Details of the Target

General Information of Target

Target ID LDTP06549
Target Name Hsp90 co-chaperone Cdc37 (CDC37)
Gene Name CDC37
Gene ID 11140
Synonyms
CDC37A; Hsp90 co-chaperone Cdc37; Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRK
VAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLS
KDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVH
LVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTK
IKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYES
LPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPG
DPLLEAVPKTGDEKDVSV
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
CDC37 family
Subcellular location
Cytoplasm
Function Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity.
TTD ID
T94366
Uniprot ID
Q16543
DrugMap ID
TT5SOEU
Ensemble ID
ENST00000222005.7
HGNC ID
HGNC:1735
ChEMBL ID
CHEMBL1795123

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.45  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
TG42
 Probe Info  		4.12  LDD0326  [3]
TH214
 Probe Info  		Y331(17.38)  LDD0258  [4]
TH216
 Probe Info  		Y248(20.00); Y155(12.36)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
Nap-2
 Probe Info  		N.A.  LDD0435  [6]
STPyne
 Probe Info  		K101(4.95); K110(6.99); K121(5.84); K126(8.32)  LDD0277  [7]
BTD
 Probe Info  		C64(5.50)  LDD1699  [8]
ONAyne
 Probe Info  		N.A.  LDD0273  [7]
OPA-S-S-alkyne
 Probe Info  		K60(2.43)  LDD3494  [9]
Probe 1
 Probe Info  		Y248(55.84); Y278(168.95); Y298(9.26)  LDD3495  [10]
HHS-482
 Probe Info  		Y155(0.75)  LDD0285  [11]
HHS-475
 Probe Info  		Y155(0.70); Y248(0.79); Y278(0.86)  LDD0264  [12]
HHS-465
 Probe Info  		Y248(1.14); Y278(8.12)  LDD2237  [13]
DBIA
 Probe Info  		C336(0.98)  LDD0078  [14]
ATP probe
 Probe Info  		K330(0.00); K69(0.00); K154(0.00); K121(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C203(0.00); C336(0.00); C64(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [17]
IPIAA_L
 Probe Info  		C64(0.00); C336(0.00)  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C203(0.00); C336(0.00); C64(0.00)  LDD0037  [16]
ATP probe
 Probe Info  		N.A.  LDD0035  [19]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [20]
NAIA_4
 Probe Info  		C308(0.00); C336(0.00)  LDD2226  [21]
WYneN
 Probe Info  		N.A.  LDD0021  [22]
WYneO
 Probe Info  		N.A.  LDD0022  [22]
Compound 10
 Probe Info  		N.A.  LDD2216  [23]
Compound 11
 Probe Info  		N.A.  LDD2213  [23]
IPM
 Probe Info  		C54(0.00); C64(0.00)  LDD0147  [20]
NHS
 Probe Info  		K132(0.00); K101(0.00)  LDD0010  [22]
NPM
 Probe Info  		N.A.  LDD0016  [22]
SF
 Probe Info  		K154(0.00); Y155(0.00); Y278(0.00)  LDD0028  [24]
TFBX
 Probe Info  		C64(0.00); C308(0.00)  LDD0148  [20]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [25]
Ox-W18
 Probe Info  		N.A.  LDD2175  [26]
1c-yne
 Probe Info  		K352(0.00); K369(0.00); K323(0.00); K110(0.00)  LDD0228  [27]
Acrolein
 Probe Info  		N.A.  LDD0217  [28]
Methacrolein
 Probe Info  		N.A.  LDD0218  [28]
W1
 Probe Info  		N.A.  LDD0236  [29]
AOyne
 Probe Info  		12.80  LDD0443  [30]
NAIA_5
 Probe Info  		C233(0.00); C203(0.00); C64(0.00); C308(0.00)  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.11  LDD1714  [31]
C106
 Probe Info  		16.11  LDD1793  [31]
C108
 Probe Info  		11.24  LDD1795  [31]
C141
 Probe Info  		11.55  LDD1823  [31]
C153
 Probe Info  		17.39  LDD1834  [31]
C178
 Probe Info  		25.81  LDD1857  [31]
C277
 Probe Info  		14.42  LDD1947  [31]
C284
 Probe Info  		22.63  LDD1954  [31]
C326
 Probe Info  		7.52  LDD1990  [31]
C350
 Probe Info  		22.16  LDD2011  [31]
FFF probe11
 Probe Info  		6.75  LDD0471  [32]
FFF probe12
 Probe Info  		12.06  LDD0473  [32]
FFF probe13
 Probe Info  		10.86  LDD0475  [32]
FFF probe14
 Probe Info  		18.35  LDD0477  [32]
FFF probe2
 Probe Info  		6.31  LDD0463  [32]
FFF probe3
 Probe Info  		6.78  LDD0464  [32]
JN0003
 Probe Info  		10.10  LDD0469  [32]
VE-P
 Probe Info  		N.A.  LDD0396  [33]
DA-2
 Probe Info  		N.A.  LDD0070  [34]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C64(0.56); C54(0.41)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C64(0.73); C54(0.85)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C64(0.79); C54(0.74)  LDD2095  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C64(0.63); C54(1.14)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C64(1.12); C54(1.85)  LDD2152  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C64(1.02); C54(1.14)  LDD2103  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C64(0.50)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C64(0.57)  LDD2131  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C308(2.92)  LDD0372  [35]
