Details of the Target

General Information of Target

Target ID LDTP11695
Target Name Kinesin light chain 2 (KLC2)
Gene Name KLC2
Gene ID 64837
Synonyms
Kinesin light chain 2; KLC 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTLQGRADLSGNQGNAAGRLATVHEPVVTQWAVHPPAPAHPSLLDKMEKAPPQPQHEGLK
SKEHLPQQPAEGKTASRRVPRLRAVVESQAFKNILVDEMDMMHARAATLIQANWRGYWLR
QKLISQMMAAKAIQEAWRRFNKRHILHSSKSLVKKTRAEEGDIPYHAPQQVRFQHPEENR
LLSPPIMVNKETQFPSCDNLVLCRPQSSPLLQPPAAQGTPEPCVQGPHAARVRGLAFLPH
QTVTIRFPCPVSLDAKCQPCLLTRTIRSTCLVHIEGDSVKTKRVSARTNKARAPETPLSR
RYDQAVTRPSRAQTQGPVKAETPKAPFQICPGPMITKTLLQTYPVVSVTLPQTYPASTMT
TTPPKTSPVPKVTIIKTPAQMYPGPTVTKTAPHTCPMPTMTKIQVHPTASRTGTPRQTCP
ATITAKNRPQVSLLASIMKSLPQVCPGPAMAKTPPQMHPVTTPAKNPLQTCLSATMSKTS
SQRSPVGVTKPSPQTRLPAMITKTPAQLRSVATILKTLCLASPTVANVKAPPQVAVAAGT
PNTSGSIHENPPKAKATVNVKQAAKVVKASSPSYLAEGKIRCLAQPHPGTGVPRAAAELP
LEAEKIKTGTQKQAKTDMAFKTSVAVEMAGAPSWTKVAEEGDKPPHVYVPVDMAVTLPRG
QLAAPLTNASSQRHPPCLSQRPLAAPLTKASSQGHLPTELTKTPSLAHLDTCLSKMHSQT
HLATGAVKVQSQAPLATCLTKTQSRGQPITDITTCLIPAHQAADLSSNTHSQVLLTGSKV
SNHACQRLGGLSAPPWAKPEDRQTQPQPHGHVPGKTTQGGPCPAACEVQGMLVPPMAPTG
HSTCNVESWGDNGATRAQPSMPGQAVPCQEDTGPADAGVVGGQSWNRAWEPARGAASWDT
WRNKAVVPPRRSGEPMVSMQAAEEIRILAVITIQAGVRGYLARRRIRLWHRGAMVIQATW
RGYRVRRNLAHLCRATTTIQSAWRGYSTRRDQARHWQMLHPVTWVELGSRAGVMSDRSWF
QDGRARTVSDHRCFQSCQAHACSVCHSLSSRIGSPPSVVMLVGSSPRTCHTCGRTQPTRV
VQGMGQGTEGPGAVSWASAYQLAALSPRQPHRQDKAATAIQSAWRGFKIRQQMRQQQMAA
KIVQATWRGHHTRSCLKNTEALLGPADPSASSRHMHWPGI
Target Bioclass
Other
Family
Kinesin light chain family
Subcellular location
Cytoplasm, cytoskeleton
Function
Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends.
Uniprot ID
Q9H0B6
Ensemble ID
ENST00000316924.9
HGNC ID
HGNC:20716

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.S151Y .
CAL27 SNV: p.K381R .
COLO792 SNV: p.R501K .
CORL23 SNV: p.D322V .
FADU SNV: p.Q76H .
HT115 SNV: p.A530T .
JEKO1 SNV: p.A128T .
JHH7 SNV: p.L393F .
JURKAT SNV: p.Q93Ter; p.Q118Ter .
KMRC3 SNV: p.T451S .
KYSE30 SNV: p.A126V .
