  CL110 HEK-293T C499(2.82); C154(1.08); C1104(0.69); C157(1.20)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C499(2.89); C154(1.33); C1104(0.70); C157(1.48)  LDD0979  [2]
 LDCM0382  CL112 HEK-293T C499(1.29); C1100(0.90); C157(1.23); C502(1.29)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C499(0.83); C1100(0.82); C157(1.26); C502(0.83)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C499(1.45); C1100(0.69); C157(1.70); C502(1.45)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C499(0.93); C1100(0.91); C157(1.37); C502(0.93)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C499(0.80); C1100(0.71); C157(1.71); C502(0.80)  LDD0984  [2]
 LDCM0387  CL117 HCT 116 C499(1.48); C502(1.48)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C499(0.90); C502(0.90)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C499(1.13); C502(1.13)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C499(1.53); C154(1.17); C502(1.46); C69(1.05)  LDD0988  [2]
 LDCM0391  CL120 HCT 116 C499(1.28); C502(1.28)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C499(1.60); C154(0.83); C1100(0.69); C157(1.07)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C499(1.51); C154(1.05); C1100(0.75); C157(1.22)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C499(3.18); C154(1.33); C1100(0.88); C157(1.31)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C499(1.27); C154(1.25); C1100(0.82); C157(1.17)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C154(0.94); C157(0.91); C72(0.81)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C154(0.98); C157(1.00); C72(1.11)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C154(0.89); C157(0.83); C72(0.97)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C154(1.09); C157(1.06); C72(1.12)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C499(1.29); C154(0.80); C502(1.33); C69(0.97)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C499(1.34); C154(0.98); C502(1.51); C69(1.19)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C499(2.26); C154(0.77); C502(1.78); C69(1.25)  LDD1000  [2]
 LDCM0403  CL16 HEK-293T C154(1.12); C1100(1.71); C1104(1.06); C157(0.94)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C154(1.32); C1100(0.96); C1104(0.95); C157(1.42)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C154(1.08); C1100(0.92); C1104(1.24); C157(1.21)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C154(1.03); C1100(0.92); C1104(1.06); C157(1.10)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C499(1.55); C154(1.33); C502(1.55); C69(1.06)  LDD1005  [2]
 LDCM0408  CL20 HEK-293T C154(0.95); C1100(0.84); C1104(0.94); C157(1.08)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C154(4.09); C1100(1.10); C1104(1.05); C157(2.71)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C154(1.36); C1100(0.92); C1104(1.05); C157(1.33)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C154(0.78); C1100(1.65); C1104(0.88); C157(0.89)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C154(0.88); C1100(1.23); C1104(0.93); C157(1.12)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C154(0.99); C1100(1.18); C1104(0.92); C157(1.19)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C154(0.88); C1100(0.97); C1104(0.90); C157(1.09)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C154(0.98); C1100(0.94); C1104(1.14); C157(1.13)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C154(1.18); C1100(1.14); C1104(0.97); C157(1.18)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C154(1.05); C1100(1.00); C1104(0.88); C157(1.07)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C499(1.21); C154(1.04); C502(1.38); C69(1.13)  LDD1016  [2]
 LDCM0419  CL30 HEK-293T C154(0.94); C1100(0.80); C1104(0.93); C157(1.11)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C499(1.26); C154(1.16); C1100(0.84); C157(0.96)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C499(1.18); C154(0.81); C1100(0.73); C157(0.85)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C499(1.32); C154(1.38); C1100(0.65); C157(1.49)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C499(1.09); C154(1.22); C1100(1.04); C157(1.13)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C499(1.12); C154(1.93); C1100(0.69); C157(1.29)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C499(1.12); C154(1.10); C1100(0.87); C157(1.07)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C499(1.23); C154(1.53); C1100(0.73); C157(1.36)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C499(1.58); C154(1.95); C1100(0.44); C157(1.72)  LDD1026  [2]
 LDCM0429  CL4 HEK-293T C499(1.41); C154(1.03); C502(1.44); C69(1.09)  LDD1027  [2]
 LDCM0430  CL40 HEK-293T C499(0.95); C154(1.63); C1100(0.63); C157(1.48)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C499(1.51); C154(1.28); C1100(0.51); C157(1.24)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C499(0.98); C154(0.83); C1100(0.54); C157(0.95)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C499(1.06); C154(1.19); C1100(0.50); C157(1.70)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C499(1.19); C154(1.66); C1100(0.74); C157(1.30)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C499(1.88); C154(1.27); C1100(0.48); C157(1.21)  LDD1033  [2]
 LDCM0436  CL46 HCT 116 C499(1.94); C502(1.94)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C499(1.29); C502(1.29)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C499(1.25); C502(1.25)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C499(0.94); C502(0.94)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C499(1.15); C154(0.90); C502(1.32); C69(0.99)  LDD1038  [2]