 LDCM0214  AC1 HEK-293T C336(0.99); C203(0.92)  LDD1507  [36]
 LDCM0215  AC10 HEK-293T C336(1.02); C203(0.96); C183(1.03)  LDD1508  [36]
 LDCM0226  AC11 HEK-293T C336(1.03); C203(0.82); C64(1.28); C183(0.93)  LDD1509  [36]
 LDCM0237  AC12 HEK-293T C336(1.04); C203(0.75); C183(1.00)  LDD1510  [36]
 LDCM0259  AC14 HEK-293T C336(1.04); C203(0.63); C64(1.53); C183(1.10)  LDD1512  [36]
 LDCM0270  AC15 HEK-293T C336(1.02); C203(1.15); C64(1.19); C183(1.14)  LDD1513  [36]
 LDCM0276  AC17 HEK-293T C336(0.97); C203(0.86)  LDD1515  [36]
 LDCM0277  AC18 HEK-293T C336(1.03); C203(0.86); C183(1.04)  LDD1516  [36]
 LDCM0278  AC19 HEK-293T C336(0.94); C203(0.69); C64(0.57); C183(0.88)  LDD1517  [36]
 LDCM0279  AC2 HEK-293T C336(1.07); C203(0.86); C183(0.99)  LDD1518  [36]
 LDCM0280  AC20 HEK-293T C336(1.01); C203(0.75); C183(0.92)  LDD1519  [36]
 LDCM0281  AC21 HEK-293T C336(0.96); C203(0.90); C64(1.09); C183(0.88)  LDD1520  [36]
 LDCM0282  AC22 HEK-293T C336(0.95); C203(0.78); C64(1.37); C183(0.89)  LDD1521  [36]
 LDCM0283  AC23 HEK-293T C336(1.02); C203(1.08); C64(1.39); C183(1.04)  LDD1522  [36]
 LDCM0284  AC24 HEK-293T C336(0.97); C203(1.16); C64(1.11); C183(1.02)  LDD1523  [36]
 LDCM0285  AC25 HEK-293T C336(0.97); C203(0.97)  LDD1524  [36]
 LDCM0286  AC26 HEK-293T C336(1.02); C203(0.94); C183(1.05)  LDD1525  [36]
 LDCM0287  AC27 HEK-293T C336(1.01); C203(0.92); C64(1.44); C183(0.90)  LDD1526  [36]
 LDCM0288  AC28 HEK-293T C336(0.99); C203(0.82); C183(0.94)  LDD1527  [36]
 LDCM0289  AC29 HEK-293T C336(0.99); C203(1.01); C64(1.21); C183(0.89)  LDD1528  [36]
 LDCM0290  AC3 HEK-293T C336(0.99); C203(0.80); C64(1.29); C183(0.98)  LDD1529  [36]
 LDCM0291  AC30 HEK-293T C336(0.94); C203(0.74); C64(1.46); C183(1.12)  LDD1530  [36]
 LDCM0292  AC31 HEK-293T C336(0.91); C203(1.06); C64(1.12); C183(1.13)  LDD1531  [36]
 LDCM0293  AC32 HEK-293T C336(1.04); C203(1.02); C64(1.20); C183(1.41)  LDD1532  [36]
 LDCM0294  AC33 HEK-293T C336(0.98); C203(0.98)  LDD1533  [36]
 LDCM0295  AC34 HEK-293T C336(1.03); C203(0.87); C183(1.07)  LDD1534  [36]
 LDCM0296  AC35 HEK-293T C336(1.03); C203(0.93); C64(1.55); C183(1.02)  LDD1535  [36]
 LDCM0297  AC36 HEK-293T C336(1.03); C203(0.83); C183(1.07)  LDD1536  [36]
 LDCM0298  AC37 HEK-293T C336(1.04); C203(0.97); C64(2.20); C183(1.03)  LDD1537  [36]
 LDCM0299  AC38 HEK-293T C336(0.99); C203(0.71); C64(1.53); C183(0.91)  LDD1538  [36]
 LDCM0300  AC39 HEK-293T C336(1.00); C203(1.27); C64(1.36); C183(1.08)  LDD1539  [36]
 LDCM0301  AC4 HEK-293T C336(1.02); C203(0.97); C183(1.24)  LDD1540  [36]
 LDCM0302  AC40 HEK-293T C336(1.02); C203(1.14); C64(1.24); C183(1.12)  LDD1541  [36]
 LDCM0303  AC41 HEK-293T C336(0.95); C203(0.87)  LDD1542  [36]
 LDCM0304  AC42 HEK-293T C336(1.01); C203(0.95); C183(1.00)  LDD1543  [36]
 LDCM0305  AC43 HEK-293T C336(1.06); C203(0.88); C64(1.39); C183(0.91)  LDD1544  [36]
 LDCM0306  AC44 HEK-293T C336(1.02); C203(0.77); C183(0.77)  LDD1545  [36]
 LDCM0307  AC45 HEK-293T C336(0.95); C203(0.97); C64(1.48); C183(0.97)  LDD1546  [36]
 LDCM0308  AC46 HEK-293T C336(0.98); C203(0.63); C64(1.45); C183(1.15)  LDD1547  [36]
 LDCM0309  AC47 HEK-293T C336(0.93); C203(1.21); C64(1.21); C183(1.31)  LDD1548  [36]
 LDCM0310  AC48 HEK-293T C336(1.01); C203(1.27); C64(1.24); C183(0.96)  LDD1549  [36]
 LDCM0311  AC49 HEK-293T C336(0.95); C203(0.84)  LDD1550  [36]
 LDCM0312  AC5 HEK-293T C336(1.04); C203(0.98); C64(1.23); C183(1.10)  LDD1551  [36]
 LDCM0313  AC50 HEK-293T C336(1.01); C203(0.93); C183(1.04)  LDD1552  [36]
 LDCM0314  AC51 HEK-293T C336(1.03); C203(0.86); C64(1.40); C183(0.84)  LDD1553  [36]
 LDCM0315  AC52 HEK-293T C336(1.00); C203(0.71); C183(0.88)  LDD1554  [36]
 LDCM0316  AC53 HEK-293T C336(1.01); C203(1.04); C64(1.12); C183(0.95)  LDD1555  [36]
 LDCM0317  AC54 HEK-293T C336(0.96); C203(0.57); C64(1.40); C183(0.88)  LDD1556  [36]
 LDCM0318  AC55 HEK-293T C336(0.99); C203(1.16); C64(1.30); C183(0.88)  LDD1557  [36]
 LDCM0319  AC56 HEK-293T C336(0.98); C203(0.99); C64(1.17); C183(0.91)  LDD1558  [36]
 LDCM0320  AC57 HEK-293T C336(0.95); C203(0.93)  LDD1559  [36]
 LDCM0321  AC58 HEK-293T C336(1.00); C203(0.90); C183(1.02)  LDD1560  [36]
 LDCM0322  AC59 HEK-293T C336(1.02); C203(0.96); C64(1.40); C183(1.12)  LDD1561  [36]