MOLT4 Deletion: p.A486QfsTer7 IA-alkyne    Probe Info 
NALM6 Deletion: p.G567AfsTer11 .
NCIH1048 SNV: p.K297T .
OVK18 Insertion: p.T568HfsTer7 .
PEO1 SNV: p.N203T .
PF382 SNV: p.R96W .
SW837 SNV: p.E215K .
TOV21G Deletion: p.L31AfsTer15 .
ZR751 SNV: p.E215K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
TG42
 Probe Info  		4.38  LDD0326  [3]
STPyne
 Probe Info  		K257(5.26); K318(7.55); K480(10.00); K490(5.56)  LDD0277  [4]
Probe 1
 Probe Info  		Y382(84.73); Y389(18.23)  LDD3495  [5]
BTD
 Probe Info  		C305(1.89)  LDD1700  [6]
DA-P3
 Probe Info  		5.02  LDD0181  [7]
AHL-Pu-1
 Probe Info  		C474(2.02)  LDD0169  [8]
HHS-482
 Probe Info  		Y208(1.44); Y292(0.65)  LDD0285  [9]
HHS-475
 Probe Info  		Y250(0.68); Y208(0.97); Y431(1.06); Y292(1.08)  LDD0264  [10]
HHS-465
 Probe Info  		Y208(10.00); Y292(7.29)  LDD2237  [11]
DBIA
 Probe Info  		C474(1.14)  LDD0080  [12]
ATP probe
 Probe Info  		N.A.  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
Lodoacetamide azide
 Probe Info  		C474(0.00); C334(0.00)  LDD0037  [14]
IPM
 Probe Info  		N.A.  LDD0025  [16]
NAIA_4
 Probe Info  		C441(0.00); C474(0.00)  LDD2226  [17]
WYneN
 Probe Info  		N.A.  LDD0021  [18]
SF
 Probe Info  		Y292(0.00); Y208(0.00)  LDD0028  [19]
TFBX
 Probe Info  		C305(0.00); C375(0.00); C221(0.00)  LDD0148  [16]
Phosphinate-6
 Probe Info  		C441(0.00); C58(0.00); C305(0.00)  LDD0018  [20]
Acrolein
 Probe Info  		C221(0.00); C375(0.00); C474(0.00)  LDD0217  [21]
Methacrolein
 Probe Info  		C474(0.00); C221(0.00); C375(0.00)  LDD0218  [21]
W1
 Probe Info  		C221(0.00); C305(0.00); C375(0.00); C334(0.00)  LDD0236  [22]
AOyne
 Probe Info  		15.00  LDD0443  [23]
NAIA_5
 Probe Info  		C441(0.00); C474(0.00); C334(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C092
 Probe Info  		39.67  LDD1783  [24]
C225
 Probe Info  		5.28  LDD1898  [24]
C265
 Probe Info  		12.91  LDD1936  [24]
C277
 Probe Info  		7.41  LDD1947  [24]
C296
 Probe Info  		11.47  LDD1966  [24]
C313
 Probe Info  		13.93  LDD1980  [24]
C314
 Probe Info  		13.27  LDD1981  [24]
C326
 Probe Info  		7.21  LDD1990  [24]
C383
 Probe Info  		13.27  LDD2042  [24]
FFF probe13
 Probe Info  		20.00  LDD0475  [25]
FFF probe2
 Probe Info  		16.82  LDD0463  [25]
FFF probe9
 Probe Info  		5.03  LDD0470  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C221(0.66)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C221(0.96)  LDD2112  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C221(1.05)  LDD2152  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C221(0.35)  LDD2132  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C474(2.02)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C474(0.90)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C474(0.87)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C334(0.82)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C334(0.85)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C334(0.76)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C334(0.69)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C334(0.75)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C334(0.77)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C334(0.72)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C334(0.68)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C334(0.84)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C334(0.86)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C474(1.08)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C334(0.77)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C334(0.78)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C334(0.83)  LDD0546  [12]
 LDCM0230  AC113 PaTu 8988t C334(0.93)  LDD1109  [12]
 LDCM0231  AC114 PaTu 8988t C334(1.30)  LDD1110  [12]
 LDCM0232  AC115 PaTu 8988t C334(0.97)  LDD1111  [12]
 LDCM0233  AC116 PaTu 8988t C334(0.90)  LDD1112  [12]
 LDCM0234  AC117 PaTu 8988t C334(0.93)  LDD1113  [12]
 LDCM0235  AC118 PaTu 8988t C334(1.14)  LDD1114  [12]
 LDCM0236  AC119 PaTu 8988t C334(0.87)  LDD1115  [12]
 LDCM0237  AC12 HCT 116 C474(0.85)  LDD0554  [12]
 LDCM0238  AC120 PaTu 8988t C334(1.03)  LDD1117  [12]
 LDCM0239  AC121 PaTu 8988t C334(1.06)  LDD1118  [12]
 LDCM0240  AC122 PaTu 8988t C334(1.27)  LDD1119  [12]
 LDCM0241  AC123 PaTu 8988t C334(1.04)  LDD1120  [12]
 LDCM0242  AC124 PaTu 8988t C334(1.00)  LDD1121  [12]
 LDCM0243  AC125 PaTu 8988t C334(1.11)  LDD1122  [12]
 LDCM0244  AC126 PaTu 8988t C334(1.11)  LDD1123  [12]
 LDCM0245  AC127 PaTu 8988t C334(1.03)  LDD1124  [12]
 LDCM0246  AC128 HCT 116 C474(0.67)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C474(0.79)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C474(0.82)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C474(0.78)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C474(0.75)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C474(0.86)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C474(0.90)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C474(0.67)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C474(1.09)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C474(0.74)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C474(0.71)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C474(0.76)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C474(0.82)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C474(0.62)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C474(0.66)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C474(0.80)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C334(0.93); C474(1.46)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C334(0.51); C474(0.94)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C334(0.67); C474(1.00)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C334(0.65); C474(0.89)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C334(0.56); C474(0.98)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C334(0.53); C474(1.60)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C334(0.54); C474(1.18)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C474(0.80)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C334(0.89); C474(1.03)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C334(0.80); C474(1.03)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C334(0.53); C474(0.92)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C334(0.52); C474(1.09)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C334(0.56