 LDCM0441  CL50 HCT 116 C499(0.99); C502(0.99)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C499(1.13); C502(1.13)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C499(1.77); C502(1.77)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C499(1.01); C502(1.01)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C499(1.34); C502(1.34)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C499(1.53); C502(1.53)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C499(0.99); C502(0.99)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C499(0.90); C502(0.90)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C499(1.52); C502(1.52)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C499(0.89); C502(0.89)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C499(2.15); C154(0.94); C502(1.66); C69(1.12)  LDD1049  [2]
 LDCM0452  CL60 HCT 116 C499(1.10); C502(1.10)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C499(1.07); C154(1.31); C1100(1.42); C157(1.31)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C499(1.46); C154(1.21); C1100(1.47); C157(1.21)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C499(1.32); C154(1.13); C1100(1.64); C157(1.13)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C499(13.50); C154(2.11); C1100(1.94); C157(2.11)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C499(1.35); C154(1.32); C1100(1.33); C157(1.32)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C499(3.34); C154(1.55); C1100(1.22); C157(1.55)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C499(1.56); C154(1.35); C1100(1.41); C157(1.35)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C499(2.30); C154(1.95); C1100(1.25); C157(1.95)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C499(1.95); C154(1.81); C1100(1.41); C157(1.81)  LDD1059  [2]
 LDCM0462  CL7 HEK-293T C499(1.03); C154(0.78); C502(1.32); C69(0.83)  LDD1060  [2]
 LDCM0463  CL70 HEK-293T C499(1.42); C154(1.45); C1100(1.42); C157(1.45)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C499(1.35); C154(1.77); C1100(1.17); C157(1.77)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C499(1.24); C154(1.39); C1100(1.20); C157(1.39)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C499(3.31); C154(1.65); C1100(1.25); C157(1.65)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C499(1.84); C154(1.63); C1100(1.05); C157(1.63)  LDD1065  [2]
 LDCM0469  CL76 HCT 116 C499(0.94); C502(0.94)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C499(1.09); C502(1.09)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C499(1.21); C502(1.21)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C499(1.22); C502(1.22)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C154(1.43); C502(1.70); C69(1.01)  LDD1071  [2]
 LDCM0474  CL80 HCT 116 C499(0.92); C502(0.92)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C499(1.07); C502(1.07)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C499(1.43); C502(1.43)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C499(1.22); C502(1.22)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C499(1.68); C502(1.68)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C499(1.23); C502(1.23)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C499(1.00); C502(1.00)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C499(1.24); C502(1.24)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C499(1.18); C502(1.18)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C499(1.87); C502(1.87)  LDD0800  [2]
 LDCM0484  CL9 HEK-293T C154(1.00); C502(1.29); C69(1.18)  LDD1082  [2]
 LDCM0485  CL90 HCT 116 C499(1.84); C502(1.84)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C499(1.20); C1100(1.13); C157(0.82); C502(1.20)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C499(2.25); C1100(1.01); C157(0.70); C502(1.68)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C499(1.63); C1100(0.98); C157(0.90); C502(1.36)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C499(1.98); C1100(0.77); C157(1.44); C502(1.63)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C499(2.62); C1100(0.67); C157(1.20); C502(2.00)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C499(1.91); C1100(0.87); C157(0.60); C502(1.61)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C499(2.14); C1100(0.90); C157(0.85); C502(1.69)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C499(2.00); C1100(0.95); C157(0.93); C502(1.53)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C499(1.95); C1100(1.09); C157(0.72); C502(1.49)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C271(0.89); C108(1.53)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C499(3.13); C154(1.55); C1100(0.92); C157(1.55)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C499(0.98); C154(1.41); C1100(0.59); C157(1.12)  LDD1025  [2]
 LDCM0022  KB02 HCT 116 C154(4.03); C157(4.03)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C154(3.24); C157(3.24)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C154(1.66); C157(1.66)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Copper transport protein ATOX1 (ATOX1) ATX1 family O00244
COMM domain-containing protein 1 (COMMD1) . Q8N668

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cisplatin Small molecular drug DB00515
Copper . DB09130

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402