 LDCM0323  AC6 HEK-293T C336(1.01); C203(0.84); C64(1.18); C183(1.00)  LDD1562  [36]
 LDCM0324  AC60 HEK-293T C336(1.01); C203(1.00); C183(1.02)  LDD1563  [36]
 LDCM0325  AC61 HEK-293T C336(0.90); C203(0.93); C64(1.12); C183(0.97)  LDD1564  [36]
 LDCM0326  AC62 HEK-293T C336(1.04); C203(0.80); C64(1.33); C183(0.96)  LDD1565  [36]
 LDCM0327  AC63 HEK-293T C336(0.97); C203(0.97); C64(1.21); C183(0.98)  LDD1566  [36]
 LDCM0328  AC64 HEK-293T C336(0.96); C203(1.08); C64(1.11); C183(0.97)  LDD1567  [36]
 LDCM0334  AC7 HEK-293T C336(0.98); C203(1.15); C64(1.29); C183(1.25)  LDD1568  [36]
 LDCM0345  AC8 HEK-293T C336(0.99); C203(1.01); C64(1.19); C183(0.96)  LDD1569  [36]
 LDCM0545  Acetamide MDA-MB-231 C64(0.27); C54(0.39)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C64(0.65)  LDD2113  [8]
 LDCM0248  AKOS034007472 HEK-293T C336(0.94); C203(0.96); C64(1.21); C183(1.09)  LDD1511  [36]
 LDCM0356  AKOS034007680 HEK-293T C336(0.93); C203(0.91)  LDD1570  [36]
 LDCM0275  AKOS034007705 HEK-293T C336(1.00); C203(1.15); C64(1.13); C183(0.97)  LDD1514  [36]
 LDCM0020  ARS-1620 HCC44 C336(0.98)  LDD0078  [14]
 LDCM0498  BS-3668 MDA-MB-231 C64(0.26); C54(0.40)  LDD2091  [8]
 LDCM0367  CL1 HEK-293T C336(1.00); C203(0.96); C183(1.12)  LDD1571  [36]
 LDCM0368  CL10 HEK-293T C336(0.83); C203(1.07); C64(0.35); C183(1.09)  LDD1572  [36]
 LDCM0369  CL100 HEK-293T C336(0.96); C203(0.96); C183(0.99)  LDD1573  [36]
 LDCM0370  CL101 HEK-293T C336(0.92); C203(0.94); C183(1.06)  LDD1574  [36]
 LDCM0371  CL102 HEK-293T C336(0.90); C203(0.78); C183(0.94)  LDD1575  [36]
 LDCM0372  CL103 HEK-293T C336(1.01); C203(0.85); C183(0.93)  LDD1576  [36]
 LDCM0373  CL104 HEK-293T C336(1.00); C203(0.99); C183(1.04)  LDD1577  [36]
 LDCM0374  CL105 HEK-293T C336(1.01); C203(0.93); C183(0.99)  LDD1578  [36]
 LDCM0375  CL106 HEK-293T C336(0.97); C203(0.86); C183(0.73)  LDD1579  [36]
 LDCM0376  CL107 HEK-293T C336(1.05); C203(0.77); C183(1.07)  LDD1580  [36]
 LDCM0377  CL108 HEK-293T C336(0.92); C203(0.94); C183(0.88)  LDD1581  [36]
 LDCM0378  CL109 HEK-293T C336(1.00); C203(1.11); C183(0.90)  LDD1582  [36]
 LDCM0379  CL11 HEK-293T C336(1.01); C203(1.10); C64(0.46); C183(1.35)  LDD1583  [36]
 LDCM0380  CL110 HEK-293T C336(0.94); C203(0.85); C183(0.99)  LDD1584  [36]
 LDCM0381  CL111 HEK-293T C336(0.97); C203(0.81); C183(1.03)  LDD1585  [36]
 LDCM0382  CL112 HEK-293T C336(0.94); C203(1.17); C183(1.20)  LDD1586  [36]
 LDCM0383  CL113 HEK-293T C336(1.01); C203(1.07); C183(1.01)  LDD1587  [36]
 LDCM0384  CL114 HEK-293T C336(0.93); C203(0.88); C183(0.94)  LDD1588  [36]
 LDCM0385  CL115 HEK-293T C336(0.98); C203(0.88); C183(1.02)  LDD1589  [36]
 LDCM0386  CL116 HEK-293T C336(0.94); C203(1.23); C183(1.03)  LDD1590  [36]
 LDCM0387  CL117 HEK-293T C336(1.00); C203(0.94); C183(1.06)  LDD1591  [36]
 LDCM0388  CL118 HEK-293T C336(0.97); C203(0.83); C183(1.05)  LDD1592  [36]
 LDCM0389  CL119 HEK-293T C336(1.02); C203(0.85); C183(1.11)  LDD1593  [36]
 LDCM0390  CL12 HEK-293T C336(0.98); C203(1.26); C64(0.49); C183(1.30)  LDD1594  [36]
 LDCM0391  CL120 HEK-293T C336(0.97); C203(1.18); C183(1.05)  LDD1595  [36]
 LDCM0392  CL121 HEK-293T C336(0.99); C203(0.94); C183(1.00)  LDD1596  [36]
 LDCM0393  CL122 HEK-293T C336(1.03); C203(0.78); C183(0.83)  LDD1597  [36]
 LDCM0394  CL123 HEK-293T C336(0.91); C203(0.74); C183(0.86)  LDD1598  [36]
 LDCM0395  CL124 HEK-293T C336(0.94); C203(1.08); C183(1.04)  LDD1599  [36]
 LDCM0396  CL125 HEK-293T C336(0.95); C203(0.85); C183(1.18)  LDD1600  [36]
 LDCM0397  CL126 HEK-293T C336(0.94); C203(0.88); C183(0.99)  LDD1601  [36]
 LDCM0398  CL127 HEK-293T C336(0.99); C203(0.95); C183(0.90)  LDD1602  [36]
 LDCM0399  CL128 HEK-293T C336(0.97); C203(0.86); C183(1.01)  LDD1603  [36]
 LDCM0400  CL13 HEK-293T C336(1.01); C203(0.80); C183(1.11)  LDD1604  [36]
 LDCM0401  CL14 HEK-293T C336(1.03); C203(0.92); C183(1.13)  LDD1605  [36]
 LDCM0402  CL15 HEK-293T C336(1.01); C203(0.72); C183(0.80)  LDD1606  [36]
 LDCM0403  CL16 HEK-293T C336(0.96); C203(1.00); C183(1.10)  LDD1607  [36]
 LDCM0404  CL17 HEK-293T C336(0.97); C203(0.91)  LDD1608  [36]
 LDCM0405  CL18 HEK-293T C336(1.05); C203(0.96); C183(1.04)  LDD1609  [36]
 LDCM0406  CL19 HEK-293T C336(1.07); C203(0.75); C64(0.88); C183(0.95)  LDD1610  [36]
 LDCM0407  CL2 HEK-293T C336(1.11); C203(1.02); C183(1.03)  LDD1611  [36]
 LDCM0408  CL20 HEK-293T C336(1.08); C203(0.83); C183(1.16)  LDD1612  [36]