); C474(1.04)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C334(0.60); C474(1.03)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C334(0.90); C474(0.94)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C334(0.75); C474(1.16)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C474(0.78); C334(1.01)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C474(0.86); C334(0.94)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C474(0.83); C334(0.89)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C474(1.01)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C474(0.74); C334(1.09)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C334(0.87); C474(0.95)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C474(0.89); C334(0.95)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C474(0.92); C334(1.03)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C474(0.78); C334(1.15)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C334(0.90)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C334(0.93)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C334(0.94)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C334(0.83)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C334(0.94)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C474(0.96)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C334(0.91)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C334(1.01)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C334(0.88)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C334(0.85)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C334(0.82)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C334(0.97)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C334(1.14)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C334(1.08)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C334(1.16)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C334(1.03)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C474(0.81)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C334(0.88)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C334(1.08)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C334(0.94)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C334(1.07)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C334(1.05)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C334(0.94)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C334(0.93); C474(1.93)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C334(0.82); C474(1.41)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C334(0.92); C474(1.76)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C334(0.87); C474(1.81)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C474(0.88)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C334(0.91); C474(2.00)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C334(0.78); C474(1.81)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C334(0.91); C474(1.78)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C334(0.83); C474(1.43)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C334(0.85); C474(1.88)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C334(0.84); C474(1.11)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C334(0.86); C474(1.57)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C334(0.83); C474(0.89)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C334(0.88); C474(1.01)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C334(0.74); C474(1.10)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C474(1.03)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C334(0.99); C474(1.11)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C474(0.82); C334(1.32)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C334(0.79); C474(1.06)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C334(0.97); C474(1.08)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C334(0.95); C474(1.06)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C474(1.01); C334(1.10)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C474(0.82); C334(1.19)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C334(0.79); C474(1.08)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C334(0.96)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C334(1.03)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C474(0.97)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C334(0.73)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C334(1.11)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C334(0.80)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C334(0.78)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C334(0.86)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C334(0.76)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C334(0.73)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C334(0.80)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C334(1.26)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C334(0.96)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C474(0.95)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C334(0.80)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C334(1.31)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C334(0.92)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C334(0.70); C474(1.20)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C334(0.79); C474(1.16)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C334(0.89); C474(1.20)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C334(0.90); C474(1.05)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C334(0.87); C474(1.04)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C334(0.77); C474(1.15)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C334(0.75); C474(1.21)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C334(0.88); C474(1.13)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C334(0.82); C474(1.11)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C334(0.77); C474(1.05)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C334(0.83); C474(0.99)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C334(0.88); C474(1.12)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C334(0.87); C474(1.14)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C334(0.81); C474(1.04)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C334(0.77); C474(1.22)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C334(0.68)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C334(0.81)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C474(0.88)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C474(1.05)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C474(0.83)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 11.87  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C375(0.43); C221(0.62); C305(0.74)  LDD2091  [6]
