Details of the Target

General Information of Target

Target ID LDTP11643
Target Name Superkiller complex protein 8 (SKIC8)
Gene Name SKIC8
Gene ID 80349
Synonyms
WDR61; Superkiller complex protein 8; Ski8; Meiotic recombination REC14 protein homolog; WD repeat-containing protein 61) [Cleaved into: Superkiller complex protein 8, N-terminally processed; WD repeat-containing protein 61, N-terminally processed)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAEVLPSARWQYCGAPDGSQRAVLVQFSNGKLQSPGNMRFTLYENKDSTNPRKRNQRIL
AAETDRLSYVGNNFGTGALKCNTLCRHFVGILNKTSGQMEVYDAELFNMQPLFSDVSVES
ELALESQTKTYREKMDSCIEAFGTTKQKRALNTRRMNRVGNESLNRAVAKAAETIIDTKG
VTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTS
EEILKMIEENSHCTFVIEALKSLPSDVESRDRQARCIWFLDTLIKFRAHRVVKRKSALGP
GVPHIINTKLLKHFTCLTYNNGRLRNLISDSMKAKITAYVIILALHIHDFQIDLTVLQRD
LKLSEKRMMEIAKAMRLKISKRRVSVAAGSEEDHKLGTLSLPLPPAQTSDRLAKRRKIT
Target Bioclass
Other
Subcellular location
Nucleus
Function
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Also acts as a component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling.
Uniprot ID
Q9GZS3
Ensemble ID
ENST00000267973.7
HGNC ID
HGNC:30300