 LDCM0409  CL21 HEK-293T C336(0.86); C203(0.88); C64(0.31); C183(1.03)  LDD1613  [36]
 LDCM0410  CL22 HEK-293T C336(0.99); C203(0.81); C64(0.37); C183(1.23)  LDD1614  [36]
 LDCM0411  CL23 HEK-293T C336(0.95); C203(1.26); C64(0.33); C183(1.37)  LDD1615  [36]
 LDCM0412  CL24 HEK-293T C336(0.96); C203(1.26); C64(0.36); C183(1.35)  LDD1616  [36]
 LDCM0413  CL25 HEK-293T C336(1.11); C203(0.68); C183(1.03)  LDD1617  [36]
 LDCM0414  CL26 HEK-293T C336(1.12); C203(0.86); C183(1.01)  LDD1618  [36]
 LDCM0415  CL27 HEK-293T C336(1.13); C203(0.84); C183(0.89)  LDD1619  [36]
 LDCM0416  CL28 HEK-293T C336(1.00); C203(1.12); C183(0.98)  LDD1620  [36]
 LDCM0417  CL29 HEK-293T C336(1.05); C203(0.89)  LDD1621  [36]
 LDCM0418  CL3 HEK-293T C336(1.07); C203(1.01); C183(1.17)  LDD1622  [36]
 LDCM0419  CL30 HEK-293T C336(1.02); C203(0.87); C183(1.11)  LDD1623  [36]
 LDCM0420  CL31 HEK-293T C336(0.98); C203(0.62); C64(0.78); C183(1.11)  LDD1624  [36]
 LDCM0421  CL32 HEK-293T C336(0.99); C203(0.70); C183(1.12)  LDD1625  [36]
 LDCM0422  CL33 HEK-293T C336(0.79); C203(0.84); C64(0.27); C183(0.81)  LDD1626  [36]
 LDCM0423  CL34 HEK-293T C336(0.90); C203(0.69); C64(0.34); C183(1.09)  LDD1627  [36]
 LDCM0424  CL35 HEK-293T C336(0.94); C203(1.28); C64(0.30); C183(1.56)  LDD1628  [36]
 LDCM0425  CL36 HEK-293T C336(0.89); C203(1.10); C64(0.31); C183(1.19)  LDD1629  [36]
 LDCM0426  CL37 HEK-293T C336(1.01); C203(0.80); C183(1.13)  LDD1630  [36]
 LDCM0428  CL39 HEK-293T C336(1.03); C203(0.86); C183(0.95)  LDD1632  [36]
 LDCM0429  CL4 HEK-293T C336(1.00); C203(0.72); C183(1.00)  LDD1633  [36]
 LDCM0430  CL40 HEK-293T C336(0.99); C203(0.96); C183(1.13)  LDD1634  [36]
 LDCM0431  CL41 HEK-293T C336(0.98); C203(0.98)  LDD1635  [36]
 LDCM0432  CL42 HEK-293T C336(1.01); C203(0.82); C183(1.07)  LDD1636  [36]
 LDCM0433  CL43 HEK-293T C336(1.08); C203(0.77); C64(0.81); C183(0.90)  LDD1637  [36]
 LDCM0434  CL44 HEK-293T C336(0.96); C203(0.86); C183(1.03)  LDD1638  [36]
 LDCM0435  CL45 HEK-293T C336(0.84); C203(0.86); C64(0.37); C183(1.16)  LDD1639  [36]
 LDCM0436  CL46 HEK-293T C336(0.89); C203(0.92); C64(0.31); C183(1.49)  LDD1640  [36]
 LDCM0437  CL47 HEK-293T C336(0.91); C203(1.15); C64(0.27); C183(1.04)  LDD1641  [36]
 LDCM0438  CL48 HEK-293T C336(1.01); C203(1.10); C64(0.24); C183(0.90)  LDD1642  [36]
 LDCM0439  CL49 HEK-293T C336(1.16); C203(0.83); C183(1.11)  LDD1643  [36]
 LDCM0440  CL5 HEK-293T C336(1.04); C203(0.90)  LDD1644  [36]
 LDCM0441  CL50 HEK-293T C336(1.04); C203(0.85); C183(0.84)  LDD1645  [36]
 LDCM0443  CL52 HEK-293T C336(1.02); C203(1.08); C183(1.26)  LDD1646  [36]
 LDCM0444  CL53 HEK-293T C336(1.00); C203(0.83)  LDD1647  [36]
 LDCM0445  CL54 HEK-293T C336(1.01); C203(0.86); C183(1.02)  LDD1648  [36]
 LDCM0446  CL55 HEK-293T C336(1.05); C203(0.85); C64(0.81); C183(1.37)  LDD1649  [36]
 LDCM0447  CL56 HEK-293T C336(1.02); C203(0.86); C183(1.02)  LDD1650  [36]
 LDCM0448  CL57 HEK-293T C336(0.84); C203(0.94); C64(0.32); C183(0.99)  LDD1651  [36]
 LDCM0449  CL58 HEK-293T C336(0.89); C203(0.66); C64(0.41); C183(0.90)  LDD1652  [36]
 LDCM0450  CL59 HEK-293T C336(0.89); C203(1.19); C64(0.30); C183(1.39)  LDD1653  [36]
 LDCM0451  CL6 HEK-293T C336(1.03); C203(0.74); C183(0.89)  LDD1654  [36]
 LDCM0452  CL60 HEK-293T C336(0.96); C203(1.17); C64(0.34); C183(1.32)  LDD1655  [36]
 LDCM0453  CL61 HEK-293T C336(1.08); C203(1.14); C183(1.01)  LDD1656  [36]
 LDCM0454  CL62 HEK-293T C336(1.05); C203(0.90); C183(0.99)  LDD1657  [36]
 LDCM0455  CL63 HEK-293T C336(1.12); C203(0.80); C183(0.92)  LDD1658  [36]
 LDCM0456  CL64 HEK-293T C336(0.92); C203(0.91); C183(0.92)  LDD1659  [36]
 LDCM0457  CL65 HEK-293T C336(1.03); C203(0.96)  LDD1660  [36]
 LDCM0458  CL66 HEK-293T C336(1.02); C203(0.84); C183(1.13)  LDD1661  [36]
 LDCM0459  CL67 HEK-293T C336(1.03); C203(0.79); C64(0.89); C183(0.86)  LDD1662  [36]
 LDCM0460  CL68 HEK-293T C336(1.02); C203(0.87); C183(1.10)  LDD1663  [36]
 LDCM0461  CL69 HEK-293T C336(0.93); C203(0.87); C64(0.36); C183(1.19)  LDD1664  [36]
 LDCM0462  CL7 HEK-293T C336(1.04); C203(0.84); C64(1.00); C183(0.95)  LDD1665  [36]
 LDCM0463  CL70 HEK-293T C336(0.93); C203(0.80); C64(0.42); C183(1.07)  LDD1666  [36]
 LDCM0464  CL71 HEK-293T C336(0.95); C203(1.33); C64(0.31); C183(1.17)  LDD1667  [36]
 LDCM0465  CL72 HEK-293T C336(0.95); C203(1.08); C64(0.46); C183(1.15)  LDD1668  [36]
 LDCM0466  CL73 HEK-293T C336(0.98); C203(0.72); C183(0.92)  LDD1669  [36]
 LDCM0467  CL74 HEK-293T C336(1.10); C203(0.94); C183(0.86)  LDD1670  [36]