 LDCM0087  Capsaicin HEK-293T 4.54  LDD0185  [7]
 LDCM0108  Chloroacetamide HeLa C375(0.00); C221(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C441(2.61); C474(1.15)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C334(1.09); C474(1.93)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C334(0.94); C474(2.06)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C474(1.18)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C474(0.69)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C474(1.10)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C474(0.84)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C474(0.97)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C334(0.90); C474(1.01)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C474(0.84); C334(0.87)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C334(0.87); C474(0.94)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C474(0.85); C334(1.01)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C474(0.95); C334(0.96)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C334(1.01); C474(1.83)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C334(0.98); C474(1.16)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C334(0.87); C474(0.99)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C334(0.88)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C334(0.84)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C334(0.91)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C334(1.01)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C334(0.96)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C334(0.97)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C334(1.03)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C334(0.97)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C334(0.97); C474(1.72)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C334(1.08)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C334(1.00); C474(1.25)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C334(0.97); C474(1.57)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C334(0.85); C474(1.19)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C334(0.87); C474(1.67)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C474(0.95); C334(1.07)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C474(0.95); C334(1.07)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C474(0.85); C334(1.22)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C474(0.78); C334(0.93)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C334(0.94); C474(1.26)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C334(1.01); C474(1.95)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C334(1.04); C474(1.59)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C334(1.18); C474(1.33)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C474(1.12); C334(1.23)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C474(1.34); C334(1.39)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C334(1.19); C474(1.47)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C334(1.11); C474(1.41)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C334(0.90); C474(1.71)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C334(0.96); C474(1.39)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C334(1.03); C474(1.98)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C334(0.93); C474(1.31)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C334(0.89); C474(1.44)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C334(0.87); C474(1.95)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C334(0.93); C474(1.36)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C334(1.09); C474(1.64)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C334(1.05); C474(1.54)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C334(1.05); C474(1.76)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C334(0.94); C474(1.38)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C334(1.02); C474(1.90)  LDD0736  [12]
 LDCM0420  CL31 PaTu 8988t C334(1.16)  LDD1299  [12]
 LDCM0421  CL32 HCT 116 C474(1.14)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C474(1.13)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C474(1.21)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C474(1.23)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C474(0.94)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C474(1.01)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C474(1.02)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C334(0.90); C474(1.80)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C474(1.10)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C474(1.22)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C474(1.00)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C474(1.05)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C474(1.10)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C474(1.07)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C334(1.22)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C334(1.13)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C334(1.11)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C334(0.91)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C334(1.11); C474(1.11)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C334(1.07)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C334(1.11)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C334(1.01)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C334(1.01)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C334(1.17)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C334(1.11)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C334(1.06)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C334(1.20)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C334(1.04)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C334(1.08)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C334(1.10); C474(1.81)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C334(1.08)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