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		6.91  LDD0066  [1]
TH211
 Probe Info  		Y282(20.00); Y120(14.47)  LDD0257  [2]
DBIA
 Probe Info  		C266(1.84)  LDD3323  [3]
HHS-475
 Probe Info  		Y120(0.77); Y213(0.80)  LDD0264  [4]
HHS-465
 Probe Info  		Y213(10.00)  LDD2237  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C303(0.00); C266(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [8]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C303(0.00); C241(0.00); C266(0.00)  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0025  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
Acrolein
 Probe Info  		C266(0.00); C303(0.00)  LDD0217  [11]
NAIA_5
 Probe Info  		C303(0.00); C266(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C165
 Probe Info  		17.15  LDD1845  [12]
C249
 Probe Info  		13.93  LDD1922  [12]
C282
 Probe Info  		29.04  LDD1952  [12]
C314
 Probe Info  		17.39  LDD1981  [12]
C326
 Probe Info  		13.45  LDD1990  [12]
C376
 Probe Info  		8.34  LDD2036  [12]
C391
 Probe Info  		13.64  LDD2050  [12]
FFF probe13
 Probe Info  		13.07  LDD0475  [13]
FFF probe2
 Probe Info  		12.82  LDD0463  [13]
FFF probe3
 Probe Info  		20.00  LDD0464  [13]
STS-2
 Probe Info  		N.A.  LDD0138  [14]
DA-2
 Probe Info  		N.A.  LDD0071  [15]
OEA-DA
 Probe Info  		11.73  LDD0046  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C266(1.05)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C266(1.06)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C266(0.99)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C266(1.00)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C266(1.02)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C266(0.99); C303(1.06)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C266(1.02)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C266(1.00)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C266(0.98)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C266(1.08)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C266(1.01)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C266(1.01)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C266(1.01)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C266(1.03); C303(0.95)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C266(0.96)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C266(1.01)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C266(1.06)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C266(1.01)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C266(1.02)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C266(1.04)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C266(0.96)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C266(0.99)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C266(1.05); C303(1.01)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C266(1.06)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C266(1.01)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C266(1.02)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C266(1.00)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C266(1.02)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C266(1.05)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C266(1.03)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C266(0.97); C303(1.23)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C266(1.08)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C266(0.97)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C266(0.98)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C266(1.07)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C266(0.95)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C266(1.01)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C266(1.03)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C266(0.96)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C266(1.03); C303(1.17)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C266(0.96)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C266(1.02)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C266(1.02)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C266(1.07)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C266(0.93)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C266(0.99)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C266(1.04)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C266(0.99)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C266(1.08); C303(1.19)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C266(1.05)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C266(0.95)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C266(1.06)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C266(1.00)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C266(0.98)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C266(0.94)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C266(0.95)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C266(0.98)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C266(1.05); C303(1.08)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C266(0.95)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C266(0.97); C303(1.18)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C266(1.08)  LDD1569  [17]
 LDCM0248  AKOS034007472 HEK-293T C266(0.97)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C266(1.02)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C266(1.00)  LDD1514  [17]
 LDCM0108  Chloroacetamide HeLa C266(0.00); C303(0.00); H184(0.00); H189(0.00)  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C266(1.93)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C266(1.09)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C266(0.93)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C266(0.96)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C266(1.01)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C266(1.00)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C266(0.95)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C266(1.00)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C266(0.97)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C266(1.02)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C266(1.00)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C266(0.98)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C266(0.98)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C266(1.09); C303(0.93)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C266(0.95)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C266(0.97)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C266(0.94)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C266(1.12)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C266(0.96)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C266(0.94)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C266(0.98)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C266(0.98)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C266(1.00)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C266(0.95)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C266(1.03)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C266(0.96)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C266(0.95)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C266(1.00)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C266(0.91)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C266(0.98)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C266(0.99)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C266(0.95)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C266(0.99)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C266(0.95)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C266(0.98)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C266(1.00)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C266(0.93)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C266(0.95)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C266(0.93)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C266(1.10)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C266(1.04)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C266(1.09)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C266(1.09)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C266(0.98)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C266(1.07)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C266(1.09); C303(1.07)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C266(1.08)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C266(1.14)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C266(1.04)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C266(0.91)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C266(1.03)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C266(1.06)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C266(0.92)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C266(1.10)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C266(0.98)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C266(1.05)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C266(1.02)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C266(1.02)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C266(1.04); C303(0.93)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C266(1.14)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C266(1.06)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C266(0.93)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C266(0.98)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C266(1.00)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C266(0.94)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C266(1.07)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C266(1.04)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C266(1.04)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C266(0.98)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C266(1.09)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C266(1.02); C303(0.99)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C266(1.06)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C266(1.10)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C266(1.00)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C266(0.99)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C266(1.01)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C266(0.88)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C266(1.02)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C266(1.01)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C266(1.03)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C266(0.96)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C266(1.02)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C266(1.06); C303(1.10)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C266(1.07)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C266(1.05)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C266(1.06)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C266(1.03)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C266(0.95)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C266(0.90)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C266(0.97)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C266(1.03)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C266(0.94)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C266(1.00)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C266(1.04)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C266(1.15)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C266(0.98)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C266(1.01); C303(0.99)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C266(1.00)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C266(1.10)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C266(1.00)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C266(1.00)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C266(0.88)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C266(0.99)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C266(1.07)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C266(1.05)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C266(1.08)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C266(1.03)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C266(1.06)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C266(1.04); C303(1.08)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C266(1.06)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C266(1.00)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C266(1.04)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C266(0.93)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C266(1.00)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C266(0.96)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C266(1.06)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C266(0.81)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C266(1.00)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C266(1.00)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C266(1.00)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C266(0.95)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C266(0.92); C303(0.97)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C266(0.99)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C266(0.99)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C266(0.99)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C266(0.94)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C266(0.90)  LDD1698  [17]
 LDCM0468  Fragment33 HEK-293T C266(0.91)  LDD1671  [17]
 LDCM0427  Fragment51 HEK-293T C266(1.04)  LDD1631  [17]
 LDCM0116  HHS-0101 DM93 Y120(0.77); Y213(0.80)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y120(0.44); Y213(0.80)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y120(0.43); Y213(0.83)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y213(0.86); Y120(1.03)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y120(0.61); Y213(0.85)  LDD0268  [4]
 LDCM0107  IAA HeLa H184(0.00); C266(0.00); H189(0.00); C303(0.00)  LDD0221  [11]
 LDCM0022  KB02 HEK-293T C266(0.97)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C266(0.90)  LDD1497  [17]
 LDCM0024  KB05 SKMEL24 C266(1.84)  LDD3323  [3]
 LDCM0109  NEM HeLa H184(0.00); H189(0.00)  LDD0223  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal ATPase PEX1 (PEX1) AAA ATPase family O43933
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Dopamine beta-hydroxylase (DBH) Copper type II ascorbate-dependent monooxygenase family P09172
Superoxide dismutase [Cu-Zn] (SOD1) Cu-Zn superoxide dismutase family P00441
Probable helicase senataxin (SETX) DNA2/NAM7 helicase family Q7Z333
Frataxin, mitochondrial (FXN) Frataxin family Q16595
Nitric oxide synthase 3 (NOS3) NOS family P29474
Presenilin-2 (PSEN2) Peptidase A22A family P49810
Parkinson disease protein 7 (PARK7) Peptidase C56 family Q99497
Ras-related protein Rab-7a (RAB7A) Rab family P51149
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
mRNA export factor GLE1 (GLE1) GLE1 family Q53GS7
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Peroxisome assembly protein 26 (PEX26) Peroxin-26 family Q7Z412
Alpha-synuclein (SNCA) Synuclein family P37840
Beta-synuclein (SNCB) Synuclein family Q16143
Vesicle-associated membrane protein-associated protein B/C (VAPB) VAMP-associated protein (VAP) (TC 9.B.17) family O95292
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-D10 (HOXD10) Abd-B homeobox family P28358
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-10 (ATXN10) Ataxin-10 family Q9UBB4
Ataxin-1 (ATXN1) ATXN1 family P54253
Progranulin (GRN) Granulin family P28799
Ganglioside-induced differentiation-associated protein 1 (GDAP1) GST superfamily Q8TB36
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
RING finger protein 11 (RNF11) . Q9Y3C5
RNA polymerase-associated protein CTR9 homolog (CTR9) . Q6PD62
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
15 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
16 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402