 LDCM0469  CL76 HEK-293T C336(0.98); C203(1.04); C183(1.08)  LDD1672  [36]
 LDCM0470  CL77 HEK-293T C336(0.95); C203(0.78)  LDD1673  [36]
 LDCM0471  CL78 HEK-293T C336(1.04); C203(0.86); C183(1.05)  LDD1674  [36]
 LDCM0472  CL79 HEK-293T C336(1.05); C203(0.79); C64(0.88); C183(0.93)  LDD1675  [36]
 LDCM0473  CL8 HEK-293T C336(0.90); C203(0.82); C183(1.08)  LDD1676  [36]
 LDCM0474  CL80 HEK-293T C336(1.06); C203(0.82); C183(1.05)  LDD1677  [36]
 LDCM0475  CL81 HEK-293T C336(0.90); C203(0.99); C64(0.49); C183(1.03)  LDD1678  [36]
 LDCM0476  CL82 HEK-293T C336(0.94); C203(0.75); C64(0.43); C183(1.19)  LDD1679  [36]
 LDCM0477  CL83 HEK-293T C336(0.94); C203(1.15); C64(0.33); C183(1.33)  LDD1680  [36]
 LDCM0478  CL84 HEK-293T C336(0.94); C203(1.01); C64(0.43); C183(1.11)  LDD1681  [36]
 LDCM0479  CL85 HEK-293T C336(1.09); C203(0.76); C183(1.03)  LDD1682  [36]
 LDCM0480  CL86 HEK-293T C336(0.99); C203(1.01); C183(0.88)  LDD1683  [36]
 LDCM0481  CL87 HEK-293T C336(1.04); C203(0.89); C183(1.15)  LDD1684  [36]
 LDCM0482  CL88 HEK-293T C336(0.97); C203(0.83); C183(1.10)  LDD1685  [36]
 LDCM0483  CL89 HEK-293T C336(1.01); C203(0.89)  LDD1686  [36]
 LDCM0484  CL9 HEK-293T C336(0.99); C203(1.00); C64(0.44); C183(1.33)  LDD1687  [36]
 LDCM0485  CL90 HEK-293T C336(0.94); C203(0.61); C183(0.85)  LDD1688  [36]
 LDCM0486  CL91 HEK-293T C336(1.08); C203(0.75); C64(1.07); C183(0.99)  LDD1689  [36]
 LDCM0487  CL92 HEK-293T C336(0.98); C203(0.97); C183(1.07)  LDD1690  [36]
 LDCM0488  CL93 HEK-293T C336(0.85); C203(0.88); C64(0.48); C183(1.04)  LDD1691  [36]
 LDCM0489  CL94 HEK-293T C336(0.88); C203(0.89); C64(0.52); C183(0.95)  LDD1692  [36]
 LDCM0490  CL95 HEK-293T C336(0.83); C203(0.77); C64(0.36); C183(1.19)  LDD1693  [36]
 LDCM0491  CL96 HEK-293T C336(0.87); C203(0.94); C64(0.58); C183(1.08)  LDD1694  [36]
 LDCM0492  CL97 HEK-293T C336(1.04); C203(0.83); C183(0.98)  LDD1695  [36]
 LDCM0493  CL98 HEK-293T C336(1.01); C203(0.90); C183(1.12)  LDD1696  [36]
 LDCM0494  CL99 HEK-293T C336(1.03); C203(0.98); C183(0.81)  LDD1697  [36]
 LDCM0191  Compound 21 HEK-293T 3.31  LDD0508  [32]
 LDCM0495  E2913 HEK-293T C336(1.10); C203(0.88); C183(1.09)  LDD1698  [36]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C64(0.69)  LDD1702  [8]
 LDCM0625  F8 Ramos C64(2.11); C336(0.93); C308(1.19); C54(2.33)  LDD2187  [37]
 LDCM0572  Fragment10 Ramos C64(0.44); C336(0.63); C308(1.14); C54(0.56)  LDD2189  [37]
 LDCM0573  Fragment11 Ramos C64(0.06); C336(0.25); C308(5.26); C54(1.15)  LDD2190  [37]
 LDCM0574  Fragment12 Ramos C64(0.40); C336(0.60); C308(1.38); C54(0.62)  LDD2191  [37]
 LDCM0575  Fragment13 Ramos C64(0.64); C336(1.27); C308(1.08); C54(0.65)  LDD2192  [37]
 LDCM0576  Fragment14 Ramos C64(0.54); C336(0.68); C308(0.88); C54(0.65)  LDD2193  [37]
 LDCM0579  Fragment20 Ramos C64(0.33); C336(0.65); C308(1.59); C54(0.58)  LDD2194  [37]
 LDCM0580  Fragment21 Ramos C64(0.66); C336(1.01); C308(1.54); C54(0.59)  LDD2195  [37]
 LDCM0582  Fragment23 Ramos C64(0.84); C336(0.47); C308(1.17); C54(0.47)  LDD2196  [37]
 LDCM0578  Fragment27 Ramos C64(0.75); C336(1.06); C308(1.29); C54(1.18)  LDD2197  [37]
 LDCM0586  Fragment28 Ramos C64(0.43); C336(1.03); C308(1.96); C54(0.60)  LDD2198  [37]
 LDCM0588  Fragment30 Ramos C64(0.84); C336(1.31); C308(1.14); C54(1.03)  LDD2199  [37]
 LDCM0589  Fragment31 Ramos C64(0.51); C336(1.18); C308(2.24); C54(0.82)  LDD2200  [37]
 LDCM0590  Fragment32 Ramos C64(0.66); C336(0.56); C308(1.02); C54(0.71)  LDD2201  [37]
 LDCM0468  Fragment33 HEK-293T C336(1.07); C203(0.84); C183(0.94)  LDD1671  [36]
 LDCM0596  Fragment38 Ramos C64(0.63); C336(0.90); C308(0.87); C54(1.34)  LDD2203  [37]
 LDCM0566  Fragment4 Ramos C64(0.62); C336(0.76); C308(0.84); C54(0.51)  LDD2184  [37]
 LDCM0427  Fragment51 HEK-293T C336(1.07); C203(0.97); C183(0.76)  LDD1631  [36]
 LDCM0610  Fragment52 Ramos C64(0.81); C336(1.34); C308(1.45); C54(0.85)  LDD2204  [37]
 LDCM0614  Fragment56 Ramos C64(0.73); C336(1.33); C308(1.07); C54(0.75)  LDD2205  [37]
 LDCM0569  Fragment7 Ramos C64(0.53); C336(0.58); C308(0.89); C54(0.38)  LDD2186  [37]
 LDCM0571  Fragment9 Ramos C64(0.37); C336(0.60); C308(0.90); C54(0.36)  LDD2188  [37]
 LDCM0116  HHS-0101 DM93 Y155(0.70); Y248(0.79); Y278(0.86)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y155(0.66); Y248(0.83); Y278(1.08)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y155(0.32); Y278(0.68); Y248(0.72)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y155(0.78); Y248(1.03); Y278(1.05)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y155(0.88); Y278(0.89); Y248(1.38)  LDD0268  [12]