C474(0.78)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C474(0.80)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C474(1.01)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C474(0.81)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C474(0.87)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C474(0.96)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C474(0.80)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C474(0.76)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C474(0.83)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C334(0.98); C474(1.29)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C474(0.84)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C474(0.74)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C474(0.82)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C474(0.78)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C474(0.84)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C334(0.94)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C334(0.83)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C334(0.74)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C334(0.85)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C334(0.92); C474(1.21)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C334(1.04)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C334(0.82)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C334(0.83)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C334(0.81)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C334(0.90)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C334(0.85)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C334(0.82)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C334(0.88)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C334(0.89)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C334(0.89)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C334(0.96); C474(1.57)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C334(0.78)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C474(0.96)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C474(1.00)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C474(0.97)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C474(1.13)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C474(1.11)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C474(0.96)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C474(1.18)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C474(1.10)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C474(1.07)  LDD0811  [12]
 LDCM0634  CY-0357 Hep-G2 C474(0.92)  LDD2228  [17]
 LDCM0495  E2913 HEK-293T C305(0.95); C375(1.12); C221(0.85)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C474(1.17)  LDD1702  [6]
 LDCM0468  Fragment33 HCT 116 C474(0.72)  LDD0785  [12]
 LDCM0427  Fragment51 HCT 116 C474(1.03)  LDD0744  [12]
 LDCM0116  HHS-0101 DM93 Y250(0.68); Y208(0.97); Y431(1.06); Y292(1.08)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y208(0.80); Y250(0.82); Y292(0.82); Y431(0.86)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y298(0.06); Y250(0.60); Y208(0.71); Y292(0.91)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y250(0.72); Y208(0.74); Y431(0.85); Y292(0.91)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y292(0.85); Y208(0.92); Y250(0.99); Y431(1.74)  LDD0268  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [21]
 LDCM0123  JWB131 DM93 Y208(1.44); Y292(0.65)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y208(0.28); Y292(0.70)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y208(2.28); Y292(0.80)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y208(3.79); Y292(2.18)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y208(2.15); Y292(1.29)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y208(1.52); Y292(0.39)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y208(0.47); Y292(0.50)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y208(1.04); Y292(0.78)  LDD0292  [9]
 LDCM0022  KB02 HCT 116 C474(1.14)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C474(1.06)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C474(1.31)  LDD0082  [12]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C375(0.72)  LDD2121  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C221(1.00); C305(1.03)  LDD2093  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C221(0.61)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C221(1.05); C305(1.51)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C221(0.56)  LDD2104  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C375(0.88); C305(1.04)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C221(0.55)  LDD2108  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C375(0.74); C221(1.25)  LDD2111  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C221(2.43)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C375(0.89)  LDD2120  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C334(0.73)  LDD2123  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C221(1.03)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C375(1.27)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C221(0.78)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C221(0.48)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C221(1.83)  LDD2135  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C221(1.12)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C305(1.89)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C221(0.88)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C221(0.58)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C375(1.06); C221(0.77)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C221(2.35)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C221(0.99)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C375(2.45)  LDD2147  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C221(0.55); C305(0.44)  LDD2150  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C221(0.80)  LDD2153  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C441(0.07)  LDD2206  [27]
 LDCM0032  Oleacein HEK-293T 4.21  LDD0184  [7]
 LDCM0628  OTUB2-COV-1 HEK-293T C441(1.03)  LDD2207  [27]
 LDCM0029  Quercetin HEK-293T 5.02  LDD0181  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
FYVE and coiled-coil domain-containing protein 1 (FYCO1) . Q9BQS8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.