 LDCM0123  JWB131 DM93 Y155(0.75)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y155(0.42)  LDD0286  [11]
 LDCM0125  JWB146 DM93 Y155(0.72)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y155(4.21)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y155(1.68)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y155(0.75)  LDD0290  [11]
 LDCM0129  JWB202 DM93 Y155(0.48)  LDD0291  [11]
 LDCM0130  JWB211 DM93 Y155(0.69)  LDD0292  [11]
 LDCM0022  KB02 HCT 116 C336(1.01)  LDD0080  [14]
 LDCM0023  KB03 HCT 116 C336(1.02)  LDD0081  [14]
 LDCM0024  KB05 HCT 116 C336(1.09)  LDD0082  [14]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C64(1.11); C54(1.11)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C64(0.45); C54(0.65)  LDD2121  [8]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C54(0.58)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C64(1.07); C54(1.22)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C54(0.83)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C64(0.87); C54(1.06)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C64(2.30); C54(2.59)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C64(0.47); C54(0.83)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C64(0.74)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C64(0.80); C54(0.74)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C64(0.75); C54(0.91)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C64(0.97); C54(0.80)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C64(0.81)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C64(0.77); C54(0.65)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C64(1.73); C54(1.25)  LDD2105  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C64(0.75); C54(0.72)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C64(0.97); C54(0.97)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C64(0.78); C54(0.49)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C64(0.58); C54(0.97)  LDD2109  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C54(0.90)  LDD2110  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C64(0.77); C54(1.16)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C64(0.86)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C64(0.37)  LDD2115  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C64(0.77); C54(0.92)  LDD2116  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C54(0.93)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C64(3.70); C54(3.02)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C64(0.78); C54(0.85)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C64(0.78); C54(0.88)  LDD2122  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C64(0.39); C54(0.83)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C64(0.46); C54(0.81)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C64(0.67); C54(0.87)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C64(0.54); C54(0.97)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C64(0.86); C54(1.29)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C64(0.57); C54(0.71)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C64(0.67); C54(1.00)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C64(0.36)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C64(0.30)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C64(0.54); C54(0.75)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C64(0.89); C54(1.16)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C64(0.96); C54(0.97)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C54(2.01); C64(1.18)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C64(0.51); C54(0.80)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C64(0.61); C54(0.54)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C64(0.81); C54(0.90)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C64(5.84)  LDD2144  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C54(0.96)  LDD2146  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C64(4.16); C54(3.01)  LDD2147  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C64(0.30)  LDD2148  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C54(1.00)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C64(0.28); C54(0.73)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C64(0.37); C54(0.84)  LDD2151  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C64(1.50); C54(1.47)  LDD2153  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C336(0.77)  LDD2206  [38]
 LDCM0628  OTUB2-COV-1 HEK-293T C336(0.84)  LDD2207  [38]
 LDCM0131  RA190 MM1.R C336(1.36)  LDD0304  [39]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 56 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytosolic 5'-nucleotidase 1A (NT5C1A) 5'-nucleotidase type 3 family Q9BXI3
26S proteasome regulatory subunit 10B (PSMC6) AAA ATPase family P62333
Actin, cytoplasmic 1 (ACTB) Actin family P60709
Actin, cytoplasmic 2 (ACTG1) Actin family P63261
Protein arginine N-methyltransferase 5 (PRMT5) Protein arginine N-methyltransferase family O14744
Cullin-4B (CUL4B) Cullin family Q13620
Heat shock protein HSP 90-alpha (HSP90AA1) Heat shock protein 90 family P07900
Nitric oxide synthase 3 (NOS3) NOS family P29474
Presenilin-1 (PSEN1) Peptidase A22A family P49768
Serine/threonine-protein phosphatase 5 (PPP5C) PPP phosphatase family P53041
Serine/threonine-protein kinase 38-like (STK38L) AGC Ser/Thr protein kinase family Q9Y2H1
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
RAC-gamma serine/threonine-protein kinase (AKT3) AGC Ser/Thr protein kinase family Q9Y243
Serine/threonine-protein kinase H2 (PSKH2) CAMK Ser/Thr protein kinase family Q96QS6
Testis-specific serine/threonine-protein kinase 6 (TSSK6) CAMK Ser/Thr protein kinase family Q9BXA6
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Serine/threonine-protein kinase STK11 (STK11) CAMK Ser/Thr protein kinase family Q15831
Cyclin-dependent kinase 13 (CDK13) CMGC Ser/Thr protein kinase family Q14004
Cyclin-dependent kinase 15 (CDK15) CMGC Ser/Thr protein kinase family Q96Q40
Cyclin-dependent kinase 4 (CDK4) CMGC Ser/Thr protein kinase family P11802
Cyclin-dependent kinase 6 (CDK6) CMGC Ser/Thr protein kinase family Q00534
Cyclin-dependent kinase 9 (CDK9) CMGC Ser/Thr protein kinase family P50750
Proto-oncogene serine/threonine-protein kinase mos (MOS) Ser/Thr protein kinase family P00540
Serine/threonine-protein kinase PDIK1L (PDIK1L) Ser/Thr protein kinase family Q8N165
Serine/threonine-protein kinase ULK3 (ULK3) Ser/Thr protein kinase family Q6PHR2
Aurora kinase B (AURKB) Ser/Thr protein kinase family Q96GD4
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) Ser/Thr protein kinase family O15111
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) Ser/Thr protein kinase family O14920
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE) Ser/Thr protein kinase family Q14164
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) STE Ser/Thr protein kinase family Q99558
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) STE Ser/Thr protein kinase family O43318
Kinase suppressor of Ras 2 (KSR2) TKL Ser/Thr protein kinase family Q6VAB6
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
LIM domain kinase 2 (LIMK2) TKL Ser/Thr protein kinase family P53671
RAF proto-oncogene serine/threonine-protein kinase (RAF1) TKL Ser/Thr protein kinase family P04049
Muscle, skeletal receptor tyrosine-protein kinase (MUSK) Tyr protein kinase family O15146
Protein-tyrosine kinase 6 (PTK6) Tyr protein kinase family Q13882
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Tyrosine-protein kinase Fer (FER) Tyr protein kinase family P16591
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Discoidin domain-containing receptor 2 (DDR2) Tyr protein kinase family Q16832
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Tyrosine-protein kinase Fyn (FYN) Tyr protein kinase family P06241
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) SAICAR synthetase family; AIR carboxylase family P22234
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
TNF receptor-associated factor 3 (TRAF3) TNF receptor-associated factor family Q13114
Neuronal-specific septin-3 (SEPTIN3) Septin GTPase family Q9UH03
E3 ubiquitin-protein ligase Midline-1 (MID1) TRIM/RBCC family O15344
BTB/POZ domain-containing protein 3 (BTBD3) . Q9Y2F9
E3 SUMO-protein ligase ZBED1 (ZBED1) . O96006
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Nuclear receptor-interacting protein 3 (NRIP3) . Q9NQ35
Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4) . Q02790
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein E (APOE) Apolipoprotein A1/A4/E family P02649
Copper homeostasis protein cutC homolog (CUTC) CutC family Q9NTM9
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
MyoD family inhibitor (MDFI) MDFI family Q99750
Syntaxin-1A (STX1A) Syntaxin family Q16623
Kelch-like protein 2 (KLHL2) . O95198
N-terminal EF-hand calcium-binding protein 1 (NECAB1) . Q8N987
Transcription factor
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G protein-coupled receptor associated sorting protein 3 (GPRASP3) GPRASP family Q6PI77
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Golgin-45 (BLZF1) . Q9H2G9
THAP domain-containing protein 7 (THAP7) . Q9BT49
Zinc finger and BTB domain-containing protein 26 (ZBTB26) . Q9HCK0
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Zinc finger protein 276 (ZNF276) . Q8N554
Other
Click To Hide/Show 47 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiomotin-like protein 2 (AMOTL2) Angiomotin family Q9Y2J4
Large ribosomal subunit protein bL9m (MRPL9) Bacterial ribosomal protein bL9 family Q9BYD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (KCTD13) BACURD family Q8WZ19
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1) BACURD family Q13829
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
Caveolae-associated protein 1 (CAVIN1) CAVIN family Q6NZI2
Cancer/testis antigen family 45 member A1 (CT45A1) CT45 family Q5HYN5
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Protein FAM118A (FAM118A) FAM118 family Q9NWS6
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) IFIT family O14879
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type II cytoskeletal 2 oral (KRT76) Intermediate filament family Q01546
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Lamin-B2 (LMNB2) Intermediate filament family Q03252
Peripherin (PRPH) Intermediate filament family P41219
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) MAD1 family Q9Y6D9
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Serine/arginine repetitive matrix protein 4 (SRRM4) NSR100 family A7MD48
Paraneoplastic antigen Ma2 (PNMA2) PNMA family Q9UL42
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Ropporin-1A (ROPN1) Ropporin family Q9HAT0
Microtubule nucleation factor SSNA1 (SSNA1) SSNA1 family O43805
Synaptonemal complex central element protein 2 (SYCE2) SYCE family Q6PIF2
TNF receptor-associated factor 5 (TRAF5) TNF receptor-associated factor family O00463
Synaptonemal complex protein 3 (SYCP3) XLR/SYCP3 family Q8IZU3
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
CGG triplet repeat-binding protein 1 (CGGBP1) . Q9UFW8
Coiled-coil domain-containing protein 152 (CCDC152) . Q4G0S7
F-box/WD repeat-containing protein 2 (FBXW2) . Q9UKT8
Fetal and adult testis-expressed transcript protein (FATE1) . Q969F0
GRAM domain-containing protein 2B (GRAMD2B) . Q96HH9
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
Heat shock factor 2-binding protein (HSF2BP) . O75031
KATNB1-like protein 1 (KATNBL1) . Q9H079
Mirror-image polydactyly gene 1 protein (MIPOL1) . Q8TD10
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
Sequestosome-1 (SQSTM1) . Q13501
TNFAIP3-interacting protein 1 (TNIP1) . Q15025
Zinc finger protein 843 (ZNF843) . Q8N446

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 Proteome-Wide Identification of On- and Off-Targets of Bcl-2 Inhibitors in Native Biological Systems by Using Affinity-Based Probes (AfBPs). Chembiochem. 2018 Nov 2;19(21):2312-2320. doi: 10.1002/cbic.201800380. Epub 2018 Oct 18.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
23 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
24 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
25 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
26 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
27 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
28 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
29 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
30 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
31 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
32 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
33 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
34 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
35 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
36 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
37 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
38 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
39 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.